Dr Timothy Hercus

Adjunct Senior Research Fellow Centre for Cancer Biology

City West Campus (HB11-26)
tel +61 8 830 27947

email Timothy.Hercus@unisa.edu.au

Research

Research focus

Biochemistry and Cell Biology
Clinical Sciences
Immunology
Oncology and Carcinogenesis
Pharmacology and Pharmaceutical Sciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID

Open access indicates that an output is open access.

Chapters

Year	Output
2023	Shing, KS, Kan, WL, Nero, TL, Hercus, TR, Tvorogov, D, Metcalfe, RD, Griffin, MD, De Weerd, NA, Guthridge, MA, Hertzog, PJ, Lopez, AF & Parker, MW 2023, 'Cytokine receptors and their ligands', in Ralph A Bradshaw et al. (eds), Encyclopedia of Cell Biology, 2nd, Elsevier, UK, vol. 4, pp. 21-45. 1
2015	Dhagat, U, Nero, T, Kan, W, Hercus, T, Broughton, S, de Weerd, N, Jenkins, B, Mansell, A, Guthridge, M, Hertzog, P, Lopez, A & Parker, M 2015, 'Cytokine receptors and their ligands', Encyclopedia of cell biology, Academic Press, US, vol. 3, pp. 22-36.

Journal Articles

Year	Output
2023	Kan, WL, Dhagat, U, Kaufmann, KB, Hercus, TR, Toubia, J, Barry, EF, Gomez, GA, Dottore, M, Samaraweera, SE, Goodall, GJ, Thomas, D, Tvorogov, D, D'Andrea, RJ & Lopez, AF and 12 other authors 2023, 'Distinct assemblies of heterodimeric cytokine receptors govern stemness programs in leukemia', Cancer Discovery, vol. 13, no. 8, pp. 1922-1947. Open access
2023	Pant, H, Hercus, TR, Tumes, DJ, Yip, KH, Parker, MW, Owczarek, CM, Lopez, AF & Huston, DP 2023, 'Translating the biology of β common receptor-engaging cytokines into clinical medicine', Journal of Allergy and Clinical Immunology, vol. 151, no. 2, pp. 324-344. 1 1
2022	Wang, H, Tumes, DJ, Hercus, TR, Yip, K, Aloe, C, Vlahos, R, Lopez, AF, Wilson, N, Owczarek, CM & Bozinovski, S 2022, 'Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models', Cell Death and Disease, vol. 13, no. 2, article no. 137, pp. 1-11. Open access 5 4 5
2022	Yip, KH, McKenzie, D, Ramshaw, HS, Chao, J, McClure, BJ, Pant, H, Grimbaldeston, MA, Hercus, TR, Lopez, AF & Tumes, DJ and 12 other authors 2022, 'Targeting the human β𝒸 receptor inhibits contact dermatitis in a transgenic mouse model', Journal of Investigative Dermatology, vol. 142, no. 4, pp 1103-1113.e11. Open access 2 2
2021	Kan, WL, Cheung Tung Shing, KS, Nero, TL, Hercus, TR, Tvorogov, D, Parker, MW & Lopez, AF 2021, 'Messing with βc: a unique receptor with many goals', Seminars in Immunology, vol. 54, article 101513, pp. 1-14. Open access 1 3
2018	Broughton, SE, Hercus, TR, Nero, TL, Kan, WL, Barry, EF, Dottore, M, Cheung Tung Shing, KS, Morton, CJ, Dhagat, U, Hardy, MP, Wilson, NJ, Downton, MT, Schieber, C, Hughes, TP, Lopez, AF & Parker, MW 2018, 'A dual role for the N-terminal domain of the IL-3 receptor in cell signalling', Nature Communications, vol. 9, no. 1, article no. 386, pp. 1-15. Open access 21 22 5
2018	Dhagat, U, Hercus, TR, Broughton, SE, Nero, TL, Cheung Tung Shing, KS, Barry, EF, Thomson, CA, Bryson, S, Pai, EF, McClure, BJ, Schrader, JW, Lopez, AF & Parker, MW 2018, 'The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities', mAbs, vol. 10, no. 7, pp. 1018-1029. Open access 6 5 11
2018	Hercus, TR, Kan, WL, Broughton, SE, Tvorogov, D, Ramshaw, HS, Thompson, EJ, McKenzie, DR, Tergaonkar, V, Hughes, T, Samuel, MS, Bonder, CS, Grimbaldeston, MA & Lopez, A F and 10 other authors 2018, 'Role of the β common (βc) family of cytokines in health and disease', Cold Spring Harbor Perspectives in Biology, vol. 10, no. 6, article no. a028514, pp. 1-26. Open access 24 14 5
2018	Tvorogov, D, Thomas, D, Liau, NP, Dottore, M, Barry, EF, Lathi, M, Kan, WL, Hercus, TR, Stomski, F, Hughes, TP, Tergaonkar, V, Parker, MW, Ross, DM, Majeti, R, Babon, JJ & Lopez, AF 2018, 'Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis', Science Advances, vol. 4, no. 11, article no. eaat3834, pp. 1-13. Open access 34 31 3
2016	Broughton, SE, Hercus, TR, Nero, TL, Dottore, M, McClure, BJ, Dhagat, U, Taing, H, Gorman, MA, King-Scott, J, Lopez, AF & Parker, MW 2016, 'Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling', Structure, vol. 24, no. 8, pp. 1271-1281. Open access 33 31 4
2016	Gargett, T, Christo, SN, Hercus, TR, Abbas, N, Singhal, N, Lopez, AF & Brown, MP 2016, 'GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro', Clinical and Translational Immunology, vol. 5, no. 12, article no. e119. Open access 31 25 6
2016	Panousis, C, Dhagat, U, Edwards, KM, Rayzman, V, Hercus, TR, Dottore, M, McClure, BJ, Lopez, AF & Owczarek, CM and 12 other authors 2016, 'CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors', mAbs, vol. 8, no.3, pp. 436-453. Open access 34 28 3
2015	Broughton, SE, Nero, TL, Dhagat, U, Kan, WL, Hercus, TR, Tvorogov, D, Lopez, AF & Parker, MW 2015, 'The βc receptor family - Structural insights and their functional implications', Cytokine, vol. 74, no. 2, pp. 247-258. 60 52 1
2014	Broughton, SE, Hercus, TR, Hardy, MP, McClure, BJ, Nero, TL, Dottore, M, Huyhn, H, Braley, H, Barry, EF, Kan, WL, Dhagat, U, Scotney, P, Hartman, D, Busfield, SJ, Owczarek, CM, Nash, AD, Wilson, NJ, Parker, MW & Lopez, AF 2014, 'Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody', Cell Reports, vol. 8, no. 2, pp. 410-419. Open access 43 37 19
2013	Hercus, TR, Dhagat, U, Kan, WL, Broughton, SE, Nero, TL, Perugini, M, Sandow, JJ, D'Andrea, RJ, Ekert, PG, Hughes, T, Parker, MW & Lopez, AF 2013, 'Signalling by the βc family of cytokines', Cytokine and Growth Factor Reviews, vol. 24, no. 3, pp. 189-201. Open access 75 67
2012	Broughton, SE, Dhagat, U, Hercus, TR, Nero, TL, Grimbaldeston, MA, Bonder, CS, Lopez, AF & Parker, MW 2012, 'The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling', Immunological Reviews, vol. 250, no. 1, pp. 277-302. 178 165
2012	Hercus, TR, Broughton, SE, Ekert, PG, Ramshaw, HS, Perugini, M, Grimbaldeston, M, Woodcock, JM, Thomas, D, Pitson, S, Hughes, T, D'Andrea, RJ, Parker, MW & Lopez, AF 2012, 'The GM-CSF receptor family: mechanism of activation and implications for disease', Growth Factors, vol. 30, no. 2, pp. 63-75. Open access 57 54
2010	Perugini, M, Brown, AL, Salerno, DG, Booker, GW, Stojkoski, C, Hercus, TR, Lopez, AF, Hibbs, ML, Gonda, TJ & D'Andrea, RJ 2010, 'Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit', Blood, vol. 115, no. 16, pp. 3346-3353. Open access 54 47

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Australian Cancer Research Foundation	AUSTRALIA
CSL Limited	AUSTRALIA
Deakin University	AUSTRALIA
Hudson Institute of Medical Research	AUSTRALIA
IBM Australia	AUSTRALIA
Ludwig Institute for Cancer Research	AUSTRALIA
Monash University	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
RMIT University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
St. Vincent's Institute of Medical Research	AUSTRALIA
Stanford University	UNITED STATES
Texas A and M University	UNITED STATES
University Health Network	CANADA
University of Adelaide	AUSTRALIA
University of British Columbia	CANADA
University of Melbourne	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Toronto	CANADA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Women's and Children's Health Network	AUSTRALIA

more less

Dr Timothy Hercus

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

External engagement & recognition

Collaborations

Collaborations

Gallery