Stuart obtained his PhD at La Trobe University, and subsequently undertook research positions at Wageningen University, The Netherlands, and then the University of New South Wales. He moved to Adelaide in 1998 and began his current research interests in examining cell signalling pathways controlled by sphingolipids, and how they contribute to cancer, viral infections, wound healing and other conditions. His research has primarily focused on the molecular mechanisms governing the sphingosine kinases, the pivotal enzymes controlling sphingolipid metabolism, determining how these are altered in disease, and approaches to target these to improve human health. His laboratory has made a number of important contributions to the field, including... Read more
About me
Stuart obtained his PhD at La Trobe University, and subsequently undertook research positions at Wageningen University, The Netherlands, and then the University of New South Wales. He moved to Adelaide in 1998 and began his current research interests in examining cell signalling pathways controlled by sphingolipids, and how they contribute to cancer, viral infections, wound healing and other conditions. His research has primarily focused on the molecular mechanisms governing the sphingosine kinases, the pivotal enzymes controlling sphingolipid metabolism, determining how these are altered in disease, and approaches to target these to improve human health. His laboratory has made a number of important contributions to the field, including the cloning of the first human sphingosine kinase, and identification of key phosphorylations and protein interactions relating to the sphingosine kinases that have (patho)physiological significance, as well as the development of novel inhibitors with potential clinical application.
Research
Excludes commercial-in-confidence projects.
New approaches to enhance immunotherapy for brain tumours, NHMRC - Ideas Grants, 01/01/2023 - 25/12/2025
Targeting sphingolipid metabolism in disease, NHMRC - Senior Principal Research Fellowship, 01/01/2019 - 31/12/2023
A new therapeutic target for proteasome inhibitor resistant multiple myeloma, NHMRC - Project Grant, 01/01/2019 - 31/12/2022
Developing clinically relevant models of recurrent glioblastoma, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022
Dihydroceramide Desaturase-1 (Des1) Inhibitors for the Treatment of Fibrotic Disease, NHMRC - Development Grant, 01/01/2019 - 12/12/2021
Identification and targeting of the master regulators of glioma cancer cell plasticity to overcome therapy resistance in glioblastoma., Neurosurgical Research Foundation, 24/08/2020 - 21/08/2021
Targeting cyclin-dependent kinase 4 in glioblastoma, Neurosurgical Research Foundation, 24/08/2020 - 21/08/2021
Targeting Sphingolipid Metabolism in Acute Myeloid Leukaemia Project, The Hospital Research Foundation, 01/04/2018 - 31/03/2021
Targeting sphingosine kinase 1 to sensitise acute myeloid leukaemia to BH3 mimetic therapy, NHMRC - Project Grant, 01/01/2018 - 31/12/2020
Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 02/03/2020
Modulating sphingolipid signalling to enhance wound healing, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Investigating the role of 14-3-3ζ in medulloblastoma, Neurosurgical Research Foundation, 01/01/2018 - 31/03/2019
Stereotactic alignment and injection system for the generation of xenografts of human brain tumours into the brains of mice for pre-clinical testing of new and existing therapeutics, Neurosurgical Research Foundation, 01/01/2018 - 31/12/2018
Defining the mechanisms regulating tissue mechano-reciprocity in wound healing, NHMRC - Project Grant, 01/01/2016 - 31/12/2018
Sphingosine kinase as a target for anti-cancer therapy, NHMRC - Research Fellowship, 01/01/2014 - 31/12/2018
Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018
Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 31/03/2018
Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer, NHMRC - Project Grant, 01/01/2015 - 31/12/2017
Targeting sphingosine kinases to improve glioblastoma therapy, Neurosurgical Research Foundation, 21/06/2016 - 30/09/2017
Targeting Sphingosine Kinase 1C Degradation to Enhance Chemosensitivity', Central Adelaide Local Health Network Incorporated, 01/01/2016 - 30/06/2017
Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017
Liquid handling robot and cell analysis systems, Neurosurgical Research Foundation, 17/10/2016 - 30/05/2017
Enhancing wound healing via modulation of the sphingosine kinase/ sphingosine 1-phosphate pathway, Royal Adelaide Hospital, 12/02/2015 - 28/02/2016
A new target for allergic inflammation: the sphingolipid pathway, NHMRC - Project Grant, 01/01/2014 - 31/12/2015
Targeting sphingosine kinase 1c degradation to enhance cancer chemotherapeutic sensitivity, Cancer Council SA - Beat Cancer, 01/01/2015 - 31/12/2015
Roles and regulations of sphingosine kinase 1 during dengue virus infection, NHMRC - Project Grant, 01/01/2014 - 31/12/2015
Targetting the CIB1-sphingosine kinase interaction in oncogenesis, NHMRC - Project Grant, 01/01/2014 - 30/04/2015
Research
Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus
Open access indicates that an output is open access.
Year | Output |
---|---|
2018 |
2
1
|
2013 |
1
|
Year | Output |
---|---|
2023 |
4
|
2023 |
Open access
|
2023 |
|
2022 |
Open access
5
6
9
|
2022 |
Open access
10
9
3
|
2022 |
Open access
8
7
12
|
2022 |
Open access
2
1
1
|
2022 |
Open access
7
6
|
2022 |
Open access
11
6
78
|
2022 |
Open access
2
2
4
|
2022 |
Open access
2
1
|
2022 |
Open access
4
3
90
|
2022 |
Open access
8
6
15
|
2021 |
25
20
6
|
2021 |
Open access
22
18
3
|
2021 |
|
2021 |
5
4
|
2021 |
Open access
2
2
2
|
2021 |
5
4
2
|
2020 |
40
37
|
2020 |
Open access
28
24
5
|
2020 |
Open access
25
22
7
|
2019 |
Open access
7
6
5
|
2019 |
21
16
7
|
2019 |
Open access
25
24
1
|
2019 |
Open access
9
8
2
|
2019 |
Open access
16
15
5
|
2019 |
Open access
9
9
|
2019 |
Open access
7
8
1
|
2018 |
Open access
44
48
1
|
2018 |
Open access
24
23
6
|
2018 |
Open access
218
208
7
|
2018 |
Open access
56
56
4
|
2018 |
Open access
16
16
2
|
2017 |
Open access
10
10
2
|
2017 |
Open access
7
7
1
|
2017 |
Open access
52
51
60
|
2017 |
Open access
61
56
85
|
2017 |
Open access
6
6
6
|
2017 |
Open access
23
21
1
|
2017 |
Open access
35
34
7
|
2017 |
Open access
27
26
|
2017 |
Open access
26
23
8
|
2016 |
50
46
6
|
2016 |
Open access
17
15
1
|
2016 |
Open access
7
6
|
2016 |
Open access
60
57
|
2016 |
Open access
4
|
2016 |
Open access
49
47
|
2016 |
Open access
71
72
6
|
2016 |
Open access
46
43
1
|
2016 |
Open access
13
12
8
|
2016 |
Open access
28
27
1
|
2015 |
Open access
16
15
2
|
2015 |
Open access
43
38
|
2015 |
Open access
1
|
2015 |
Open access
26
24
1
|
2015 |
Open access
16
16
1
|
2015 |
Open access
69
68
3
|
2015 |
Open access
28
22
25
|
2015 |
Open access
64
62
1
|
2015 |
Open access
56
52
|
2015 |
Open access
28
23
3
|
2014 |
Open access
93
88
1
|
2014 |
Open access
3
|
2014 |
Open access
24
23
|
2014 |
Open access
61
57
|
2014 |
Open access
117
105
28
|
2013 |
Open access
25
25
3
|
2013 |
36
33
|
2013 |
31
32
|
2013 |
Open access
136
127
4
|
2013 |
Open access
19
16
4
|
2012 |
Open access
115
112
|
2012 |
Open access
57
54
|
2012 |
Open access
109
101
|
2012 |
32
32
|
2012 |
60
58
|
2012 |
31
|
2012 |
22
23
|
2011 |
10
10
|
2011 |
28
25
|
2011 |
26
|
2011 |
Open access
44
35
|
2011 |
47
51
|
2011 |
22
18
|
2011 |
252
238
|
2011 |
21
20
|
2011 |
Open access
30
26
|
2011 |
Open access
40
40
|
2010 |
122
|
2010 |
Open access
50
48
|
2010 |
Open access
104
98
|
2010 |
76
72
|
2010 |
68
65
|
2010 |
Open access
36
33
|
2010 |
Open access
25
24
|
2010 |
Open access
30
28
|
2010 |
Open access
160
151
|
2010 |
Open access
67
63
|
2010 |
62
60
|
2009 |
Open access
36
32
|
2009 |
Open access
17
14
|
2009 |
Open access
27
26
|
2009 |
Open access
7
7
|
2009 |
Open access
31
23
|
2009 |
Open access
48
42
|
2009 |
Open access
18
16
|
2009 |
28
27
|
2008 |
Open access
49
42
|
2008 |
Open access
45
43
|
2008 |
75
|
2008 |
20
|
2008 |
Open access
|
Research
Details | Registry | Status |
---|---|---|
Modulators of 14-3-3 functionality and uses thereof Woodcock, Joanna; Lopez, Angel; Pitson, Stuart M; Samuel, Michael S; Coolen, Carl |
United States | Filed |
Modulators of 14-3-3 functionality and uses thereof Woodcock, Joanna; Lopez, Angel; Pitson, Stuart; Samuel, Michael; Coolen, Carl |
WO | Filed |
External engagement & recognition
Organisation | Country |
---|---|
A-Star, Institute of Molecular and Cell Biology | SINGAPORE |
Australian National University | AUSTRALIA |
Babraham Institute | UNITED KINGDOM |
Baker Heart and Diabetes Institute | AUSTRALIA |
Central Adelaide Local Health Network Incorporated | AUSTRALIA |
Centre Hospitalier Universitaire de Nantes Hôtel Dieu | FRANCE |
Centre Hospitalier Universitaire de Tours | FRANCE |
Charité - Universitätsmedizin Berlin | GERMANY |
CHU la Timone | FRANCE |
City University of New York | UNITED STATES |
City University Of New York, Queens College | UNITED STATES |
Columbia University | UNITED STATES |
Columbia University College of Physicians and Surgeons | UNITED STATES |
Cornell University | UNITED STATES |
Curtin University | AUSTRALIA |
Department of Pathology, CHRU de Lille | FRANCE |
Flinders Medical Centre | AUSTRALIA |
Flinders University | AUSTRALIA |
Garvan Medical Institute | AUSTRALIA |
Griffith University | AUSTRALIA |
Guangzhou Medical University | CHINA |
Hanson Centre for Cancer Research | AUSTRALIA |
Hanson Institute | AUSTRALIA |
Harvard University | UNITED STATES |
Hôpitaux de Toulouse | FRANCE |
Imperial College of Science, Technology and Medicine | UNITED KINGDOM |
Institut de Pharmacologie et de Biologie Structurale | FRANCE |
Institut Universitaire du Cancer de Toulouse–Oncopôle (IUCT-O) | FRANCE |
Institute of Medical and Veterinary Science | AUSTRALIA |
Kanazawa University | JAPAN |
La Trobe University | AUSTRALIA |
Ludwig Maximilian University | GERMANY |
Medical University of Graz | AUSTRIA |
Medical University of Innsbruck | AUSTRIA |
Medical University of South Carolina | UNITED STATES |
Monash Institute of Pharmaceutical Sciences | AUSTRALIA |
Monash University | AUSTRALIA |
Nanyang Technological University | SINGAPORE |
National Institutes of Health | UNITED STATES |
National University of Singapore | SINGAPORE |
Palacky University | CZECH REPUBLIC |
QIMR Berghofer Medical Research Institute | AUSTRALIA |
Queen Elizabeth Hospital | AUSTRALIA |
Queensland University of Technology | AUSTRALIA |
Repatriation General Hospital | AUSTRALIA |
Royal Adelaide Hospital | AUSTRALIA |
Royal Eye & Ear Hospital | AUSTRALIA |
SA Pathology | AUSTRALIA |
Shanghai University | CHINA |
South Australian Health and Medical Research Institute (SAHMRI) | AUSTRALIA |
Southern Medical University | CHINA |
St. Vincent's Institute of Medical Research | AUSTRALIA |
Stanford University | UNITED STATES |
The Alfred Hospital | AUSTRALIA |
The Kinghorn Cancer Centre | AUSTRALIA |
Toulouse University | FRANCE |
University of Adelaide | AUSTRALIA |
University of Auckland | NEW ZEALAND |
University of Chicago | UNITED STATES |
University of Connecticut | UNITED STATES |
University of Essen | GERMANY |
University of Illinois at Chicago | UNITED STATES |
University of Iowa | UNITED STATES |
University of Kent | UNITED KINGDOM |
University of Louisville | UNITED STATES |
University of Melbourne | AUSTRALIA |
University of New South Wales | AUSTRALIA |
University of North Carolina at Chapel Hill | UNITED STATES |
University of Paris | FRANCE |
University of Queensland | AUSTRALIA |
University of South Australia | AUSTRALIA |
University of Strathclyde | UNITED KINGDOM |
University of Sydney | AUSTRALIA |
University of Tennessee | UNITED STATES |
University of Texas | UNITED STATES |
University of Toronto | CANADA |
University Of Toulouse | FRANCE |
University of Toulouse - Jean Jaures | FRANCE |
University of Zurich | SWITZERLAND |
Walter and Eliza Hall Institute of Medical Research | AUSTRALIA |
Washington University | UNITED STATES |
Westmead Hospital | AUSTRALIA |
External engagement & recognition
Engagement/recognition | Year |
---|---|
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2017 |
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2016 |
Project GrantNational Health and Medical Research Council (NHMRC) |
2016 |
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2015 |
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2014 |
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2013 |
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2012 |
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2011 |
NHMRC Senior Research FellowInstitute of Medical and Veterinary Science (IMVS) |
2010 |
Teaching & student supervision
Supervisions from 2010 shown
Thesis title | Student status |
---|---|
110188-Enhancing therapy of acute myeloid leukaemia by predicting drivers of relapse | Current |
Defining the origin of schizophrenia like defects arising from 14-3-3 zeta deficiency. | Current |
Identifying optimal immunotherapy combinations for the treatment of brain tumours | Current |
Investigating the role of CD47 in cancer to develop novel antitumor treatment strategies | Current |
Novel angiocrine roles for Igf1 in epidermal development and wound healing | Current |
Targeting sphingosine kinase 1 to improve acute myeloid leukaemia chemotherapy. | Current |
Understanding the role of 14-3-3 proteins in lung cancer initiation, progression and metastasis. | Current |
Investigating the roles of 14-3-3zeta in the mammary tumour microenvironment | Completed |
Peroxisome proliferator-activated receptor gamma interacts with sphingosine 1-phosphate to regulate vascular function | Completed |
Targeting sphingolipid metabolism in proteasome inhibitor-resistant multiple myeloma | Completed |
Targeting sphingosine kinase 1 in acute myeloid leukaemia | Completed |