Professor Allison Cowin

Research Professor Future Industries Institute

Mawson Lakes Campus (V2-04)
tel +61 8 830 25018

email Allison.Cowin@unisa.edu.au

Research Degree Supervisor

About me

Wound Healing
Antibody therapies
Regenerative Medicine

Professor Allison Cowin is a leader in wound healing, internationally renowned for her work on the cytoskeletal protein Flightless I and how it negatively impacts on tissue repair. She is an NHMRC Senior Research Fellow and Professor of Regenerative Medicine at the Future Industries Institute UniSA, leading a group of 12 research scientists and students investigating all aspects of wound healing and regenerative biology. She is Program 2 Leader of the Wound Management Innovation Cooperative Research Centre and project leader in the Cooperative Research Centre for Cell Therapy Manufacturing.

Future Industries Institute

The Institute partners with today’s industries, to create the industries of tomorrow.

Tweets by @UniversitySA

Research

Research themes

Healthy futures

Research focus

Biochemistry and Cell Biology
Clinical Sciences
Biomedical Engineering
Biological Sciences
Materials Engineering

Highlights

The Cowin Laboratory focusses on developing new approaches to improve tissue repair and regeneration particularly in the context of wound healing. A range of projects are underway investigating the role of the cytoskeleton in cellular processes involved in wound repair as well as more applied research aimed at developing new delivery technologies for targeting specific therapies into wounds. From NHMRC funded research through to the involvement in two Cooperative research Centres Professor Cowin aims to improve the way wounds repair and reduce the prevalence of scar formation post burn injury.

Research

Projects

Excludes commercial-in-confidence projects.

New approaches for improving wound repair, NHMRC - Research Fellowship, 01/01/2016 - 31/12/2020
Cell Therapy Manufacturing CRC Scholarship, Cell Therapy Manufacturing CRC, 20/03/2017 - 06/07/2020
Plasma-soft tissue interactions: advancing a new era of plasma technologies, ARC - Discovery Projects, 01/04/2016 - 31/12/2019
Modulating sphingolipid signalling to enhance wound healing, NHMRC - Project Grant, 01/01/2017 - 31/12/2019
Development of a systemic antibody therapy for burns, Channel 7 Children's Research Foundation of SA, 01/01/2018 - 31/12/2019
CTM 1.24 - Cryopreservation of MSCs on CytoPatch, Cell Therapy Manufacturing CRC, 19/02/2018 - 31/03/2019
Development of a new pericyte therapy for the treatment of diabetic wounds, DART - General Research Grant, 01/01/2018 - 31/12/2018
Defining the mechanisms regulating tissue mechano-reciprocity in wound healing, NHMRC - Project Grant, 01/01/2016 - 31/12/2018
2.04 - Development of a stem cell dressing for the treatment of diabetic wounds, Cell Therapy Manufacturing CRC, 01/08/2017 - 31/05/2018
2-03 Preclinical Assessment of MultiStem® polymer patches for the treatment of diabetic foot ulcers, Cell Therapy Manufacturing CRC, 01/01/2014 - 31/12/2017
Flii nanotechnology (WMI 2-08), Wound Management Innovation CRC, 01/01/2013 - 31/03/2017
Reducing inflammation to improve burn injury repair, Channel 7 Children's Research Foundation of SA, 01/01/2016 - 31/12/2016
Study to determine if improving the skins barrier function reduces susceptibility to blister wound infection, DEBRA Australia, 11/12/2014 - 31/03/2016
Dampening inflammation with Flightless, NHMRC - Project Grant, 01/01/2013 - 31/12/2015
Development of new wound treatments, NHMRC - Research Fellowship, 01/01/2011 - 31/12/2015
Development of new dressings for burn injuries, Channel 7 Children's Research Foundation of SA, 01/01/2014 - 30/09/2015
The role of actin remodeling protein, Flightless I, in tissue regeneration, NHMRC - Project Grant, 03/12/2012 - 28/02/2015
Development of systemic therapy for treatment of blistered areas, DEBRA Australia, 01/02/2014 - 31/12/2014
Function of flightless protein in the development of SCC in children with fragile skin, DEBRA Australia, 21/01/2013 - 31/03/2014
1-04 (Cowin) preclinical model development, Wound Management Innovation CRC, 01/01/2013 - 31/12/2013
Development of monoclonal antibody therapy for treating wounds, NHMRC - Development Grant, 03/12/2012 - 31/12/2013
Function of Flightless I in the skin blistering disorder epidermolysis bullosa, NHMRC - Project Grant, 03/12/2012 - 31/12/2013
1-04 Preclinical model developement, Wound Management Innovation CRC, 09/09/2010 - 30/06/2013

