Dr Theodosia Teo

Research Associate UniSA Clinical & Health Sciences

City West Campus (HB7-25)

email Theodosia.Teo@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

Theo received her Ph.D. in cancer biology at the University of South Australia in 2015 where she worked in the laboratory of Prof. Shudong Wang studying the therapeutic potential of a protein target in cancer. During her Ph.D., she managed to extend her skills by deploying a multidisciplinary approach comprising computational structural biology, biochemical and cell biology, to facilitate her research analysis. Theo continued to pursue her research as a postdoctoral research associate in the same group upon the completion of her Ph.D. for a year. After that, she spent 2.5 years working in the industry with Intertek Agricultural company, where she was able to operate a series of high throughput SNPline PCR genotyping system to help... Read more

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Orcid
Scopus

Research

Research focus

Medicinal and Biomolecular Chemistry
Pharmacology and Pharmaceutical Sciences
Organic Chemistry
Biochemistry and Cell Biology
Theoretical and Computational Chemistry

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2015	Kumarasiri, M, Teo, T & Wang, S 2015, 'Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery', Future Medicinal Chemistry, vol. 7, no. 2, pp. 91-102. 7 8 1
2015	Teo, T, Lam, F, Yu, M, Yang, Y, MC Basnet, S, Albrecht, H, Sykes, M & Wang, S 2015, 'Pharmacologic inhibition of MNKs in acute myeloid leukemia', Molecular Pharmacology, vol. 88, no. 2, pp. 380-389. Open access 30 27 6
2015	Teo, T, Yang, Y, Yu, M, MC Basnet, S, Gillam, T, Hou, J, Schmid, R, Kumarasiri, M, Diab, S, Albrecht, H, Sykes, M & Wang, S 2015, 'An integrated approach for discovery of highly potent and selective Mnk inhibitors: screening, synthesis and SAR analysis', European Journal of Medicinal Chemistry, vol. 103, pp. 539-550. 30 27 7
2014	Teo, T, Yu, M, Yang, Y, Gillam, TA, Lam, F, Sykes, MJ & Wang, S 2014, 'Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells', Cancer Letters, vol. 357, pp. 612-623. 41 39
2013	Hou, J, Teo, THS, Sykes, MJ & Wang, S 2013, 'Insights into the importance of DFD-motif and insertion I1 in stabilizing the DFD-out conformation of Mnk2 kinase', ACS Medicinal Chemistry Letters, vol. 4, no. 8, pp. 736-741. Open access 12 11

