Dr Yoon Lim

Research Fellow Centre for Cancer Biology

City West Campus (HB10-35)
tel +61 8 830 21489

email Yoon.Lim@unisa.edu.au

Alternative contact

Research Degree Supervisor

About me

Cell death
Apoptosis
Caspases
Cancer
Cell signalling

Dr Yoon Lim is Research Fellow at the Centre for Cancer Biology (CCB), UniSA and SA Pathology. Yoon has over 11 years of experience in cell death in neurobiology and cancer biology.

Yoon completed his PhD in Neuroscience in 2016 (University of South Australia). Yoon’s PhD project focused on the signalling mechanisms of neurotrophins and their importance in neuronal survival, proliferation, and neurological disorders, including glioma, resulting in 17 primary research articles (3 as first author).

Before his PhD, Yoon worked for a biotech company in South Korea (2000 – 2007). Yoon discovered several diagnostic marker candidates for autoimmune diseases and cancer and developed a novel system for... Read more

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

Research

Research focus

Oncology and Carcinogenesis
Biochemistry and Cell Biology
Medical and Health Sciences
Neurosciences
Clinical Sciences

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2024	Dawar, S, Benitez, MC, Lim, Y, Dite, TA, Yousef, JM, Thio , N, Garciaz, S, Jackson, TD, Milne, J V, Dagley, LF, Phillips, WA, Kumar, S & Clemons, NJ 2024, 'Caspase-2 protects against ferroptotic cell death', Cell Death and Disease, vol. 15, no. 3, article no. 182, pp. 1-12. Open access 5 6
2024	Nicolson, S, Manning, JA, Lim, Y, Jiang, X, Kolze, E, Dayan, S, Umargamwala, R, Xu, T, Sandow, JJ, Webb, AI, Webb, A I, Kumar, S & Denton, D 2024, 'The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy', Communications Biology, vol. 7, no. 1, pp. 1-24. Open access 1 1 7
2024	Vora, S, Andrew, A, Kumar, RP, Nazareth, D, Bonfim-Melo, A, Lim, Y, Ong, XY, Fernando, M, He, Y, Hooper, JD, McMillan, NA, Urosevic, J, Travers, J, Saeh, J, Kumar, S, Jones, MJ & Gabrielli, B 2024, 'Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition', Cell Death and Disease, vol. 15, no. 11, article no. 810, pp. 1-9. Open access 1 1 1
2022	Kumar, S, Dorstyn, L & Lim, Y 2022, 'The role of caspases as executioners of apoptosis', Biochemical Society Transactions, vol. 50, no. 1, pp. 33-45. Open access 32 30 4
2022	Kutyna, MM, Kok, CH, Lim, Y, Tran, ENH, Campbell, D, Paton, S, Thompson-Peach, C, Lim, K, Cakouros, D, Arthur, A, Hughes, T, Kumar, S, Thomas, D, Gronthos, S & Hiwase, DK 2022, 'A senescence stress secretome is a hallmark of therapy-related myeloid neoplasm stromal tissue occurring soon after cytotoxic exposure', Leukemia, vol. 36, no. 11, pp. 2678-2689. Open access 14 14 5
2021	Lim, Y, De Bellis, D, Sandow, JJ, Capalbo, L, D'Avino, PP, Murphy, JM, Webb, A I, Dorstyn, L & Kumar, S 2021, 'Phosphorylation by Aurora B kinase regulates caspase-2 activity and function', Cell Death and Differentiation, vol. 28, pp. 349-366. Open access 21 21 13
2020	Li, H, Lin, LY, Zhang, Y, Lim, Y, Rahman, M, Beck, A, Al-Hawwas, M, Feng, S, Bobrovskaya, L & Zhou, XF 2020, 'Pro-BDNF knockout causes abnormal motor behaviours and early death in mice', Neuroscience, vol. 438, pp. 145-157. 12 9 1
2019	Dorstyn, L, Hackett-Jones, E, Nikolic, A, Norris, MD, Lim, Y, Toubia, J, Haber, M & Kumar, S 2019, 'Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling', Cell Death and Disease, vol. 10, no. 2, pp. 1-16. Open access 7 6 6
2018	Lim, Y, De Bellis, D, Dorstyn, L & Kumar, S 2018, 'p53 accumulation following cytokinesis failure in the absence of caspase-2', Cell Death and Differentiation, vol. 25, no. 11, pp. 2050-2052. Open access 11 10 3
2018	Lim, Y, Wu, LLY, Chen, S, Sun, Y, Vijayaraj, SL, Yang, M, Bobrovskaya, L, Keating, D, Li, XJ & Zhou, X-F 2018, 'HAP1 is required for endocytosis and signalling of BDNF and its receptors in neurons', Molecular Neurobiology, vol. 55, no. 3, pp. 1815-1830. Open access 22 19
2018	Saadipour, K, Mañucat-Tan, NB, Lim, Y, Keating, DJ, Smith, KS, Zhong, JH, Liao, H, Bobrovskaya, L, Wang, YJ, Chao, M V & Zhou, XF 2018, 'p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis', Journal of Neurochemistry, vol. 144, no. 3, pp. 302-317. Open access 27 25 1
2017	Dawar, S, Lim, Y, Puccini, J, White, M, Thomas, P, Bouchier-Hayes, L, Green, D, Dorstyn, L & Kumar, S 2017, 'Caspase-2-mediated cell death is required for deleting aneuploid cells', Oncogene, vol. 36, no. 19, pp. 2704-2714. Open access 54 51 10
2017	Lim, YY, Rainey-Smith, S, Lim, Y, Laws, SM, Gupta, V, Porter, T, Bourgeat, P, Ames, D, Fowler, C, Salvado, O, Villemagne, VL, Rowe, CC, Masters, CL, Zhou, XF, Martins, RN & Maruff, P 2017, 'BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF', International Psychogeriatrics, vol. 29, no. 11, pp. 1825-1834. 22 18 7
2017	Mackenzie, KD, Lim, Y, Duffield, MD, Chataway, T, Zhou, X-F & Keating, DJ 2017, 'Huntingtin-associated protein-1 (HAP1) regulates endocytosis and interacts with multiple trafficking-related proteins', Cellular Signalling, vol. 35, pp. 176-187. 28 27
2016	Han, Y-C, Lim, Y, Duffieldl, MD, Li, H, Liu, J, Abdul, MNP, Yang, M, Keating, DJ & Zhou, X-F 2016, 'Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules', Stem Cells International, vol. 2016, article no. 4304916, pp. 1-11. Open access 49 47 6
2016	Mackenzie, KD, Lumsden, A, Guo, F, Duffield, MD, Chataway, T, Lim, Y, Zhou, X-F & Keating, DJ 2016, 'Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking', Journal of Neurochemistry, vol. 138, no. 5, pp. 710-721. Open access 22 22 1
2015	Johnson, ME, Lim, Y, Senthilkumaran, M, Zhou, X-F & Bobrovskaya, L 2015, 'Investigation of tyrosine hydroxylase and BDNF in a low-dose rotenone model of Parkinson's disease', Journal of Chemical Neuroanatomy, vol. 70, pp. 33-41. 31 26
2015	Lim, Y, Zhong, J-H & Zhou, X-F 2015, 'Development of mature BDNF-specific sandwich ELISA', Journal of Neurochemistry, vol. 134, no. 1, pp. 75-85. 44 41 3
2015	Xiong, J, Zhou, L, Lim, Y, Yang, M, Zhu, y, Li, Z- W, Fu, D-L & Zhou, X-F 2015, 'Mature brain-derived neurotrophic factor and its receptor TrkB are upregulated in human glioma tissues', Oncology Letters. Open access 29 31 1
2013	Saadipour, K, Yang, M, Lim, Y, Georgiou, K, Sun, Y, Keating, D, Liu, J, Wang, Y-R, Gai, W-P, Zhong, J-h, Wang, Y-J & Zhou, X-F 2013, 'Amyloid beta1-42 (Aβ42) up-regulates the expression of sortilin via the p75NTR/RhoA signaling pathway', Journal of Neurochemistry, vol. 127, no. 2, pp. 152-162. Open access 41 37
2013	Xiong, J, Zhou, L, Lim, Y, Yang, M, Zhu, Y, Li, Z, Zhou, FH-h, Xiao, Z & Zhou, X-F 2013, 'Mature BDNF promotes the growth of glioma cells in vitro', Oncology Reports: An International Journal Devoted to Fundamental and Applied Research in Oncology, vol. 30, no. 6, pp. 2719-2724. Open access 37 35
2013	Xiong, J, Zhou, L, Yang, M, Lim, Y, Zhu, Y-h, Fu, D-l, Li, Z-w, Zhong, J-h, Xiao, Z-c & Zhou, X-F 2013, 'ProBDNF and its receptors are upregulated in glioma and inhibit the growth of glioma cells in vitro', Neuro-Oncology, vol. 15, no. 8, pp. 990-1007. Open access 57 51
2013	Yang, M, Virassamy, B, Vijayaraj, S, Lim, Y, Saadipour, K, Wang, Y, Han, Y, Zhong, J, Morales, C & Zhou, X-F 2013, 'The intracellular domain of sortilin interacts with amyloid precursor protein and regulates its lysosomal and lipid raft trafficking', PLoS One, vol. 8, no. 5, article no. e63049. Open access 28 26
2013	Zhou, L, Xiong, J, Lim, Y, Ruan, Y, Huang, C, Zhu, Y, Zhong, J-h, Xiao, Z & Zhou, X-F 2013, 'Upregulation of blood proBDNF and its receptors in major depression', Journal of Affective Disorders, vol. 150, no. 3, pp. 776-784. 127 117
2012	Sun, Y, Lim, Y, Li, F, Liu, S, Lu, J-J, Haberberger, R, Zhong, J-H & Zhou, X-F 2012, 'ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA', PLoS One, vol. 7, no. 4, article no. e35883, pp. 1-12. Open access 131 92
2012	Yang, G-Z, Yang, M, Lim, Y, Lu, J-J, Wang, T-H, Qi, J-G, Zhong, J-H & Zhou, X-F 2012, 'Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons', Journal of Neurochemistry, vol. 122, no. 5, pp. 1010-1022. Open access 32 31
2011	Wang, Y-J, Wang, X, Lu, J-J, Li, Q-X, Gao, C-Y, Liu, X-H, Sun, Y, Yang, M, Lim, Y, Evin, G, Zhong, J-H, Masters, C & Zhou, X-F 2011, 'p75NTR regulates Aß deposition by increasing Aß production but inhibiting Aß aggregation with its extracellular domain', Journal of Neuroscience, vol. 31, no. 6, pp. 2292-2304. Open access 86 79
2011	Yang, M, Lim, Y, Li, X, Zhong, J-H & Zhou, X-F 2011, 'Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing', Journal of Biological Chemistry, vol. 286, no. 18, pp. 16272-16284. Open access 66 59

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
AstraZeneca	AUSTRALIA
Austin Health	AUSTRALIA
Baylor College of Medicine	UNITED STATES
China Pharmaceutical University	CHINA
Cogstate Limited	AUSTRALIA
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Daping Hospital	CHINA
Edith Cowan University	AUSTRALIA
Emory University	UNITED STATES
Flinders University	AUSTRALIA
Griffith University	AUSTRALIA
Hollywood Private Hospital	AUSTRALIA
Kunming Medical University	CHINA
Kunming Psychological Crisis Intervention and Research Center	CHINA
McGill University	CANADA
Mental Health Research Institute	UNITED STATES
Monash University	AUSTRALIA
National Ageing Research Institute	AUSTRALIA
New York University	UNITED STATES
Peter MacCallum Cancer Centre	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Sichuan University	CHINA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
St. Jude Children's Research Hospital	UNITED STATES
Third Military Medical University	CHINA
Tianjin Medical University	CHINA
University of Adelaide	AUSTRALIA
University of Cambridge	UNITED KINGDOM
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University School of Medicine	UNITED STATES
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Yunnan First People's Hospital	CHINA
Yunnan Mental Hospital	CHINA

External engagement & recognition

Engagement/recognition	Year
Committee Member for the Early/Mid Career Researcher Symposium Centre for Cancer Biology	2019
Laboratory Representative University of Adelaide Medical School	2019
Member Australian Society for Biochemistry and Molecular Biology	2019
Member Australia and New Zealand Society for Cell and Developmental Biology	2019
Organising committee for 2019 ANZSCDB National Scientific Meeting Australia and New Zealand Society for Cell and Developmental Biology	2019
South Australia State Representative Australia and New Zealand Society for Cell and Developmental Biology	2019
Co-Organiser of the 8th ANZSCDB Adelaide Meeting Australia and New Zealand Society for Cell and Developmental Biology	2018
Member Australian Society for Biochemistry and Molecular Biology	2018
Member Australia and New Zealand Society for Cell and Developmental Biology	2018
Poster Judge for the Adelaide Protein Group Student Awards Adelaide Protein Group	2018
Session chair for the ANZSCDB Adelaide Meeting Australia and New Zealand Society for Cell and Developmental Biology	2018
South Australia State Representative Australia and New Zealand Society for Cell and Developmental Biology	2018
Travel fellowship Japanese and Australian Meeting on Cell Death	2018
Member Australian Society for Biochemistry and Molecular Biology	2017
Member Australia and New Zealand Society for Cell and Developmental Biology	2017
Poster Judge for the ComBio 2017 Australia and New Zealand Society for Cell and Developmental Biology	2017
Representative of the Centre for Cancer Biology at SAHMRI HDR Recruitment Event South Australian Health and Medical Research Institute (SAHMRI)	2017
Judge for Student Oral Presentation at the ANZSCDB Meeting Australia and New Zealand Society for Cell and Developmental Biology	2016
Member Australia and New Zealand Society for Cell and Developmental Biology	2016
Member Australian Society for Biochemistry and Molecular Biology	2016
Member Australia and New Zealand Society for Cell and Developmental Biology	2015

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Investigating the functions of the ubiquitin ligase NEDD4-2 in kidney disease.	Current
Modulation of NEDD4-2 expression and activity as a cellular mechanism for ameliorating kidney disease	Current
New mechanisms regulating the biogenesis of extracellular vesicles	Current
The role for caspase-2 in mammary development and fat biology	Completed

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Dr Yoon Lim

Alternative contact

Alternative contact details

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Committee Member for the Early/Mid Career Researcher Symposium

Laboratory Representative

Member

Member

Organising committee for 2019 ANZSCDB National Scientific Meeting

South Australia State Representative

Co-Organiser of the 8th ANZSCDB Adelaide Meeting

Member

Member

Poster Judge for the Adelaide Protein Group Student Awards

Session chair for the ANZSCDB Adelaide Meeting

South Australia State Representative

Travel fellowship

Member

Member

Poster Judge for the ComBio 2017

Representative of the Centre for Cancer Biology at SAHMRI HDR Recruitment Event

Judge for Student Oral Presentation at the ANZSCDB Meeting

Member

Member

Member

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery