This laboratory has a long standing interest in neurotrophins and their receptors in neural development and neurological disorders. In recent years, we are interested in how neurotrophins and their receptors signal in the neurodegenerative disease such as Alzheimer’s disease. BDNF is one of the most studied neurotrophins which is critical for brain functions such as learning and memory. Its precursor has a different role to that of mature BDNF. We have been investigating its role in spinal cord injury, in pain and in nerve development. Neurotrophins can be potential drugs for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases or nerve injuries including spinal cord injury and stroke.
... Read moreAbout me
This laboratory has a long standing interest in neurotrophins and their receptors in neural development and neurological disorders. In recent years, we are interested in how neurotrophins and their receptors signal in the neurodegenerative disease such as Alzheimer’s disease. BDNF is one of the most studied neurotrophins which is critical for brain functions such as learning and memory. Its precursor has a different role to that of mature BDNF. We have been investigating its role in spinal cord injury, in pain and in nerve development. Neurotrophins can be potential drugs for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases or nerve injuries including spinal cord injury and stroke.
We are also interested in developing methods to treat neurological diseases. We use a variety of techniques including biochemical, immunological, molecular and histological approaches in our research projects. The research activities are funded by NHMRC, ARC, UniSA and other funding agencies.
Currently, the lab has running 3 NHMRC grants and 1 ARC grant.
The laboratory is interested to take honours, Msc and PhD students. It has been successful in educating honours students, Msc students and PhD students. The graduates of honours and MScs are 100% either employed, or go to medicine training or PhD training. This lab has educated over a dozen PhD graduates who are all leaders in the academics and administraters in different parts of the world. There are a number of honours, Msc and PhD research projects available and Scholarships which support the high degree students.
Investigators: Xin-Fu Zhou, MSc, PhD Miao Yang, MBBS, PhD Yanchuang Han PhD Jianjun Lu, MBBS, PhD Support Staff : Jin-Hua Zhong Hua Li Annie Sun, BMSc Yoon Lim, BMSc Visiting Scholars Willian Shan Liu Shangqing (Sandrich) Liu Students Ying Sun, MBBS, MSc, PhD student Yoon Lim MSc, PhD student Khalil Saadipour, Msc, PhD student
About me
About me
Doctor of Philosophy The University of Melbourne
Master of Science PLA Military Medical Colldge
Research
Excludes commercial-in-confidence projects.
Characterization of beta cell-like cells coverted from human urine stem cells, Channel 7 Children's Research Foundation of SA, 01/01/2018 - 31/12/2018
Research and development on the application of stem cells for regenerative medicine, Bonus Capital Limited, 18/08/2015 - 15/12/2018
The roles of neurotrophins and their receptors in the development of Alzheimer's disease and spinal cord injury, NHMRC - Research Fellowship, 01/03/2012 - 31/12/2017
Generation of beta cell precursors from human somatic cells using only small molecules, Bio Research Complex Company Ltd, 23/05/2014 - 31/12/2016
Effects of Borneal derivatives on Amyloidgenesis in ad mice, Fujian Kangshimei Pty Ltd, 01/08/2015 - 30/09/2016
Generation of hematopoietic progenitor cells from reprogrammed somatic cells using small molecules, Cancer Council SA - Beat Cancer, 01/01/2014 - 15/03/2015
Use of the p75NTR extracellular domain as a therapeutic target for the treatment of Alzheimer's disease, NHMRC - Project Grant, 01/03/2012 - 31/12/2014
A role of sortilin in the development of Alzheimer's disease, NHMRC - Project Grant, 01/01/2012 - 30/11/2013
Research
Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus
Open access indicates that an output is open access.
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2014 |
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2021 |
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2021 |
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2020 |
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2020 |
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2020 |
1
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2020 |
1
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2020 |
2
1
1
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2020 |
1
1
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2020 |
1
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2020 |
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2020 |
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2020 |
1
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2019 |
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1
1
1
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2019 |
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2
2
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2019 |
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5
3
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2019 |
2
3
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2019 |
Open access
6
6
7
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2019 |
Open access
10
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2019 |
Open access
5
5
11
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2019 |
6
5
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2019 |
2
1
7
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2019 |
6
5
1
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2019 |
1
1
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2019 |
Open access
9
6
1
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2019 |
Open access
8
15
1
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2018 |
62
49
359
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2018 |
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10
8
1
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2018 |
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2018 |
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10
16
1
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2018 |
5
5
1
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2018 |
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3
3
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2018 |
Open access
6
7
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2018 |
Open access
8
6
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2018 |
16
13
88
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2018 |
12
11
81
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2018 |
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8
7
2
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2018 |
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18
20
5
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2018 |
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2018 |
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2018 |
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11
11
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2018 |
7
7
1
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2018 |
Open access
14
15
1
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2018 |
20
17
57
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2018 |
Open access
6
5
1
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2018 |
2
2
7
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2018 |
18
18
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2018 |
3
3
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2018 |
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8
8
7
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2018 |
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12
14
1
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2017 |
8
9
7
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2017 |
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14
14
10
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2017 |
40
34
19
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2017 |
18
20
10
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2017 |
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1
1
10
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2017 |
Open access
10
9
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2017 |
9
6
7
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2017 |
11
12
1
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2017 |
16
17
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2017 |
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18
16
3
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2017 |
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17
16
3
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2017 |
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2017 |
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19
16
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2017 |
Open access
13
10
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2017 |
11
11
3
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2017 |
19
17
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2017 |
4
3
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2016 |
Open access
44
42
2
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2016 |
2
2
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2016 |
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16
16
7
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2016 |
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36
32
6
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2016 |
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62
62
11
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2016 |
24
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1
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2016 |
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3
3
2
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2016 |
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23
23
2
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2016 |
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10
10
1
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2016 |
14
14
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2016 |
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8
7
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2016 |
Open access
28
26
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2016 |
Open access
30
24
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2016 |
Open access
10
9
25
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2015 |
Open access
75
69
103
|
2015 |
20
16
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2015 |
26
24
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2015 |
6
6
1
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2015 |
13
12
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2015 |
9
10
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2015 |
Open access
28
25
1
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2015 |
Open access
37
73
19
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2015 |
Open access
14
14
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2015 |
Open access
47
45
27
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2015 |
Open access
1
1
4
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2014 |
Open access
34
33
1
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2014 |
11
15
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2014 |
Open access
22
40
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2014 |
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22
21
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2014 |
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14
20
1
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2014 |
18
18
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2014 |
9
10
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2014 |
Open access
19
20
10
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2014 |
27
25
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2014 |
14
15
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2014 |
6
5
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2014 |
Open access
17
19
1
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2013 |
Open access
15
13
6
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2013 |
Open access
5
3
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2013 |
20
20
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2013 |
15
15
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2013 |
Open access
35
31
2
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2013 |
13
13
2
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2013 |
Open access
24
22
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2013 |
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32
29
1
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2013 |
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18
16
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2013 |
10
10
1
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2013 |
12
12
|
2013 |
83
74
3
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2012 |
11
10
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2012 |
22
21
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2012 |
6
7
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2012 |
Open access
107
70
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2012 |
Open access
52
48
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2012 |
Open access
27
25
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2012 |
4
3
|
2012 |
56
55
3
|
2011 |
Open access
17
17
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2011 |
14
13
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2011 |
Open access
35
34
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2011 |
10
9
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2011 |
21
21
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2011 |
7
1
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2011 |
29
26
1
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2011 |
Open access
60
55
9
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2011 |
44
41
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2011 |
Open access
50
47
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2011 |
34
33
4
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2011 |
Open access
13
12
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2010 |
3
3
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2010 |
Open access
18
4
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2010 |
13
12
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2010 |
30
30
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2010 |
19
18
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2010 |
31
29
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2010 |
39
38
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2010 |
Open access
52
46
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2009 |
Li, F, Li, L, Song, X-Y, Zhong, J, Luo, XG, Xian, CJ & Zhou, X-F 2009, 'Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats - Possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor', European Journal of Neuroscience. |
2009 |
11
10
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2009 |
71
60
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2009 |
48
43
|
2009 |
144
130
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2009 |
Open access
38
36
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2008 |
16
14
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2008 |
48
46
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2008 |
20
15
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2008 |
9
8
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2008 |
Song, X-Y, Li, F, Zhang, F, Zhong, J & Zhou, X-F 2008, 'Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spina cord injury', PLoS One. |
Research
Research
Details | Registry | Status |
---|---|---|
Zhou, Xinfu; Parikh, Ankit; Garg, Sanjay |
CN | Filed |
Zhou, Xinfu; Parikh, Ankit; Garg, Sanjay |
WO | Filed |
External engagement & recognition
Organisation | Country |
---|---|
Anhui Medical University | CHINA |
Anhui Provincial Hospital | CHINA |
Army Medical University | PAKISTAN |
Austin Health | AUSTRALIA |
Banner Sun Health Research Institute | UNITED STATES |
Capital Medical University | CHINA |
Central South University | CHINA |
Chengdu Medical College | CHINA |
China Center of Disease Control | CHINA |
China Pharmaceutical University | CHINA |
China-Japan Friendship Hospital | CHINA |
Chinese Academy of Medical Sciences | CHINA |
Chinese Academy of Sciences | CHINA |
Chinese Centre for Disease Control and Preventation | CHINA |
Chongqing Medical University | CHINA |
Cogstate Limited | AUSTRALIA |
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation) | AUSTRALIA |
Daping Hospital | CHINA |
East China University of Science and Technology | CHINA |
Edith Cowan University | AUSTRALIA |
Emory University | UNITED STATES |
First People's Hospital of Qujin | CHINA |
First peoples hospital of Yunnan province | CHINA |
Flinders University | AUSTRALIA |
Fujian Kangshimei Pty Ltd | CHINA |
Fujian Medical University | CHINA |
General Hospital of Chinese People's Armed Police Forces | CHINA |
General Hospital of Guangzhou Military Command | CHINA |
Hamad Bin Khalifa University | QATAR |
Harvard University | UNITED STATES |
Hollywood Private Hospital | AUSTRALIA |
Home for the Aged Guangzhou | CHINA |
Kennedy Krieger Institute | UNITED STATES |
Kunming Medical College | CHINA |
Kunming Medical University | CHINA |
Kunming Psychological Crisis Intervention and Research Center | CHINA |
Kunming University of Science and Technology | CHINA |
La Trobe University | AUSTRALIA |
Lanzhou General Hospital | CHINA |
Luzhou Medical College | CHINA |
McGill University | CANADA |
Mental Health Center of Chongqing | CHINA |
Mental Health Research Institute | UNITED STATES |
Monash University | AUSTRALIA |
Nanjing University | CHINA |
Nankai University | CHINA |
National Ageing Research Institute | AUSTRALIA |
National Institutes of Health | UNITED STATES |
National University of Singapore | SINGAPORE |
New York University | UNITED STATES |
Northern Adelaide Local Health Network | AUSTRALIA |
NYU Langone Medical Center | UNITED STATES |
Peking Union Medical College | CHINA |
PLA 123 Hospital | CHINA |
Qingdao Central Hospital | CHINA |
Qingdao University | CHINA |
Royal Adelaide Hospital | AUSTRALIA |
Rush University | UNITED STATES |
Rutgers University | UNITED STATES |
SA Pathology | AUSTRALIA |
Second Affiliated Hospital of Kunming Medical University | CHINA |
Second Xiangya Hospital of Central-South University | CHINA |
Shandong University | CHINA |
Shandong University of Technology | CHINA |
Shanghai Jiao Tong University | CHINA |
Shanghai Yile Biotechnology Co. | CHINA |
Shezhen Children's Hospital | CHINA |
Shijiazhuang Maternity and Child Healthcare Hospital | CHINA |
Sichuan University | CHINA |
Skirball Institute of Biomolecular Medicine | UNITED STATES |
Soochow University | CHINA |
South Australian Health and Medical Research Institute (SAHMRI) | AUSTRALIA |
Southeast University | CHINA |
Sun Yat-Sen University | CHINA |
Tangdu Hospital, Fourth Military Medical University | CHINA |
The General Hospital of Guangzhou Military Command | CHINA |
The Mental Hospital of Yunnan Province | CHINA |
Third Military Medical University | CHINA |
Tianjin Haihe Hospital | CHINA |
Tianjin Medical University | CHINA |
Tianjin Mental Health Center | CHINA |
Tianjin University | CHINA |
Tsinghua University | CHINA |
Tufts University | UNITED STATES |
University of Adelaide | AUSTRALIA |
University of British Columbia | CANADA |
University of Melbourne | AUSTRALIA |
University of Minnesota, Twin Cities | UNITED STATES |
University of Queensland | AUSTRALIA |
University of South Australia | AUSTRALIA |
University of South Florida | UNITED STATES |
University of Tennessee | UNITED STATES |
University of Utah | UNITED STATES |
University of Western Australia | AUSTRALIA |
University School of Medicine | UNITED STATES |
Wayne State University | UNITED STATES |
West China Hospital | CHINA |
West China Hospital of Sichuan University | CHINA |
West China School of Medicine/West China Hospital of Sichuan University | CHINA |
Women's and Children's Hospital | AUSTRALIA |
Xiangya Hospital | CHINA |
Xiangya Hospital of Central South University | CHINA |
Xiangya Hospital of Central-South University | CHINA |
Xinxiang Medical University | CHINA |
Yunnan Agricultural University | CHINA |
Yunnan First People's Hospital | CHINA |
Yunnan Mental Hospital | CHINA |
Yunnan University | CHINA |
Zhejiang University | CHINA |
External engagement & recognition
Engagement/recognition | Year |
---|---|
Associate EditorNeurotoxicity Research |
2018 |
Associate EditorNeurotoxicity Research |
2017 |
MemberSociety for Neuroscience |
2017 |
MemberAustralian Neuroscience Society |
2017 |
MemberNeurotoxicity Society |
2017 |
Research FellowshipNational Health and Medical Research Council (NHMRC) |
2012 |
Teaching & student supervision
Supervisions from 2010 shown
Thesis title | Student status |
---|---|
`Neurotrophin related biomarkers in depression' | Current |
`Understanding the Role of Neurotrophins in the Pathogenesis of Alzheimer's Disease'. | Current |
Functional analysis of proBDNF in angiogenesis and stroke | Current |
Generation of neural stem cells from human fibroblasts by small molecules | Current |
Investigation into the precursor of brain derived neurotrophic factor in major depression | Current |
Neuroprotection in Parkinson's disease | Current |
Pharmacological and pharmacokinetic study of p75ecdfc in the animal model of Alzheimer's disease | Current |
Scutellarin inhibits the proliferation and metastasis of colorectal cancer through CDC42 signaling pathway and associated with CDC42BPA regulated by HRAS and interacted with RAPGEF6 as well as Rac | Current |
A role for p75 neurotrophin receptor in Neurodegeneration in Alzheimer's disease and tauopathy | Completed |
Development of combined therapy for Alzheimer’s disease: a mechanistic study | Completed |
Development of novel dosage forms to repurpose the drugs for Alzheimer's disease | Completed |
Functions of proBDNF and its signaling receptor p75 in neuroprotection after ischemic stroke | Completed |
Hypoglycaemia-associated autonomic failure: the involvement of catecholamine producing cells in the brain and adrenal gland | Completed |
Investigation into a small molecule aided conversion of human urine cells into hepatocyte-like cells and beta-like cells in vitro | Completed |
Investigation into signalling mechanisms of BDNF in neurological disorders | Completed |
Potential function of neurotrophic factors in growth plate cartilage bony repair and skeletal cell formation | Completed |
Roles of precursor of brain-derived neurotrophic factor in neuronal development and neurodegeneration | Completed |
Roles of the precursor of brain derived neurotrophic factor in neuronal development and regeneration | Completed |
The role of sortilin in regulating the pathological hallmarks and behavioural symptoms in Alzheimer’s disease | Completed |