Professor Xin-Fu Zhou

Adjunct Research Professor UniSA Clinical & Health Sciences

City West Campus (HB6-26)
tel +61 8 830 22329

email Xin-Fu.Zhou@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

This laboratory has a long standing interest in neurotrophins and their receptors in neural development and neurological disorders. In recent years, we are interested in how neurotrophins and their receptors signal in the neurodegenerative disease such as Alzheimer’s disease. BDNF is one of the most studied neurotrophins which is critical for brain functions such as learning and memory. Its precursor has a different role to that of mature BDNF. We have been investigating its role in spinal cord injury, in pain and in nerve development. Neurotrophins can be potential drugs for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases or nerve injuries including spinal cord injury and stroke.

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UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

Tweets by @UniversitySA

Research

Research themes

An age friendly world
Healthy futures

Research focus

Neurosciences
Biochemistry and Cell Biology
Medical and Health Sciences
Clinical Sciences
Biological Sciences

Highlights

Neuroscience, neuron development, neurotrophins
spinal cord injury, nerve regeneration, neural plasticity
Neuropathic pain, affective pain and mechanisms
Neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease
Mood disorders, depression

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2014	Dai, R-P & Zhou, X-F 2014, 'Neurotrophins and pain', in RM Kostrzewa (ed.), Handbook of neurotoxicity, Springer, US, vol. 3, pp. 1805-1823. 1
2014	Lu, J, Yang, M, Sun, Y & Zhou, XF 2014, 'Synthesis, trafficking and release of BDNF', Handbook of Neurotoxicity, Springer, US, vol. 3, pp. 1955-1971. 2
2014	Wang, Y-J, Zeng, F, Saadipour, K & Zhou, X-F 2014, 'p75NTR: A molecule with multiple functions in amyloid-beta metabolism and neurotoxicity', in RM Kostrzewa (ed.), Handbook of neurotoxicity, 1st ed., Springer, United States, vol. 3, pp. 1925-1944.

Journal Articles

Year	Output
2021	Hu, ZL, Luo, C, Hurtado, PR, Li, H, Wang, S, Hu, B, Xu, JM, Liu, Y, Feng, SQ, Hurtado-Perez, E, Chen, K, Zhou, XF, Li, CQ & Dai, RP 2021, 'Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis', Theranostics, vol. 11, no. 2, pp. 715-730. Open access 4
2021	Lin, L, Zhou, X-F & Bobrovskaya, L 2021, 'Blockage of p75NTR ameliorates depressive-like behaviours of mice under chronic unpredictable mild stress', Behavioural Brain Research, vol. 396, article no. 112905, pp. 1-5.
2020	Deng, I, Corrigan, F, Zhai, G, Zhou, X-F & Bobrovskaya, L 2020, 'Lipopolysaccharide animal models of Parkinson's disease: recent progress and relevance to clinical disease', Brain, Behavior, & Immunity - Health, vol. 4, article no. 100060, pp. 1-12. Open access
2020	Fang, J, Wei, Z, Zheng, D, Ying, T, Hong, H, Hu, D, Lin, Y, Jiang, X, Wu, L, Lan, T, Yang, Z, Zhou, X & Chen, L 2020, 'Recombinant extracellular domain (p75ECD) of the neurotrophin receptor p75 attenuates myocardial ischemia-reperfusion injury by inhibiting the p-JNK/caspase-3 signaling pathway in rat microvascular pericytes', Journal of the American Heart Association, vol. 9, no. 13, pp. 1-24. Open access 1
2020	Kelliny, S, Lam, H, Parikh, A, Wang, Y, Bobrovskaya, L, Upton, R & Zhou, X 2020, 'Preclinical study of the pharmacokinetics of p75ECD-Fc, a novel human recombinant protein for treatment of Alzheimer's disease, in sprague dawley rats', Current Drug Metabolism, vol. 21, no. 3, pp. 235-244. 2
2020	Li, H, Lin, LY, Zhang, Y, Lim, Y, Rahman, M, Beck, A, Al-Hawwas, M, Feng, S, Bobrovskaya, L & Zhou, XF 2020, 'Pro-BDNF knockout causes abnormal motor behaviours and early death in mice', Neuroscience, vol. 438, pp. 145-157. 1
2020	Lin, L, Kelliny, S, Liu, L, Al-Hawwas, M, Zhou, X & Bobrovskaya, L 2020, 'Peripheral ProBDNF delivered by an AAV vector to the muscle triggers depression-like behaviours in mice', Neurotoxicity Research, vol. 38, no. 3, pp. 626-639. 2 2 1
2020	Liu, D, Pavathuparambil Abdul Manaph, N, Al-Hawwas, M, Bobrovskaya, L, Xiong, LL & Zhou, XF 2020, 'Coating materials for neural stem/progenitor cell culture and differentiation', Stem Cells and Development, vol. 29, no, 8, pp. 463-474. 2 1
2020	Liu, D, Rychkov, G, Al-Hawwas, M, Pavathuparambil Abdul Manaph, N, Zhou, F, Bobrovskaya, L, Liao, H & Zhou, XF 2020, 'Conversion of human urine-derived cells into neuron-like cells by small molecules', Molecular Biology Reports: An International Journal on Molecular and Cellular Biology, vol. 47, no. 4, pp. 2713-2722. 1
2020	Rahman, M, Luo, H, Bobrovskaya, L & Zhou, X-F 2020, 'Neuroprotective effects of anti-proBDNF in a rat photothrombotic ischemic model', Neuroscience, in press, pp. 1-10. 2
2020	Xiong, L-L, Xue, L-L, Du, R-L, Zhou, H-L, Tan, Y-X, Ma, Z, Jin, Y, Zhang, Z-B, Xu, Y, Hu, Q, Bobrovskaya, L, Zhou, X-F, Liu, J & Wang, T-H 2020, 'Vi4-miR-185-5p-Igfbp3 network protects the brain from neonatal hypoxic ischemic injury via promoting neuron survival and suppressing the cell apoptosis', Frontiers in Cell and Developmental Biology, vol. 8, article no. 529544, pp. 1-18. Open access 1
2020	Xiong, LL, Qin, YX, Xiao, QX, Jin, Y, Al-Hawwas, M, Ma, Z, Wang, YC, Belegu, V, Zhou, XF, Xue, LL, Du, RL, Liu, J, Bai, X & Wang, TH 2020, 'MicroRNA339 targeting PDXK improves motor dysfunction and promotes neurite growth in the remote cortex subjected to spinal cord transection', Frontiers in Cell and Developmental Biology, vol. 8, article no. 577, pp. 1-17. Open access 1
2020	Yang, C, Ning, L, Zhou, F, Sun, Q, Meng, H, Han, Z, Liu, Y, Huang, W, Liu, S, Li, X, Zheng, B, Ming, D & Zhou, X 2020, 'Downregulation of adhesion molecule CHL1 in B cells but not T cells of patients with major depression and in the brain of mice with chronic stress', Neurotoxicity Research, online, pp. 1-15.
2020	Yu, YQ, Zhang, YL, Wang, Z, Liu, Y, Li, H, Zhou, X-F, Hu, ZL & Dai, RP 2020, 'Involvement of proBDNF in monocytes/macrophages with gastrointestinal disorders in depressive mice', Neurotoxicity Research, online, pp. 1-13. 1
2019	Chen, S, Liang, T, Zhou, FH, Cao, Y, Wang, C, Wang, FY, Li, F, Zhou, XF, Zhang, JY & Li, CQ 2019, 'Regular music exposure in juvenile rats facilitates conditioned fear extinction and reduces anxiety after foot shock in adulthood', BioMed Research International, vol. 2019, article no. 8740674, pp. 1-10. Open access 2 3 1
2019	Johnson, ME, Zhou, X-F & Bobrovskaya, L 2019, 'The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: relevance to early Parkinson's disease', Journal of Chemical Neuroanatomy, vol. 97, pp. 23-32. Open access 2 2
2019	Lin, L, Luo, S, Al-Hawwas, M, Herselman, M, Zhou, X & Bobrovskaya, L 2019, 'The long-term effects of ethanol and corticosterone on the mood-related behaviours and the balance between mature BDNF and proBDNF in mice', Journal of Molecular Neuroscience, vol. 69, no. 1, pp. 60-68. Open access 5 4
2019	Luo, HY, Rahman, M, Bobrovskaya, L & Zhou, X-F 2019, 'The level of proBDNF in blood lymphocytes is correlated with that in the brain of rats with photothrombotic ischemic stroke', Neurotoxicity Research, vol. 36, no. 1, pp. 49-57. 2 3
2019	Manucat-Tan, NB, Shen, LL, Bobrovskaya, L, Al-hawwas, M, Zhou, FH, Wang, YJ & Zhou, XF 2019, 'Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model', Aging, vol. 11, no. 17. pp. 6762-6791. Open access 6 6 7
2019	Saadipour, K, Tiberi, A, Lomardo, S, Grajales, E, Montroull, L, Manucat-Tan, NB, LaFrancois, J, Cammer, M, Mathews, PM, Scharfman, HE, Liao, FF, Friedman, WJ, Zhou, XF, Tesco, G & Chao, M V 2019, 'Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor', Molecular and Cellular Neuroscience, vol. 99, article no. 103395, pp. 1-15. Open access 10
2019	Shen, LL, Li, WW, Xu, YL, Gao, SH, Xu, MY, Bu, XL, Liu, YH, Wang, J, Zhu, J, Zeng, F, Yao, XQ, Gao, CY, Xu, ZQ, Zhou, XF & Wang, YJ 2019, 'Neurotrophin receptor p75 mediates amyloid β-induced tau pathology', Neurobiology of Disease, vol. 132, article no. 104567 pp. 1-12. Open access 6 5 11
2019	Wang, Z, Wu, J-L, Zhong, F, Liu, Y, Yu, Y-Q, Sun, J-J, Wang, S, Li, H, Zhou, X-F, Hu, Z-L & Dai, R-P 2019, 'Upregulation of proBDNF in the mesenteric lymph nodes in septic mice', Neurotoxicity Research, vol. 36, no. 3, pp. 540-550. 6 6
2019	Xu, Y, Li, WW, Wang, J, Zhu, C, Shen, YY, Shi, AY, Zeng, GH, Xu, ZQ, Zhou, XF & Wang, YJ 2019, 'Neurotrophin receptor p75 mRNA level in peripheral blood cells of patients with Alzheimer's disease', Neurotoxicity Research, vol. 36, no. 1, pp. 101-107. 2 1 7
2019	Yang, C, Zhang, X, Liu, Y, Du, J, Liang, R, Yu, M, Zhang, F, Mu, X, Li, F, Zhou, L, Zhou, F, Meng, F, Wang, S, Ming, D & Zhou, X 2019, 'Antidepressant drugs correct the imbalance between probdnf/p75ntr/sortilin and mature bdnf/trkb in the brain of mice with chronic stress', Neurotoxicity Research, online, pp. 1-12. 6 5 1
2019	Yang, CY, Yang, J-Y, Xiong, Y-X, Zhuang, X-F, Su, H, Hu, S, Ma, J-Q, Zhou, X-F, Luo, H-Y & Sun, J 2019, 'Panax notoginsenoside Rb1 restores the neurotrophic imbalance following photothrombotic stroke in rats', Neurotoxicity Research, vol. 36, no. 3, pp. 441-451. 1 1
2019	Zhang, Z-B, Tan, Y-X, Zhao, Q, Xiong, L-L, Liu, J, Xu, F-F, Xu, Y, Bobrovskaya, L, Zhou, X-F & Wang, T-H 2019, 'miRNA-7a-2-3p inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model', Frontiers in Neuroscience, vol. 13, article 16, pp. 1-10. Open access 10 7 1
2019	Zhong, F, Liu, L, Wei, JL, Hu, ZL, Li, L, Wang, S, Xu, JM, Zhou, XF, Li, CQ, Yang, ZY & Dai, RP 2019, 'Brain-derived neurotrophic factor precursor in the hippocampus regulates both depressive and anxiety-like behaviors in rats', Frontiers in Psychiatry, vol. 10, article no. 776, pp. 1-11. Open access 9 15 1
2018	Bu, X-L, Xiang, Y, Jin, W-S, Wang, J, Zhou, X-F & Wang, Y and 17 other authors 2018, 'Blood-derived amyloid-β protein induces Alzheimer's disease pathologies', Molecular Psychiatry, vol. 23, no. 9, pp. 1948-1956. 64 54 358
2018	Duan, HQ, Wu, Q-L, Yao, X, Fan, B-Y, Shi, H-Y, Zhao, C-X, Zhang, Y, Li, B, Sun, C, Kong, X-H, Zhou, X-F & Feng, S-Q 2018, 'Nafamostat mesilate attenuates inflammation and apoptosis and promotes locomotor recovery after spinal cord injury', CNS Neuroscience and Therapeutics, vol. 24, no. 5, pp. 429-438. Open access 10 9 1
2018	Huang, H, Young, W, Chen, L, Feng, S, Zhou, X-F & Li, T 2018, 'Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)', Cell Transplantation, vol. 27, no. 2, pp. 310-324. Open access 10 16 1
2018	Liu, D, Manaph, NPA, Al-Hawwas, M, Zhou, XF & Liao, H 2018, 'Small molecules for neural stem cell induction', Stem Cells and Development, vol. 27, no. 5, pp. 297-312. 6 5 1
2018	Liu, S, Guo, W, Zhou, H, Tang, L, Feng, S, Zhong, JH & Zhou, XF 2018, 'proBDNF inhibits the proliferation and migration of OLN-93 oligodendrocytes', Molecular Medicine Reports, vol. 18, no. 4, pp. 3809-3817. Open access 3 3
2018	Mañucat-Tan, NB, Saadipour, K, Wang, Y-J, Bobrovskaya, L & Zhou, X-F 2018, 'Cellular trafficking of amyloid precursor protein in amyloidogenesis physiological and pathological significance', Molecular Neurobiology, vol. 56, no. 2, pp. 812-830. Open access 6 7
2018	Parikh, A, Kathawala, K, Li, J, Chen, C, Shan, Z, Cao, X, Wang, Y-J, Garg, S & Zhou, X-f 2018, 'Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer's disease model', Drug Design Development and Therapy, vol. 12, pp. 2111-2128. Open access 8 6
2018	Parikh, A, Kathawala, K, Li, J, Chen, C, Shan, Z, Cao, X, Zhou, X-F & Garg, S 2018, 'Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease', Drug Delivery and Translational Research, vol. 8, no. 5, pp. 1406-1420. 17 13 88
2018	Parikh, A, Kathawala, K, Song, Y, Zhou, XF & Garg, S 2018, 'Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability', Drug Delivery and Translational Research, vol. 8, no. 5, pp. 1389-1405. 12 12 81
2018	Parikh, A, Kathawala, K, Tan, CC, Garg, S & Zhou, X-F 2018, 'Self-nanomicellizing solid dispersion of edaravone: part I - oral bioavailability improvement', Drug Design Development and Therapy, vol. 12, pp. 2051-2069. Open access 8 7 1
2018	Pavathuparambil Abdul Manaph, N, Al-Hawaas, M, Bobrovskaya, L, Coates, PT & Zhou, XF 2018, 'Urine-derived cells for human cell therapy', Stem Cell Research and Therapy, vol. 9, no. 1, article no. 189, pp. 1-12. Open access 19 21 3
2018	Pavathuparambil Abdul Manaph, N, Al-Hawwas, M & Zhou, XF 2018, 'A direct and non-invasive method for kidney delivery of therapeutics in mice', MethodsX, vol. 5, pp. 1440-1446. Open access
2018	Pavathuparambil Abdul Manaph, N, Al-Hawwas, M, Liu, L, Liu, D, Hayball, J & Zhou, XF 2018, 'Facial vein injection of human cells in severe combined immunodeficiency (SCID) neonatal mice', MethodsX, vol. 5, pp. 1281-1286. Open access
2018	Rahman, M, Luo, H, Sims, NR, Bobrovskaya, L & Zhou, XF 2018, 'Investigation of mature BDNF and proBDNF signaling in a rat photothrombotic ischemic model', Neurochemical Research, vol. 43, no. 3, pp. 637-649. Open access 11 12
2018	Ruan, C-S, Liu, J, Yang, M, Saadipour, K, Zeng, YQ, Liao, H, Wang, YJ, Bobrovskaya, L & Zhou, X-F 2018, 'Sortilin inhibits amyloid pathology by regulating non-specific degradation of APP', Experimental Neurology, vol. 299, Part A, pp. 75-85. 7 7 1
2018	Saadipour, K, Mañucat-Tan, NB, Lim, Y, Keating, DJ, Smith, KS, Zhong, JH, Liao, H, Bobrovskaya, L, Wang, YJ, Chao, M V & Zhou, XF 2018, 'p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis', Journal of Neurochemistry, vol. 144, no. 3, pp. 302-317. Open access 14 16 1
2018	Shen, L-L, Mañucat-Tan, NB, Gao, S-H, Li, W-W, Zeng, F, Zhu, C, Wang, J, Bu, X-L, Liu, Y-H, Gao, C-Y, Xu, Z-Q, Bobrovskaya, L, Lei, P, Yu, J-T, Song, W, Zhou, H-D, Yao, X-Q, Zhou, X-F & Wang, Y-J 2018, 'The ProNGF/p75NTR pathway induces tau pathology and is a therapeutic target for FTLD-tau', Molecular Psychiatry, vol. 23, no. 8, pp. 1813-1824. 20 18 57
2018	Su, YW, Chim, SM, Zhou, L, Hassanshahi, M, Chung, R, Fan, C, Song, Y, Foster, BK, Prestidge, CA, Peymanfar, Y, Tang, Q, Butler, LM, Gronthos, S, Chen, D, Xie, Y, Chen, L, Zhou, XF, Xu, J & Xian, CJ 2018, 'Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats', Bone, vol. 116, pp. 232-247. Open access 7 5 1
2018	Wang, Y-R, Wang, J, Liu, Y-H, Hu, G-L, Gao, C-Y, Wang, Y-J, Zhou, X-F & Zeng, F 2018, 'Cysteine-rich repeat domains 2 and 4 are amyloid-beta binding domains of neurotrophin receptor p75NTR and potential targets to block amyloid-beta neurotoxicity', Journal of Alzheimer's Disease, vol. 63, no. 1, pp. 139 -147. 2 2 7
2018	Yan, Y-T, Li, S-D, Li, C, Xiong, Y-X, Lu, X-H, Zhou, X-F, Yang, L-Q, Pu, L-J & Luo, H-Y 2018, 'Panax notoginsenoside saponins Rb1 regulates the expressions of Akt/ mTOR/PTEN signals in the hippocampus after focal cerebral ischemia in rats', Behavioural Brain Research, vol. 345, pp. 83-92. 18 19
2018	Yi, X, Liu, YH, Zhou, X-F, Wang, YJ, Deng, J, Liu, J, He, HB & Xu, ZQ 2018, 'The influence of abdominal and ectopic fat accumulation on carotid intima-media thickness: a Chongqing study', Journal of Stroke and Cerebrovascular Diseases, vol. 27, no. 7, pp. 1992-1997. 3 3
2018	Zeng, YQ, Cui, YB, Gu, JH, Liang, C & Zhou, XF 2018, 'Scutellarin mitigates Aβ-induced neurotoxicity and improves behavior impairments in AD mice', Molecules, vol. 23, no. 4, article no. 869, pp. 1-12. Open access 8 8 7
2018	Zhou, L, Xiong, J, Ruan, C-S, Ruan, Y, Liu, D, Bao, J-J & Zhou, X-F 2018, 'ProBDNF/p75NTR/sortilin pathway is activated in peripheral blood of patients with alcohol dependence', Translational Psychiatry, vol. 7, article no. 2, pp. 1-10. Open access 12 14 1
2018	Zhou, X-F, Zeng, Y-Q, Guo, Y, Ruan, C-S & Bobrovskaya, L 2018, 'A pilot study in modeling mood disorders in mice by chronic tail-suspension stress', Neuropsychiatry, vol. 8, no. 5, pp. 1586-1592. Open access
2017	Chen, J, Zhang, T, Jiao, S, Zhou, X, Zhong, J, Wang, Y, Liu, J, Deng, J, Wang, S & Xu, Z 2017, 'ProBDNF accelerates brain amyloid-β deposition and learning and memory impairment in APPswePS1dE9 transgenic mice', Journal of Alzheimer's Disease, vol. 59, no. 3, pp. 941-949. 9 10 7
2017	Hu, X, Hu, Z-L, Li, Z, Ruan, C-S, Qiu, W-Y, Pan, A, Li, C-Q, Cai, Y, Shen, L, Chu, Y, Tang, B-S, Cai, H, Zhou, X-F, Ma, C & Yan, X-X 2017, 'Sortilin fragments deposit at senile plaques in human cerebrum', Frontiers in Neuroanatomy, vol. 11, article no. 45, pp. 1-19. Open access 15 15 10
2017	Jin, W-S, Shen, L-L, Bu, X-L, Zhang, W-W, Chen, S-H, Huang, Z-L, Xiong, J-X, Gao, C-Y, Dong, Z, He, Y-N, Hu, Z-A, Zhou, H-D, Song, W, Zhou, X-F, Wang, Y-Z & Wang, Y-J 2017, 'Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model', Acta Neuropathologica, vol. 134, no. 2, pp. 207-220. 41 34 19
2017	Li, J-Y, Liu, J, Pavathuparambil Abdul Manaph, N, Bobrovskaya, L & Zhou, X-F 2017, 'ProBDNF inhibits proliferation, migration and differentiation of mouse neural stem cells', Brain Research, vol. 1668, pp. 46-55. 18 20 10
2017	Liang, C, Yuan, J-P, DIng, T, Yan, L, Ling, L, Zhou, X-F & Zeng, Y-Q 2017, 'Neuroprotective effect of Fagopyrum dibotrys extract against Alzheimer's disease', Evidence-Based Complementary and Alternative Medicine, vol. 2017. Open access 1 1 10
2017	Lim, Y, Wu, LLY, Chen, S, Sun, Y, Vijayaraj, SL, Yang, M, Bobrovskaya, L, Keating, D, Li, XJ & Zhou, X-F 2017, 'HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons', Molecular Neurobiology, vol. 54, pp. 1-16. Open access 11 9
2017	Lim, YY, Rainey-Smith, S, Lim, Y, Laws, SM, Gupta, V, Porter, T, Bourgeat, P, Ames, D, Fowler, C, Salvado, O, Villemagne, VL, Rowe, CC, Masters, CL, Zhou, XF, Martins, RN & Maruff, P 2017, 'BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF', International Psychogeriatrics, vol. 29, no. 11, pp. 1825-1834. 9 7 7
2017	Liu, Y, Li, C, Wang, J, Fang, Y, Sun, H, Tao, X, Zhou, X-F & Liao, H 2017, 'Nafamostat mesilate improves neurological outcome and axonal regeneration after stroke in rats', Molecular Neurobiology, vol. 54 no. 6, pp. 4217-4231. 11 12 1
2017	Mackenzie, KD, Lim, Y, Duffield, MD, Chataway, T, Zhou, X-F & Keating, DJ 2017, 'Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins', Cellular Signalling, vol. 35, pp. 176-187. 16 17
2017	Parikh, A, Kathawala, K, Tan, CC, Garg, S & Zhou, X-F 2017, 'Development of a novel oral delivery system of edaravone for enhancing bioavailability', International Journal of Pharmaceutics, vol. 515, no 1-2, pp. 490-500. Open access 18 17 3
2017	Parikh, A, Kathawala, K, Tan, CC, Garg, S & Zhou, XF 2017, 'Lipid-based nanosystem of edaravone: development, optimization, characterization and in vitro/in vivo evaluation', Drug Delivery, vol. 24, no. 1, pp. 962-978. Open access 17 17 3
2017	Ruan, C-S, Bobrovskaya, L & Zhou, X-F 2017, 'Female wild-type and APP/PS1 transgenic mice deficient in Sort1 are prone to anxiety-like behavior at older ages', Neuropsychiatry, vol. 7, no. 6, pp. 1047-1052. Open access
2017	Su, Y-W, Zhou, X-F, Foster, BK, Grills, BL, Xu, J & Xian, CJ 2017, 'Roles of neurotrophins in skeletal tissue formation and healing', Journal of Cellular Physiology, vol. 233, no. 3, pp. 2133-2145. Open access 21 17
2017	Wang, S, Li, M, Guo, Y, Li, C, Wu, L, Zhou, X-F, Luo, Y, An, D, Li, S, Luo, H & Pu, L 2017, 'Effects of Panax notoginseng ginsenoside Rb1 on abnormal hippocampal microenvironment in rats', Journal of Ethnopharmacology, vol. 202, pp. 138-146. Open access 14 11
2017	Xiong, L-L, Hu, Y, Zhang, P, Zhang, Z, Li, L-H, Gao, G-D, Zhou, X-F & Wang, T-H 2017, 'Neural stem cell transplantation promotes functional recovery from traumatic brain injury via brain derived neurotrophic factor-mediated neuroplasticity', Molecular Neurobiology, vol. 55, no. 3, pp. 1-16. 13 12 3
2017	Yang, C, Bai, Y, Ruan, C, Zhou, F, Li, F, Li, C & Zhou, X 2017, 'Injection of anti-proBDNF in anterior cingulate cortex (ACC) reverses chronic stress-induced adverse mood behaviors in mice', Neurotoxicity Research, vol. 31, no. 2, pp. 298-308. 19 17
2017	Yang, J-W, Ma, W, Yang, Y-L, Wang, X-B, Li, X-T, Wang, T-t, Wang, X-P, Gao, W, Li, J-Y, Zhou, X-F, Guo, J-H & Li, L-Y 2017, 'Region-specific expression of precursor and mature brain-derived neurotrophic factors after chronic alcohol exposure', American Journal of Drug and Alcohol Abuse, vol. 43, no. 5, pp. 602-608. 4 3
2016	Bai, Y-Y, Ruan, C-S, Yang, C-R, Li, J-Y, Kang, Z-L, Zhou, L, Liu, D, Zeng, Y-Q, Wang, T-H, Tian, C-F, Liao, H, Bobrovskaya, L & Zhou, X-F 2016, 'ProBDNF signaling regulates depression-like behaviors in rodents under chronic stress', Neuropsychopharmacology, vol. 41, no. 12, pp. 2882-2892. Open access 46 45 2
2016	Ding, Y-Q, Li, X-Y, Xia, G-N, Ren, H-Y, Zhou, X-F, Su, B-Y & Qi, J-G 2016, 'ProBDNF inhibits collective migration and chemotaxis of rat Schwann cells', Tissue and Cell, vol. 48, no. 5, pp. 503-510. 2 2
2016	Fang, Y, Yao, L, Li, C, Wang, J, Wang, J, Chen, S, Zhou, X-F & Liao, H 2016, 'The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice', Journal of Neuroinflammation, vol. 13, no. 56, pp. 1-17. Open access 17 16 7
2016	Han, Y-C, Lim, Y, Duffieldl, MD, Li, H, Liu, J, Abdul, MNP, Yang, M, Keating, DJ & Zhou, X-F 2016, 'Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules', Stem Cells International, vol. 2016, article no. 4304916, pp. 1-11. Open access 36 32 6
2016	Jiao, S, Shen, L, Zhu, C, Bu, X, Liu, Y, Liu, C, Yao, X, Zhang, L, Zhou, H, Walker, D, Tan, J, Götz, J, Zhou, X & Wang, Y 2016, 'Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer's disease', Translational Psychiatry, vol. 6, no. 10 article no. e907, pp. 1-11. Open access 63 62 11
2016	Li, C, Wang, J, Fang, Y, Liu, Y, Chen, T, Sun, H, Zhou, X-F & Liao, H 2016, 'Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats', Brain Behavior and Immunity, vol. 56, pp. 230-245. 25 23 1
2016	Li, F, Cao, W-Y, Huang, F-L, Kang, W-J, Zhong, X-L, Hu, Z-L, Wang, H-T, Zhang, J, Zhang, J-Y, Dai, R-P, Zhou, X-F & Li, C-Q 2016, 'Roles of NMDA and dopamine in food-foraging decision-making strategies of rats in the social setting', BMC Neuroscience, vol. 17, article no. 3. Open access 3 3 2
2016	Luo, C, Zhong, X-L, Zhou, FH, Li, J-y, Zhou, P, Xu, J-M, Song, B, Li, C-Q, Zhou, X-F & Dai, R-P 2016, 'Peripheral brain derived neurotrophic factor precursor regulates pain as an inflammatory mediator', Scientific Reports, vol. 6, no. 2, article no. 27171, pp. 1-11. Open access 24 23 2
2016	Mackenzie, KD, Lumsden, A, Guo, F, Duffield, MD, Chataway, T, Lim, Y, Zhou, X-F & Keating, DJ 2016, 'Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking', Journal of Neurochemistry, vol. 138, no. 5, pp. 710-721. Open access 10 10 1
2016	Ruan, C-S, Yang, C-R, Li, J-Y, Luo, H-Y, Bobrovskaya, L & Zhou, X-F 2016, 'Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior', Experimental Neurology, vol. 281 pp. 99-108. 15 14
2016	Senthilkumaran, M, Zhou, X-F & Bobrovskaya, L 2016, 'Challenges in modelling hypoglycaemia-associated autonomic failure: A review of human and animal studies', International Journal of Endocrinology, vol. 2016, article no. 9801640, pp. 1-13. Open access 8 7
2016	Shan, Z-n, Tian, R, Zhang, M, Gui, Z-h, Wu, J, Ding, M, Zhou, X-F & He, J 2016, 'miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3', Oncotarget, vol. 7, no. 48, pp. 78813-78826. Open access 28 27
2016	Su, Y-W, Chung, R, Ruan, C-S, Chim, SM, Kuek, V, Dwivedi, PP, Mohammadhossein Hassanshahi , Chen, K-M, Xie, Y, Chen, L, Foster, BK, Rosen, V, Zhou, X-F, Xu, J & Xian, CJ 2016, 'Neurotrophin-3 induces BMP-2 and VEGF activities and promotes the bony repair of injured growth plate cartilage and bone in rats', Journal of Bone and Mineral Research, v. 31, no. 6, pp. 1258-1274. Open access 31 26
2016	Wang, Q-H, Wang, Y-R, Zhang, T, Jiao, S-S, Liu, Y-H, Zeng, F, Li, J, Yao, X-Q, Zhou, H-D, Zhou, X-F & Wang, Y-J 2016, 'Intramuscular delivery of p75NTR ectodomain by an AAV vector attenuates cognitive deficits and Alzheimer's disease-like pathologies in APP/PS1 transgenic mice', Journal of Neurochemistry, vol. 138, no. 1, pp. 163-173. Open access 12 9 24
2015	Jiao, S-S, Yao, X-Q, Liu, Y-H, Wang, Q-H, Lu, J, Liu, J, Parikh, A, Zhong, J-H, Zhou, X-F & Wang, Y-J and 17 other authors 2015, 'Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits', Proceedings of the National Academy of Sciences of USA, vol. 112, no. 16, pp. 5225-5230. Open access 75 71 103
2015	Johnson, ME, Lim, Y, Senthilkumaran, M, Zhou, X-F & Bobrovskaya, L 2015, 'Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease', Journal of Chemical Neuroanatomy, vol. 70, pp. 33-41. 20 16
2015	Lim, Y, Zhong, J-H & Zhou, X-F 2015, 'Development of mature BDNF-specific sandwich ELISA', Journal of Neurochemistry, vol. 134, no. 1, pp. 75-85. 27 26
2015	Rong, R, Wang, Y-C, Hu, L-q, He, Q-q, Zhou, X-F, Wang, T-h & Bu, P-l 2015, 'Role of endogenous PDGF-BB in cultured cardiomyocytes exposed to hypoxia', Neuropeptides, vol. 50, pp. 43-49. 6 6 1
2015	Ruan, C, Zhou, F, He, Z, Wang, S, Yang, C, Shen, Y, Guo, Y, Zhao, H, Chen, L, Liu, D, Liu, J, Baune, B, Xiao, Z & Zhou, X 2015, 'Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors', Neuroscience, vol. 293, pp. 12- 22. 13 12
2015	Wang, X, Ba, Y, Xiong, L-l, Li, X-l, Zou, Y, Zhu, Y, Zhou, X-F, Wang, T-h, Wang, F, Tian, H & Li, J 2015, 'Endogenous TGFB1 Plays a Crucial Role in Functional Recovery After Traumatic Brain Injury Associated with Smad3 Signal in Rats', Neurochemical Research, vol. 40, no. 8, pp. 1671-1680. 9 10
2015	Wang, X-Q, Zhong, X-L, Li, Z-B, Wang, H-T, Zhang, J, Li, F, Zhang, J-Y, Dai, R-P, Zhou, X-F, Li, C-Q, Li, Z-Y & Bi, F-F 2015, 'Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats', BMC Neuroscience, vol. 16, pp. 1-12. Open access 28 25 1
2015	Xiang, Y, Bu, X-L, Liu, Y-H, Zhu, C, Shen, L-L, Jiao, S-S, Zhu, X-Y, Giunta, B, Tan, J, Song, W-H, Zhou, H-D, Zhou, X-F & Wang, Y-J 2015, 'Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer's disease', Acta Neuropathologica, vol. 130, no. 4, pp. 487-499. Open access 37 75 19
2015	Xiong, J, Zhou, L, Lim, Y, Yang, M, Zhu, y, Li, Z- W, Fu, D-L & Zhou, X-F 2015, 'Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues', Oncology Letters. Open access 14 14
2015	Yao, J, Jiao, S, Saadipour, K, Zeng, F, Zhong, J, Zhou, X & Wang, Y and 18 other authors 2015, 'p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease', Molecular Psychiatry, vol. 20, no. 11, pp. 1301-1310. Open access 48 46 27
2015	Zhou, FH-h, Yu, Y, Zhou, X-F & Xian, CJ 2015, 'Methotrexate chemotherapy triggers touch-evoked pain and increased CGRP-positive sensory fibres in the tibial periosteum of young rats', Bone, vol. 73, pp. 24-31. Open access 1 1 4
2014	Li, C-Q, Luo, Y-W, Bi, F-F, Cui, T-T, Song, L, Cao, W-Y, Zhang, J-Y, Li, F, Xu, J-M, Hao, W, Xing, X-W, Zhou, FH, Zhou, X-F & Dai, R-P 2014, 'Development of anxiety-like behavior via hippocampal IGF-2 signaling in the offspring of parental morphine exposure: effect of enriched environment', Neuropsychopharmacology, 39, no. 12, pp. 2777-2787. Open access 34 33 1
2014	Liu, Y-H, Jiao, S-S, Wang, Y-R, Bu, X-L, Yao, X-Q, Xiang, Y, Wang, Q-H, Wang, L, Deng, J, Li, J, Zhou, X-F, Zhou, H-D & Wang, Y-J 2014, 'Associations between ApoEɛ4 carrier status and serum BDNF levels, new insights into the molecular mechanism of ApoEɛ4 actions in Alzheimer's disease', Molecular Neurobiology, vol. 51, no. 3, pp. 1271-1277. 11 15
2014	Liu, Y-H, Wang, Y-R, Xiang, Y, Zhou, H-D, Giunta, B, Manucat-Tan, NB, Tan, J, Zhou, X-F & Wang, Y-J 2014, 'Clearance of amyloid-beta in Alzheimer's disease: shifting the action site from center to periphery', Molecular Neurobiology, vol. 51, no. 1, pp. 1-7. Open access 22 42
2014	Mackenzie, KD, Duffield, MD, Peiris, H, Phillips, L, Zanin, MP, Teo, EH, Zhou, X-F & Keating, DJ 2014, 'Huntingtin-associated protein 1 regulates exocytosis, vesicle docking, readily releasable pool size and fusion pore stability in mouse chromaffin cells', The Journal of Physiology, vol. 592, no. 7, pp. 1505-1518. Open access 22 22
2014	Ruan, C, Wang, S-F, Shen, Y-J, Guo, Y, Yang, C-R, Zhou, FH, Tan, L-T, Zhou, L, Liu, J-J, Wang, W-Y, Xiao, Z-C & Zhou, X-F 2014, 'Deletion of TRIM32 protects mice from anxiety- and depression-like behaviors under mild stress', European Journal of Neuroscience, vol. 40, no. 4, pp. 2680-2690. Open access 14 20 1
2014	Wang, W, Wang, F, Liu, J, Zhao, W, Zhao, Q, He, M, Qian, B-J, Xu, Y, Liu, R, Liu, S-J, Liu, W, Liu, J, Zhou, X-F & Wang, T-Y 2014, 'SNAP25 Ameliorates Sensory Deficit in Rats with Spinal Cord Transection', Molecular Neurobiology, vol. 50, no. 2, pp. 290-304. 18 18
2014	Wang, Y-C, Xia, Q-J, Ba, Y-C, Wang, T-Y, Lin, N, Zou, Y, Shang, F-F, Zhou, X-F, Wang, T-H, Fu, X-M & Qi, J-G 2014, 'Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad', Cytotherapy, vol. 16, pp. 1000-1010. 9 9
2014	Xiang, J, Yang, H, Zhao, T, Sun, M, Xu, X, Zhou, X-F, Li, S-H & Li, X-J 2014, 'Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting', Journal of Clinical Investigation, vol. 124, no. 1, pp. 85-98. Open access 20 20 10
2014	Yang, C, Bai, Y, Ruan, C, Zhou, H, Liu, D, Wang, X, Shen, L, Zheng, H & Zhou, X 2014, 'Enhanced aggressive behaviour in a mouse model of depression', Neurotoxicity Research, vol. 27, no. 2, pp. 129-142. 27 27
2014	Yang, C, Zhang, Z, Bai, Y, Zhou, HF, Zhou, L, Ruan, C, Li, F, Li, C, Zheng, H, Shen, L & Zhou, X 2014, 'Foraging activity is reduced in a mouse model of depression', Neurotoxicity Research, vol. 25, no. 3, pp. 235-247. 14 15
2014	Yang, X, Liu, J, Liu, Z-J, Xia, Q-J, He, M, Liu, R, Liu, W, Wang, W, Liu, J, Zhou, X-F, Zhang, Y-H & Wang, T-H 2014, 'Reversal of bone cancer pain by HSV-1-mediated silencing of CNTF in an afferent area of the spinal cord associated with AKT-ERK signal inhibition', Current Gene Therapy: The International Journal for In-Depth Reviews on Gene Therapy, vol. 14, no. 5, pp. 377-388. 6 5
2014	Zeng, Y-Q, Wang, Y-J & Zhou, X-F 2014, 'Effects of (-)epicatechin on the pathology of APP/PS1 transgenic mice', Frontiers in Neurology, vol. 5, article no. 69, pp. 1-10. Open access 18 20 1
2013	Guo, J, Wang, J, Liang, C, Yan, J, Wang, Y, Liu, G, Jiang, Z, Zhang, L, Wang, X, Wang, Y-J, Zhou, X-F & Liao, H 2013, 'proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro', Stem Cell Research, vol. 11, no. 2, pp. 874-887. Open access 15 13 6
2013	Li, Y, Jiang, Y, Xiong, J, Zhou, X-F, Wang, Y & Li, G 2013, 'A monoclonal antibody against the extracellular domain of P75 neurotrophin receptor', Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, vol. 32, no. 1, pp. 55-59. Open access 5 3
2013	Luo, Y, Zou, Y, Yang, L, Liu, J, Liu, S, Liu, J, Zhou, X, Zhang, W & Wang, T 2013, 'Transplantation of NSCs with OECs alleviates neuropathic pain associated with NGF downregulation in rats following spinal cord injury', Neuroscience Letters, vol. 549, pp. 103-108. 20 20
2013	Majd, S, Chegini, F, Chataway, T, Zhou, X-F & Gai, WP 2013, 'Reciprocal induction between α-synuclein and β-amyloid in adult rat neurons', Neurotoxicity Research, vol. 23, no. 1, pp. 69-78. 15 15
2013	Saadipour, K, Yang, M, Lim, Y, Georgiou, K, Sun, Y, Keating, D, Liu, J, Wang, Y-R, Gai, W-P, Zhong, J-h, Wang, Y-J & Zhou, X-F 2013, 'Amyloid beta1-42 (Aβ42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway', Journal of Neurochemistry, vol. 127, no. 2, pp. 152-162. Open access 35 31 2
2013	Shang, F-F, Zhao, W, Zhao, Q, Liu, J, Li, D-W, Zhang, H, Zhou, X-F, Li, C-Y & Wang, T-H 2013, 'Upregulation of eIF-5A1 in the paralyzed muscle after spinal cord transection associates with spontaneous hindlimb locomotor recovery in rats by upregulation of the ErbB, MAPK and neurotrophin signal pathways', Journal of Proteomics, vol. 91, pp. 188-199. 13 13 2
2013	Xiong, J, Zhou, L, Lim, Y, Yang, M, Zhu, Y, Li, Z, Zhou, FH-h, Xiao, Z & Zhou, X-F 2013, 'Mature BDNF promotes the growth of glioma cells in vitro', Oncology Reports: An International Journal Devoted to Fundamental and Applied Research in Oncology, vol. 30, no. 6, pp. 2719-2724. Open access 24 23
2013	Xiong, J, Zhou, L, Yang, M, Lim, Y, Zhu, Y-h, Fu, D-l, Li, Z-w, Zhong, J-h, Xiao, Z-c & Zhou, X-F 2013, 'ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro', Neuro-Oncology, vol. 15, no. 8, pp. 990-1007. Open access 32 29 1
2013	Yang, M, Virassamy, B, Vijayaraj, S, Lim, Y, Saadipour, K, Wang, Y, Han, Y, Zhong, J, Morales, C & Zhou, X-F 2013, 'The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking', PLoS One, vol. 8, no. 5, article no. e63049. Open access 18 16
2013	Zeng, F, Deng, Y-P, Yi, X, Cao, H-Y, Zou, H-Q, Wang, X, Liang, C-R, Wang, Y-R, Zhang, L-L, Gao, C-Y, Xu, Z-Q, Lian, Y, Wang, L, Zhou, X-F, Zhou, H-D & Wang, Y-J 2013, 'No association of SORT1 gene polymorphism with sporadic Alzheimer's disease in the Chinese Han population', NeuroReport, vol. 24, no. 9, pp. 464-468. 10 10 1
2013	Zheng, F, Zou, H-Q, Zhou, H-D, Li, J, Wang, L, Cao, H-Y, Yi, X, Wang, X, Liang, C-R, Wang, Y-R, Zhang, A-Q, Tan, X-L, Peng, K-R, Zhang, L, Gao, C-Y, Xu, Z-Q, Wen, A-Q, Lian, Y, Zhou, X-F & Wang, Y-J 2013, 'The relationship between single nucleotide polymorphisms of the NTRK2 gene and sporadic Alzheimer's disease in the Chinese Han population', Neuroscience Letters, vol. 550, pp. 55-59. 12 12
2013	Zhou, L, Xiong, J, Lim, Y, Ruan, Y, Huang, C, Zhu, Y, Zhong, J-h, Xiao, Z & Zhou, X-F 2013, 'Upregulation of blood proBDNF and its receptors in major depression', Journal of Affective Disorders, vol. 150, no. 3, pp. 776-784. 85 75 3
2012	Li, F, Cao, W, Li, M, Xu, Y, Zhang, J, Zhang, J, Luo, X, Dai, R, Zhou, X & Li, C 2012, 'A simple method for detection of food foraging behavior in the rat : involvement of NMDA and dopamine receptors in the behavior', Neuroscience, vol. 205, no. 15, pp. 73-80. 11 10
2012	Li, F, Li, M, Cao, W, Xu, Y, Luo, Y, Zhong, X, Zhang, J, Dai, R, Zhou, X-F, Li, Z & Li, C 2012, 'Anterior cingulate cortical lesion attenuates food foraging in rats', Brain Research Bulletin, vol. 88, no. 6, pp. 602-608. 22 21
2012	Li, H, Li, C, Dai, R, Shi, X, Xu, J, Zhang, J, Zhou, X, Li, Z & Luo, X 2012, 'Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats', Neural Regeneration Research, vol. 7, no. 7, pp. 517-522. 6 7
2012	Sun, Y, Lim, Y, Li, F, Liu, S, Lu, J-J, Haberberger, R, Zhong, J-H & Zhou, X-F 2012, 'ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA', PLoS One, vol. 7, no. 4, article no. e35883, pp. 1-12. Open access 108 70
2012	Yan, J, Zhou, X, Guo, J-J, Mao, L, Wang, Y-J, Sun, J, Sun, L-X, Zhang, L-Y, Zhou, X-F & Liao, H 2012, 'Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro', Journal of Neurochemistry, vol. 120, no. 5, pp. 721-731. Open access 54 49
2012	Yang, G-Z, Yang, M, Lim, Y, Lu, J-J, Wang, T-H, Qi, J-G, Zhong, J-H & Zhou, X-F 2012, 'Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons', Journal of Neurochemistry, vol. 122, no. 5, pp. 1010-1022. Open access 27 25
2012	Yu, H, Yang, M, Wang, Y, Xiao, R & Zhou, X-F 2012, 'p75NTR is mainly responsible for Aβ toxicity but not for its internalization : a primary study', Neurological Sciences, vol. 33, no. 5, pp. 1043-1050. 4 3
2012	Zhang, F, Kang, Z, Li, W, Xiao, Z & Zhou, X 2012, 'Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease', Journal of Clinical Neuroscience, vol. 19, no. 7, pp. 946-949. 56 55 3
2011	Aguilar, SEA, Pollard, AN, Smith, M & Zhou, X-F 2011, 'Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats', BMC Neuroscience, vol. 12, article no. 11, pp. 1-13. Open access 18 17
2011	Bastian, I, Tam, TS, Zhou, X-F, Kazenwadel, J, Van Der Hoek, M, Michael, MZ, Gibbins, I & Haberberger, RV 2011, 'Differential expression of microRNA-1 in dorsal root ganglion neurons', Histochemistry and Cell Biology, vol. 135, no. 1, pp. 37-45. 14 13
2011	Dai, R, Li, C, Zhang, J, Li, F, Shi, X, Zhang, J & Zhou, X-F 2011, 'Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical hypersensitivity in rats after incision', Anesthesiology, vol. 115, no. 3, pp. 604-613. Open access 36 34
2011	Jia, L, Yu, Z, Hui, L, Yu-Guang, G, Zhou, X-F, Chao, Y, Yanbin, X, Xi, Z, Jun, W, Xin-Hua, H & Ting-Hua, W 2011, 'Fas and FasL expression in the spinal cord following cord hemisection in the monkey', Neurochemical Research, vol. 36 no. 3, pp. 419-425. 10 9
2011	Li, F, Wang, X-S, Dai, R-P, Zhang, J-Y, Zhou, X-F, Hao, W & Li, C-Q 2011, 'The activation of NMDA receptor-ERK pathway in the central amygdala is required for the expression of morphine-conditioned place preference in the rat', Neurotoxicity Research, vol. 20 no. 4, pp. 362-371. 21 21
2011	Lockshin, LS, Cohen, E & Zhou, X-F 2011, 'What Influences five-star Beijing restaurants in making wine lists?', Journal of Wine Research, vol. 22, no. 3, pp. 227-243. 7
2011	Tam, TS, Bastian, I, Zhou, X-F, Van Der Hoek, M, Michael, MZ, Gibbons, I & Haberberger, R 2011, 'MicroRNA-143 expression in dorsal root ganglion neurons', Cell and Tissue Research, vol. 346, no. 2, pp. 163-173. 29 26
2011	Wang, Y-J, Wang, X, Lu, J-J, Li, Q-X, Gao, C-Y, Liu, X-H, Sun, Y, Yang, M, Lim, Y, Evin, G, Zhong, J-H, Masters, C & Zhou, X-F 2011, 'p75NTR regulates Aß deposition by increasing Aß production but inhibiting Aß aggregation with its extracellular domain', Journal of Neuroscience, vol. 31, no. 6, pp. 2292-2304. Open access 61 56
2011	Xu, Z-Q, Sun, Y, Li, H-Y, Lim, Y, Zhong, J-H & Zhou, X-F 2011, 'Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice', European Journal of Neuroscience, vol. 33 no. 8, pp. 1376-1384. 44 41
2011	Yang, M, Lim, Y, Li, X, Zhong, J-H & Zhou, X-F 2011, 'Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing', Journal of Biological Chemistry, vol. 286, no. 18, pp. 16272-16284. Open access 51 47
2011	Zeng, F, Lu, J-J, Zhou, X-F & Wang, Y-J 2011, 'Roles of p75NTR in the pathogenesis of Alzheimer's disease: a novel therapeutic target', Biochemical Pharmacology, vol. 82, no. 10, pp. 1500-1509. 34 34
2011	Zhou, X-F & Wang, Y-J 2011, 'The p75NTR extracellular domain: a potential molecule regulating the solubility and removal of amyloid-β', Prion, vol. 5 no. 3, pp. 161-163. Open access 14 12
2010	Aguilar, SE, Pollard, A, Smith, M & Zhou, X-F 2010, 'Sciatic nerve conditioning lesion increases macrophage response but it does not promote the regeneration of injured optic nerves', Brain Research, vol. 1361, pp. 12-22. 3 3
2010	Li, C-Q, Zhang, J-W, Dai, RP, Wang, J, Luo, XG & Zhou, X-F 2010, 'Surgical incision induces anxiety-like behavior and amygdala sensitization: Effects of morphine and gabapentin', Pain Research and Treatment, vol. 2010, article no. 705874, pp. 1-9. Open access 18 4
2010	Li, F, Zhang, J-W, Wei, R, Luo, XG, Zhang, J-Y, Zhou, X-F, Li, C & Dai, R 2010, 'Sex-differential modulation of visceral pain by brain derived neurotrophic factor (BDNF) in rats', Neuroscience Letters, vol. 478 no. 3, pp. 184-187. 13 12
2010	WANG, Y, Valadares, D, Sun, Y, Wang, X, Zhong, J, Liu, X-H, Majd, S, Chen, L, Gao, C-Y, Chen, S, Lim, Y, Pollard, A, Aguilar, E, Gai, WP, Yang, M & Zhou, X-F 2010, 'Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism', Neurotoxicity Research, vol. 17, no. 3, pp. 257-267. 32 30
2010	Wang, Y, Zhou, H & Zhou, X-F 2010, 'Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid-ß clearance', Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1065-1075. 19 18
2010	Wang, Y-J, Gao, C-Y, Yang, M, Liu, X-H, Sun, Y, Pollard, A, Dong, X-Y, Wu, X-B, Zhong, J-H, Zhou, H-D & Zhou, X-F 2010, 'Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer's disease', Brain Behavior and Immunity, vol. 24, no. 8, pp. 1281-1293. 32 29
2010	Wong, I, Liao, H, Bai, X, Zaknic, A, Zhong, J, Guan, Y, Li, H-Y, Wang, Y-J & Zhou, X-F 2010, 'ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury', Brain Behavior and Immunity, vol. 24 no. 4, pp. 585-597. 39 38
2010	Wu, LL-y, Fan, Y, Li, S, Li, X-J & Zhou, X-F 2010, 'Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release', Journal of Biological Chemistry, vol. 285 no. 8, pp. 5614-5623. Open access 53 47
2009	Li, F, Li, L, Song, X-Y, Zhong, J, Luo, XG, Xian, CJ & Zhou, X-F 2009, 'Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats - Possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor', European Journal of Neuroscience.
2009	Song, X-Y, Zhang, F-H, Zhou, FH, Zhong, J & Zhou, X-F 2009, 'Deletion of p75NTR impairs regeneration of peripheral nerves in mice', Life Sciences, vol. 84, no. 3-4, pp. 61-68. 11 10
2009	Thomas, P, Wang, Y-J, Zhong, J-H, Kosaraju, S, O'Callaghan, NJ, Zhou, X-F & Fenech, M 2009, 'Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease', Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, vol. 661, no. 1-2, pp. 25-34. 71 60
2009	Wang, Y-J, Pollard, A, Zhong, J-H, Dong, X-Y, Wu, X-B, Zhou, H-D & Zhou, X-F 2009, 'Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease', Neurobiology of Aging, vol. 30, no. 3, pp. 364-376. 48 43
2009	Wang, Y-J, Thomas, P, Zhong, J-H, Bi, F-F, Kosaraju, S, Pollard, A, Fenech, M & Zhou, X-F 2009, 'Consumption of grape seed extract prevents amyloid-β deposition and attenuates inflammation in brain of an Alzheimer's disease mouse', Neurotoxicity Research, vol. 15, no. 1, pp. 3-14. 146 133
2009	Wu, LL-y & Zhou, X-F 2009, 'Huntingtin associated protein 1 and its functions', Cell Adhesion and Migration, vol. 3 no. 1, pp. 71-76. Open access 39 36
2008	Bi, F-F, Xiao, YH, Hu, H, Tian, FF, Wu, Y, Ding, L & Zhou, X-F 2008, 'Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats', Brain Research, vol. 1191, pp. 30-38. 16 14
2008	Fan, Y-J, Wu, L, Li., Wang, Y & Zhou, X-F 2008, 'Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats', European Journal of Neuroscience, vol. 27 no. 9, pp. 2380-2390. 48 46
2008	Feng, S-Q, Zhou, X-F, Rush, RA & Ferguson, IA 2008, 'Graft of pre-injured sural nerve promotes regeneration of corticospinal tract and functional recovery in rats with chronic spinal cord injury', Brain Research, vol. 1209, pp. 40-48. 20 15
2008	Li, H-Y & Zhou, X-F 2008, 'Potential conversion of adult clavicle-derived chondrocytes into neural lineage cells in vitro', Journal of Cellular Physiology, vol. 214 no. 3, pp. 630-644. 9 8
2008	Song, X-Y, Li, F, Zhang, F, Zhong, J & Zhou, X-F 2008, 'Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spina cord injury', PLoS One.

Research

Patents

Details	Registry	Status
Edaravone dosage form Zhou, Xinfu; Parikh, Ankit; Garg, Sanjay	CN	Filed
Edaravone dosage form Zhou, Xinfu; Parikh, Ankit; Garg, Sanjay	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Anhui Medical University	CHINA
Anhui Provincial Hospital	CHINA
Army Medical University	PAKISTAN
Austin Health	AUSTRALIA
Banner Sun Health Research Institute	UNITED STATES
Capital Medical University	CHINA
Central South University	CHINA
Chengdu Medical College	CHINA
China Center of Disease Control	CHINA
China Pharmaceutical University	CHINA
China-Japan Friendship Hospital	CHINA
Chinese Academy of Medical Sciences	CHINA
Chinese Academy of Sciences	CHINA
Chinese Centre for Disease Control and Preventation	CHINA
Chongqing Medical University	CHINA
Cogstate Limited	AUSTRALIA
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)	AUSTRALIA
Daping Hospital	CHINA
East China University of Science and Technology	CHINA
Edith Cowan University	AUSTRALIA
Emory University	UNITED STATES
First People's Hospital of Qujin	CHINA
First peoples hospital of Yunnan province	CHINA
Flinders University	AUSTRALIA
Fujian Kangshimei Pty Ltd	CHINA
Fujian Medical University	CHINA
General Hospital of Chinese People's Armed Police Forces	CHINA
General Hospital of Guangzhou Military Command	CHINA
Hamad Bin Khalifa University	QATAR
Harvard University	UNITED STATES
Hollywood Private Hospital	AUSTRALIA
Home for the Aged Guangzhou	CHINA
Kennedy Krieger Institute	UNITED STATES
Kunming Medical College	CHINA
Kunming Medical University	CHINA
Kunming Psychological Crisis Intervention and Research Center	CHINA
Kunming University of Science and Technology	CHINA
La Trobe University	AUSTRALIA
Lanzhou General Hospital	CHINA
Luzhou Medical College	CHINA
McGill University	CANADA
Mental Health Center of Chongqing	CHINA
Mental Health Research Institute	UNITED STATES
Monash University	AUSTRALIA
Nanjing University	CHINA
Nankai University	CHINA
National Ageing Research Institute	AUSTRALIA
National Institutes of Health	UNITED STATES
National University of Singapore	SINGAPORE
New York University	UNITED STATES
Northern Adelaide Local Health Network	AUSTRALIA
NYU Langone Medical Center	UNITED STATES
Peking Union Medical College	CHINA
PLA 123 Hospital	CHINA
Qingdao Central Hospital	CHINA
Qingdao University	CHINA
Royal Adelaide Hospital	AUSTRALIA
Rush University	UNITED STATES
Rutgers University	UNITED STATES
SA Pathology	AUSTRALIA
Second Affiliated Hospital of Kunming Medical University	CHINA
Second Xiangya Hospital of Central-South University	CHINA
Shandong University	CHINA
Shandong University of Technology	CHINA
Shanghai Jiao Tong University	CHINA
Shanghai Yile Biotechnology Co.	CHINA
Shezhen Children's Hospital	CHINA
Shijiazhuang Maternity and Child Healthcare Hospital	CHINA
Sichuan University	CHINA
Skirball Institute of Biomolecular Medicine	UNITED STATES
Soochow University	CHINA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
Southeast University	CHINA
Sun Yat-Sen University	CHINA
Tangdu Hospital, Fourth Military Medical University	CHINA
The General Hospital of Guangzhou Military Command	CHINA
The Mental Hospital of Yunnan Province	CHINA
Third Military Medical University	CHINA
Tianjin Haihe Hospital	CHINA
Tianjin Medical University	CHINA
Tianjin Mental Health Center	CHINA
Tianjin University	CHINA
Tsinghua University	CHINA
Tufts University	UNITED STATES
University of Adelaide	AUSTRALIA
University of British Columbia	CANADA
University of Melbourne	AUSTRALIA
University of Minnesota, Twin Cities	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of South Florida	UNITED STATES
University of Tennessee	UNITED STATES
University of Utah	UNITED STATES
University of Western Australia	AUSTRALIA
University School of Medicine	UNITED STATES
Wayne State University	UNITED STATES
West China Hospital	CHINA
West China Hospital of Sichuan University	CHINA
West China School of Medicine/West China Hospital of Sichuan University	CHINA
Women's and Children's Hospital	AUSTRALIA
Xiangya Hospital	CHINA
Xiangya Hospital of Central South University	CHINA
Xiangya Hospital of Central-South University	CHINA
Xinxiang Medical University	CHINA
Yunnan Agricultural University	CHINA
Yunnan First People's Hospital	CHINA
Yunnan Mental Hospital	CHINA
Yunnan University	CHINA
Zhejiang University	CHINA

External engagement & recognition

Engagement/recognition	Year
Associate Editor Neurotoxicity Research	2018
Associate Editor Neurotoxicity Research	2017
Member Society for Neuroscience	2017
Member Australian Neuroscience Society	2017
Member Neurotoxicity Society	2017
Research Fellowship National Health and Medical Research Council (NHMRC)	2012

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
`Neurotrophin related biomarkers in depression'	Current
`Understanding the Role of Neurotrophins in the Pathogenesis of Alzheimer's Disease'.	Current
Functional analysis of proBDNF in angiogenesis and stroke	Current
Generation of neural stem cells from human fibroblasts by small molecules	Current
Investigation of BDNF and its precursor protein proBDNF in depression	Current
Neuroprotection in Parkinson's disease	Current
Pharmacological and pharmacokinetic study of p75ecdfc in the animal model of Alzheimer's disease	Current
Scutellarin inhibits the proliferation and metastasis of colorectal cancer through CDC42 signaling pathway and associated with CDC42BPA regulated by HRAS and interacted with RAPGEF6 as well as Rac	Current
A role for p75 neurotrophin receptor in Neurodegeneration in Alzheimer's disease and tauopathy	Completed
Development of combined therapy for Alzheimer’s disease: a mechanistic study	Completed
Development of novel dosage forms to repurpose the drugs for Alzheimer's disease	Completed
Functions of proBDNF and its signaling receptor p75 in neuroprotection after ischemic stroke	Completed
Hypoglycaemia-associated autonomic failure: the involvement of catecholamine producing cells in the brain and adrenal gland	Completed
Investigation into a small molecule aided conversion of human urine cells into hepatocyte-like cells and beta-like cells in vitro	Completed
Investigation into signalling mechanisms of BDNF in neurological disorders	Completed
Potential function of neurotrophic factors in growth plate cartilage bony repair and skeletal cell formation	Completed
Roles of precursor of brain-derived neurotrophic factor in neuronal development and neurodegeneration	Completed
Roles of the precursor of brain derived neurotrophic factor in neuronal development and regeneration	Completed
The role of sortilin in regulating the pathological hallmarks and behavioural symptoms in Alzheimer’s disease	Completed

Professor Xin-Fu Zhou

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