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Dr Zlatko Kopecki

  • Foundation Fellow (Senior Research Fellow) Future Industries Institute
  • Mawson Lakes Campus (V2-06 )
  • tel +61 8 830 26384
  • mob +61 421 876 516
  • email Zlatko.Kopecki@unisa.edu.au
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About me

About me

Dr Zlatko Kopecki
  • wound healing
  • skin blistering
  • fibrosis
  • cancer
  • inflammation and infection

Previous NHMRC ECR Research Fellow (2012-2015) and a current Foundation Fellow (2015-2020) at the newly established Future Industries Institute, developing novel therapeutics for wound repair and working on understanding the mechanisms involved in wound healing, scar formation and fragile skin syndromes. Research involving skin blistering diseases, cell adhesion, tissue regeneration, skin cancer and fibrosis as well as industry driven research questions. Integration of different approaches and biomaterials for the development of novel wound dressings. Use of small and large animal models of wound healing, carcinogenesis, infection and skin blistering. Aim to use these models and knowledge gained to develop... Read more

Future Industries Institute

The Institute partners with today’s industries, to create the industries of tomorrow.

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About me

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About me

Previous NHMRC ECR Research Fellow (2012-2015) and a current Foundation Fellow (2015-2020) at the newly established Future Industries Institute, developing novel therapeutics for wound repair and working on understanding the mechanisms involved in wound healing, scar formation and fragile skin syndromes. Research involving skin blistering diseases, cell adhesion, tissue regeneration, skin cancer and fibrosis as well as industry driven research questions. Integration of different approaches and biomaterials for the development of novel wound dressings. Use of small and large animal models of wound healing, carcinogenesis, infection and skin blistering. Aim to use these models and knowledge gained to develop potential new therapies for the treatment of wounds to help improve the repair process.

Google Scholar publication list

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Professional Associations

DEBRA - Australia

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Experience

Qualifications

  • Doctor of Philosophy The University of Adelaide

  • Bachelor of Labortory Medicine Honours University of South Australia

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Research

Research themes

  • An age friendly world
  • Cancer
  • Healthy futures

Research focus

  • Clinical Sciences
  • Biochemistry and Cell Biology
  • Oncology and Carcinogenesis
  • Biological Sciences
  • Nursing
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Research

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Projects

Excludes commercial-in-confidence projects.

  • Development of simple, effective and pain-free diagnostic tool for patients with mild EB., DEBRA Australia, 26/02/2018 - 30/09/2019

  • Combating blister infection one step at a time, DEBRA Australia, 01/01/2017 - 31/12/2017

  • Study to determine if improving the skins barrier function reduces susceptibility to blister wound infection, DEBRA Australia, 11/12/2014 - 31/03/2016

  • Development of new therapy for children suffering from skin blistering diseases, NHMRC - Early Career Fellowship, 05/12/2012 - 31/12/2015

  • Development of systemic therapy for treatment of blistered areas, DEBRA Australia, 01/02/2014 - 31/12/2014

  • Function of flightless protein in the development of SCC in children with fragile skin, DEBRA Australia, 21/01/2013 - 31/03/2014

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Research

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Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year Output
2015

Kopecki, Z, Yang, GN, Jackson, JE, Melville, EL, Calley, MP, Murrell, DF, Darby, IA, O'Toole, EA, Samuel, MS & Cowin, A 2015, 'Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression', Oncotarget, vol. 6, no. 34, pp. 35426-36440.

Open access 11 12

Chapters

Year Output
2019

Boyle, S & Kopecki, Z 2019, 'Mechanical force and actin dynamics during cutaneous Squamous Cell Carcinoma (cSCC) progression: opportunities for novel treatment modalities', Squamous Cell Carcinoma-Hallmark and treatment modalities, IntechOpen, UK, pp. 1-22.

Open access 2
2016

Kopecki, Z & Cowin, AJ 2016, 'The role of actin remodelling proteins in wound healing and tissue regeneration', in V Alexandrescu (ed.), Wound healing: new insights into ancient challenges, IntechOpen, UK, ch. 6, pp. 1-22.

Open access

Journal Articles

Year Output
2019

Haidari, H, Goswami, N, Bright, R, Kopecki, Z, Cowin, AJ, Garg, S & Vasilev, K 2019, 'The interplay between size and valence state on the antibacterial activity of sub-10 nm silver nanoparticles', Nanoscale Advances, vol. 1, no. 6, pp. 2365-2371.