Journal Articles

Year	Output
2023	Chen, R, Hassankhani, R, Long, Y, Basnet, SK, Teo, T, Yang, Y, Mekonnen, L, Yu, M & Wang, S 2023, 'Discovery of potent Inhibitors of cyclin-dependent kinases 7 and 9: design, synthesis, structure-activity relationship analysis and biological evaluation', ChemMedChem: chemistry enabling drug discovery, vol. 18, no. 3, article no. e202200582. Open access 4 4 11
2023	Fanta, BS, Mekonnen, L, Basnet, SK, Teo, T, Lenjisa, J, Khair, NZ, Kou, L, Tadesse, S, Sykes, MJ, Yu, M & Wang, S 2023, '2-Anilino-4-(1-methyl-1H-pyrazol-4-yl)pyrimidine-derived CDK2 inhibitors as anticancer agents: design, synthesis & evaluation', Bioorganic and Medicinal Chemistry, vol. 80, article no. 117158, pp. 1-15. Open access 13 12 1
2023	Sintayehu Fanta, B, Lenjisa, J, Teo, T, Kou, L, Mekonnen, L, Yang, Y, Basnet, SK, Hassankhani, R, Sykes, MJ, Yu, M & Wang, S 2023, 'Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-derived CDK2 inhibitors as potential anticancer agents: design, synthesis, and evaluation', Molecules, vol. 28, no. 7, article no. 2951, pp. 1-21. Open access 5 4 2
2022	Islam, S, Teo, T, Kumarasiri, M, Slater, M, Martin, JH, Wang, S & Head, R 2022, 'Combined In silico and In vitro evidence supporting an aurora a kinase inhibitory role of the anti-viral drug rilpivirine and an anti-proliferative influence on cancer cells', Pharmaceuticals, vol. 15, no. 10, article no. 1186, pp. 1-16. Open access 5 5 9
2022	Teo, T, Kasirzadeh, S, Albrecht, H, Sykes, MJ, Yang, Y & Wang, S 2022, 'An overview of CDK3 in cancer: clinical significance and pharmacological implications', Pharmacological Research, vol. 180, pp. 1-15. 8 8 2
2021	Yu, M, Long, Y, Yang, Y, Li, M, Teo, T, Noll, B, Philip, S & Wang, S 2021, 'Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation', European Journal of Medicinal Chemistry, vol. 218, article no. 113391. Open access 9 7
2021	Yu, M, Teo, T, Yang, Y, Li, M, Long, Y, Philip, S, Noll, B, Heinemann, GK, Diab, S, Eldi, P, Mekonnen, L, Anshabo, AT, Rahaman, MH, Milne, R, Hayball, JD & Wang, S 2021, 'Potent and orally bioavailable CDK8 inhibitors: design, synthesis, structure-activity relationship analysis and biological evaluation', European Journal of Medicinal Chemistry, vol. 214, pp. 1-22. Open access 14 12 1
2020	Emadi, F, Teo, T, Rahaman, MH & Wang, S 2020, 'CDK12: a potential therapeutic target in cancer', Drug Discovery Today, vol. 25, no. 12, pp. 2257-2267. 26 25 1
2019	Rahaman, MH, Lam, F, Zhong, L, Teo, T, Adams, J, Yu, M, Milne, RW, Pepper, C, Lokman, NA, Ricciardelli, C, Oehler, MK & Wang, S 2019, 'Targeting CDK9 for treatment of colorectal cancer', Molecular Oncology, vol. 13, no. 10, pp. 2178-2193. Open access 45 42
2018	Philip, S, Kumarasiri, M, Teo, T, Yu, M & Wang, S 2018, 'Cyclin-dependent kinase 8: a new hope in targeted cancer therapy?', Journal of Medicinal Chemistry, vol. 61, no. 12, pp. 5073-5092. 92 88 13
2017	Diab, S, Abdelaziz, AM, Li, P, Teo, T, Basnet, SK, Noll, B, Rahaman, MH, Lu, J, Hou, J, Yu, M, Le, BT, Albrecht, H, Milne, RW & Wang, S 2017, 'Dual inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia', European Journal of Medicinal Chemistry, vol. 139, pp. 762-772. Open access 23 21
2017	Kumarasiri, M, Teo, T, Yu, M, Philip, S, Basnet, SK, Albrecht, H, Sykes, MJ, Wang, P & Wang, S 2017, 'In search of novel CDK8 inhibitors by virtual screening', Journal of Chemical Information and Modeling, vol. 57, no. 3, pp. 413-416. 15 16 2
2017	Zeleke, S, Yu, M, Mekonnen, LB, Lam, F, Islam, S, Tomusange, K, Rahaman, MH, Noll, B, MC Basnet, S, Teo, T, Albrecht, H, Milne, R & Wang, S 2017, 'Highly potent, selective, and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependent kinases 4 and 6 inhibitors as anticancer drug candidates: design, synthesis, and evaluation', Journal of Medicinal Chemistry, vol. 60, no. 5, pp. 1892-1915. Open access 68 62 9
2015	Kumarasiri, M, Teo, T & Wang, S 2015, 'Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery', Future Medicinal Chemistry, vol. 7, no. 2, pp. 91-102. 7 8 1
2015	MC Basnet, S, Diab, S, Schmid, R, Yu, M, Yang, Y, Gillam, TA, Teo, T, Li, P, Peat, T, Albrecht, H & Wang, S 2015, 'Identification of a highly conserved allosteric binding site on Mnk1 and Mnk2', Molecular Pharmacology, vol. 88, no. 5, pp. 935-948. Open access 15 15 3
2015	Teo, T, Lam, F, Yu, M, Yang, Y, MC Basnet, S, Albrecht, H, Sykes, M & Wang, S 2015, 'Pharmacologic inhibition of MNKs in acute myeloid leukemia', Molecular Pharmacology, vol. 88, no. 2, pp. 380-389. Open access 30 27 6
2015	Teo, T, Yang, Y, Yu, M, MC Basnet, S, Gillam, T, Hou, J, Schmid, R, Kumarasiri, M, Diab, S, Albrecht, H, Sykes, M & Wang, S 2015, 'An integrated approach for discovery of highly potent and selective Mnk inhibitors: screening, synthesis and SAR analysis', European Journal of Medicinal Chemistry, vol. 103, pp. 539-550. 30 27 7
2015	Yu, M, Li, P, MC Basnet, S, Kumarasiri, M, Diab, S, Teo, T, Albrecht, H & Wang, S 2015, 'Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d[pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation', European Journal of Medicinal Chemistry, vol. 95, pp. 116-126. 37 37 3
2014	Diab, S, Kumarasiri, M, Yu, M, Teo, T, Proud, C, Milne, R & Wang, S 2014, 'MAP kinase-interacting kinases: emerging targets against cancer', Chemistry and Biology, vol. 21, no. 4, pp. 441-452. Open access 87 83
2014	Diab, S, Teo, THS, Kumarasiri, M, Li, P, Yu, M, Lam, F, MC Basnet, S, Sykes, MJ, Albrecht, H, Milne, R & Wang, S 2014, 'Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors : synthesis, SAR analysis and biological evaluation', ChemMedChem: chemistry enabling drug discovery, vol. 9, no. 5, pp. 962-972. Open access 77 74
2014	Lam, F, Abbas, AY, Shao, H, Teo, T, Adams, J, Li, P, Bradshaw, TD, Fischer, PM, Walsby, E, Pepper, C, Chen, Y, Ding, J & Wang, S 2014, 'Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73', Oncotarget, vol. 5, no. 17, pp. 7691-7704. Open access 50 49
2014	Lu, T, Goh, AW, Yu, M, Adams, J, Lam, F, Teo, T, Li, P, Noll, B, Zhong, L, Diab, S, Chahrour, O, Hu, A, Abbas, AY, Liu, X, Huang, S, Sumby, CJ, Milne, R, Midgley, C & Wang, S 2014, 'Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities', Journal of Medicinal Chemistry, vol. 57, no. 6, pp. 2275-2291. Open access 30 28
2014	Teo, T, Yu, M, Yang, Y, Gillam, TA, Lam, F, Sykes, MJ & Wang, S 2014, 'Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells', Cancer Letters, vol. 357, pp. 612-623. 41 39
2013	Hou, J, Teo, THS, Sykes, MJ & Wang, S 2013, 'Insights into the importance of DFD-motif and insertion I1 in stabilizing the DFD-out conformation of Mnk2 kinase', ACS Medicinal Chemistry Letters, vol. 4, no. 8, pp. 736-741. Open access 12 11
2013	Laurie, KJ, Dave, A, Strage, T, Souzeau, E, Chataway, T, Sykes, MJ, Casey, T, Teo, TT, Pater, J, Craig, JE, Sharma, S & Burdon, KP 2013, 'Identification of a novel oligomerization disrupting mutation in CRYAA associated with congenital cataract in a South Australian family', Human Mutation, vol. 34, no. 3, pp. 435-438. 29 27

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Cardiff University	UNITED KINGDOM
Chinese Academy of Sciences	CHINA
Cresset Discovery	UNITED KINGDOM
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Flinders University	AUSTRALIA
Open University	UNITED KINGDOM
University of Adelaide	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Nottingham	UNITED KINGDOM
University of South Australia	AUSTRALIA
University of Southampton	UNITED KINGDOM
Women's and Children's Hospital	AUSTRALIA
Yabao Pharmaceutical Group Co., Ltd	CHINA

External engagement & recognition

Engagement/recognition	Year
Invited Talk Centre for Cancer Biology	2015
Member Royal Australian Chemical Institute	2015
Student travel bursary RACI Biomolecular Conference	2013
Best Honours Student in Chemistry John Alexander Voules Brown Prize	2011
Best 3rd Year Student Mayne Pharma Prize	2010
Highest Overall GPA in Bachelor of Pharmaceutical Science Mayne Pharma Prize	2010

Other

2019 - Editorial board memeber of Bristish Journal of Cancer - Nature

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Novel small-molecule inhibitors as potential anticancer agents: design, synthesis, and evaluation	Current
Preclinical evaluation of transcription regulator/ tyrosine kinase inhibitors for the treatment of cancer	Current
Preclinical evaluation of TAM kinase inhibitors as potential anticancer agents	Completed

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Dr Theodosia Teo

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Highlights

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Invited Talk

Member

Student travel bursary

Best Honours Student in Chemistry

Best 3rd Year Student

Highest Overall GPA in Bachelor of Pharmaceutical Science

Other

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery