Dr Michelle Su

Research Fellow UniSA Clinical & Health Sciences

City West Campus (HB6-25)
tel +61 8 830 22103

email Yu-Wen.Su@unisa.edu.au

Available for media comment
Research Degree Supervisor

Research

Research focus

Biological Sciences
Clinical Sciences
Medical and Health Sciences
Pharmacology and Pharmaceutical Sciences
Biochemistry and Cell Biology

Highlights

1. Conducting research into the pathophysiology of children’s growth plate and bone injury repair and its molecular regulation.

2. Examining the potential function and action mechanisms of neurotrophins, particularly neurotrophin-3 (NT-3) in regulating the osteogenesis, angiogenesis, osteoclastogenesis and chondrogenesis during growth plate and bone injury repair in rats.

3. Investigating the interactions between NT-3 and other growth factors such as bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) during in vitro skeletal cell formation.

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2017	Lee, AM, Shandala, T, Soo, PP, Su, Y-W, King, TJ, Chen, K-M, Howe, PR & Xian, CJ 2017, 'Effects of resveratrol supplementation on methotrexate chemotherapy‐induced bone loss', Nutrients, vol 9. no. 3, article no. 255, pp. 1-15. Open access 18 14 15
2013	Raghu Nadhanan, R, Fan, C-M, Su, Y-W, Howe, PR & Xian, CJ 2013, 'Fish oil in comparison to folinic acid for protection against adverse effects of methotrexate chemotherapy on bone', Journal of Orthopaedic Research, vol. 32, no. 4, pp. 587-596. Open access 6 11
2013	Raghu, NR, Skinner, J, Chung, R, Su, Y-W, Howe, PR & Xian, CJ 2013, 'Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats', PLoS One, vol. 8, no. 8, article no. e71592, pp. 1-12. Open access 16 24 1
2012	Raghu, NR, Abimosleh, SM, Su, Y-W, Scherer, MA, Howarth, GS & Xian, CJ 2012, 'Dietary emu oil supplementation suppresses 5-fluorouracil chemotherapy-induced inflammation, osteoclast formation, and bone loss', American Journal of Physiology: Endocrinology and Metabolism, vol. 302, no. 11, pp. 1440-1449. Open access 31 30 3

Journal Articles

Year	Output
2022	Peymanfar, Y, Su, Y-W, Hassanshahi, M & Xian, CJ 2022, 'Methotrexate treatment suppresses osteoblastic differentiation by inducing Notch2 signaling and blockade of Notch2 rescues osteogenesis by preserving Wnt/β-catenin signaling', Journal of Orthopaedic Research, vol. 40, no. 10, pp. 2258-2270. 2
2022	Peymanfar, Y, Su, YW & Xian, CJ 2022, 'Notch2 blockade mitigates methotrexate chemotherapy-induced bone loss and marrow adiposity', Cells, vol. 11, no. 9, pp. 1-21. Open access
2022	Yaser, P, Su, Y-W, Hassanshahi, M & Xian, CJ 2022, 'Therapeutic targeting notch2 protects bone micro-vasculatures from methotrexate chemotherapy-induced adverse effects in rats', Cells, vol. 11, no. 15, article no. 2382. Open access 3
2022	Zhang, Y, Liu, L, Pillman, KA, Hayball, J, Su, YW & Xian, CJ 2022, 'Differentially expressed miRNAs in bone after methotrexate treatment', Journal of Cellular Physiology, vol. 237, no. 1, pp. 965-982. Open access 1 3
2021	Fan, J, Su, YW, Hassanshahi, M, Chia-ming Fan, Peymanfar, Y, Piergentili, A, Del Bello, F, Quaglia, W & Xian, CJ 2021, 'β-Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats', Journal of Cellular Physiology, vol. 236, no. 5, pp. 3740-3751. Open access 1 1 1
2021	Su, YW, Fan, J, Fan, CM, Peymanfar, Y, Zhang, YL & Xian, CJ 2021, 'Roles of apoptotic chondrocyte-derived CXCL12 in the enhanced chondroclast recruitment following methotrexate and/or dexamethasone treatment', Journal of Cellular Physiology, vol. 236, no. 8, pp. 5966-5979. Open access
2021	Yu-Wen, S, Wong, DS, Fan, J, Chung, R, Wang, L, Chen, Y, Xian, CH, Yao, L, Wang, L, Foster, BK, Xu, J & Xian, CJ 2021, 'Enhanced BMP signalling causes growth plate cartilage dysrepair in rats', Bone, vol. 145, pp. 1-13. 2 2 32
2021	Zhang, YL, Liu, L, Su, Y-W & Xian, CJ 2021, 'miR-542-3p attenuates bone loss and marrow adiposity following methotrexate treatment by targeting sFRP-1 and smurf2', International Journal of Molecular Sciences, vol. 22, no. 20, article no. 10988, pp. 1-19. Open access 1 1 1
2021	Zhang, YL, Liu, L, Su, YW & Xian, CJ 2021, 'miR-6315 attenuates methotrexate treatment-induced decreased osteogenesis and increased adipogenesis potentially through modulating TGF-β/smad2 signalling', Biomedicines, vol. 9, no. 12, article no. 1926. Open access 1
2019	Hassanshahi, A, Hassanshahi, M, Khabbazi, S, Hosseini-Khah, Z, Peymanfar, Y, Qhalamkari, S, Su, YW & Xian, CJ 2019, 'Adipose-derived stem cells for wound healing', Journal of Cellular Physiology, vol. 234, no. 6, pp. 7903-7914. Open access 48 42 1
2019	Hassanshahi, M, Hassanshahi, A, Khabbazi, S, Su, YW & Xian, CJ 2019, 'Bone marrow sinusoidal endothelium as a facilitator/regulator of cell egress from the bone marrow', Critical Reviews in Oncology Hematology, vol. 137, pp. 43-56. Open access 6 6
2019	Hassanshahi, M, Khabbazi, S, Peymanfar, Y, Hassanshahi, A, Hosseini-Khah, Z, Su, Y-W & Xian, CJ 2019, 'Critical limb ischemia: Current and novel therapeutic strategies', Journal of Cellular Physiology, vol. 234, no. 9, pp. 14445-14459. Open access 10 9 5
2019	Hassanshahi, M, Su, YW, Fan, CM, Khabbazi, S, Hassanshahi, A & Xian, CJ 2019, 'Methotrexate chemotherapy-induced damages in bone marrow sinusoids: An in vivo and in vitro study', Journal of Cellular Biochemistry, vol. 120, no. 3, pp. 3220-3231. 10 11
2019	Hassanshahi, M, Su, YW, Khabbazi, S, Fan, CM, Chen, KM, Wang, JF, Qian, A, Howe, PR, Yan, DW, Zhou, HD & Xian, CJ 2019, 'Flavonoid genistein protects bone marrow sinusoidal blood vessels from damage by methotrexate therapy in rats', Journal of Cellular Physiology, vol. 234, no. 7, pp. 11276-11286. Open access 8 8
2019	Khabbazi, S, Hassanshahi, M, Hassanshahi, A, Peymanfar, Y, Su, Y-W & Xian, CJ 2019, 'Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression', Naunyn-Schmiedebergs Archives of Pharmacology, vol. 392, no. 2, pp. 123-133. Open access 6 7
2019	Lee, AM, Bowen, JM, Su, Y-W, Plews, E, Chung, R, Keefe, DM & Xian, CJ 2019, 'Individual or combination treatments with lapatinib and paclitaxel cause potential bone loss and bone marrow adiposity in rats', Journal of Cellular Biochemistry, vol. 120, no. 3, pp. 4180-4191. Open access 1 1
2019	Tang, Q, Su, YW, Fan, CM, Chung, R, Hassanshahi, M, Peymanfar, Y & Xian, CJ 2019, 'Release of CXCL12 from apoptotic skeletal cells contributes to bone growth defects following dexamethasone therapy in rats', Journal of Bone and Mineral Research, vol. 34, no. 2, pp. 310-326. Open access 5 6 15
2018	Fan, CM, Su, YW, Howe, PR & Xian, CJ 2018, 'Long chain omega-3 polyunsaturated fatty acid supplementation protects against adriamycin and cyclophosphamide chemotherapy-induced bone marrow damage in female rats', International Journal of Molecular Sciences, vol. 19, no. 2, pp. 1-15. Open access 5 3
2018	Su, Y-W, Zhou, X-F, Foster, BK, Grills, BL, Xu, J & Xian, CJ 2018, 'Roles of neurotrophins in skeletal tissue formation and healing', Journal of Cellular Physiology, vol. 233, no. 3, pp. 2133-2145. Open access 29 25
2018	Su, YW, Chim, SM, Zhou, L, Hassanshahi, M, Chung, R, Fan, C, Song, Y, Foster, BK, Prestidge, CA, Peymanfar, Y, Tang, Q, Butler, LM, Gronthos, S, Chen, D, Xie, Y, Chen, L, Zhou, XF, Xu, J & Xian, CJ 2018, 'Osteoblast derived-neurotrophin‑3 induces cartilage removal proteases and osteoclast-mediated function at injured growth plate in rats', Bone, vol. 116, pp. 232-247. Open access 11 10 1
2017	Hassanshahi, M, Hassanshahi, A, Khabbazi, S, Su, Y-W & Xian, CJ 2017, 'Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy', Angiogenesis, vol. 20, no. 4, pp. 427-442. Open access 29 30 1
2017	Lee, AM, Shandala, T, Soo, PP, Su, Y-W, King, TJ, Chen, K-M, Howe, PR & Xian, CJ 2017, 'Effects of resveratrol supplementation on methotrexate chemotherapy‐induced bone loss', Nutrients, vol 9. no. 3, article no. 255, pp. 1-15. Open access 18 14 15
2017	Su, Y-W, Chen, K-M, Mohammadhossein Hassanshahi , Qian Tang, Howe, PR & Xian, CJ 2017, 'Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals', Annals of the New York Academy of Sciences, vol. 1403, pp. 109-117. Open access 16 13 1
2016	Su, Y-W, Chung, R, Ruan, C-S, Chim, SM, Kuek, V, Dwivedi, PP, Mohammadhossein Hassanshahi , Chen, K-M, Xie, Y, Chen, L, Foster, BK, Rosen, V, Zhou, X-F, Xu, J & Xian, CJ 2016, 'Neurotrophin-3 induces BMP-2 and VEGF activities and promotes the bony repair of injured growth plate cartilage and bone in rats', Journal of Bone and Mineral Research, v. 31, no. 6, pp. 1258-1274. Open access 43 35
2014	Chim, SM, Kuek, V, Chow, ST, Lim, BS, Tickner, J, Zhao, J, Chung, R, Yu-Wen, S, Zhang, G, Erber, W, Xian, CJ, Rosen, V & Xu, J 2014, 'EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades', Journal of Cellular Physiology, vol. 230, no. 1, pp. 82-94. Open access 31 32 2
2013	Raghu Nadhanan, R, Fan, C-M, Su, Y-W, Howe, PR & Xian, CJ 2013, 'Fish oil in comparison to folinic acid for protection against adverse effects of methotrexate chemotherapy on bone', Journal of Orthopaedic Research, vol. 32, no. 4, pp. 587-596. Open access 6 11
2013	Raghu, NR, Skinner, J, Chung, R, Su, Y-W, Howe, PR & Xian, CJ 2013, 'Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats', PLoS One, vol. 8, no. 8, article no. e71592, pp. 1-12. Open access 16 24 1
2013	Zhang, P, Zhao, M, Liang, G, Yin, G, Huang, D, Su, F, Zhai, H, Wang, L, Su, Y & Lu, Q 2013, 'Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris', Journal of Autoimmunity, vol. 41, pp. 17-24. 104 90
2012	Raghu, NR, Abimosleh, SM, Su, Y-W, Scherer, MA, Howarth, GS & Xian, CJ 2012, 'Dietary emu oil supplementation suppresses 5-fluorouracil chemotherapy-induced inflammation, osteoclast formation, and bone loss', American Journal of Physiology: Endocrinology and Metabolism, vol. 302, no. 11, pp. 1440-1449. Open access 31 30 3
2009	Su, Y-W, Liang, C, Jin, H-F, Tang, X-Y, Han, W, Chai, L-J, Zhang, C-Y, Geng, B, Tang, C-S & Du, J-B 2009, 'Hydrogen sulfide regulates cardiac function and structure in adriamycin-induced cardiomyopathy', Journal of Orthopaedic Research, vol. 73, pp. 741-749. Open access 61 29

Other outputs

2015. Chim SM, Chow ST, Kuek V, Lim BS, Tickner J, Chung R, Su YW, Zhang G, Rosen V, Xian CJ, Xu J. EGFL7 is expressed by osteoclasts and osteoblasts in the bone microenvironment, and induces endothelial cell activities and ERK1/2, STAT3, and FAK phosphorylation. J Cell Physiol. 2015 Jan; 230(1):82-94.

2016. Su YW, Chung R, Ruan CS, Chim SM, Kuek V, Dwivedi PP, Hassanshahi M, Chen KM, Xie Y, Chen L, Foster BK, Rosen V, Zhou XF, Xu J, Xian CJ. Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats. J Bone Miner Res. 2016 Jun; 31(6):1258-74. Epub 2016 Feb 16.

2017. Su YW, Zhou XF, Foster BK, Grills BL, Xu J, Xian CJ. Roles of Neurotrophins in Skeletal Tissue Formation and Healing. J Cell Physiol. 2017 Mar 30. doi: 10.1002/jcp.25936. [Epub ahead of print]

2017. Su YW, Chen KM, Hassanshahi M, Tang Q, Howe PR, Xian CJ. Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals. Ann N Y Acad Sci. 2017 Jun 29. doi: 10.1111/nyas.13380. [Epub ahead of print].

2017. Hassanshahi M, Hassanshahi A, Khabbazi S, Su YW, Xian CJ. Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy. Angiogenesis. Accepted on 17 Sep 2017.

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Beijing Genomics Institute	CHINA
Central South University	CHINA
Chinese Academy of Sciences	CHINA
Daping Hospital	CHINA
Flinders Medical Centre	AUSTRALIA
Guangxi Medical University	CHINA
Harvard University	UNITED STATES
Hong Kong Baptist University	HONG KONG
Islamic Azad University	IRAN
Islamic Azad University Shahrekord Branch	IRAN
La Trobe University	AUSTRALIA
Lanzhou General Hospital	CHINA
Mazandaran University of Medical Sciences	IRAN
Ministry of Education	CHINA
Ningbo University	CHINA
Northwestern Polytechnical University	CHINA
Peking University First Hospital	CHINA
Rush University	UNITED STATES
Second Xiangya Hospital of Central-South University	CHINA
Shenzhen University	CHINA
Shiraz University Of Medical Sciences	IRAN
Third Affiliated Hospital of Southern Medical University	CHINA
Third Military Medical University	CHINA
Tongji University	CHINA
Università degli Studi di Camerino	ITALY
University of Adelaide	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Southern Queensland	AUSTRALIA
University of Western Australia	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Christopher & Margie Nordin Young Investigator Poster Award Australian and New Zealand Bone and Mineral Society	2013

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Targeting BMP signalling for enhancing growth plate regeneration	Current
Potential regulatory roles of miRNA(s) in bone loss and marrow adiposity following methotrexate treatment in rats	Completed
Roles of chemokine CXCL12 in bone growth defects induced by methotrexate and dexamethasone chemotherapeutic treatment	Completed
Roles of Notch2 signalling pathway in bone & bone marrow micro-vasculature damage following methotrexate chemotherapy in rats	Completed

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Dr Michelle Su

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Other projects

Outputs

Highlights

Journal Articles

Other outputs

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Christopher & Margie Nordin Young Investigator Poster Award

Teaching & student supervision

Courses and programs

Research degree supervision

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