Open access 1 1 1
2019

Kopecki, Z, Has, C, Yang, G, Bruckner-Tuderman, L & Cowin, A 2019, 'Flightless I, a contributing factor to skin blistering in Kindler syndrome patients?', Journal of Cutaneous Pathology, in press, pp. 1-8.

2019

Kopecki, Z, Yang, G, Treloar, S, Mashtoub, S, Howarth, G, Cummins, A & Cowin, A 2019, 'Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis', Scientific Reports, vol. 9, no. 1, article no. 12792, pp. 1-10.

Open access
2019

Shi, G, Liu, T, Kopecki, Z, Cowin, A, Lee, I, Pai, J-H, Lowe, SE & Zhong, YL 2019, 'A multifunctional wearable device with fraphene/ailver nanowire nanocomposite for highly sensitive strain sensing and drug delivery', Journal of Carbon Research, vol. 5, no. 2, article no. 17, pp. 1-16.

Open access 1 14
2019

Stevens, N, Cowin, A & Kopecki, Z 2019, 'Skin barrier and autoimmunity-mechanisms and novel therapeutic approaches for autoimmune blistering diseases of the skin', Frontiers in Immunology, vol. 10, article no. 1089, pp. 1-11.

Open access 2 2 9
2018

Kopecki, Z, Stevens, NE, Chong, HT, Yang, GN & Cowin, AJ 2018, 'Flightless I alters the inflammatory response and autoantibody profile in an OVA-induced atopic dermatitis skin-like disease', Frontiers in Immunology, vol. 9, article no. 1833, pp. 1- 10.

Open access 2 2 6
2018

Kopecki, Z, Stevens, NE, Yang, GN, Melville, E & Cowin, AJ 2018, 'Recombinant leucine-rich repeat flightless-interacting protein-1 improves healing of acute wounds through its effects on proliferation inflammation and collagen deposition', International Journal of Molecular Sciences, vol. 19, no. 7, pp. 1-12.

Open access 1 2
2018

Ogunniyi, AD, Kopecki, Z, Hickey, EE, Khazandi, M, Peel, E, Belov, K, Boileau, A, Garg, S, Venter, H, Chan, WY, Hill, PB, Page, SW, Cowin, AJ & Trott, DJ 2018, 'Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing', PLoS One, vol. 13, no. 7, article no. e0200195, pp. 1-13.

Open access 3 4 3
2017

Chong, H, Yang, G, Sidhu, S, Ibbetson, J, Kopecki, Z & Cowin, A 2017, 'Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis', British Journal of Dermatology, vol. 176, no.3, pp. 705–712.

4 4
2017

Haidari, H, Zhang, Q, Melville, E, Kopecki, Z, Song, Y, Cowin, AJ & Garg, S 2017, 'Development of topical delivery systems for flightless neutralizing antibody', Journal of Pharmaceutical Sciences, vol. 106, no. 7, pp. 1795-1804.

Open access 1 3
2017

Kopecki, Z, Ogunniyi, D, Trott, D & Cowin, A 2017, 'Fighting chronic wound infection: one model at a time', Wound Practice and Research, vol. 25, no. 1, pp. 6-13.

2
2016

Kopecki, Z, Ludwig, RJ & Cowin, AJ 2016, 'Cytoskeletal regulation of inflammation and its impact on skin blistering disease epidermolysis bullosa acquisita', International Journal of Molecular Sciences, vol. 17, no. 7, article no. 1116, pp. 1-13.

Open access 7 7 1
2016

Yang, G, Kopecki, Z & Cowin, A 2016, 'Role of actin cytoskeleton in the regulation of epithelial cutaneous stem cells', Stem Cells and Development, vol. 25, no. 10, pp. 749-759.

2 1
2015

Kopecki, Z & Cowin, A 2015, 'Commentary: new advances in the development of therapies for treating inherited skin fragility disorders', Wound Practice and Research, vol. 23, no. 4, pp. 184-190.

2015

Kopecki, Z, Yang, GN, Jackson, JE, Melville, EL, Calley, MP, Murrell, DF, Darby, IA, O'Toole, EA, Samuel, MS & Cowin, A 2015, 'Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression', Oncotarget, vol. 6, no. 34, pp. 35426-36440.

Open access 11 12
2015

Menz, C, Parsi, MK, Adams, JR, Sideek, MA, Kopecki, Z, Cowin, AJ & Gibson, MA 2015, 'LTBP-2 has a single high-affinity binding site for FGF-2 and blocks FGF-2-induced cell proliferation', PLoS One, vol. 10, no. 8, article no. e0135577, pp. 1-18.

Open access 9 9 2
2015

Sideek, MA, Teia, A, Kopecki, Z, Cowin, AJ & Gibson, MA 2015, 'Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar', Journal of Molecular Histology, vol. 47, no. 1, pp. 35-45.

Open access 10 12 1
2014

Chan, H, Kopecki, Z, Walters, J, Powell, B, Arkell, R & Cowin, A 2014, 'Cytoskeletal protein Flightless I differentially affects TGF-β isoform expression in both in vitro and in vivo wound models', Wound Practice and Research, vol. 22, no. 3, pp. 169-181.

2014

Kopecki, Z, Yang, GN, Arkell, RM, Jackson, JE, Melville, E, Iwata, H, Ludwig, RJ, Zillikens, D, Murrell, DF & Cowin, AJ 2014, 'Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering', Journal of Pathology, vol. 232, no. 5, pp. 541-552.

13 16 2
2014

Ruzehaji, N, Kopecki, Z, Melville, E, Appleby, SL, Bonder, CS, Arkell, RM, Fitridge, R & Cowin, AJ 2014, 'Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes', Diabetologia, vol. 57, no. 2, pp. 402-412.

Open access 15 14
2014

Stevens, LJ, McKenna, S, Marty, J, Cowin, AJ & Kopecki, Z 2014, 'Understanding the outcomes of a home nursing programme for patients with epidermolysis bullosa: an Australian perspective', International Wound Journal, vol. 13, no. 5, pp. 863-869.

3 3
2013

Chong, HT, Kopecki, Z & Cowin, AJ 2013, 'Lifting the silver flakes: the pathogenesis and management of chronic plaque psoriasis', BioMed Research International, vol. 2013, article no. 168321, pp. 1-9.

Open access 19 21 7
2013

Jackson, JE, Kopecki, Z & Cowin, AJ 2013, 'Nanotechnological advances in cutaneous medicine', Journal of Nanomaterials, vol. 2013, article no. 808234, pp. 1-8.

Open access 2 3
2012

Cowin, AJ, Lei, N, Franken, L, Ruzehaji, N, Offenhäuser, C, Kopecki, Z & Murray, RZ 2012, 'Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation', Communicative and Integrative Biology, vol. 5, no. 6, pp. 546-549.

Open access 7 3
2012

Jackson, JE, Kopecki, Z, Adams, DH & Cowin, AJ 2012, 'Flii neutralizing antibodies improve wound healing in porcine preclinical studies', Wound Repair and Regeneration, vol. 20, no. 4, pp. 523-536.

20 25
2011

Kopecki, Z, Arkell, RM, Strudwick, XL, Hirose, M, Ludwig, RJ, Kern, JS, Bruckner-Tuderman, L, Zillikens, D, Murrell, DF & Cowin, AJ 2011, 'Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita', Journal of Pathology, vol. 225, no. 3, pp. 401-413.

26 27
2011

Kopecki, Z, O'Neill, GM, Arkell, RM & Cowin, AJ 2011, 'Regulation of focal adhesions by Flightless I involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway', Journal of Investigative Dermatology, vol. 131, no. 7, pp. 1450-1459.

Open access 21 22
2009

Kopecki, Z, Arkell, R, Powell, BC & Cowin, AJ 2009, 'Flightless I Regulates Hemidesmosome Formation and Integrin-Mediated Cellular Adhesion and Migration during Wound Repair', Journal of Investigative Dermatology, vol. 129, no. 8, pp. 2031-2045.

Open access 43 46
2008

Adams, DH, Strudwick, XL, Kopecki, Z, Hooper-Jones, JA, Matthaei, K I, Campbell, HD, Powell, BC & Cowin, A 2008, 'Gender specific effects on the actin-remodelling protein Flightless I and TGF-β1 contribute to impaired wound healing in aged skin', The International Journal of Biochemistry and Cell Biology, vol. 40 no. 8, pp. 1555-1569.

25 24
2008

Kopecki, Z & Cowin, AJ 2008, 'Flightless I: An actin-remodelling protein and an important negative regulator of wound repair', The International Journal of Biochemistry and Cell Biology, vol. 40, no. 8, pp. 1415-1419.

41 44

Reports

Year Output
2018

Cowin, A, Strudwick, X & Kopecki, Z 2018, Assessment of biofilm solution on wound infection and healing using in-vivo preclinical models, University of South Australia, Australia.

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External engagement & recognition

Collaborations

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External engagement & recognition

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Collaborations

Organisation Country
Australian National University AUSTRALIA
Brightsky Australia AUSTRALIA
Center for cancer biologly AUSTRALIA
Dystrophic Epidermolysis Bullosa Research Association AUSTRALIA
Griffith University AUSTRALIA
John Curtin School of Medical Research AUSTRALIA
Luoda Pharma Pty Ltd AUSTRALIA
QIMR Berghofer Medical Research Institute AUSTRALIA
Queen Elizabeth Hospital AUSTRALIA
Queen Mary University of London UNITED KINGDOM
Queensland University of Technology AUSTRALIA
RMIT University AUSTRALIA
Royal Adelaide Hospital AUSTRALIA
Royal Alexandra Hospital for Children AUSTRALIA
SA Pathology AUSTRALIA
University Medical Centre Freiburg GERMANY
University of Adelaide AUSTRALIA
University of Dundee UNITED KINGDOM
University of Freiburg GERMANY
University of London UNITED KINGDOM
University of Lübeck GERMANY
University of New South Wales AUSTRALIA
University of South Australia AUSTRALIA
University of Sydney AUSTRALIA
Women and Children's Health Research Institute CANADA
Women's & Children's Health Research Institute Inc AUSTRALIA
Women's and Children's Health Network AUSTRALIA
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External engagement & recognition

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External engagement & recognition

Engagement/recognition Year

Committee Member

DEBRA-International

2022

Director

DEBRA, Australia

2022

Committee Member

Australasian Wound and Tissue Repair Society

2021

Best runner up - Best Literature Review

Coloplast Biatain Literacy Awards

2018

Runner up - Coloplast Bitain Literary Award (Best Review Article)

Wound Practice and Research Journal

2018

Vice-President

Australasian Wound and Tissue Repair Society

2018

Flinders Foundation CommunityAward

Leadership and Innovation in Health

2017

Invited Speaker

DEBRA International Congress, NZ

2017

Invited Speaker

Department of Dermatology, Uni. Lubeck Germany

2017

Tall Poppy Award

Australian Institute of Policy and Science

2017

Young Tall Poppy Award (SA)

Australian Institute of Policy and Science

2017

Young Investigator Award

Australasian Wound and Tissue Repair Society

2016

Australian Representative

DEBRA-International

2015

Committee Member and ECR Representative

Australasian Wound and Tissue Repair Society

2015

Early Career Fellowships

National Health and Medical Research Council (NHMRC)

2015

National Board Director, Chair of Clinical Advisory Committee and Member, EB Services

DEBRA, Australia

2015

Committee Member and ECR Representative

Australasian Wound and Tissue Repair Society

2014

National Board Director, Chair of Clinical Advisory Committee and Member, EB Services

DEBRA, Australia

2014

Honorary Research Fellowship

Centre for Cutaneous Research, Queen Mary University of London

2013

Honorary Research Fellowship

Queen Mary Uni. London, UK

2013

National Board Director, Chair of Clinical Advisory Committee and Member, EB Services

DEBRA, Australia

2013

Best Early Career Researcher Oral Presentation

Australian Wound and Tissue Repair Society

2012

Best poster Award

European Society for Investigative Dermatology Conference

2012

Early Career Fellowships

National Health and Medical Research Council (NHMRC)

2012

Finalist, Tall Poppy Award

Australian Institute of Policy and Science

2012

Honorary Research Fellowship

Centre for Cutaneous Research, Queen Mary University of London

2012

Finalist, Science and Excellence Awards SA

Government of South Australia

2011

Best Poster Award

Australian Wound and Tissue Repair Society Research Conference

2010

Best Review Article

Wound Practice and Research Journal

2010

Young Investigator Award - Finalist

Women's and Children's Hospital Foundation

2010

Plenary Speaker

European Society for Investigative Dermatology Conference

2009
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Courses and programs

Courses I teach and/or co-ordinate

  • BIOL 2037 Immunology (2019)
  • BIOL 1012 Biology B (2019)
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Teaching & student supervision

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Research degree supervision

Supervisions from 2010 shown

Thesis title Student status
Development of a novel stem cell therapy for treatment of Epidermolysis Bullosa Current
Development of new approaches for the treatment of infected wounds Current
Development of therapeutic treatments to combat burn wound infection Current
Role of flightless protein in colon cancer and healing of mucosal wounds Current
The role of Flightless I (Flii) in the healing of digital flexor tendon adhesions Completed
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Gallery

Dr Zlatko Kopecki
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