Professor Xin-Fu Zhou

Adjunct Professor UniSA Clinical & Health Sciences

City East Campus ()
tel +61 8 830 24977

email Xin-Fu.Zhou@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

This laboratory has a long standing interest in neurotrophins and their receptors in neural development and neurological disorders. In recent years, we are interested in how neurotrophins and their receptors signal in the neurodegenerative disease such as Alzheimer’s disease. BDNF is one of the most studied neurotrophins which is critical for brain functions such as learning and memory. Its precursor has a different role to that of mature BDNF. We have been investigating its role in spinal cord injury, in pain and in nerve development. Neurotrophins can be potential drugs for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases or nerve injuries including spinal cord injury and stroke.

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UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

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Research

Research focus

Neurosciences
Biochemistry and Cell Biology
Medical and Health Sciences
Biological Sciences
Clinical Sciences

Highlights

Neuroscience, neuron development, neurotrophins
spinal cord injury, nerve regeneration, neural plasticity
Neuropathic pain, affective pain and mechanisms
Neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease
Mood disorders, depression

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2023	Kelliny, S, Deng, I, Zhou, XF & Bobrovskaya, L 2023, 'Sporadic Alzheimer's disease animal model using streptozotocin and APP/PS1 mice', in CR Martin, VB Patel & VR Preedy (eds), Handbook of Animal Models in Neurological Disorders, Academic Press, UK, ch. 2, pp. 17-30.
2023	Shen, LL, Zeng, F, Saadipour, K, Lu, JJ, Zhou, XF & Wang, YJ 2023, 'p75NTR: A molecule with multiple functions in amyloid-β metabolism and neurotoxicity', in Richard M. Kostrzewa (ed.), Handbook of Neurotoxicity, Second Edition, 2nd, Springer, Switzerland, ch. 69, pp. 1729-1745.
2014	Dai, R-P & Zhou, X-F 2014, 'Neurotrophins and pain', in RM Kostrzewa (ed.), Handbook of neurotoxicity, Springer, US, vol. 3, pp. 1805-1823. 2
2014	Lu, J, Yang, M, Sun, Y & Zhou, XF 2014, 'Synthesis, trafficking and release of BDNF', Handbook of Neurotoxicity, Springer, US, vol. 3, pp. 1955-1971. 9
2014	Wang, Y-J, Zeng, F, Saadipour, K & Zhou, X-F 2014, 'p75NTR: A molecule with multiple functions in amyloid-beta metabolism and neurotoxicity', in RM Kostrzewa (ed.), Handbook of neurotoxicity, 1st ed., Springer, United States, vol. 3, pp. 1925-1944. 1

Journal Articles

Year	Output
2025	Kelliny, S, Zhou, X-F & Bobrovskaya, L 2025, 'Alzheimer's disease and frontotemporal dementia: a review of pathophysiology and therapeutic approaches', Journal of Neuroscience Research, vol. 103, no. 5, article no. e70046, pp. 1-43. Open access
2024	Cade, S, Prestidge, C, Zhou, XF & Bobrovskaya, L 2024, 'The effects of a bioavailable curcumin formulation on Alzheimer's disease pathologies: A potential risk for neuroinflammation', Ibrain, vol. 10, no. 4, pp. 391-547. Open access 1
2024	Hu, Y, Sun, YF, Yuan, H, Liu, J, Chen, L, Liu, DH, Xu, Y, Zhou, XF, Ding, L, Zhang, ZT, Xiong, LL, Xue, LL & Wang, TH 2024, 'Vof16-miR-185-5p-GAP43 network improves the outcomes following spinal cord injury via enhancing self-repair and promoting axonal growth', CNS Neuroscience and Therapeutics, vol. 30, article no. e14535, pp. 1-21. Open access 7 7
2024	Lian, Y, Jia, Y-J, Wong, J, Zhou, X-F, Song, W, Guo, J, Masters, CL & Wang, Y-J 2024, 'Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer's disease', Molecular Psychiatry, vol. 29, no. 2, pp. 297-305. 8 9
2024	Lu, X-Y, Li, M-Q, Li, Y-T, Yao, J-Y, Zhang, L-X, Zeng, Z-H, Yu-Liu, Chen, Z-R, Li, C-Q, Zhou, X-F & Li, F 2024, 'Oral edaravone ameliorates behavioral deficits and pathologies in a valproic acid-induced rat model of autism spectrum disorder', Neuropharmacology, vol. 258, article no. 110089, pp. 1-13. 2 1
2024	Ma, YY, Li, X, Yu, ZY, Luo, T, Tan, CR, Bai, YD, Xu, G, Sun, BD, Bu, XL, Liu, YH, Jin, WS, Gao, YQ, Zhou, XF, Liu, J & Wang, YJ 2024, 'Oral antioxidant edaravone protects against cognitive deficits induced by chronic hypobaric hypoxia at high altitudes', Translational Psychiatry, vol. 14, no. 1, article no. 145, pp. 1-13. Open access 2
2024	Yang, CR, Liang, R, Liu, Y, Meng, FJ, Zhou, F, Zhang, XY, Ning, L, Wang, ZQ, Liu, S & Zhou, XF 2024, 'Upregulation of proBDNF/p75NTR signaling in immune cells and its correlation with inflammatory markers in patients with major depression', The FASEB Journal, vol. 38, no. 1, pp. 1-18. Open access 9 7
2023	Cade, S, Zhou, X-F & Bobrovskaya, L 2023, 'An imbalance in the pro/mature BDNF ratio occurs in multiple brain regions during normal ageing in wild-type mice', Journal of Molecular Neuroscience, vol. 73, no. 6, pp. 469-484. Open access 8 7
2023	Herselman, MF, Lin, L, Luo, S, Yamanaka, A, Zhou, XF & Bobrovskaya, L 2023, 'Sex-dependent effects of chronic restraint stress on mood-related behaviours and neurochemistry in mice', International Journal of Molecular Sciences, vol. 24, no. 12, article no. 10353, pp. 1-19. Open access 8 8 1
2023	Liu, J, van Beusekom, H, Le Bu, X, Chen, G, Zhou, X-F & Wang, YJ and 35 other authors 2023, 'Preserving cognitive function in patients with Alzheimer's disease: the Alzheimer's disease neuroprotection research initiative (ADNRI)', vol. 1, no. 2, pp. 84-98. Open access 13
2022	Cade, S, Zhou, X-F & Bobrovskaya, L 2022, 'The role of brain-derived neurotrophic factor and the neurotrophin receptor p75NTR in age-related brain atrophy and the transition to Alzheimer's disease', Reviews in the Neurosciences, vol. 33, no. 5, pp. 515-529. Open access 9 8 1
2022	Deng, I, Garg, S, Zhou, X-F & a Bobrovskaya, L 2022, 'The effects of novel formulations of edaravone and curcumin in the mouse intrastriatal lipopolysaccharide model of Parkinson's disease', Frontiers in Bioscience (Scholar Edition), vol. 14, no. 2, pp.1-17. Open access 4 3
2022	Herselman, MF, Bailey, S, Deo, P, Zhou, X-F, Gunn, KM & Bobrovskaya, L 2022, 'The effects of walnuts and academic stress on mental health, general well-being and the gut microbiota in a sample of university students: a randomised clinical trial', Nutrients, vol. 14, no. 22, article no, 4776, pp. 1-35. Open access 13 9 685
2022	Lin, L, Herselman, MF, Zhou, X-F & Bobrovskaya, L 2022, 'Effects of corticosterone on BDNF expression and mood behaviours in mice', Physiology and Behavior, vol. 247, article no. 113721. Open access 28 29
2022	Liu, D, Rychkov, G, Hurtado, P, Luo, HY, Zhang, T, Bobrovskaya, L & Zhou, XF 2022, 'Conversion of human fibroblasts into induced neural stem cells by small molecules', International Journal of Molecular Sciences, vol. 23, no. 3, article no. 1740. Open access 5 4 1
2022	Shen, W-Y, Luo, C, Hurtado, PR, Liu, X-J, Luo, R-Y, Li, H, Hu, Z-L, Xu, J-M, Coulson, EJ, Zhao, M, Zhou, X-F & Dai, R-P 2022, 'Up-regulation of proBDNF/p75NTR signaling in antibody-secreting cells drives systemic lupus erythematosus', Science Advances, vol. 8, no. 3, article no. eabj2797. Open access 19 19
2022	Wang, L, Zeng, YQ, Gu, JH, Song, R, Cang, PH, Xu, YX, Shao, Xx, Pu, LJ, Luo, HY & Zhou, XF 2022, 'Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway', European Journal of Pharmacology, vol. 920, article no. 174846. Open access 16 15
2022	Xiong, J, Deng, I, Kelliny, S, Lin, L, Bobrovskaya, L & Zhou, X-F 2022, 'Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice', Metabolic Brain Disease, vol. 37, no. 6, pp. 1941-1957. Open access 15 14 561
2022	Xiong, L-L, Chen, L, Deng, IB, Zhou, X-F & Wang, T-H 2022, 'P75 neurotrophin receptor as a therapeutic target for drug development to treat neurological diseases', European Journal of Neuroscience, vol. 56, no. 8, pp. 5299-5318. 11 10
2022	Yang, C-R, Ding, H-J, Yu, M, Zhou, F-H, Han, CY, Liang, R, Zhang, X-Y, Zhang, X-L, Meng, F-J, Wang, S, Li, D-D, Sun, W-Z, Meng, B & Zhou, X-F 2022, 'proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines', The FASEB Journal, vol. 36, no. 3, article no. e22180. Open access 18 18
2022	Zhao, L-Q, Parikh, A, Xiong, YX, Ye, Q-Y, Ying-Guo, Zhou, X-F & Luo, H-Y 2022, 'Neuroprotection of oral edaravone on middle cerebral artery occlusion in rats', Neurotoxicity Research, vol. 40, no. 4, pp. 995-1006. 6 5
2021	Chen, L, Zhou, YP, Liu, HY, Gu, JH, Zhou, XF & Yue-Qin, Z 2021, 'Long-term oral administration of hyperoside ameliorates AD-related neuropathology and improves cognitive impairment in APP/PS1 transgenic mice', Neurochemistry International, vol. 151, article no. 105196, pp. 1-7. 23 19
2021	Deng, I, Corrigan, F, Garg, S, Zhou, XF & Bobrovskaya, L 2021, 'Further characterization of intrastriatal lipopolysaccharide model of parkinson's disease in c57bl/6 mice', International Journal of Molecular Sciences, vol. 22, no. 14, pp. 1-20. Open access 12 11 11
2021	Deng, I, Wiese, MD, Zhou, XF & Bobrovskaya, L 2021, 'The efficacy of systemic administration of lipopolysaccharide in modelling pre-motor Parkinson's disease in C57BL/6 mice', NeuroToxicology, vol. 85, pp. 254-264. Open access 13 12 1
2021	Hu, ZL, Luo, C, Hurtado, PR, Li, H, Wang, S, Hu, B, Xu, JM, Liu, Y, Feng, SQ, Hurtado-Perez, E, Chen, K, Zhou, XF, Li, CQ & Dai, RP 2021, 'Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis', Theranostics, vol. 11, no. 2, pp. 715-730. Open access 29 29
2021	Kelliny, S, Bobrovskaya, L, Zhou, X-F & Upton, R 2021, 'Pharmacokinetic modelling of human recombinant protein, p75ECD-Fc: a novel therapeutic approach for treatment of Alzheimer's disease, in serum and tissue of Sprague Dawley rats', European Journal of Drug Metabolism and Pharmacokinetics, vol. 46, no. 2, pp. 235-248. Open access 2 2
2021	Kelliny, S, Lin, L, Deng, I, Xiong, J, Zhou, F, Al-Hawwas, M, Bobrovskaya, L & Zhou, XF 2021, 'A new approach to model sporadic Alzheimer's disease by intracerebroventricular streptozotocin injection in APP/PS1 mice', Molecular Neurobiology, vol. 58, no. 8, pp. 3692-3711. Open access 13 11 7
2021	Kelliny, S, Xiong, J, Bobrovskaya, L & Zhou, XF 2021, 'Preclinical validation of a novel oral Edaravone formulation for treatment of frontotemporal dementia', Neurotoxicity Research, vol. 39, no. 6, pp. 1689-1707. 4 4 7
2021	Lin, L, Fu, Xy, Zhou, X, Liu, D, Bobrovskaya, L & Zhou, L 2021, 'Analysis of blood mature BDNF and proBDNF in mood disorders with specific ELISA assays', Journal of Psychiatric Research, vol. 133, pp. 166-173. 28 25 157
2021	Lin, L, Zhou, X-F & Bobrovskaya, L 2021, 'Blockage of p75NTR ameliorates depressive-like behaviours of mice under chronic unpredictable mild stress', Behavioural Brain Research, vol. 396, article no. 112905, pp. 1-5. Open access 10 9
2021	Liu, D, Bobrovskaya, L & Zhou, XF 2021, 'Cell therapy for neurological disorders: the perspective of promising cells', Biology, vol. 10, no. 11, article no. 1142, pp. 1-23. Open access 16 11
2021	Ma, W, Yang, JW, Wang, XB, Luo, T, Zhou, L, Lagares, A, Li, H, Liang, Z, Liu, KP, Zang, CH, Li, CY, Wu, Z, Guo, JH, Zhou, XF & Li, LY 2021, 'Negative regulation by proBDNF signaling of peripheral neurogenesis in the sensory ganglia of adult rats', Biomedicine and Pharmacotherapy, v. 144, article no. 112273, pp. 1-14. Open access 4 4
2021	Xiong, LL, Chen, J, Du, RL, Liu, J, Chen, YJ, Al Hawwas, M, Zhou, XF, Wang, TH, Yang, SJ & Bai, X 2021, 'Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage', Neural Regeneration Research, vol. 16, no. 8, pp. 1453-1459. Open access 30 29
2021	Xiong, LL, Tan, YX, Du, RL, Peng, Y, Xue, LL, Liu, J, Al-Hawwas, M, Bobrovskaya, L, Liu, DH, Chen, L, Wang, TH & Zhou, XF 2021, 'Effect of sutellarin on neurogenesis in neonatal hypoxia-ischemia rat model: potential mechanisms of action', American Journal of Chinese Medicine, vol. 49, no. 3, pp. 677-703. 10 7
2021	Zeng, Y-Q, Gu, J-H, Chen, L, Zhang, T-T & Zhou, X-F 2021, 'Gastrodin as a multi-target protective compound reverses learning memory deficits and AD-like pathology in APP/PS1 transgenic mice', Journal of Functional Foods, v. 77, article no. 104324, pp. 1-8. Open access 22 17
2021	Zhou, L, Niu, RZ, Zhou, HS, Wang, ZM, Wang, FL, Yang, XX, Deng, I, Zhu, ZQ, Zhou, XF & Xiong, LL 2021, 'CT imaging character of different brain regions in different ages of Diannan small-ear pigs', Ibrain, vol. 7, no. 2, pp. 90-94. Open access
2021	Zhou, R, Chen, LL, Yang, H, Li, L, Liu, J, Chen, L, Hong, WJ, Wang, CG, Ma, JJ, Huang, J, Zhou, XF, Liu, D & Zhou, HD 2021, 'Effect of high cholesterol regulation of lrp1 and rage on aβ transport across the blood-brain barrier in Alzheimer's disease', Current Alzheimer Research, vol. 18, no. 5, pp. 428-442. 31 29
2021	Zhou, X-F 2021, 'ESCAPE-NA1 trial brings hope of neuroprotective drugs for acute ischemic stroke: highlights of the phase 3 clinical trial on nerinetide', Neuroscience Bulletin, vol. 37, no. 4, pp. 579-581. 14 13
2021	Zidan, AA, Al-Hawwas, M, Perkins, GB, Mourad, GM, Stapledon, CJ, Bobrovskaya, L, Zhou, X-F & Hurtado, PR 2021, 'Characterization of urine stem cell-derived extracellular vesicles reveals B cell stimulating cargo', International Journal of Molecular Sciences, vol. 22, no. 1, pp. 1-21. Open access 20 18
2021	Zidan, AA, Perkins, G, Al-Hawwas, M, Elhossiny, A, Yang, J, Bobrovskaya, L, Mourad, GM, Zhou, XF & Hurtado, PR 2021, 'Urine stem cells are equipped to provide B cell survival signals', Stem Cells, vol. 39, no. 6, pp. 803-818. Open access 6 6 5
2020	Deng, I, Corrigan, F, Zhai, G, Zhou, X-F & Bobrovskaya, L 2020, 'Lipopolysaccharide animal models of Parkinson's disease: recent progress and relevance to clinical disease', Brain, Behavior, & Immunity - Health, vol. 4, article no. 100060, pp. 1-12. Open access 87 7
2020	Fang, J, Wei, Z, Zheng, D, Ying, T, Hong, H, Hu, D, Lin, Y, Jiang, X, Wu, L, Lan, T, Yang, Z, Zhou, X & Chen, L 2020, 'Recombinant extracellular domain (p75ECD) of the neurotrophin receptor p75 attenuates myocardial ischemia-reperfusion injury by inhibiting the p-JNK/caspase-3 signaling pathway in rat microvascular pericytes', Journal of the American Heart Association, vol. 9, no. 13, pp. 1-24. Open access 17 17
2020	Kelliny, S, Lam, H, Parikh, A, Wang, Y, Bobrovskaya, L, Upton, R & Zhou, X 2020, 'Preclinical study of the pharmacokinetics of p75ECD-Fc, a novel human recombinant protein for treatment of Alzheimer's disease, in sprague dawley rats', Current Drug Metabolism, vol. 21, no. 3, pp. 235-244. 8 7
2020	Li, H, Lin, LY, Zhang, Y, Lim, Y, Rahman, M, Beck, A, Al-Hawwas, M, Feng, S, Bobrovskaya, L & Zhou, XF 2020, 'Pro-BDNF knockout causes abnormal motor behaviours and early death in mice', Neuroscience, vol. 438, pp. 145-157. 14 11 1
2020	Lin, L, Kelliny, S, Liu, L, Al-Hawwas, M, Zhou, X & Bobrovskaya, L 2020, 'Peripheral ProBDNF delivered by an AAV vector to the muscle triggers depression-like behaviours in mice', Neurotoxicity Research, vol. 38, no. 3, pp. 626-639. 7 7 1
2020	Liu, D, Pavathuparambil Abdul Manaph, N, Al-Hawwas, M, Bobrovskaya, L, Xiong, LL & Zhou, XF 2020, 'Coating materials for neural stem/progenitor cell culture and differentiation', Stem Cells and Development, vol. 29, no, 8, pp. 463-474. 26 24
2020	Liu, D, Rychkov, G, Al-Hawwas, M, Pavathuparambil Abdul Manaph, N, Zhou, F, Bobrovskaya, L, Liao, H & Zhou, XF 2020, 'Conversion of human urine-derived cells into neuron-like cells by small molecules', Molecular Biology Reports: An International Journal on Molecular and Cellular Biology, vol. 47, no. 4, pp. 2713-2722. 15 16 6
2020	Rahman, M, Luo, H, Bobrovskaya, L & Zhou, X-F 2020, 'Neuroprotective effects of anti-proBDNF in a rat photothrombotic ischemic model', Neuroscience, vol. 446, pp. 261-270. 3 3 2
2020	Shen, W-Y, Luo, C, Reinaldo Hurtado, P, Hurtado-Perez, E, Luo, R-Y, Hu, Z-L, Li, H, Xu, J-M, Zhou, X-F & Dai, R-P 2020, 'The regulatory role of ProBDNF in monocyte function: Implications in Stanford type-A aortic dissection disease', The FASEB Journal, vol. 34, pp. 2541-2553. Open access 24 25
2020	Xiong, L-L, Xue, L-L, Du, R-L, Zhou, H-L, Tan, Y-X, Ma, Z, Jin, Y, Zhang, Z-B, Xu, Y, Hu, Q, Bobrovskaya, L, Zhou, X-F, Liu, J & Wang, T-H 2020, 'Vi4-miR-185-5p-Igfbp3 network protects the brain from neonatal hypoxic ischemic injury via promoting neuron survival and suppressing the cell apoptosis', Frontiers in Cell and Developmental Biology, vol. 8, article no. 529544, pp. 1-18. Open access 29 24 1
2020	Xiong, LL, Qin, YX, Xiao, QX, Jin, Y, Al-Hawwas, M, Ma, Z, Wang, YC, Belegu, V, Zhou, XF, Xue, LL, Du, RL, Liu, J, Bai, X & Wang, TH 2020, 'MicroRNA339 targeting PDXK improves motor dysfunction and promotes neurite growth in the remote cortex subjected to spinal cord transection', Frontiers in Cell and Developmental Biology, vol. 8, article no. 577, pp. 1-17. Open access 7 8
2020	Yang, C, Ning, L, Zhou, F, Sun, Q, Meng, H, Han, Z, Liu, Y, Huang, W, Liu, S, Li, X, Zheng, B, Ming, D & Zhou, X 2020, 'Downregulation of adhesion molecule CHL1 in B cells but not T cells of patients with major depression and in the brain of mice with chronic stress', Neurotoxicity Research, vol. 38, no. 4, pp. 914-928. 15 13
2020	Yang, C, Zhang, X, Liu, Y, Du, J, Liang, R, Yu, M, Zhang, F, Mu, X, Li, F, Zhou, L, Zhou, F, Meng, F, Wang, S, Ming, D & Zhou, X 2020, 'Antidepressant drugs correct the imbalance between probdnf/p75ntr/sortilin and mature bdnf/trkb in the brain of mice with chronic stress', Neurotoxicity Research, vol. 37, pp. 171-182. 37 33
2020	Yu, YQ, Zhang, YL, Wang, Z, Liu, Y, Li, H, Zhou, X-F, Hu, ZL & Dai, RP 2020, 'Involvement of proBDNF in monocytes/macrophages with gastrointestinal disorders in depressive mice', Neurotoxicity Research, vol. 38, no. 4, pp. 1063-1063. 6 7
2019	Chen, S, Liang, T, Zhou, FH, Cao, Y, Wang, C, Wang, FY, Li, F, Zhou, XF, Zhang, JY & Li, CQ 2019, 'Regular music exposure in juvenile rats facilitates conditioned fear extinction and reduces anxiety after foot shock in adulthood', BioMed Research International, vol. 2019, article no. 8740674, pp. 1-10. Open access 10 8
2019	Johnson, ME, Zhou, X-F & Bobrovskaya, L 2019, 'The effects of rotenone on TH, BDNF and BDNF-related proteins in the brain and periphery: relevance to early Parkinson's disease', Journal of Chemical Neuroanatomy, vol. 97, pp. 23-32. Open access 16 15
2019	Lin, L, Luo, S, Al-Hawwas, M, Herselman, M, Zhou, X & Bobrovskaya, L 2019, 'The long-term effects of ethanol and corticosterone on the mood-related behaviours and the balance between mature BDNF and proBDNF in mice', Journal of Molecular Neuroscience, vol. 69, no. 1, pp. 60-68. Open access 17 15 6
2019	Luo, HY, Rahman, M, Bobrovskaya, L & Zhou, X-F 2019, 'The level of proBDNF in blood lymphocytes is correlated with that in the brain of rats with photothrombotic ischemic stroke', Neurotoxicity Research, vol. 36, no. 1, pp. 49-57. 13 10
2019	Manucat-Tan, NB, Shen, LL, Bobrovskaya, L, Al-hawwas, M, Zhou, FH, Wang, YJ & Zhou, XF 2019, 'Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model', Aging, vol. 11, no. 17. pp. 6762-6791. Open access 21 19 7
2019	Saadipour, K, Tiberi, A, Lomardo, S, Grajales, E, Montroull, L, Manucat-Tan, NB, LaFrancois, J, Cammer, M, Mathews, PM, Scharfman, HE, Liao, FF, Friedman, WJ, Zhou, XF, Tesco, G & Chao, M V 2019, 'Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor', Molecular and Cellular Neuroscience, vol. 99, article no. 103395, pp. 1-15. Open access 9 8
2019	Shen, LL, Li, WW, Xu, YL, Gao, SH, Xu, MY, Bu, XL, Liu, YH, Wang, J, Zhu, J, Zeng, F, Yao, XQ, Gao, CY, Xu, ZQ, Zhou, XF & Wang, YJ 2019, 'Neurotrophin receptor p75 mediates amyloid β-induced tau pathology', Neurobiology of Disease, vol. 132, article no. 104567 pp. 1-12. Open access 45 38
2019	Wang, Z, Wu, J-L, Zhong, F, Liu, Y, Yu, Y-Q, Sun, J-J, Wang, S, Li, H, Zhou, X-F, Hu, Z-L & Dai, R-P 2019, 'Upregulation of proBDNF in the mesenteric lymph nodes in septic mice', Neurotoxicity Research, vol. 36, no. 3, pp. 540-550. 20 19
2019	Xu, Y, Li, WW, Wang, J, Zhu, C, Shen, YY, Shi, AY, Zeng, GH, Xu, ZQ, Zhou, XF & Wang, YJ 2019, 'Neurotrophin receptor p75 mRNA level in peripheral blood cells of patients with Alzheimer's disease', Neurotoxicity Research, vol. 36, no. 1, pp. 101-107. 5 5
2019	Yang, CY, Yang, J-Y, Xiong, Y-X, Zhuang, X-F, Su, H, Hu, S, Ma, J-Q, Zhou, X-F, Luo, H-Y & Sun, J 2019, 'Panax notoginsenoside Rb1 restores the neurotrophic imbalance following photothrombotic stroke in rats', Neurotoxicity Research, vol. 36, no. 3, pp. 441-451. 4 3
2019	Zhang, Z-B, Tan, Y-X, Zhao, Q, Xiong, L-L, Liu, J, Xu, F-F, Xu, Y, Bobrovskaya, L, Zhou, X-F & Wang, T-H 2019, 'miRNA-7a-2-3p inhibits neuronal apoptosis in oxygen-glucose deprivation (OGD) model', Frontiers in Neuroscience, vol. 13, article 16, pp. 1-10. Open access 33 30 1
2019	Zhong, F, Liu, L, Wei, JL, Hu, ZL, Li, L, Wang, S, Xu, JM, Zhou, XF, Li, CQ, Yang, ZY & Dai, RP 2019, 'Brain-derived neurotrophic factor precursor in the hippocampus regulates both depressive and anxiety-like behaviors in rats', Frontiers in Psychiatry, vol. 10, article no. 776, pp. 1-11. Open access 34 42
2018	Bu, X-L, Xiang, Y, Jin, W-S, Wang, J, Zhou, X-F & Wang, Y and 17 other authors 2018, 'Blood-derived amyloid-β protein induces Alzheimer's disease pathologies', Molecular Psychiatry, vol. 23, no. 9, pp. 1948-1956. 170 146
2018	Duan, HQ, Wu, Q-L, Yao, X, Fan, B-Y, Shi, H-Y, Zhao, C-X, Zhang, Y, Li, B, Sun, C, Kong, X-H, Zhou, X-F & Feng, S-Q 2018, 'Nafamostat mesilate attenuates inflammation and apoptosis and promotes locomotor recovery after spinal cord injury', CNS Neuroscience and Therapeutics, vol. 24, no. 5, pp. 429-438. Open access 31 32
2018	Huang, H, Young, W, Chen, L, Feng, S, Zhou, X-F & Li, T 2018, 'Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)', Cell Transplantation, vol. 27, no. 2, pp. 310-324. Open access 34 39
2018	Lim, Y, Wu, LLY, Chen, S, Sun, Y, Vijayaraj, SL, Yang, M, Bobrovskaya, L, Keating, D, Li, XJ & Zhou, X-F 2018, 'HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons', Molecular Neurobiology, vol. 55, no. 3, pp. 1815-1830. Open access 23 20
2018	Liu, D, Manaph, NPA, Al-Hawwas, M, Zhou, XF & Liao, H 2018, 'Small molecules for neural stem cell induction', Stem Cells and Development, vol. 27, no. 5, pp. 297-312. 18 16
2018	Liu, S, Guo, W, Zhou, H, Tang, L, Feng, S, Zhong, JH & Zhou, XF 2018, 'proBDNF inhibits the proliferation and migration of OLN-93 oligodendrocytes', Molecular Medicine Reports, vol. 18, no. 4, pp. 3809-3817. Open access 12 13
2018	Mañucat-Tan, NB, Saadipour, K, Wang, Y-J, Bobrovskaya, L & Zhou, X-F 2018, 'Cellular trafficking of amyloid precursor protein in amyloidogenesis physiological and pathological significance', Molecular Neurobiology, vol. 56, no. 2, pp. 812-830. Open access 26 25
2018	Parikh, A, Kathawala, K, Li, J, Chen, C, Shan, Z, Cao, X, Wang, Y-J, Garg, S & Zhou, X-f 2018, 'Self-nanomicellizing solid dispersion of edaravone: part II: in vivo assessment of efficacy against behavior deficits and safety in Alzheimer's disease model', Drug Design Development and Therapy, vol. 12, pp. 2111-2128. Open access 23 21
2018	Parikh, A, Kathawala, K, Li, J, Chen, C, Shan, Z, Cao, X, Zhou, X-F & Garg, S 2018, 'Curcumin-loaded self-nanomicellizing solid dispersion system: part II: in vivo safety and efficacy assessment against behavior deficit in Alzheimer disease', Drug Delivery and Translational Research, vol. 8, no. 5, pp. 1406-1420. 38 32 88
2018	Parikh, A, Kathawala, K, Song, Y, Zhou, XF & Garg, S 2018, 'Curcumin-loaded self-nanomicellizing solid dispersion system: part I: development, optimization, characterization, and oral bioavailability', Drug Delivery and Translational Research, vol. 8, no. 5, pp. 1389-1405. 38 31 81
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2013	Yang, M, Virassamy, B, Vijayaraj, S, Lim, Y, Saadipour, K, Wang, Y, Han, Y, Zhong, J, Morales, C & Zhou, X-F 2013, 'The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking', PLoS One, vol. 8, no. 5, article no. e63049. Open access 28 26
2013	Zeng, F, Deng, Y-P, Yi, X, Cao, H-Y, Zou, H-Q, Wang, X, Liang, C-R, Wang, Y-R, Zhang, L-L, Gao, C-Y, Xu, Z-Q, Lian, Y, Wang, L, Zhou, X-F, Zhou, H-D & Wang, Y-J 2013, 'No association of SORT1 gene polymorphism with sporadic Alzheimer's disease in the Chinese Han population', NeuroReport, vol. 24, no. 9, pp. 464-468. 13 13
2013	Zheng, F, Zou, H-Q, Zhou, H-D, Li, J, Wang, L, Cao, H-Y, Yi, X, Wang, X, Liang, C-R, Wang, Y-R, Zhang, A-Q, Tan, X-L, Peng, K-R, Zhang, L, Gao, C-Y, Xu, Z-Q, Wen, A-Q, Lian, Y, Zhou, X-F & Wang, Y-J 2013, 'The relationship between single nucleotide polymorphisms of the NTRK2 gene and sporadic Alzheimer's disease in the Chinese Han population', Neuroscience Letters, vol. 550, pp. 55-59. 20 19
2013	Zhou, L, Xiong, J, Lim, Y, Ruan, Y, Huang, C, Zhu, Y, Zhong, J-h, Xiao, Z & Zhou, X-F 2013, 'Upregulation of blood proBDNF and its receptors in major depression', Journal of Affective Disorders, vol. 150, no. 3, pp. 776-784. 131 121
2012	Li, F, Cao, W, Li, M, Xu, Y, Zhang, J, Zhang, J, Luo, X, Dai, R, Zhou, X & Li, C 2012, 'A simple method for detection of food foraging behavior in the rat : involvement of NMDA and dopamine receptors in the behavior', Neuroscience, vol. 205, no. 15, pp. 73-80. 19 17
2012	Li, F, Li, M, Cao, W, Xu, Y, Luo, Y, Zhong, X, Zhang, J, Dai, R, Zhou, X-F, Li, Z & Li, C 2012, 'Anterior cingulate cortical lesion attenuates food foraging in rats', Brain Research Bulletin, vol. 88, no. 6, pp. 602-608. 28 27
2012	Li, H, Li, C, Dai, R, Shi, X, Xu, J, Zhang, J, Zhou, X, Li, Z & Luo, X 2012, 'Expression of acetylated histone 3 in the spinal cord and the effect of morphine on inflammatory pain in rats', Neural Regeneration Research, vol. 7, no. 7, pp. 517-522. 11 11
2012	Sun, Y, Lim, Y, Li, F, Liu, S, Lu, J-J, Haberberger, R, Zhong, J-H & Zhou, X-F 2012, 'ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA', PLoS One, vol. 7, no. 4, article no. e35883, pp. 1-12. Open access 133 95
2012	Yan, J, Zhou, X, Guo, J-J, Mao, L, Wang, Y-J, Sun, J, Sun, L-X, Zhang, L-Y, Zhou, X-F & Liao, H 2012, 'Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro', Journal of Neurochemistry, vol. 120, no. 5, pp. 721-731. Open access 74 68
2012	Yang, G-Z, Yang, M, Lim, Y, Lu, J-J, Wang, T-H, Qi, J-G, Zhong, J-H & Zhou, X-F 2012, 'Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons', Journal of Neurochemistry, vol. 122, no. 5, pp. 1010-1022. Open access 32 32
2012	Yu, H, Yang, M, Wang, Y, Xiao, R & Zhou, X-F 2012, 'p75NTR is mainly responsible for Aβ toxicity but not for its internalization : a primary study', Neurological Sciences, vol. 33, no. 5, pp. 1043-1050. 4 4
2012	Zhang, F, Kang, Z, Li, W, Xiao, Z & Zhou, X 2012, 'Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease', Journal of Clinical Neuroscience, vol. 19, no. 7, pp. 946-949. 89 78
2011	Aguilar, SEA, Pollard, AN, Smith, M & Zhou, X-F 2011, 'Macrophage presence is essential for the regeneration of ascending afferent fibres following a conditioning sciatic nerve lesion in adult rats', BMC Neuroscience, vol. 12, article no. 11, pp. 1-13. Open access 22 21
2011	Bastian, I, Tam, TS, Zhou, X-F, Kazenwadel, J, Van Der Hoek, M, Michael, MZ, Gibbins, I & Haberberger, RV 2011, 'Differential expression of microRNA-1 in dorsal root ganglion neurons', Histochemistry and Cell Biology, vol. 135, no. 1, pp. 37-45. 16 15
2011	Dai, R, Li, C, Zhang, J, Li, F, Shi, X, Zhang, J & Zhou, X-F 2011, 'Biphasic activation of extracellular signal-regulated kinase in anterior cingulate cortex distinctly regulates the development of pain-related anxiety and mechanical hypersensitivity in rats after incision', Anesthesiology, vol. 115, no. 3, pp. 604-613. Open access 49 46
2011	Jia, L, Yu, Z, Hui, L, Yu-Guang, G, Zhou, X-F, Chao, Y, Yanbin, X, Xi, Z, Jun, W, Xin-Hua, H & Ting-Hua, W 2011, 'Fas and FasL expression in the spinal cord following cord hemisection in the monkey', Neurochemical Research, vol. 36 no. 3, pp. 419-425. 14 13
2011	Li, F, Wang, X-S, Dai, R-P, Zhang, J-Y, Zhou, X-F, Hao, W & Li, C-Q 2011, 'The activation of NMDA receptor-ERK pathway in the central amygdala is required for the expression of morphine-conditioned place preference in the rat', Neurotoxicity Research, vol. 20 no. 4, pp. 362-371. 28 28
2011	Lockshin, LS, Cohen, E & Zhou, X-F 2011, 'What Influences five-star Beijing restaurants in making wine lists?', Journal of Wine Research, vol. 22, no. 3, pp. 227-243. 14
2011	Tam, TS, Bastian, I, Zhou, X-F, Van Der Hoek, M, Michael, MZ, Gibbons, I & Haberberger, R 2011, 'MicroRNA-143 expression in dorsal root ganglion neurons', Cell and Tissue Research, vol. 346, no. 2, pp. 163-173. 39 35
2011	Wang, Y-J, Wang, X, Lu, J-J, Li, Q-X, Gao, C-Y, Liu, X-H, Sun, Y, Yang, M, Lim, Y, Evin, G, Zhong, J-H, Masters, C & Zhou, X-F 2011, 'p75NTR regulates Aß deposition by increasing Aß production but inhibiting Aß aggregation with its extracellular domain', Journal of Neuroscience, vol. 31, no. 6, pp. 2292-2304. Open access 87 80
2011	Xu, Z-Q, Sun, Y, Li, H-Y, Lim, Y, Zhong, J-H & Zhou, X-F 2011, 'Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice', European Journal of Neuroscience, vol. 33 no. 8, pp. 1376-1384. 57 53
2011	Yang, M, Lim, Y, Li, X, Zhong, J-H & Zhou, X-F 2011, 'Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing', Journal of Biological Chemistry, vol. 286, no. 18, pp. 16272-16284. Open access 66 59
2011	Zeng, F, Lu, J-J, Zhou, X-F & Wang, Y-J 2011, 'Roles of p75NTR in the pathogenesis of Alzheimer's disease: a novel therapeutic target', Biochemical Pharmacology, vol. 82, no. 10, pp. 1500-1509. 60 56
2011	Zhou, X-F & Wang, Y-J 2011, 'The p75NTR extracellular domain: a potential molecule regulating the solubility and removal of amyloid-β', Prion, vol. 5 no. 3, pp. 161-163. Open access 21 20
2010	Aguilar, SE, Pollard, A, Smith, M & Zhou, X-F 2010, 'Sciatic nerve conditioning lesion increases macrophage response but it does not promote the regeneration of injured optic nerves', Brain Research, vol. 1361, pp. 12-22. 3 3
2010	Li, C-Q, Zhang, J-W, Dai, RP, Wang, J, Luo, XG & Zhou, X-F 2010, 'Surgical incision induces anxiety-like behavior and amygdala sensitization: Effects of morphine and gabapentin', Pain Research and Treatment, vol. 2010, article no. 705874, pp. 1-9. Open access 27 21
2010	Li, F, Zhang, J-W, Wei, R, Luo, XG, Zhang, J-Y, Zhou, X-F, Li, C & Dai, R 2010, 'Sex-differential modulation of visceral pain by brain derived neurotrophic factor (BDNF) in rats', Neuroscience Letters, vol. 478 no. 3, pp. 184-187. 15 13
2010	WANG, Y, Valadares, D, Sun, Y, Wang, X, Zhong, J, Liu, X-H, Majd, S, Chen, L, Gao, C-Y, Chen, S, Lim, Y, Pollard, A, Aguilar, E, Gai, WP, Yang, M & Zhou, X-F 2010, 'Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism', Neurotoxicity Research, vol. 17, no. 3, pp. 257-267. 35 34
2010	Wang, Y, Zhou, H & Zhou, X-F 2010, 'Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid-ß clearance', Journal of Alzheimer's Disease, vol. 21, no. 4, pp. 1065-1075. 23 22
2010	Wang, Y-J, Gao, C-Y, Yang, M, Liu, X-H, Sun, Y, Pollard, A, Dong, X-Y, Wu, X-B, Zhong, J-H, Zhou, H-D & Zhou, X-F 2010, 'Intramuscular delivery of a single chain antibody gene prevents brain Aβ deposition and cognitive impairment in a mouse model of Alzheimer's disease', Brain Behavior and Immunity, vol. 24, no. 8, pp. 1281-1293. 42 38
2010	Wong, I, Liao, H, Bai, X, Zaknic, A, Zhong, J, Guan, Y, Li, H-Y, Wang, Y-J & Zhou, X-F 2010, 'ProBDNF inhibits infiltration of ED1+ macrophages after spinal cord injury', Brain Behavior and Immunity, vol. 24 no. 4, pp. 585-597. 58 57
2010	Wu, LL-y, Fan, Y, Li, S, Li, X-J & Zhou, X-F 2010, 'Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release', Journal of Biological Chemistry, vol. 285 no. 8, pp. 5614-5623. Open access 67 59
2009	Li, L, Li, F, Xian, CJ, Luo, XG, Zhou, X-F, Zhong, J & Song, X-Y 2009, 'Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats - Possible roles of brain-derived neurotrophic factor, TrkB and p75 neurotrophin receptor', European Journal of Neuroscience.
2009	Song, X-Y, Zhang, F-H, Zhou, FH, Zhong, J & Zhou, X-F 2009, 'Deletion of p75NTR impairs regeneration of peripheral nerves in mice', Life Sciences, vol. 84, no. 3-4, pp. 61-68. 14 13
2009	Thomas, P, Wang, Y-J, Zhong, J-H, Kosaraju, S, O'Callaghan, NJ, Zhou, X-F & Fenech, M 2009, 'Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease', Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, vol. 661, no. 1-2, pp. 25-34. 87 71
2009	Wang, Y-J, Pollard, A, Zhong, J-H, Dong, X-Y, Wu, X-B, Zhou, H-D & Zhou, X-F 2009, 'Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease', Neurobiology of Aging, vol. 30, no. 3, pp. 364-376. 55 47
2009	Wang, Y-J, Thomas, P, Zhong, J-H, Bi, F-F, Kosaraju, S, Pollard, A, Fenech, M & Zhou, X-F 2009, 'Consumption of grape seed extract prevents amyloid-β deposition and attenuates inflammation in brain of an Alzheimer's disease mouse', Neurotoxicity Research, vol. 15, no. 1, pp. 3-14. 201 177
2009	Wu, LL-y & Zhou, X-F 2009, 'Huntingtin associated protein 1 and its functions', Cell Adhesion and Migration, vol. 3 no. 1, pp. 71-76. Open access 52 45
2008	Fan, Y-J, Wu, L, Li., Wang, Y & Zhou, X-F 2008, 'Differential effects of pro-BDNF on sensory neurons after sciatic nerve transection in neonatal rats', European Journal of Neuroscience, vol. 27 no. 9, pp. 2380-2390. 58 55
2008	Feng, S-Q, Zhou, X-F, Rush, RA & Ferguson, IA 2008, 'Graft of pre-injured sural nerve promotes regeneration of corticospinal tract and functional recovery in rats with chronic spinal cord injury', Brain Research, vol. 1209, pp. 40-48. 22 17
2008	Hu, H, Zhou, X-F, Tian, FF, Xiao, YH, Wu, Y, Bi, F-F & Ding, L 2008, 'Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats', Brain Research, vol. 1191, pp. 30-38. 17 14
2008	Li, H-Y & Zhou, X-F 2008, 'Potential conversion of adult clavicle-derived chondrocytes into neural lineage cells in vitro', Journal of Cellular Physiology, vol. 214 no. 3, pp. 630-644. 9 8
2008	Zhang, F, Song, X-Y, Zhong, J, Zhou, X-F & Li, F 2008, 'Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spina cord injury', PLoS One.

Research

Patents

Details	Registry	Status
Edaravone dosage form Zhou, Xinfu; Parikh, Ankit; Garg, Sanjay	CN	Filed
Edaravone dosage form Zhou, Xinfu; Parikh, Ankit; Garg, Sanjay	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Alexandria University	EGYPT
Anhui Medical University	CHINA
Anhui Provincial Hospital	CHINA
Army Medical University	PAKISTAN
Austin Health	AUSTRALIA
Banner Sun Health Research Institute	UNITED STATES
Bengbu Medical College	CHINA
Capital Medical University	CHINA
Central South University	CHINA
Chengdu Medical College	CHINA
China Center of Disease Control	CHINA
China Pharmaceutical University	CHINA
China-Japan Friendship Hospital	CHINA
Chinese Academy of Medical Sciences	CHINA
Chinese Academy of Sciences	CHINA
Chinese Centre for Disease Control and Preventation	CHINA
Chinese Institute for Brain Research	CHINA
Chinese People's Armed Police General Hospital	CHINA
Chongqing Medical University	CHINA
Cogstate Limited	AUSTRALIA
Complutense University of Madrid	SPAIN
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Daping Hospital	CHINA
East China University of Science and Technology	CHINA
Edith Cowan University	AUSTRALIA
Emory University	UNITED STATES
First People's Hospital of Qujin	CHINA
First peoples hospital of Yunnan province	CHINA
First people's hospital of Yunnan province	CHINA
Flinders University	AUSTRALIA
Fujian Kangshimei Pty Ltd	CHINA
Fujian Medical University	CHINA
General Hospital of Guangzhou Military Command	CHINA
Hamad bin Khalifa University	QATAR
Harvard University	UNITED STATES
Hollywood Private Hospital	AUSTRALIA
Home for the Aged Guangzhou	CHINA
Jinan University (China)	CHINA
Kennedy Krieger Institute	UNITED STATES
Kunming Medical College	CHINA
Kunming Medical University	CHINA
Kunming Psychological Crisis Intervention and Research Center	CHINA
Kunming University of Science and Technology	CHINA
La Trobe University	AUSTRALIA
Lanzhou General Hospital	CHINA
Luzhou Medical College	CHINA
McGill University	CANADA
Mental Health Center of Chongqing	CHINA
Mental Health Research Institute	UNITED STATES
Monash University	AUSTRALIA
Nanjing University	CHINA
Nankai University	CHINA
National Ageing Research Institute	AUSTRALIA
National Institutes of Health	MALAYSIA
National University of Singapore	SINGAPORE
New York University	UNITED STATES
Northern Adelaide Local Health Network	AUSTRALIA
NYU Langone Medical Center	UNITED STATES
Peking Union Medical College	CHINA
PLA 123 Hospital	CHINA
Qingdao Central Hospital	CHINA
Qingdao University	CHINA
Royal Adelaide Hospital	AUSTRALIA
Rush University	UNITED STATES
Rutgers University	UNITED STATES
SA Pathology	AUSTRALIA
Second Affiliated Hospital of Kunming Medical University	CHINA
Second Xiangya Hospital of Central-South University	CHINA
Shandong University	CHINA
Shandong University of Technology	CHINA
Shanghai Jiao Tong University	CHINA
Shanghai Yile Biotechnology Co.	CHINA
Shanxi Medical University	CHINA
Shezhen Children's Hospital	CHINA
Shijiazhuang Maternity and Child Healthcare Hospital	CHINA
Sichuan University	CHINA
Skirball Institute of Biomolecular Medicine	UNITED STATES
Soochow University	TAIWAN
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
Southeast University	CHINA
Southwest Medical University	CHINA
Sun Yat-Sen University	CHINA
Suzhou Auzone Biotechnology	CHINA
Tangdu Hospital, Fourth Military Medical University	CHINA
The General Hospital of Guangzhou Military Command	CHINA
The Mental Hospital of Yunnan Province	CHINA
Third Military Medical University	CHINA
Tianjin Anding Hospital	CHINA
Tianjin Haihe Hospital	CHINA
Tianjin Medical University	CHINA
Tianjin Medical University Cancer Institute and Hospital	CHINA
Tianjin Medical University General Hospital	CHINA
Tianjin Mental Health Center	CHINA
Tianjin University	CHINA
Tsinghua University	CHINA
Tufts University	UNITED STATES
University Medical Center	UNITED STATES
University of Adelaide	AUSTRALIA
University of British Columbia	CANADA
University of Melbourne	AUSTRALIA
University of Michigan	UNITED STATES
University of Minnesota, Twin Cities	UNITED STATES
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of South Florida	UNITED STATES
University of Sydney	AUSTRALIA
University of Tennessee	UNITED STATES
University of Utah	UNITED STATES
University of Western Australia	AUSTRALIA
University School of Medicine	UNITED STATES
Wayne State University	UNITED STATES
Wenzhou Medical University	CHINA
West China Hospital	CHINA
West China Hospital of Sichuan University	CHINA
West China School of Medicine/West China Hospital of Sichuan University	CHINA
Women's and Children's Hospital	AUSTRALIA
Xiangya Hospital	CHINA
Xiangya Hospital of Central-South University	CHINA
Xinxiang Medical University	CHINA
Yunnan Agricultural University	CHINA
Yunnan First People's Hospital	CHINA
Yunnan Key Laboratory of Stem Cells and Regeneration Medicine	CHINA
Yunnan Mental Hospital	CHINA
Yunnan University	CHINA
Zhejiang University	CHINA
Zunyi Medical University	CHINA

External engagement & recognition

Engagement/recognition	Year
Associate Editor Neurotoxicity Research	2018
Associate Editor Neurotoxicity Research	2017
Member Society for Neuroscience	2017
Member Neurotoxicity Society	2017
Member Australian Neuroscience Society	2017
Research Fellowship National Health and Medical Research Council (NHMRC)	2012

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Discovering the Roles of Orexins in Parkinson's disease	Current
A role for p75 neurotrophin receptor in Neurodegeneration in Alzheimer's disease and tauopathy	Completed
Characterisation of lipopolysaccharide models of Parkinson¿s disease, and the effects of edaravone and curcumin	Completed
Characterization of proBDNF knock out mice and effect of proBDNF on angiogenesis	Completed
Chronic stress, nutrition and gut health: possible links and implications for chronic stress-induced depression	Completed
Conversion of human urine cells and fibroblasts into neural cells with small molecules	Completed
Development of combined therapy for Alzheimer¿s disease: a mechanistic study	Completed
Development of novel dosage forms to repurpose the drugs for Alzheimer's disease	Completed
Functions of proBDNF and its signaling receptor p75 in neuroprotection after ischemic stroke	Completed
Hypoglycaemia-associated autonomic failure: the involvement of catecholamine producing cells in the brain and adrenal gland	Completed
Investigation into a small molecule aided conversion of human urine cells into hepatocyte-like cells and beta-like cells in vitro	Completed
Investigation into signalling mechanisms of BDNF in neurological disorders	Completed
Investigation of BDNF and its precursor protein proBDNF in depression	Completed
Investigation of therapeutic intervention for neonatal hypoxic-ischemic brain injury	Completed
Potential function of neurotrophic factors in growth plate cartilage bony repair and skeletal cell formation	Completed
Roles of precursor of brain-derived neurotrophic factor in neuronal development and neurodegeneration	Completed
Roles of the precursor of brain derived neurotrophic factor in neuronal development and regeneration	Completed
The role of brain derived neurotrophic factor and the neurotrophin receptor p75NTR in the pathogenesis of Alzheimer¿s disease	Completed
The role of sortilin in regulating the pathological hallmarks and behavioural symptoms in Alzheimer¿s disease	Completed
Validation of p75ECD and edaravone as neuroprotective drug candidates for neurodegenerative diseases	Completed

Professor Xin-Fu Zhou

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Chapters

Journal Articles

Current research & highlights

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Associate Editor

Associate Editor

Member

Member

Member

Research Fellowship

Teaching & student supervision

Courses and programs

Research degree supervision

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