Professor Susan Branford

Adjunct Professor Centre for Cancer Biology

City West Campus (HB8-26)
tel +61 8 830 27730

email Susan.Branford@unisa.edu.au

Research Degree Supervisor

Research

Research focus

Clinical Sciences
Cardiovascular Medicine and Haematology
Oncology and Carcinogenesis
Biochemistry and Cell Biology
Medical and Health Sciences

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID

Open access indicates that an output is open access.

Chapters

Year	Output
2021	Branford, S, Shanmuganathan, N & Hughes, TP 2021, 'Response-related predictors of survival and of treatment-free remission in CML', in R Hehlmann (ed.), Chronic Myeloid Leukemia, Springer, Switzerland, ch. 15, pp. 245-264. Open access

Journal Articles

Year	Output
2022	Branford, S 2022, 'Commentary on Dominy et al., assessment of quantitative PCR for BCR::ABL1 Transcripts in CML: Are improved outcomes in patients with e14a2 transcripts an artefact of technology?', British Journal of Haematology, vol. 197, no. 1, pp.9-10. Open access
2022	Fernandes, A, Shanmuganathan, N & Branford, S 2022, 'Genomic mechanisms influencing outcome in chronic myeloid leukemia', Cancers, vol. 14, no. 3, article no. 620. Open access
2022	Krishnan, V, Kim, DDH, Hughes, TP, Branford, S & Ong, ST 2022, 'Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers', Haematologica: The Hematology Journal, vol. 107, no. 2, pp. 358-370. Open access
2022	Shahrin, NH, Wadham, C & Branford, S 2022, 'Defining higher-risk chronic myeloid leukemia: risk scores, genomic landscape, and prognostication', Current Hematologic Malignancy Reports, online, pp. 1-10. Open access
2022	Shanmuganathan, N & Branford, S 2022, 'Multiplex technologies for the assessment of minimal residual disease and low-level mutation detection in leukaemia: mass spectrometry versus next-generation sequencing', British Journal of Haematology, vol. 196, no. 1, pp. 19-30. Open access 1 1 1
2021	Adnan Awad, S, Dufva, O, Ianevski, A, Ghimire, B, Koski, J, Maliniemi, P, Thomson, D, Schreiber, A, Heckman, CA, Koskenvesa, P, Korhonen, M, Porkka, K, Branford, S, Aittokallio, T, Kankainen, M & Mustjoki, S 2021, 'RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses', Leukemia, 1-13. Open access 15 14 6
2021	Branford, S 2021, 'Taming the gatekeeper: ponatinib dose holds the key', Blood, vol. 138, no. 21, pp. 2011-2012.
2021	Ochi, Y, Yoshida, K, Huang, Y-J, Kuo, M-C, Branford, S, Shanmuganathan, N & Shih, L-Y and 28 other authors 2021, 'Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia', Nature Communications, vol. 12, no. 1, article no. 2833, pp. 1-13. Open access 11 11 20
2021	Shanmuganathan, N, Pagani, IS, Ross, DM, Park, S, Yong, AS, Braley, J, Altamura, H, Hiwase, DK, Yeung, DT, Kim, D-W, Branford, S & Hughes, TP 2021, 'Early BCR-ABL1 kinetics are predictive of subsequent achievement of treatment-free remission in chronic myeloid leukemia', Blood, vol. 137, no. 9, pp. 1196-1207. Open access 25 22 7
2020	Branford, S 2020, 'Why is it critical to achieve a deep molecular response in chronic myeloid leukemia?', Haematologica: The Hematology Journal, vol. 105, no. 12, pp. 2730-2737. Open access 5 4 5
2020	Pagani, IS, Dang, P, Saunders, VA, Braley, J, Thieleke, A, Branford, S, Hughes, TP & Ross, DM 2020, 'Clinical utility of genomic DNA Q-PCR for the monitoring of a patient with atypical e19a2 BCR-ABL1 transcripts in chronic myeloid leukemia', Leukemia and Lymphoma, vol. 61, no. 10, pp. 2527-2529. Open access 5 3
2020	Pagani, IS, Dang, P, Saunders, VA, Grose, R, Shanmuganathan, N, Kok, CH, Carne, L, Rwodzi, Z, Watts, S, McLean, J, Braley, J, Altamura, H, Yeung, DT, Branford, S, Yong, AS, White, DL, Hughes, TP & Ross, DM 2020, 'Lineage of measurable residual disease in patients with chronic myeloid leukemia in treatment-free remission', Leukemia, vol. 34, pp. 1052-1061. Open access 24 23 3
2020	Schmitz, U, Shah, JS, Dhungel, BP, Monteuuis, G, Luu, PL, Petrova, V, Metierre, C, Nair, SS, Bailey, CG, Saunders, VA, Turhan, AG, White, DL, Branford, S, Clark, SJ, Hughes, TP, Wong, JJ & Rasko, JE 2020, 'Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients', Cancers, vol. 12, no. 12, article no. 3738, pp. 1-19. Open access 7 6 5
2020	Thomson, DW, Shahrin, NH, Wang, PP, Wadham, C, Shanmuganathan, N, Scott, HS, Dinger, ME, Hughes, TP, Schreiber, AW & Branford, S 2020, 'Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic myeloid leukemia', Leukemia, vol. 34, no. 8, pp. 2051-2063. Open access 11 10 1
2019	Branford, S, Kim, DDH, Apperley, JF, Eide, CA, Mustjoki, S, Ong, ST, Nteliopoulos, G, Ernst, T, Chuah, C, Gambacorti-Passerini, C, Mauro, MJ, Druker, BJ, Kim, D-W, Mahon, F-X, Cortes, J, Radich, JP, Hochhaus, A & Hughes, TP and 1 consortia 2019, 'Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia', Leukemia, vol. 33, no. 8, pp. 1835-1850. Open access 56 49 2
2019	Lasica, M, Willcox, A, Burbury, K, Ross, DM, Branford, S, Butler, J, Filshie, R, Januszewicz, H, Joske, D, Mills, A, Simpson, D, Tam, C, Taylor, K, Watson, AM, Wolf, M & Grigg, A 2019, 'The effect of tyrosine kinase inhibitor interruption and interferon use on pregnancy outcomes and long-term disease control in chronic myeloid leukemia', Leukemia and Lymphoma, vol. 60, no. 7, pp. 1796-1802. Open access 13 10
2019	Magistroni, V, Mauri, M, D'Aliberti, D, Mezzatesta, C, Branford, S & Piazza, R 2019, 'De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways', Haematologica: The Hematology Journal, vol. 104, no. 9, pp. 1789-1797. Open access 14 15 3
2019	Ross, DM, Pagani, IS, Irani, YD, Clarson, J, Leclercq, T, Dang, P, McLean, J, Saunders, VA, Carne, L, Reynolds, J, Ritchie, DS, White, DL, Branford, S, Hughes, TP & Yong, AS 2019, 'Lenalidomide maintenance treatment after imatinib discontinuation: results of a phase 1 clinical trial in chronic myeloid leukaemia', British Journal of Haematology, vol. 186, no. 3, pp. e56-e60. Open access 7 6 3
2019	Shanmuganathan, N & Branford, S 2019, 'The hidden pathogenesis of CML: is BCR-ABL1 the first event?', Current Hematologic Malignancy Reports, vol. 14, no. 6, pp. 501-506. Open access 8 6 1
2019	Shanmuganathan, N, Braley, JA, Yong, AS, Hiwase, DK, Yeung, DT, Ross, DM, Hughes, TP & Branford, S 2019, 'Modeling the safe minimum frequency of molecular monitoring for CML patients attempting treatment-free remission', Blood, vol. 134, no. 1, pp. 85-89. Open access 16 15 7
2019	Shanmuganathan, N, Branford, S, Hughes, TP & Hiwase, D 2019, 'Bone marrow fibrosis associated with long-term imatinib therapy: resolution after switching to a second-generation TKI', Blood Advances, vol. 3, no. 3, pp. 370-374. Open access 1 1 6
2019	Sharplin, K, Altamura, H, Taylor, K, Wellwood, J, Taylor, D & Branford, S 2019, 'Chronic myeloid leukaemia: the dangers of not knowing your BCR-ABL1 transcript', Leukemia Research, vol. 87, article no. 106231, pp. 1-3. Open access 5 5 1
2019	Singhal, D, Wee, LYA, Kutyna, MM, Chhetri, R, Schreiber, AW, Feng, J, Branford, S, D'Andrea, RJ & Hiwase, D and 18 other authors 2019, 'The mutational burden of therapy-related myeloid neoplasms is similar to primary myelodysplastic syndrome but has a distinctive distribution', Leukemia, vol. 33, no.12, pp. 2842-2853. 22 21 3
2018	Branford, S, Wang, P, Yeung, DT, Thomson, D, Wadham, C, Shahrin, NH, Marum, JE, Nataren, N, Parker, WT, Shanmuganathan, N, Donaldson, Z, Altamura, H, Georgievski, J, Brown, A, Hahn, C, White, DL, Scott, HS, Schreiber, AW & Hughes, TP and 18 other authors 2018, 'Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease', Blood, vol. 132, no. 9, pp. 948-961. Open access 87 87 8
2018	Eadie, LN, Saunders, VA, Branford, S, White, DL & Hughes, TP 2018, 'The new allosteric inhibitor asciminib is susceptible to resistance mediated by ABCB1 and ABCG2 overexpression in vitro', Oncotarget, vol. 9, no. 17, pp. 13423-13437. Open access 26 2
2018	Hiwase, D, Tan, P, D'Rozario, J, Taper, J, Powell, A, Irving, I, Wright, M, Branford, S, Yeung, DT, Anderson, L, Gervasio, O, Levetan, C, Roberts, W, Solterbeck, A, Traficante, R & Hughes, T 2018, 'Efficacy and safety of nilotinib 300 mg twice daily in patients with chronic myeloid leukemia in chronic phase who are intolerant to prior tyrosine kinase inhibitors: results from the Phase IIIb ENESTswift study', Leukemia Research, vol. 67, pp. 109-115. Open access 7 7 3
2018	Pagani, IS, Dang, P, Kommers, IO, Goyne, JM, Nicola, M, Saunders, VA, Braley, J, White, DL, Yeung, DT, Branford, S, Hughes, TP & Ross, DM 2018, 'BCR-ABL1 genomic DNA PCR response kinetics during first-line imatinib treatment of chronic myeloid leukemia', Haematologica: The Hematology Journal, vol. 103, no. 12, pp. 2026-2032. Open access 22 15 5
2018	Ross, DM, Pagani, IS, Shanmuganathan, N, Kok, CH, White, DL, Branford, S & Hughes, TP and 11 other authors and 1 constourium 2018, 'Long-term treatment-free remission of chronic myeloid leukemia with falling levels of residual leukemic cells', Leukemia, vol. 32, no. 12, pp. 2572-2579. 42 35 5
2017	Casolari, D, Nguyen, T, Butcher, C, Iarossi, D, Hahn, C, Bray, S, Neufing, P, Parker, W, Feng, J, Maung, K, Wee, A, Vidovic, L, Kok, C, Bardy, P, Branford, S, Lewis, I, Lane, S, Scott, H, Ross, D & D'Andrea, R 2017, 'A novel, somatic, transforming mutation in the extracellular domain of epidermal growth factor receptor identified in myeloproliferative neoplasm', Scientific Reports, vol. 7, article no. 2467, pp. 1-9. Open access 5 4 3
2017	Hochhaus, A, Larson, RA, Guilhot, F, Radich, JP, Branford, S, Hughes, TP, Baccarani, M, Deininger, MW, Cervantes, F, Fujihara, S, Ortmann, CE, Menssen, HD, Kantarjian, H, O'Brien, SG & Druker, BJ 2017, 'Long-term outcomes of imatinib treatment for chronic myeloid leukemia', New England Journal of Medicine, vol. 376, pp. 917-927. Open access 621 580 924
2017	Hughes, T, Leber, B, Cervantes, F, Spector, N, Pasquini, R, Clementino, N, Schwarer, A, Dorlhiac-Llacer, P, Mahon, F, Rea, D, Guerci-Bresler, A, Kamel-Reid, S, Bendit, I, Acharya, S, Glynos, T, Dalal, D, Branford, S & Lipton, J 2017, 'Sustained deep molecular responses in patients switched to nilotinib due to persistent BCR-ABL1 on imatinib: Final ENESTcmr randomized trial results', Leukemia, vol. 31, no. 11, pp. 2529-2531. Open access 31 32 2
2017	Ma, L, Boucher, JI, Paulsen, J, Matuszewski, S, Eide, CA, Ou, J, Eickelberg, G, Press, RD, Zhu, LJ, Druker, BJ, Branford, S, Wolfe, SA, Jensen, JD, Schiffer, CA, Green, MR & Bolon, DN 2017, 'CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy', Proceedings of the National Academy of Sciences of USA, vol. 114, no. 44, pp. 11751-11756. Open access 30 26 7
2017	Marum, JE, Yeung, DT, Purins, L, Reynolds, J, Parker, WT, Stangl, D, Wang, PP, Price, DJ, Tuke, J, Schreiber, AW, Scott, HS, Hughes, TP & Branford, S 2017, 'ASXL1 and BIM germ line variants predict response and identify CML patients with the greatest risk of imatinib failure', Blood Advances, vol. 1, no. 18, pp. 1369-1381. Open access 9 8 7
2017	Wylie, AA, Schoepfer, J, Jahnke, W, Cowan-Jacob, SW, Branford, S & Sellers, WR and 22 other authors 2017, 'The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1', Nature, vol. 543, no. 7647, pp. 733-737. Open access 264 253 64
2016	Branford, S 2016, 'Molecular monitoring in chronic myeloid leukemia - How low can you go?', Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, vol. 2016, no. 1, pp. 156-163. Open access 19 16 7
2016	Branford, S 2016, 'Monitoring and defining early response: where to draw the line?', Best Practice and Research: Clinical Haematology, vol. 29, no. 3 pp. 284-294. 4 5
2016	Cross, N, White, H, Ernst, T, Welden, L & Branford, S and 51 other authors 2016, 'Development and evaluation of a secondary reference panel for BCR-ABL1 quantification on the International Scale', Leukemia, vol. 30, no. 9, pp. 1844-1852. Open access 41 35 10
2016	Deininger, MW, Hodgson, JG, Shah, NP, Cortes, JE & Branford, S and 16 other authors 2016, 'Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients', Blood, vol. 127, no. 6, pp. 703-712. Open access 69 68 13
2016	Latham, S, Bartley, PA, Budgen, B, Ross, DM, Hughes, E, Branford, S, White, D, Hughes, TP & Morley, AA 2016, 'BCR-ABL1 expression, RT-qPCR and treatment decisions in chronic myeloid leukaemia', Journal of Clinical Pathology - Clinical Molecular Pathology, vol. 69, no. 9, pp. 817-821. 8 9 3
2016	Marum, JE & Branford, S 2016, 'Current developments in molecular monitoring in chronic myeloid leukemia', Therapeutic Advances in Hematology, vol. 7, no. 5, pp. 237-251. Open access 18
2016	Parker, WT, Yeung, DT, Yeoman, AL, Altamura, HK, Jamison, BA, Field, CR, Hodgson, JG, Lustgarten, S, Rivera, VM, Hughes, TP & Branford, S 2016, 'The impact of multiple low-level BCR-ABL1 mutations on response to ponatinib', Blood, vol. 127, no. 15, pp. 1870-1880. Open access 48 46 5
2016	Ross, D, Altamura, H, Hahn, C, Nicola, M, Yeoman, A, Holloway, M, Geoghegan, J, Feng, J, Schreiber, A, Branford, S, Moore, S & Scott, H 2016, 'Delayed diagnosis leading to accelerated-phase chronic eosinophilic leukemia due to a cytogenetically cryptic, imatinib-responsive TNIP1-PDFGRB fusion gene', Leukemia, vol. 30, no. 6, pp. 1402-1405. Open access 5 5
2016	Torra, OS, Beppu, L, Smith, JL, Welden, L, Georgievski, J, Gupta, K, Kumar, R, Yeung, CC, Paguirigan, A, Gooley, TA, Branford, S & Radich, JP 2016, 'Paper or plastic? BCR-ABL1 quantitation and mutation detection from dried blood spots', Blood, vol. 127, no. 2, pp. 2773-2774. Open access 12 13 1
2016	Yoshida, C, Nakamae, H, Fletcher, L, Koga, D, Sogabe, T, Matsumura, I, Kanakura, Y, Branford, S & Naoe, T 2016, 'Validation of a rapid one-step high sensitivity real-time quantitative PCR system for detecting major BCR-ABL1 mRNA on an International Scale', SpringerPlus, vol. 5, no. 569, pp. 1-7. Open access 3 2
2015	Yeung, DT, Osborn, MP, White, DL, Branford, S & Hughes, TP and 18 other authors and 1 consortium 2015, 'TIDEL-II: first-line use of imatinib in CML with early switch to nilotinib for failure to achieve time-dependent molecular targets', Blood, vol. 125, no. 6, pp. 915-923. Open access 68 59 2
2015	Yeung, DT, Tang, C, Vidovic, L, White, DL, Branford, S, Hughes, TP & Yong, AS 2015, 'KIR2DL5B genotype predicts outcomes in CML patients treated with response-directed sequential imatinib/nilotinib strategy', Blood, vol. 126, no. 25, pp. 2720-2723. Open access 19 7 11
2014	Parker, WT, Phillis, SR, Yeung, DT, Hughes, TP, Scott, HS & Branford, S 2014, 'Many BCR-ABL1 compound mutations reported in chronic myeloid leukemia patients may actually be artifacts due to PCR-mediated recombination', Blood, vol. 124, no. 1, pp. 153-155. Open access 22 20 1
2012	Parker, WT, Ho, M, Scott, HS, Hughes, TP & Branford, S 2012, 'Poor response to second-line kinase inhibitors in chronic myeloid leukemia patients with multiple low-level mutations, irrespective of their resistance profile', Blood. Open access 57 52 4

Conferences

Year	Output
2019	Branford, S & Shanmuganathan, N 2019, 'NGS in CML - new standard diagnostic procedure?', 24th Congress of the European Hematology Association, Wolters Kluwer Health, vol. 3, no. S2, pp. 48-50. Open access 1 2
2016	Wang, P, Parker, WT, Branford, S & Schreiber, AW 2016, 'BAM-matcher: a tool for rapid NGS sample matching', 15th European Conference on Computational Biology (ECCB), Oxford University Press, vol. 32, no. 17, pp. 2699-2701. Open access 22 21 16

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
ARIAD Pharmaceuticals	UNITED STATES
Austin Hospital	AUSTRALIA
Australian National University	AUSTRALIA
Blood Institute	AUSTRALIA
Brabois Hospital	FRANCE
Catholic University of Korea	KOREA, REPUBLIC OF (SOUTH)
Chang Gung University	TAIWAN
Duke-NUS Medical School	SINGAPORE
Ecole Polytechnique Federale de Lausanne	ITALY
Federal University of Parana	BRAZIL
Federal University of Parana (Universidade Federal do Parana)	BRAZIL
Federal University of Rio de Janeiro	BRAZIL
Finnish Red Cross	FINLAND
Fiona Stanley Hospital	AUSTRALIA
Flinders University	AUSTRALIA
Fred Hutchinson Cancer Research Center	UNITED STATES
Garvan Institute of Medical Research	AUSTRALIA
Greenslopes Private Hospital	AUSTRALIA
Hammersmith Hospital	UNITED KINGDOM
Helsinki University Hospital	FINLAND
Hopital Saint-Louis	FRANCE
Howard Hughes Medical Institute	UNITED STATES
Icon Cancer Care	AUSTRALIA
Kinki University	JAPAN
Kyoto University	JAPAN
Linkou Chang Gung Memorial Hospital	TAIWAN
Liverpool Hospital Elizabeth	AUSTRALIA
Mater Medical Centre	AUSTRALIA
Mater Pathology	AUSTRALIA
McMaster University	CANADA
Memorial Sloan-Kettering Cancer Center	UNITED STATES
Mito Medical Centre	JAPAN
Monash University	AUSTRALIA
Nagoya Medical Centre	JAPAN
Nambour General Hospital	AUSTRALIA
National Cancer Centre Singapore	SINGAPORE
Nepean Hospital	AUSTRALIA
New Jersey City University	UNITED STATES
Newcastle University, United Kingdom	UNITED KINGDOM
NHS Foundation Trust	UNITED KINGDOM
Novartis (Australia)	AUSTRALIA
Novartis (United Kingdom)	UNITED KINGDOM
Novartis Healthcare	UNITED STATES
Novartis Pharma AG Switzerland	SWITZERLAND
Novartis Pharmaceuticals	UNITED STATES
Oregon Health and Science University	UNITED STATES
Osaka City University	JAPAN
Osaka University	JAPAN
Otsuka Pharmaceutical	JAPAN
Peter MacCallum Cancer Centre	AUSTRALIA
Princess Margaret Hospital for Children	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Queensland Institute of Medical Research	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Brisbane and Women's Hospital	AUSTRALIA
Royal North Shore Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Singapore General Hospital	SINGAPORE
Sir Charles Gardiner Hospital	AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
St Vincents Hospital	UNITED STATES
Statistical Revelations	AUSTRALIA
The Alfred Hospital	AUSTRALIA
Toronto General Hospital	CANADA
Universidade de Sao Paulo - USP	BRAZIL
Universidade Fed de Minas Gerais	BRAZIL
Universidade Federal Do Estado Do Rio De Janeiro	BRAZIL
Universitätsklinikum Jena	GERMANY
Universite Victor Segalen	FRANCE
University Hospital, Bordeaux	FRANCE
University of Adelaide	AUSTRALIA
University of Barcelona	SPAIN
University of Bologna	ITALY
University of Bordeaux	FRANCE
University of California San Francisco	UNITED STATES
University of Chicago	UNITED STATES
University of Helsinki	FINLAND
University of Jena	GERMANY
University of Massachusetts Medical School	UNITED STATES
University of Milano Bicocca	ITALY
University of New South Wales	AUSTRALIA
University Of Paris Sud (Paris 11)	FRANCE
University of Poitiers	FRANCE
University of Queensland	AUSTRALIA
University of Sao Paulo	BRAZIL
University of South Australia	AUSTRALIA
University of Southampton	UNITED KINGDOM
University of Sydney	AUSTRALIA
University of Texas	UNITED STATES
University of Texas MD Anderson Cancer Centre	UNITED STATES
University of Toronto	CANADA
University of Turku	FINLAND
University of Utah	UNITED STATES
University of Washington	UNITED STATES
VU University Medical Center	NETHERLANDS

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Defining genomic mechanisms associated with tyrosine kinase inhibitor response, drug resistance, prognosis and progression in chronic myeloid leukaemia	Current
Enhanced bioinformatics and machine learning for improved risk stratification and outcome prediction in chronic myeloid leukaemia	Current
Interactive visualization tools for cancer genomics	Current

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Professor Susan Branford

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

Conferences

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery