Professor Stuart Pitson

Research Professor Centre for Cancer Biology

City West Campus (HB10-11)
tel +61 8 830 27832

email Stuart.Pitson@unisa.edu.au

Research Degree Supervisor

About me

Stuart obtained his PhD at La Trobe University, and subsequently undertook research positions at Wageningen University, The Netherlands, and then the University of New South Wales. He moved to Adelaide in 1998 and began his current research interests in examining cell signalling pathways controlled by sphingolipids, and how they contribute to cancer, viral infections, wound healing and other conditions. His research has primarily focused on the molecular mechanisms governing the sphingosine kinases, the pivotal enzymes controlling sphingolipid metabolism, determining how these are altered in disease, and approaches to target these to improve human health. His laboratory has made a number of important contributions to the field, including... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Orcid
Scopus

Research

Research focus

Biochemistry and Cell Biology
Clinical Sciences
Oncology and Carcinogenesis
Biological Sciences
Medical and Health Sciences

Research

Projects

Excludes commercial-in-confidence projects.

Supporting Australian Brain Cancer Research with an integrated network of platforms, Medical Research Future Fund, 01/07/2023 - 30/06/2028
Drug Target Identification Platform, Medical Research Future Fund, 30/06/2023 - 29/06/2028
Overcoming the blood-brain barrier for improved brain tumour therapy, Fay Fuller Foundation, 01/07/2024 - 30/06/2027
Targeting a common genetic alteration in glioblastoma, Neurosurgical Research Foundation, 16/09/2024 - 15/09/2026
Understanding the biology of treatment resistant brain tumours so that new therapeutic approaches can be developed, Neurosurgical Research Foundation, 04/07/2024 - 31/12/2025
A new therapeutic approach for glioblastoma, Brain Foundation - Annual Research Awards, 01/01/2025 - 31/12/2025
New approaches to enhance immunotherapy for brain tumours, NHMRC - Ideas Grants, 01/01/2023 - 25/12/2025
Targeting sphingosine kinase 1 as a novel therapeutic strategy in childhood medulloblastoma, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Combined targeting of CD47 and cysteine metabolism to treat glioblastoma, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Pre-clinical evaluation of sphingosine kinase 2 inhibitors as new glioblastoma therapeutics, Neurosurgical Research Foundation, 01/10/2024 - 30/09/2025
Targeting genetic defects in glioblastoma, Neurosurgical Research Foundation, 15/09/2024 - 12/09/2025
Bioengineering a Superior Humanized Haematopoietic Niche Derived from Mesenchymal Stem Cells for Pre-Clinical Avatar Cancer Trials, MRFF-Stem Cell Therapies Mission, 01/08/2023 - 31/07/2025
Targeting sphingolipid metabolism in disease, NHMRC - Senior Principal Research Fellowship, 01/01/2019 - 31/12/2023
A new therapeutic target for proteasome inhibitor resistant multiple myeloma, NHMRC - Project Grant, 01/01/2019 - 31/12/2022
Developing clinically relevant models of recurrent glioblastoma, Neurosurgical Research Foundation, 30/08/2021 - 31/08/2022
Dihydroceramide Desaturase-1 (Des1) Inhibitors for the Treatment of Fibrotic Disease, NHMRC - Development Grant, 01/01/2019 - 12/12/2021
Identification and targeting of the master regulators of glioma cancer cell plasticity to overcome therapy resistance in glioblastoma., Neurosurgical Research Foundation, 24/08/2020 - 21/08/2021
Targeting cyclin-dependent kinase 4 in glioblastoma, Neurosurgical Research Foundation, 24/08/2020 - 21/08/2021
Targeting Sphingolipid Metabolism in Acute Myeloid Leukaemia Project, The Hospital Research Foundation, 01/04/2018 - 31/03/2021
Targeting sphingosine kinase 1 to sensitise acute myeloid leukaemia to BH3 mimetic therapy, NHMRC - Project Grant, 01/01/2018 - 31/12/2020
Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 02/03/2020
Modulating sphingolipid signalling to enhance wound healing, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Investigating the role of 14-3-3ζ in medulloblastoma, Neurosurgical Research Foundation, 01/01/2018 - 31/03/2019
Stereotactic alignment and injection system for the generation of xenografts of human brain tumours into the brains of mice for pre-clinical testing of new and existing therapeutics, Neurosurgical Research Foundation, 01/01/2018 - 31/12/2018
Defining the mechanisms regulating tissue mechano-reciprocity in wound healing, NHMRC - Project Grant, 01/01/2016 - 31/12/2018
Sphingosine kinase as a target for anti-cancer therapy, NHMRC - Research Fellowship, 01/01/2014 - 31/12/2018
Cancer Discovery Accelerator, Australian Cancer Research Foundation, 01/06/2016 - 31/07/2018
Central Adelaide Local Health Network Incorporated Scholarship, Central Adelaide Local Health Network Incorporated, 01/01/2016 - 31/03/2018
Defining the role of a palmitoylated variant of sphingosine kinase 1 in cancer, NHMRC - Project Grant, 01/01/2015 - 31/12/2017
Targeting sphingosine kinases to improve glioblastoma therapy, Neurosurgical Research Foundation, 21/06/2016 - 30/09/2017
Targeting Sphingosine Kinase 1C Degradation to Enhance Chemosensitivity', Central Adelaide Local Health Network Incorporated, 01/01/2016 - 30/06/2017
Cancer Discovery Accelerator, Cancer Council SA - Beat Cancer, 08/06/2016 - 08/06/2017
Liquid handling robot and cell analysis systems, Neurosurgical Research Foundation, 17/10/2016 - 30/05/2017
Enhancing wound healing via modulation of the sphingosine kinase/ sphingosine 1-phosphate pathway, Royal Adelaide Hospital, 12/02/2015 - 28/02/2016

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2018	Pitman, MR, Davies, LT & Pitson, SM 2018, 'An improved isoform-selective assay for sphingosine kinase 1 activity', in A Pebay & K Turksen (eds), Sphingosine-1-Phosphate, Humana Press, Inc., US, ch. 2, pp. 9-20. 2 1
2013	Pitman, MR, Jarman, K, Leclercq, T, Pham, D & Pitson, SM 2013, 'Sphingosine kinases: biochemistry, regulation, and roles', in J Chun et al. (eds), Lysophospholipid Receptors: Signaling and Biochemistry, Wiley-Blackwell, US, ch. 9, pp. 153-183. 1

Journal Articles

Year	Output
2024	Calabrese, C, Nolte, H, Pitman, MR, Ganesan, R, Lampe, P, Laboy, R, Ripa, R, Fischer, J, Polara, R, Panda, SK, Chipurupalli, S, Gutierrez, S, Thomas, D, Pitson, SM, Antebi, A & Robinson, N 2024, 'Mitochondrial translocation of TFEB regulates complex I and inflammation', EMBO Reports, vol. 25, no. 2, pp. 704-724. Open access 3 3 38
2024	Johan, MZ, Pyne, NT, Kolesnikoff, N, Poltavets, V, Esmaeili, Z, Woodcock, JM, Lopez, AF, Cowin, AJ, Pitson, SM & Samuel, MS 2024, 'Accelerated closure of diabetic wounds by efficient recruitment of fibroblasts upon inhibiting a 14-3-3/ROCK regulatory axis', Journal of Investigative Dermatology, vol. 144, no. 11, pp. 2562-2573e4. Open access 4
2024	Li, M, Bennett, MK, Toubia, J, Pope, VS, Tea, MN, Tamang, S, Samuel, MS, Anderson, PH, Gliddon, BL, Powell, JA & Pitson, SM 2024, 'An orthotopic syngeneic mouse model of bortezomib-resistant multiple myeloma', British Journal of Haematology, 204, no. 2, pp. 566-570. Open access 1
2024	Nwosu, GO, Ross, DM, Powell, JA & Pitson, SM 2024, 'Venetoclax therapy and emerging resistance mechanisms in acute myeloid leukaemia', Cell Death and Disease, vol. 15, no. 6, article no. 413, pp. 1-11. Open access 1 1 1
2024	Polara, R, Ganesan, R, Pitson, SM & Robinson, N 2024, 'Cell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity', Cell Death and Differentiation, vol. 31, pp. 1255-1266. Open access 3
2024	Yu, W, Truong, NT, Polara, R, Gargett, T, Tea, MN, Pitson, SM, Cockshell, MP, Bonder, CS, Ebert, LM & Brown, MP 2024, 'Endogenous bystander killing mechanisms enhance the activity of novel FAP-specific CAR-T cells against glioblastoma', Clinical and Translational Immunology, vol. 13, no. 7, pp. 1-20. Open access 1 1 4
2023	Conn, VM, Gabryelska, M, Toubia, J, Kirk, K, Powell, JA, Cildir, G, Samaraweera, SE, Bailey, S, Liu, D, Wallington-Gates, CT, D'Andrea, RJ, Pitson, SM, Goodall, GJ & Conn, SJ and 15 other authors 2023, 'Circular RNAs drive oncogenic chromosomal translocations within the MLL recombinome in leukemia', Cancer Cell, vol. 41, no. 7, pp. 1309-1326. 30 29 268
2023	Lazniewska, J, Li, KL, Johnson, IR, Sorvina, A, Logan, JM, Martini, C, Moore, C, Ung, BS, Karageorgos, L, Hickey, SM, Prabhakaran, S, Heatlie, JK, Brooks, RD, Huzzell, C, Warnock, N I, Moretti, P, Pitson, SM & Brooks, DA and 10 other authors 2023, 'Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression', Scientific Reports, vol. 13, no. 1, article no. 13489, pp. 1-18. Open access 5 5
2023	Subramanian, S, Thoms, JA, Huang, Y, Cornejo-Páramo, P, Powell, JA, Lewis, ID, Pitson, SM & Pimanda, JE and 21 other authors 2023, 'Genome-wide transcription factor-binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs', Blood, vol. 142, no. 17, pp. 1448-1462. Open access 12 11 12
2023	Yip, KH, Chao, J, Coolen, C, Pant, H, Kral, A, Smith, W, Schwarz, Q, Grimbaldeston, MA, Pitson, S, Lopez, AF, Woodcock, J & Tumes, DJ 2023, 'IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ', Journal of Allergy and Clinical Immunology, vol. 152, no. 3, pp. 725-735. Open access 2 2 2
2022	Bassal, MA, Samaraweera, SE, Lim, K, Bernard, BA, Bailey, S, Toubia, J, Nguyen, T, Maung, KZY, Casolari, DA, Iarossi, DG, Powell, J, Pitson, S, Brown, AL, Robinson, N, Ross, DM, Gonda, TJ & D'Andrea, RJ and 10 other authors 2022, 'Germline mutations in mitochondrial complex I reveal genetic and targetable vulnerability in IDH1-mutant acute myeloid leukaemia', Nature Communications, vol. 13, article no. 2614, pp. 1-12. Open access 11 11 9
2022	Bennett, MK, Li, M, Tea, MN, Pitman, MR, Toubia, J, Wang, PP, Anderson, D, Creek, DJ, Orlowski, RZ, Gliddon, BL, Powell, JA, Wallington-Beddoe, CT & Pitson, SM 2022, 'Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition', Neoplasia, vol. 24, no. 1, pp. 1-11. Open access 14 13 3
2022	Ebert, LM, Vandyke, K, Johan, MZ, DeNichilo, M, Tan, LY, Myo Min, KK, Weimann, BM, Ebert, BW, Pitson, SM, Zannettino, AC, Wallington-Beddoe, CT & Bonder, CS 2022, 'Desmoglein-2 expression is an independent predictor of poor prognosis patients with multiple myeloma', Molecular Oncology, vol. 16, no. 6, pp. 1221-1240. Open access 11 11 13
2022	Gomez-Brouchet, A, Illac, C, Ledoux, A, Fortin, P-Y, de Barros, S, Vabre, C, Despas, F, Peries, S, Casaroli, C, Bouvier, C, Aubert, S, de Pinieux, G, Larousserie, F, Galmiche, L, Talmont, F, Pitson, S, Maddelein, M-L & Cuvillier, O 2022, 'Sphingosine kinase-1 is overexpressed and correlates with hypoxia in osteosarcoma: relationship with clinicopathological parameters', Cancers, vol. 14, no. 3, article no. 499, pp. 1-17. Open access 3 2
2022	Kollis, PM, Ebert, LM, Toubia, J, Bastow, CR, Ormsby, RJ, Poonnoose, S I, Lenin, S, Tea, MN, Pitson, SM, Gomez, GA, Brown, MP & Gargett, T 2022, 'Characterising distinct migratory profiles of infiltrating T-Cell subsets in human glioblastoma', Frontiers in Immunology, vol.13, pp. 1-19. Open access 16 13
2022	Lewis, AC, Pope, VS, Tea, MN, Li, M, Nwosu, GO, Nguyen, TM, Wallington-Beddoe, CT, Moretti, PA, Costabile, M, Ali, SR, Dredge, BK, Bert, AG, Goodall, GJ, Brown, AL, D'Andrea, R, Robinson, N, Pitman, MR, Ross, DM, Gliddon, BL, Powell, JA & Pitson, SM and 5 other authors 2022, 'Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia', Blood, vol. 139, no. 26, pp. 3737-3751. Open access 26 22 71
2022	Mahabaleshwar, H, Asharani, P, Loo, TY, Koh, SY, Pitman, MR, Kwok, S, Ma, J, Hu, B, Lin, F, Li Lok, X, Pitson, SM, Saunders, TE & Carney, TJ 2022, 'Slit-Robo signalling establishes a Sphingosine-1-phosphate gradient to polarise fin mesenchyme', EMBO Reports, vol. 23, no. 8, pp. 1-14. Open access 2 2 4
2022	Nwosu, GO, Powell, JA & Pitson, SM 2022, 'Targeting the integrated stress response in hematologic malignancies', Experimental Hematology and Oncology, vol. 11, no. 1, pp. 1-15. Open access 7 6 1
2022	Pitman, MR, Lewis, AC, Davies, LT, Moretti, PA, Anderson, D, Creek, DJ, Powell, JA & Pitson, SM 2022, 'The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism', Scientific Reports, vol. 12, no. 1, article no.454, pp. 1-12. Open access 10 9 90
2022	Tvorogov, D, Thompson-Peach, CA, Foßelteder, J, Dottore, M, Stomski, F, Onnesha, SA, Lim, K, Moretti, PA, Pitson, SM, Ross, DM, Reinisch, A, Thomas, D & Lopez, AF 2022, 'Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody', EMBO Reports, vol. 23, no. 4, article no. e52904. Open access 15 15 12
2021	Duszyc, K, Gomez, GA, Lagendijk, AK, Yau, MK, Nanavati, BN, Gliddon, BL, Hall, TE, Verma, S, Hogan, BM, Pitson, SM, Fairlie, DP, Parton, RG & Yap, AS 2021, 'Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion', Current Biology, vol. 31, no. 6, pp. 1326-1336. 38 35 7
2021	Lenin, S, Ponthier, E, Scheer, KG, Yeo, EC, Tea, MN, Ebert, LM, Mansilla, MO, Poonnoose, S, Baumgartner, U, Day, BW, Ormsby, RJ, Pitson, SM & Gomez, GA 2021, 'A drug screening pipeline using 2d and 3d patient-derived in vitro models for pre-clinical analysis of therapy response in glioblastoma', International Journal of Molecular Sciences, vol. 22, no. 9, article no. 4322, pp. 1-27. Open access 28 29 5
2021	Mansilla, MO, Salazar-Hernandez, C, Perrin, SL, Scheer, KG, Cildir, G, Toubia, J, Sedivakova, K, Tea, MN, Lenin, S, Ponthier, E, Yeo, EC, Tergaonkar, V, Poonnoose, S, Ormsby, RJ, Pitson, SM, Brown, MP, Ebert, LM & Gomez, GA 2021, '3D-printed microplate inserts for long term high-resolution imaging of live brain organoids', BMC Biomedical Engineering, vol. 3, article no. 6, pp. 1-13. Open access 14
2021	Pham, DH, Pitman, MR, Kumar, R, Jolly, LA, Pitson, SM & Gecz, J and 16 other authors 2021, 'Integrated in silico and experimental assessment of disease relevance of PCDH19 missense variants', Human Mutation, vol. 42, no. 8, pp. 1030-1041. 1 1
2021	Pitman, MR, Oehler, MK & Pitson, SM 2021, 'Sphingolipids as multifaceted mediators in ovarian cancer', Cellular Signalling, vol. 81, article no. 109949, pp. 1-18. 8 8
2021	Savira, F, Kompa, AR, Kelly, DJ, Magaye, R, Xiong, X, Huang, L, Liew, D, Reid, C, Kaye, D, Scullino, C V, Pitson, SM, Flynn, BL & Wang, BH 2021, 'The effect of dihydroceramide desaturase 1 inhibition on endothelial impairment induced by indoxyl sulfate', Vascular Pharmacology, vol. 141, article no. 106923, pp. 1-9. Open access 4 4 2
2021	Savira, F, Magaye, R, Scullino, C V, Flynn, BL, Pitson, SM, Anderson, D, Creek, DJ, Hua, Y, Xiong, X, Huang, L, Liew, D, Reid, C, Kaye, D, Kompa, AR & Wang, BH 2021, 'Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition', Toxicology Letters, vol. 350, pp. 133-142. 8 8 2
2020	Boyle, ST, Poltavets, V, Kular, J, Pyne, NT, Sandow, JJ, Lewis, AC, Murphy, KJ, Kolesnikoff, N, Moretti, PAB, Tea, MN, Tergaonkar, V, Timpson, P, Pitson, SM, Webb, AI, Whitfield, RJ, Lopez, AF, Kochetkova, M & Samuel, MS 2020, 'ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism', Nature Cell Biology, vol. 22, no. 7, pp. 882-895. 52 52 854
2020	Ebert, LM, Yu, W, Gargett, T, Toubia, J, Kollis, PM, Tea, MN, Ebert, BW, Bonder, CS, Oksdath Mansilla, M, Scheer, KG, Perrin, SL, Pitson, SM, Gomez, GA & Brown, MP and 8 other authors 2020, 'Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy', Clinical and Translational Immunology, vol. 9, no. 10, article no. e1191. Open access 46 41 4
2020	Tea, MN, Poonnoose, S I & Pitson, SM 2020, 'Targeting the sphingolipid system as a therapeutic direction for glioblastoma', Cancers, vol. 12, no. 1, pp. 1-25. Open access 30 29 6
2019	Al-Shujairi, WH, Clarke, JN, Davies, LT, Pitman, MR, Calvert, JK, Aloia, AL, Pitson, SM & Carr, JM 2019, 'In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection', Journal of General Virology, vol. 110, no. 4, pp. 629-641. Open access 10 9 5
2019	Bennett, MK, Wallington-Beddoe, CT & Pitson, SM 2019, 'Sphingolipids and the unfolded protein response', BBA: Molecular and Cell Biology of Lipids, vol. 1864, no. 10, pp. 1483-1494. 23 22 7
2019	Gachechiladze, M, Tichy, T, Kolek, V, Grygarkova, I, Klein, J, Mgebrishvili, G, Kharaishvili, G, Janikova, M, Smickova, P, Cierna, L, Pitson, S, Maddelein, ML, Cuvillier, O & Skarda, J 2019, 'Sphingosine kinase-1 predicts overall survival outcomes in non-small cell lung cancer patients treated with carboplatin and navelbine', Oncology Letters, vol. 18, no. 2, pp. 1259-1266. Open access 27 24 1
2019	Jiang, ZJ, Delaney, TL, Zanin, MP, Haberberger, R V, Pitson, SM, Huang, J, Alford, S, Cologna, SM, Keating, DJ & Gong, LW 2019, 'Extracellular and intracellular sphingosine-1-phosphate distinctly regulates exocytosis in chromaffin cells', Journal of Neurochemistry, vol. 149, no. 6, pp. 729-746. Open access 10 9 2
2019	Neubauer, HA, Tea, MN, Zebol, JR, Gliddon, BL, Stefanidis, C, Moretti, PA, Pitman, MR, Costabile, M, Kular, J, Stringer, BW, Day, BW, Samuel, MS, Bonder, CS, Powell, JA & Pitson, SM 2019, 'Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma', Oncogene, vol. 38, pp. 1151-1165. Open access 19 18 5
2019	Powell, JA, Pitman, MR, Zebol, JR, Moretti, PA, Neubauer, HA, Davies, LT, Lewis, AC, Dagley, LF, Webb, A I, Costabile, M & Pitson, SM 2019, 'Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1', Biochemical Journal, vol. 476, no. 21, pp. 3211-3226. Open access 11 11
2019	Wallington-Beddoe, CT, Xie, V, Tong, D, Powell, JA, Lewis, AC, Davies, L, Pitson, SM, Bradstock, KF & Bendall, LJ 2019, 'Identification of sphingosine kinase 1 as a therapeutic target in B-lineage acute lymphoblastic leukaemia', British Journal of Haematology, vol. 184, no. 3, pp. 443-447. Open access 11 11 1
2018	Lewis, AC, Wallington-Beddoe, CT, Powell, JA & Pitson, SM 2018, 'Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies', Cell Death Discovery, vol. 4, no. 1, article no. 72, pp. 1-11. Open access 56 59 1
2018	Lidgerwood, GE, Pitson, SM, Bonder, C & Pébay, A 2018, 'Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology', Progress in Lipid Research, vol. 72, pp. 42-54. Open access 28 29 6
2018	Poltavets, V, Kochetkova, M, Pitson, SM & Samuel, MS 2018, 'The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity', Frontiers in Oncology, vol. 8, article no. 431, pp. 1-19. Open access 269 263 7
2018	Wallington-Beddoe, CT, Sobieraj-Teague, M, Kuss, BJ & Pitson, SM 2018, 'Resistance to proteasome inhibitors and other targeted therapies in myeloma', British Journal of Haematology, vol. 182, pp. 11-28. Open access 79 77 5
2018	Woodcock, JM, Goodwin, KL, Sandow, JJ, Coolen, C, Perugini, MA, Webb, A I, Pitson, SM, Lopez, AF & Carver, JA 2018, 'Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity', Journal of Biological Chemistry, vol. 293, no. 1, pp. 89-99. Open access 19 19 2
2017	Al-Shujairi, WH, Clarke, JN, Davies, LT, Alsharifi, M, Pitson, SM & Carr, JM 2017, 'Intracranial injection of dengue virus induces interferon stimulated genes and CD8+ T cell infiltration by sphingosine kinase 1 independent pathways', PLoS One, vol. 12, article no. e0169814, pp. 1-21. Open access 11 11 2
2017	Aloia, AL, Calvert, JK, Clarke, JN, Davies, LT, Helbig, KJ, Pitson, SM & Carr, JM 2017, 'Investigation of sphingosine kinase 1 in interferon responses during dengue virus infection', Clinical and Translational Immunology, vol. 6, no. 7, article no. e151, pp. 1-9. Open access 7 7 1
2017	Hein, N, Cameron, DP, Hannan, KM, Nguyen, N-Y, Powell, JA, Pitson, SM & Hannan, RD and 23 other authors 2017, 'Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population', Blood, vol. 129, pp. 2882-2895. Open access 64 64 56
2017	Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782. Open access 75 72 85
2017	Rojas-Canales, D, Penko, D, Myo Min, KK, Parham, KA, Peiris, H, Haberberger, R V, Pitson, SM, Drogemuller, C, Keating, DJ, Grey, ST, Coates, PT, Bonder, CS & Jessup, CF 2017, 'Local sphingosine kinase 1 activity improves islet transplantation', Diabetes, vol. 66, no. 5, pp. 1301-1311. Open access 6 6 6
2017	Tran, HB, Jersmann, H, Truong, TT, Hamon, R, Roscioli, E, Ween, M, Pitman, MR, Pitson, SM, Hodge, G, Reynolds, PN & Hodge, S 2017, 'Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD', PLoS One, vol.12, no. 11, pp. 1-14. Open access 27 26 1
2017	Wallington-Beddoe, CT, Bennett, MK, Vandyke, K, Davies, L, Zebol, JR, Moretti, PA, Pitman, MR, Hewett, DR, Zannettino, AC & Pitson, SM 2017, 'Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress', Oncotarget, vol. 8, no. 27, pp. 43602-43616. Open access 38 37 8
2017	Zhu, W, Gliddon, B, Jarman, K, Moretti, P, Tin, T, Parise, L, Woodcock, J, Powell, J, Ruszkiewicz, A, Pitman, M & Pitson, S 2017, 'CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1', Oncogene, vol. 36, no. 18, pp. 2619-2627. Open access 29 27
2017	Zhu, W, Jarman, KE, Lokman, NA, Neubauer, HA, Davies, LT, Gliddon, BL, Taing, H, Moretti, PA, Oehler, MK, Pitman, MR & Pitson, SM 2017, 'CIB2 negatively regulates oncogenic signaling in ovarian cancer via sphingosine kinase 1', Cancer Research, vol. 77, no. 18, pp. 4823-4834. Open access 27 24 8
2016	Aurelio, L, Scullino, C V, Pitman, MR, Sexton, A, Oliver, V, Davies, L, Rebello, RJ, Furic, L, Creek, DJ, Pitson, SM & Flynn, BL 2016, 'From sphingosine kinase to dihydroceramide desaturase: A structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)', Journal of Medicinal Chemistry, vol. 59, pp. 965-984. 53 49 6
2016	Clarke, JN, Davies, LK, Calvert, JK, Gliddon, BL, Al, SWH, Aloia, AL, Helbig, KJ, Beard, MR, Pitson, SM & Carr, JM 2016, 'Reduction in sphingosine kinase 1 influences the susceptibility to dengue virus infection by altering antiviral responses', Journal of General Virology, vol. 97, no. 1, pp. 95-109. Open access 17 15
2016	Dimasi, DP, Pitson, SM & Bonder, CS 2016, 'Examining the role of sphingosine kinase-2 in the regulation of endothelial cell barrier integrity', Microcirculation, vol. 23, no. 3, pp. 248-265. Open access 8 7 3
2016	McNaughton, M, Pitman, M, Pitson, SM, Pyne, NJ & Pyne, S 2016, 'Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells', Oncotarget, vol. 7, no. 13, pp. 16663-16675. Open access 65 62
2016	Neubauer, HA & Pitson, SM 2016, 'Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence', F1000Research, vol. 5, article no. 2825 , pp. 1-12. Open access 4
2016	Neubauer, HA, Pham, DH, Zebol, JR, Moretti, PA, Peterson, AL, Leclercq, TM, Chan, H, Powell, JA, Pitman, MR, Samuel, MS, Bonder, CS, Creek, DJ, Gliddon, BL & Pitson, SM 2016, 'An oncogenic role for sphingosine kinase 2', Oncotarget, vol. 7, no. 40, pp. 64886-64899. Open access 51 48
2016	Pitman, MR, Costabile, M & Pitson, SM 2016, 'Recent advances in the development of sphingosine kinase inhibitors', Cellular Signalling, vol. 28, no. 9, pp. 1349-1363. Open access 80 80 6
2016	Schoenwaelder, SM, Darbousset, R, Cranmer, SL, Ramshaw, HS, Woodcock, J, Pitson, S, Lopez, AF & Jackson, SP and 13 other authors 2016, '14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function', Nature Communications, vol. 7, article no. 12862, pp. 1-15. Open access 51 49 1
2016	Sun, WY, Dimasi, DP, Pitman, MR, Zhuang, Y, Heddle, R, Pitson, SM, Grimbaldeston, MA & Bonder, CS 2016, 'Topical application of fingolimod perturbs cutaneous inflammation', Journal of Immunology, vol. 196, no. 9, pp. 3854-3864. Open access 14 13 11
2016	Tran, HB, Barnawi, J, Ween, M, Hamon, R, Roscioli, E, Hodge, G, Reynolds, PN, Pitson, SM, Davies, LT, Haberberger, R & Hodge, S 2016, 'Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720', Journal of Leukocyte Biology, vol. 100, no.1, pp. 195-202. Open access 29 28 1
2015	Aloia, AL, Abraham, AM, Bonder, CS, Pitson, SM & Carr, JM 2015, 'Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs', Mediators of Inflammation, vol. 2015, article no. 509306, pp. 1-13. Open access 19 18 2
2015	Barnawi, J, Tran, H, Jersmann, H, Pitson, SM, Roscioli, E, Hodge, G, Meech, R, Haberberger, R & Hodge, S 2015, 'Potential link between the sphingosine-1-phosphate (S1P) system and defective alveolar macrophage phagocytic function in chronic obstructive pulmonary disease (COPD)', PLoS One, vol. 10, no. 10, article no. e0122771. Open access 48 44
2015	Beroukas, D, Selhorst, M, Pitson, SM, Matusica, D, Gibbins, IL, Kress, M & Haberberger, R V 2015, 'Sphingosine kinase 1 in murine dorsal root ganglia', AIMS Molecular Science, vol. 2, no. 1, pp. 22-33. Open access 1
2015	Calvert, JK, Helbig, KJ, Dimasi, D, Cockshell, M, Beard, MR, Pitson, SM, Bonder, CS & Carr, JM 2015, 'Dengue virus infection of primary endothelial cells induces innate immune responses, changes in endothelial cells function and is restricted by interferon-stimulated responses', Journal of Interferon and Cytokine Research, vol. 35, no. 8, pp. 654-665. Open access 28 26
2015	Canlas, J, Holt, P, Carroll, A, Rix, S, Ryan, P, Davies, L, Matusica, D, Pitson, SM, Jessup, CF, Gibbins, IL & Haberberger, R V 2015, 'Sphingosine kinase 2-deficiency mediated changes in spinal pain processing', Frontiers in Molecular Neuroscience, vol. 8, no. 29, pp. 1-13. Open access 16 17 1
2015	Etemadi, N, Chopin, M, Anderton, H, Tanzer, MC, Rickard, JA, Abeysekera, W, Hall, C, Spall, SK, Wang, B, Xiong, Y, Hla, T, Pitson, SM, Bonder, CS, Wong, WW-L, Ernst, M, Smyth, GK, Vaux, DL, Nutt, SL, Nachbur, U & Silke, J 2015, 'TRAF2 regulates TNF and NF-kappa B signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1', eLife, vol. 4, article no. e10592, pp. 1-27. Open access 81 77 3
2015	Kular, J, Scheer, KG, Pyne, NT, Allam, AH, Pollard, AN, Magenau, A, Wright, RL, Kolesnikoff, N, Moretti, PA, Wullkopf, L, Stomski, FC, Cowin, AJ, Woodcock, JM, Grimbaldeston, MA, Pitson, SM, Timpson, P, Ramshaw, HS, Lopez, AF & Samuel, MS 2015, 'A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis', Developmental Cell, vol.35, no. 6, pp. 759 - 774. Open access 30 24 24
2015	Parham, KA, Zebol, JR, Tooley, KL, Sun, WY, Moldenhauer, LM, Cockshell, MP, Gliddon, BL, Moretti, PA, Tigyi, G, Pitson, SM & Bonder, CS 2015, 'Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis', The FASEB Journal, vol. 29, no. 9, pp. 3638-3653. Open access 76 73 1
2015	Pitman, MR, Powell, JA, Coolen, C, Moretti, PA, Zebol, JR, Pham, DH, Finnie, JW, Don, AS, Ebert, LM, Bonder, CS, Gliddon, BL & Pitson, SM 2015, 'A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties', Oncotarget, vol. 6, no. 9, pp. 7065-7083. Open access 62 59
2015	Woodcock, JM, Coolen, C, Goodwin, KL, Baek, DJ, Bittman, R, Samuel, MS, Pitson, SM & Lopez, AF 2015, 'Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics', Oncotarget, vol. 6, no. 16, pp. 14522-14536. Open access 33 29 3
2014	Ceccom, J, Loukh, N, Lauwers-, CV, Touriol, C, Nicaise, Y, Gentil, C, Uro-Coste, E, Pitson, S, Maurage, CA, Duyckaerts, C, Cuvillier, O & Delisle, M-B 2014, 'Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer's disease', Acta Neuropathologica Communications, vol. 2, pp. 1-10. Open access 105 105 1
2014	Parham, KA, Pitson, SM & Bonder, CS 2014, 'Regulation of EPCs: The Gateway to Blood Vessel Formation', New Journal of Science, vol. 2014, article no. 972043, pp. 1-16. Open access 3
2014	Pham, D, Powell, J, Gliddon, B, Moretti, P, Tsykin, A, Van Der Hoek, M, Kenyon, R, Goodall, G & Pitson, S 2014, 'Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1', Oncogene, vol. 33, no. 48, pp. 5559-5568. Open access 25 24
2014	Wallington-Beddoe, GT, Powell, JA, Tong, D, Pitson, SM, Bradstock, KF & Bendall, LJ 2014, 'Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression', Cancer Research, vol. 74, no. 10, pp. 2803-2815. Open access 66 62
2014	Yamane, D, McGivern, DR, Wauthier, E, Yi, M, Pitson, SM & Lemon, SM and 18 other authors 2014, 'Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation', Nature Medicine, vol. 20, pp. 927-935. Open access 127 115 31
2013	Carr, J, Kua, T, Clarke, J, Calvert, J, Zebol, J, Beard, M & Pitson, S 2013, 'Reduced sphingosine kinase 1 activity in dengue virus type-2 infected cells can be mediated by the 3' untranslated region of dengue virus type-2 RNA', Journal of General Virology, vol. 94, part 11, pp. 2437-2448. Open access 28 28
2013	Carr, JM, Mahalingam, S, Bonder, CS & Pitson, SM 2013, 'Sphingosine kinase 1 in viral infections', Reviews in Medical Virology, vol. 23 no. 2, pp. 73-84. 38 36
2013	Chan, H & Pitson, SM 2013, 'Post-translational regulation of sphingosine kinases', BBA: Molecular and Cell Biology of Lipids, vol. 1831, no. 1, pp. 147-156. 32 33
2013	Neubauer, HA & Pitson, SM 2013, 'Roles, regulation and inhibitors of sphingosine kinase 2', The Federation of European Biochemical Societies (FEBS) Journal, vol. 280, no. 21, pp. 5317-5336. Open access 141 137
2013	Thomas, D, Powell, JA, Green, BD, Barry, EF, Ma, Y, Woodcock, J, Fitter, S, Zannettino, AC, Pitson, SM, Hughes, TP, Lopez, AF, Shepherd, PR, Wei, AH, Ekert, PG & Guthridge, MA 2013, 'Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival', PLoS Biology, vol. 11, no. 3, article no. e1001515, pp. 1-14. Open access 19 16
2012	Bruce, CR, Risis, S, Babb, JR, Yang, C, Kowalski, GM, Selathurai, A, Lee-Young, RS, Weir, JM, Yoshioka, K, Takuwa, Y, Meikle, PJ, Pitson, SM & Febbraio, MA 2012, 'Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice', Diabetes, vol. 61, no. 12, pp. 3148-3155. Open access 123 120
2012	Hercus, TR, Broughton, SE, Ekert, PG, Ramshaw, HS, Perugini, M, Grimbaldeston, M, Woodcock, JM, Thomas, D, Pitson, S, Hughes, T, D'Andrea, RJ, Parker, MW & Lopez, AF 2012, 'The GM-CSF receptor family: mechanism of activation and implications for disease', Growth Factors, vol. 30, no. 2, pp. 63-75. Open access 60 57
2012	Juarez, JG, Harun, N, Thiene, M, Welschinger, R, Baraz, R, Pena, AD, Pitson, SM, Rettig, M, DiPersio, JF, Bradstock, KF & Bendall, LJ 2012, 'Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice', Blood, vol. 119, no. 3, pp. 707-716. Open access 116 108
2012	Lim, KG, Tonelli, F, Berdyshev, E, Gorshkova, I, Leclercq, T, Pitson, SM, Bittman, R, Pyne, S & Pyne, NJ 2012, 'Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: Functional differences between sphingosine kinase 1a and 1b', The International Journal of Biochemistry and Cell Biology, vol. 44 no. 9, pp. 1457-1464. 33 32
2012	Pitman, M, Woodcock, J, Lopez, A & Pitson, S 2012, 'Molecular targets of FTY720 (Fingolimod)', Current Molecular Medicine, vol. 12, no. 10, pp. 1207-1219. 60 58
2012	Pitman, MR, Pham, DH & Pitson, SM 2012, 'Isoform-selective assays for sphingosine kinase activity', Methods in Molecular Biology, vol. 874, pp. 21-31. 31
2012	Sun, WY, Abeynaike, LD, Escarbe, S, Smith, CD, Pitson, SM, Hickey, MJ & Bonder, CS 2012, 'Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent', American Journal of Pathology, vol. 180, no. 4, pp. 1740-1750. 22 23
2011	Barrett, JM, Parham, KA, Pippal, JB, Cockshell, MP, Moretti, PA, Brice, SL, Pitson, S & Bonder, C 2011, 'Over-expression of sphingosine kinase-1 enhances a progenitor phenotype in human endothelial cells', Microcirculation, vol. 18 no. 7, pp. 583-597. 10 10
2011	Cordts, F, Pitson, S, Tabeling, C, Gibbins, I, Moffat, DF, Jersmann, H, Hodge, S & Haberberger, R V 2011, 'Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease', Life Sciences, vol. 89 no. 21-22, pp. 806-811. 28 25
2011	Jessup, CF, Bonder, CS, Pitson, SM & Coates, PTH 2011, 'The sphingolipid rheostat: a potential target for improving pancreatic islet survival and function', Endocrine Metabolic and Immune Disorders - Drug Targets, vol. 11, no. 4, pp. 262-272. 29
2011	Leclercq, T, Moretti, PAB & Pitson, SM 2011, 'Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis', Oncogene, vol. 30, no. 3, pp. 372-378. Open access 45 37
2011	Pchejetski, D, Nunes, J, Caughlan, K, Lall, H, Pitson, SM, Waxman, J & Sumbayev, V V 2011, 'The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1a protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6', Immunology and Cell Biology, vol. 89 no. 2, pp. 268-274. 51 52
2011	Pitman, MR, Barr, RK, Gliddon, BL, Magarey, AM, Moretti, PA & Pitson, SM 2011, 'A critical role for the protein phosphatase 2A B'α regulatory subunit in dephosphorylation of sphingosine kinase 1', The International Journal of Biochemistry and Cell Biology, vol. 43, no. 3, pp. 342-347. 22 18
2011	Pitson, SM 2011, 'Regulation of sphingosine kinase and sphingolipid signaling', Trends in Biochemical Sciences, vol. 36 no. 2, pp. 97-107. 265 252
2011	Pitson, SM, Powell, JA & Bonder, CS 2011, 'Regulation of sphingosine kinase in hematological malignancies and other cancers', Anti-Cancer Agents in Medicinal Chemistry, vol. 11, no. 9, pp. 799-809. 22 22
2011	Siow, D, Anderson, C, Berdyshev, E, Skobeleva, A, Natarajan, V, Pitson, SM & Wattenberg, B 2011, 'Sphingosine kinase localization in the control of sphingolipid metabolism', Advances in Enzyme Regulation, vol. 51, no. 1, pp. 229-244. Open access 30 26
2011	Wati, S, Rawlinson, SM, Ivanov, RA, Dorstyn, L, Beard, M, Jans, DA, Pitson, S, Burrell, CJ, Li, P & Carr, JM 2011, 'Tumour necrosis factor alpha (TNF-α) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-α to activate nuclear factor kb and reduced sphingosine kinase-1 activity', Journal of General Virology, vol. 92 no. 4, pp. 807-818. Open access 43 44
2010	Jarman, KE, Moretti, PA, Zebol, JR & Pitson, SM 2010, 'Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1', Journal of Biological Chemistry, vol. 285 no. 1, pp. 483-492. 125
2010	Kim, M, Kim, M, Park, SW, Pitson, SM & Lee, HT 2010, 'Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation', American Journal of Nephrology, vol. 31, no. 4, pp. 353-362. Open access 50 49
2010	Loveridge, C, Tonelli, F, Leclercq, T, Lim, KG, Long, JS, Berdyshev, E, Tate, RJ, Natarajan, V, Pitson, SM, Pyne, NJ & Pyne, S 2010, 'The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells', Journal of Biological Chemistry, vol. 285, no. 50, pp. 38841-38852. Open access 106 100
2010	Malavaud, B, Pchejetski, D, Mazerolles, C, de Paiva, GR, Calvet, C, Doumerc, N, Pitson, S, Rischmann, P & Cuvillier, O 2010, 'Sphingosine kinase-1 activity and expression in human prostate cancer resection specimens', European Journal of Cancer, vol. 46, no. 18, pp. 3417-3424. 79 74
2010	Pitman, M & Pitson, SM 2010, 'Inhibitors of the sphingosine kinase pathway as potential therapeutics', Current Cancer Drug Targets, vol. 10, no. 4, pp. 354-367. 70 68
2010	Siow, DL, Anderson, CD, Berdyshev, E V, Skobeleva, A, Pitson, SM & Wattenberg, BW 2010, 'Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate', Journal of Lipid Research, vol. 51, no. 9, pp. 2546-2559. Open access 38 36
2010	Song, JH, Kim, M, Park, SW, Chen, SW, Pitson, SM & Lee, HT 2010, 'Isoflurane via TGF-ß1 release increases caveolae formation and organizes sphingosine kinase signaling in renal proximal tubules', American Journal of Physiology: Renal Physiology, vol. 298, no. 4, pp. 1041-1050. Open access 25 24
2010	Sun, WY, Pitson, S & Bonder, C 2010, 'Tumor necrosis factor-induced neutrophil adhesion occurs via sphingosine kinase-1-dependent activation of endothelial a 5<U+00df> 1 integrin', American Journal of Pathology, vol. 177 no. 1, pp. 436-446. Open access 32 30
2010	Tonelli, F, Lim, KG, Loveridge, C, Long, J, Pitson, SM, Tigyi, G, Bittman, R, Pyne, S & Pyne, NJ 2010, 'FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells', Cellular Signalling, vol. 22, no. 10, pp. 1536-1542. Open access 166 156
2010	Williams, SL, Milne, IR, Bagley, CJ, Gamble, JR, Vadas, MA, Pitson, SM & Khew-Goodall, Y 2010, 'A proinflammatory role for proteolytically cleaved annexin A1 in neutrophil transendothelial migration', Journal of Immunology, vol. 185 no. 5, pp. 3057-3063. Open access 74 70
2010	Woodcock, JM, Ma, Y, Coolen, C, Pham, D, Jones, C, Lopez, AF & Pitson, SM 2010, 'Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function', Cellular Signalling, vol. 22, no. 9, pp. 1291-1299. 64 62
2009	Bonder, CS, Sun, WY, Matthews, T, Cassano, C, Li, X, Ramshaw, HS, Pitson, SM, Lopez, AF, Coates, PT, Proia, RL, Vadas, MA & Gamble, JR 2009, 'Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation', Blood, vol. 113, no. 9, pp. 2108-2117. Open access 38 36
2009	Gamble, JR, Sun, WY, Li, X, Hahn, CN, Pitson, SM, Vadas, MA & Bonder, CS 2009, 'Sphingosine kinase-1 associates with integrin aVß3 to mediate endothelial cell survival', American Journal of Pathology, vol. 175, no. 5, pp. 2217-2225. Open access 17 14
2009	Lidington, D, Peter, BF, Meissner, A, Kroetsch, JT, Pitson, SM, Pohl, U & Bolz, S-S 2009, 'The phosphorylation motif at serine 225 governs the localization and function of sphingosine kinase 1 in resistance arteries', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 29 no. 11, pp. 1916-1922. Open access 27 26
2009	Limaye, V, Vadas, MA, Pitson, SM & Gamble, JR 2009, 'The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells', Cellular and Molecular Biology Letters: An International Journal, vol. 14, no. 3, pp. 411-423. Open access 7 7
2009	Limaye, V, Xia, P, Hahn, C, Smith, M, Vadas, MA, Pitson, SM & Gamble, JR 2009, 'Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells', Cellular and Molecular Biology Letters: An International Journal, vol. 14 no. 3, pp. 424-441. Open access 33 25
2009	Pitson, SM & Pébay, A 2009, 'Regulation of stem cell pluripotency and neural differentiation by lysophospholipids', NeuroSignals, vol. 17, no. 4, pp. 242-254. Open access 50 43
2009	Zebol, JR, Hewitt, NM, Moretti, PA, Lynn, HE, Lake, JA, Li, P, Vadas, MA, Wattenberg, BW & Pitson, SM 2009, 'The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1', The International Journal of Biochemistry and Cell Biology, vol. 41 no. 4, pp. 822-827. Open access 18 16
2009	ter Braak, M, Danneberg, K, Lichte, K, Liphardt, K, Ktistakis, NT, Pitson, SM, Hla, T, Jakobs, KH & zu Heringdorf, DM 2009, 'Gαq-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors', BBA: Molecular and Cell Biology of Lipids, vol. 1791, no. 5, pp. 357-370. 30 30
2008	Barr, R, Khew-Goodall, Y, Moretti, PAB, Lynn, H & Pitson, SM 2008, 'Deactivation of sphingosine kinase 1 by protein phosphatase 2A', Journal of Biological Chemistry, vol. 283, no. 50, pp. 34994-35002. Open access 50 43
2008	Gamble, JR, Pitson, SM, Bonder, C, Xia, P, Stankovic, M, Proia, RL, Vadas, M, Hahn, CN, Parsons, M & Li, X 2008, 'Basal and angiopoietin-1 mediated endothelial permeability is regulated by sphingosine kinase-1', Blood, vol. 111 no. 7, pp. 3489-3497. 76
2008	Moretti, PAB, Pitson, SM, Goodall, G & Pham, D 2008, 'Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements', Biotechniques: The Journal of Laboratory Technology for Bioresearch, vol. 45 no. 2, pp. 155-162. 20
2008	Pitson, S, Goodall, G & Guthridge, MA 2008, 'Science amongst the vines. Meeting on Signalling Systems', EMBO Reports, vol. 9 no. 5, pp. 425-428. Open access
2008	Vadas, M, Leclercq, T, Pitson, SM & Moretti, PAB 2008, 'Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity', Journal of Biological Chemistry, vol. 283, no. 15, pp. 9606-9614. Open access 48 46

Research

Patents

Details	Registry	Status
Modulators of 14-3-3 functionality and uses thereof Woodcock, Joanna; Lopez, Angel; Pitson, Stuart M; Samuel, Michael S; Coolen, Carl	United States	Filed
Modulators of 14-3-3 functionality and uses thereof Woodcock, Joanna; Lopez, Angel; Pitson, Stuart; Samuel, Michael; Coolen, Carl	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
A-Star, Institute of Molecular and Cell Biology	SINGAPORE
Australian National University	AUSTRALIA
Babraham Institute	UNITED KINGDOM
Baker Heart and Diabetes Institute	AUSTRALIA
Central Adelaide Local Health Network Incorporated	AUSTRALIA
Centre Hospitalier Universitaire de Nantes Hôtel Dieu	FRANCE
Centre Hospitalier Universitaire de Tours	FRANCE
Charite - Medical University of Berlin	GERMANY
CHU la Timone	FRANCE
City University of New York	UNITED STATES
City University Of New York, Queens College	UNITED STATES
Columbia University	UNITED STATES
Columbia University College of Physicians and Surgeons	UNITED STATES
Cornell University	UNITED STATES
Curtin University	AUSTRALIA
Department of Pathology, CHRU de Lille	FRANCE
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Garvan Medical Institute	AUSTRALIA
Goethe University Frankfurt	GERMANY
Griffith University	AUSTRALIA
Guangzhou Medical University	CHINA
Hanson Centre for Cancer Research	AUSTRALIA
Hanson Institute	AUSTRALIA
Harvard University	UNITED STATES
Hôpitaux de Toulouse	FRANCE
Imperial College of Science, Technology and Medicine	UNITED KINGDOM
Institut de Pharmacologie et de Biologie Structurale	FRANCE
Institut Universitaire du Cancer de Toulouse–Oncopôle (IUCT-O)	FRANCE
Institute of Medical and Veterinary Science	AUSTRALIA
Kanazawa University	JAPAN
La Trobe University	AUSTRALIA
Ludwig Maximilian University	GERMANY
Max Planck Institute for Biology of Ageing	GERMANY
Medical University of Graz	AUSTRIA
Medical University of Innsbruck	AUSTRIA
Medical University of South Carolina	UNITED STATES
Monash Institute of Pharmaceutical Sciences	AUSTRALIA
Monash University	AUSTRALIA
Nanyang Technological University	SINGAPORE
National Institutes of Health	UNITED STATES
National University of Singapore	SINGAPORE
Palacky University	CZECH REPUBLIC
QIMR Berghofer Medical Research Institute	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Repatriation General Hospital	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Eye & Ear Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Shanghai University	CHINA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Southern Medical University	CHINA
St. Vincent's Institute of Medical Research	AUSTRALIA
Stanford University	UNITED STATES
The Alfred Hospital	AUSTRALIA
The Kinghorn Cancer Centre	AUSTRALIA
The Queen Elizabeth Hospital	AUSTRALIA
Toulouse University	FRANCE
University of Adelaide	AUSTRALIA
University of Auckland	NEW ZEALAND
University of Chicago	UNITED STATES
University of Cologne	GERMANY
University of Connecticut	UNITED STATES
University of Dusseldorf	GERMANY
University of Essen	GERMANY
University of Illinois at Chicago	UNITED STATES
University of Iowa	UNITED STATES
University of Kent	UNITED KINGDOM
University of Louisville	UNITED STATES
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of North Carolina at Chapel Hill	UNITED STATES
University of Paris	FRANCE
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Strathclyde	UNITED KINGDOM
University of Sydney	AUSTRALIA
University of Technology Sydney	AUSTRALIA
University of Tennessee	UNITED STATES
University of Texas	UNITED STATES
University of Toronto	CANADA
University Of Toulouse	FRANCE
University of Toulouse - Jean Jaures	FRANCE
University of Zurich	SWITZERLAND
Victor Chang Cardiac Research Institute	AUSTRALIA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Washington University	UNITED STATES
Westmead Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2017
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2016
Project Grant National Health and Medical Research Council (NHMRC)	2016
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2015
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2014
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2013
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2012
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2011
NHMRC Senior Research Fellow Institute of Medical and Veterinary Science (IMVS)	2010

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
110188-Enhancing therapy of acute myeloid leukaemia by predicting drivers of relapse	Current
CD47 regulates cellular and metabolic plasticity in glioblastoma	Current
Defining the origin of schizophrenia like defects arising from 14-3-3 zeta deficiency.	Current
Identifying optimal immunotherapy combinations for the treatment of brain tumours	Current
Investigating the role of endothelial derived IGF1 in epidermal development and disease	Current
Understanding the role of 14-3-3 proteins in lung cancer initiation, progression and metastasis.	Current
Investigating the roles of 14-3-3zeta in the mammary tumour microenvironment	Completed
Peroxisome proliferator-activated receptor gamma interacts with sphingosine 1-phosphate to regulate vascular function	Completed
Targeting sphingolipid metabolism in proteasome inhibitor-resistant multiple myeloma	Completed
Targeting sphingosine kinase 1 in acute myeloid leukaemia	Completed
Targeting sphingosine kinase 1 to overcome venetoclax resistance in acute myeloid leukemia	Completed

Professor Stuart Pitson

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

Project Grant

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

NHMRC Senior Research Fellow

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery