About me
Doctor of Philosophy University of South Australia
Master of Medical Science Peking University
Masters Graduate Student Diploma in Pediatrics Peking University
Bachelor of Medicine China Medical University
1. Conducting research into the pathophysiology of children’s growth plate and bone injury repair and its molecular regulation.
2. Examining the potential function and action mechanisms of neurotrophins, particularly neurotrophin-3 (NT-3) in regulating the osteogenesis, angiogenesis, osteoclastogenesis and chondrogenesis during growth plate and bone injury repair in rats.
3. Investigating the interactions between NT-3 and other growth factors such as bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) during in vitro skeletal cell formation.
Research
Excludes commercial-in-confidence projects.
Accelerating bone healing by locally delivering osteogenic and angiogenic factor neurotrophin-3 (NT-3), Channel 7 Children's Research Foundation of SA, 01/01/2015 - 31/12/2016
Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of nutraceuticals.
Research
Research since 2008 is shown below. To see earlier years visit Scopus
Open access indicates that an output is open access.
| Year | Output |
|---|---|
| 2017 |
Open access
5
6
15
|
| 2013 |
Open access
6
6
|
| 2013 |
Open access
16
15
1
|
| 2012 |
Open access
16
17
4
|
| 2009 |
29
|
| Year | Output |
|---|---|
| 2019 |
2
1
1
|
| 2019 |
|
| 2019 |
4
|
| 2019 |
4
1
|
| 2019 |
|
| 2018 |
Open access
1
1
|
| 2018 |
6
4
|
| 2018 |
1
|
| 2018 |
1
1
1
|
| 2018 |
1
|
| 2017 |
Open access
16
11
1
|
| 2017 |
Open access
5
6
15
|
| 2017 |
Open access
6
4
1
|
| 2017 |
Open access
9
9
|
| 2016 |
Open access
15
14
|
| 2014 |
Open access
20
19
2
|
| 2013 |
Open access
6
6
|
| 2013 |
Open access
16
15
1
|
| 2013 |
60
51
|
| 2012 |
Open access
16
17
4
|
| 2009 |
29
|
2015. Chim SM, Chow ST, Kuek V, Lim BS, Tickner J, Chung R, Su YW, Zhang G, Rosen V, Xian CJ, Xu J. EGFL7 is expressed by osteoclasts and osteoblasts in the bone microenvironment, and induces endothelial cell activities and ERK1/2, STAT3, and FAK phosphorylation. J Cell Physiol. 2015 Jan; 230(1):82-94.
2016. Su YW, Chung R, Ruan CS, Chim SM, Kuek V, Dwivedi PP, Hassanshahi M, Chen KM, Xie Y, Chen L, Foster BK, Rosen V, Zhou XF, Xu J, Xian CJ. Neurotrophin-3 Induces BMP-2 and VEGF Activities and Promotes the Bony Repair of Injured Growth Plate Cartilage and Bone in Rats. J Bone Miner Res. 2016 Jun; 31(6):1258-74. Epub 2016 Feb 16.
2017. Su YW, Zhou XF, Foster BK, Grills BL, Xu J, Xian CJ. Roles of Neurotrophins in Skeletal Tissue Formation and Healing. J Cell Physiol. 2017 Mar 30. doi: 10.1002/jcp.25936. [Epub ahead of print]
2017. Su YW, Chen KM, Hassanshahi M, Tang Q, Howe PR, Xian CJ. Childhood cancer chemotherapy-induced bone damage: pathobiology and protective effects of resveratrol and other nutraceuticals. Ann N Y Acad Sci. 2017 Jun 29. doi: 10.1111/nyas.13380. [Epub ahead of print].
2017. Hassanshahi M, Hassanshahi A, Khabbazi S, Su YW, Xian CJ. Bone marrow sinusoidal endothelium: damage and potential regeneration following cancer radiotherapy or chemotherapy. Angiogenesis. Accepted on 17 Sep 2017.
Research
1. Conducting research into the pathophysiology of children’s growth plate and bone injury repair and its molecular regulation.
2. Examining the potential function and action mechanisms of neurotrophins, particularly neurotrophin-3 (NT-3) in regulating the osteogenesis, angiogenesis, osteoclastogenesis and chondrogenesis during growth plate and bone injury repair in rats.
3. Investigating the interactions between NT-3 and other growth factors such as bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) during in vitro skeletal cell formation.
External engagement & recognition
| Organisation | Country |
|---|---|
| Beijing Genomics Institute | CHINA |
| Central South University | CHINA |
| China University of Geosciences | CHINA |
| Chinese Academy of Sciences | CHINA |
| CSIRO Australia (Commonwealth Scientific Industrial Research Organisation) | AUSTRALIA |
| Daping Hospital | CHINA |
| Guangxi Medical University | CHINA |
| Harvard University | UNITED STATES |
| Hong Kong Baptist University | HONG KONG |
| Islamic Azad University | IRAN |
| Islamic Azad University Shahrekord Branch | IRAN |
| La Trobe University | AUSTRALIA |
| Lanzhou General Hospital | CHINA |
| Mazandaran University of Medical Sciences | IRAN |
| Northwestern Polytechnical University | CHINA |
| Rush University | UNITED STATES |
| Second Xiangya Hospital of Central-South University | CHINA |
| Shenzhen University | CHINA |
| Shiraz University Of Medical Sciences | IRAN |
| Third Military Medical University | CHINA |
| University of Adelaide | AUSTRALIA |
| University of Newcastle | AUSTRALIA |
| University of Queensland | AUSTRALIA |
| University of South Australia | AUSTRALIA |
| University of Southern Queensland | AUSTRALIA |
| University of Western Australia | AUSTRALIA |
| Women's and Children's Hospital | AUSTRALIA |
External engagement & recognition
| Engagement/recognition | Year |
|---|---|
Christopher & Margie Nordin Young Investigator Poster AwardAustralian and New Zealand Bone and Mineral Society |
2013 |
Teaching & student supervision
Supervisions from 2010 shown
| Thesis title | Student status |
|---|---|
| Alterations in bone -related gene expression pattern induced by growth and sex hormones in growing and ageing rats | Current |
| Investigating the molecular mechanism of BMSCs changes after cancer chemotherapy | Current |
| Study of childhood chemotherapy induced marrow adiposity as a potential factor in incidence of osteonecrosis | Current |
| Roles of chemokine CXCL12 in bone growth defects induced by methotrexate and dexamethasone chemotherapeutic treatment | Completed |