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2018	McInnes, SJ, Turner, CT, Cowin, AJ & Voelcker, NH 2018, 'Wound management using porous silicon', in Leigh Canham (ed.), Handbook of Porous Silicon: Second Edition, 2, Springer, Switzerland, ch. 131, pp. 1433-1452.
2016	Kopecki, Z & Cowin, AJ 2016, 'The role of actin remodelling proteins in wound healing and tissue regeneration', in V Alexandrescu (ed.), Wound healing: new insights into ancient challenges, IntechOpen, UK, ch. 6, pp. 1-22. Open access

Journal Articles

Year	Output
2020	Ahangar, P, Mills, SJ & Cowin, AJ 2020, 'Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair', International Journal of Molecular Sciences, vol. 21, no. 19, article no. 7038, pp. 1-15. Open access
2020	Ahangar, P, Mills, SJ, Smith, LE, Strudwick, XL, Ting, AE, Vaes, B & Cowin, AJ 2020, 'Human multipotent adult progenitor cell-conditioned medium improves wound healing through modulating inflammation and angiogenesis in mice', Stem Cell Research and Therapy, vol. 11, no. 1, article no. 299, pp. 1-16. Open access 2 1 22
2020	Fenix, K, Wijesundara, DK, Cowin, AJ, Grubor-Bauk, B & Kopecki, Z 2020, 'Immunological memory in imiquimod-induced murine model of psoriasiform dermatitis', International Journal of Molecular Sciences, vol. 21, no. 19, pp. 1-13. Open access
2020	Jackson, JE, Kopecki, Z, Anderson, PJ & Cowin, AJ 2020, 'In vitro analysis of the effect of Flightless I on murine tenocyte cellular functions', Journal of Orthopaedic Surgery and Research, vol. 15, no. 1, pp. 1-14. Open access 1 1 4
2020	Jackson, JE, Kopecki, Z, Anderson, PJ & Cowin, AJ 2020, 'Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model', Journal of Orthopaedic Surgery and Research, vol. 15, no. 1, article no. 362, pp. 1-14.
2020	Rajeev, G, Melville, E, Cowin, AJ, Prieto-Simon, B & Voelcker, NH 2020, 'Porous alumina membrane-based electrochemical biosensor for protein biomarker detection in chronic wounds', Frontiers in Chemistry, vol.8, article no. 155, pp. 1-11. Open access 1
2020	Strudwick, XL, Adams, DH, Pyne, NT, Samuel, MS, Murray, RZ & Cowin, AJ 2020, 'Systemic delivery of anti-integrin aL antibodies reduces early macrophage recruitment, inflammation, and scar formation in murine burn wounds', Advances in Wound Care, online. 1
2020	Strudwick, XL, Fitridge, R, Cowin, AJ, Hofma, BR, Ahangar, P, Thomas, HM & Mills, SJ 2020, 'Attenuation of flightless I increases human pericyte proliferation, migration and angiogenic functions and improves healing in murine diabetic wounds', International Journal of Molecular Sciences, vol. 21, no. 16, pp. 1-15. Open access 5
2019	Haidari, H, Goswami, N, Bright, R, Kopecki, Z, Cowin, AJ, Garg, S & Vasilev, K 2019, 'The interplay between size and valence state on the antibacterial activity of sub-10 nm silver nanoparticles', Nanoscale Advances, vol. 1, no. 6, pp. 2365-2371. Open access 3 3 1
2019	Kopecki, Z, Has, C, Yang, G, Bruckner-Tuderman, L & Cowin, A 2019, 'Flightless I, a contributing factor to skin blistering in Kindler syndrome patients?', Journal of Cutaneous Pathology, vol. 47, no. 2, pp. 186-189.
2019	Kopecki, Z, Yang, G, Treloar, S, Mashtoub, S, Howarth, G, Cummins, A & Cowin, A 2019, 'Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis', Scientific Reports, vol. 9, no. 1, article no. 12792, pp. 1-10. Open access 6
2019	Rajeev, G, Cowin, AJ, Voelcker, NH & Simon, BP 2019, 'Magnetic nanoparticles enhance pore blockage-based electrochemical detection of a wound biomarker', Frontiers in Chemistry, vol. 7, article no. 438, pp. 1-11. Open access 1 1 1
2019	Ravindran Girija, A, Balasubramanian, S, Bright, R, Cowin, AJ, Goswami, N & Vasilev, K 2019, 'Ultrasmall gold nanocluster based antibacterial nanoaggregates for infectious wound healing', Chemnanomat: Chemistry of Nanomaterials for Energy, Biology and More, vol. 5, no. 9, pp. 1176-1181. Open access 6 7 10
2019	Shi, G, Liu, T, Kopecki, Z, Cowin, A, Lee, I, Pai, J-H, Lowe, SE & Zhong, YL 2019, 'A multifunctional wearable device with fraphene/ailver nanowire nanocomposite for highly sensitive strain sensing and drug delivery', Journal of Carbon Research, vol. 5, no. 2, article no. 17, pp. 1-16. Open access 2 14
2019	Stevens, N, Cowin, A & Kopecki, Z 2019, 'Skin barrier and autoimmunity-mechanisms and novel therapeutic approaches for autoimmune blistering diseases of the skin', Frontiers in Immunology, vol. 10, article no. 1089, pp. 1-11. Open access 3 3 9
2018	Ahangar, P, Woodward, M & Cowin, A 2018, 'Advanced wound therapies', Wound Practice and Research, vol. 26, no. 2, pp. 58-68. 2
2018	Bhatia, R, Strudwick, X, Cowin, AJ & Szili, EJ 2018, 'Investigation of helium plasma jet-treated serum and cell media on the viability of skin cells', Journal of Biomaterials and Tissue Engineering, vol. 8, no. 6, pp. 892-899.
2018	Chowdhury, NR, Cowin, AJ, Zilm, P & Vasilev, K 2018, ''Chocolate' gold nanoparticles-one pot synthesis and biocompatibility', Nanomaterials, vol. 8, no. 7, article no 496, pp. 1-10. Open access 6 7 2
2018	Fernandez, T, Strudwick, X, Al-Bataineh, S, Short, R, Cowin, A, Whittle, J & Smith, L 2018, 'Surfaces to enhance matrix deposition for wound healing', Wound Practice and Research, vol. 26, no. 4, pp. 201-209.
2018	He, J-P, Hou, P-P, Chen, Q-T, Wang, W-J, Sun, X-Y, Yang, P-B, Li, Y-P, Yao, L-M, Li, X, Jiang, X-D, Chien, K-Y, Zhang, Z-M, Wu, Q-W, Cowin, AJ, Wu, Q & Chen, H-Z 2018, 'Flightless-I blocks p62-mediated recognition of LC3 to impede selective autophagy and promote breast cancer progression', Cancer Research, vol. 78, no. 17, pp. 4853-4864. 6 4 1
2018	Kopecki, Z, Stevens, NE, Chong, HT, Yang, GN & Cowin, AJ 2018, 'Flightless I alters the inflammatory response and autoantibody profile in an OVA-induced atopic dermatitis skin-like disease', Frontiers in Immunology, vol. 9, article no. 1833, pp. 1- 10. Open access 4 4 6
2018	Kopecki, Z, Stevens, NE, Yang, GN, Melville, E & Cowin, AJ 2018, 'Recombinant leucine-rich repeat flightless-interacting protein-1 improves healing of acute wounds through its effects on proliferation inflammation and collagen deposition', International Journal of Molecular Sciences, vol. 19, no. 7, pp. 1-12. Open access 1 2
2018	Ogunniyi, AD, Kopecki, Z, Hickey, EE, Khazandi, M, Peel, E, Belov, K, Boileau, A, Garg, S, Venter, H, Chan, WY, Hill, PB, Page, SW, Cowin, AJ & Trott, DJ 2018, 'Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing', PLoS One, vol. 13, no. 7, article no. e0200195, pp. 1-13. Open access 3 5 3
2017	Chong, H, Yang, G, Sidhu, S, Ibbetson, J, Kopecki, Z & Cowin, A 2017, 'Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis', British Journal of Dermatology, vol. 176, no.3, pp. 705–712. 8 7
2017	Haidari, H, Zhang, Q, Melville, E, Kopecki, Z, Song, Y, Cowin, AJ & Garg, S 2017, 'Development of topical delivery systems for flightless neutralizing antibody', Journal of Pharmaceutical Sciences, vol. 106, no. 7, pp. 1795-1804. Open access 2 5
2017	Kirby, GT, Mills, SJ, Vandenpoel, L, Pinxteren, J, Ting, A, Short, RD, Cowin, AJ, Michelmore, A & Smith, LE 2017, 'Development of advanced dressings for the delivery of progenitor cells', ACS Applied Materials and Interfaces, vol. 9, no. 4, pp. 3445-3454. 3 3 9
2017	Kopecki, Z, Ogunniyi, D, Trott, D & Cowin, A 2017, 'Fighting chronic wound infection: one model at a time', Wound Practice and Research, vol. 25, no. 1, pp. 6-13. 2
2017	Sideek, MA, Smith, JE, Menz, C, Adams, JR, Cowin, AJ & Gibson, MA 2017, 'A central bioactive region of LTBP-2 stimulates the expression of TGF-β1 in fibroblasts via Akt and p38 signalling pathways', International Journal of Molecular Sciences, vol.18, no.10 article no. 2114, pp. 1-17. Open access 3 3
2017	Stevens, N & Cowin, A 2017, 'Overcoming the challenges of topical antibody administration for improving healing outcomes: a review of recent laboratory and clinical approaches', Wound Practice and Research, vol. 25, no. 4, pp. 188-194. Open access
2017	Strudwick, XL, Waters, JM & Cowin, AJ 2017, 'Flightless I expression enhances murine claw regeneration following digit amputation', Journal of Investigative Dermatology, vol. 137, no. 1, pp, 228-236. 5 5 6
2017	Szili, EJ, Gaur, N, Hong, S-H, Kurita, H, Oh, J-S, Ito, M, Mizuno, A, Hatta, A, Cowin, AJ, Graves, DB & Short, RD 2017, 'The assessment of cold atmospheric plasma treatment of DNA in synthetic models of tissue fluid, tissue and cells', Journal of Physics D: Applied Physics, vol. 50, no. 27, article no. 274001, pp. 1-15. Open access 14 9 1
2017	Thomas, HM, Cowin, AJ & Mills, SJ 2017, 'The importance of pericytes in healing: wounds and other pathologies', International Journal of Molecular Sciences, vol. 18, article no. 1129, pp. 1-14. Open access 25 25 2
2016	Adams, DH, Shou, Q, Wohlmuth, H & Cowin, AJ 2016, 'Data on keratin expression in human cells cultured with Australian native plant extracts', Data in Brief, vol. 7, pp. 848-867. Open access 1
2016	Adams, DH, Shou, Q, Wohlmuth, H & Cowin, AJ 2016, 'Native Australian plant extracts differentially induce Collagen I and Collagen III in vitro and could be important targets for the development of new wound healing therapies', Fitoterapia, vol. 109, pp. 45-51. Open access 1 7
2016	Cameron, AM, Turner, CT, Adams, DH, Jackson, J, Melville, EL, Arkell, RM, Anderson, PJ & Cowin, AJ 2016, 'Flightless I is a key regulator of the fibroproliferative process in hypertrophic scarring and a target for a novel antiscarring therapy', British Journal of Dermatology, vol. 174, no. 4, pp. 786-794. Open access 6 7
2016	Kopecki, Z, Ludwig, RJ & Cowin, AJ 2016, 'Cytoskeletal regulation of inflammation and its impact on skin blistering disease epidermolysis bullosa acquisita', International Journal of Molecular Sciences, vol. 17, no. 7, article no. 1116, pp. 1-13. Open access 7 7 1
2016	Oh, J-S, Strudwick, X, Short, RD, Ogawa, K, Hatta, A, Furuta, H, Gaur, N, Hong, S-H, Cowin, AJ, Fukuhara, H, Inoue, K, Ito, M, Charles, C, Boswell, RW, Bradley, JW, Graves, DB & Szili, EJ 2016, 'How plasma induced oxidation, oxygenation, and de-oxygenation influences viability of skin cells', Applied Physics Letters, vol. 109, no. 20, article no. 203701, pp. 1-5. Open access 15 17 2
2016	Robinson, DE, Al-Bataineh, SA, Farrugia, BL, Michelmore, A, Cowin, AJ, Dargaville, TR, Short, RD, Smith, LE & Whittle, JD 2016, 'Plasma polymer and biomolecule modification of 3D scaffolds for tissue engineering', Plasma Processes and Polymers, vol. 13, no. 7, pp. 678-689. Open access 13 13 2
2016	Smith, LE, Bryant, C, Krasowska, M, Cowin, AJ, Whittle, JD, MacNeil, S & Short, RD 2016, 'Haptotatic plasma polymerized surfaces for rapid tissue regeneration and wound healing', ACS Applied Materials and Interfaces, vol. 8, no.48 , pp. 32675-32687. 4 5
2016	Turner, CT, Hasanzadeh, KM, Melville, E, Delalat, B, Harding, F, Mäkilä, E, Salonen, JJ, Cowin, AJ & Voelcker, NH 2016, 'Delivery of flightless I siRNA from porous silicon nanoparticles improves wound healing in mice', ACS Biomaterial Science and Engineering, vol. 2, no. 12, pp. 2339-2346. 14 15
2016	Turner, CT, Mcinnes, SJ, Melville, E, Cowin, A & Voelcker, NH 2016, 'Delivery of flightless I neutralizing antibody from porous silicon nanoparticles improves wound healing in diabetic mice', Advanced Healthcare Materials, vol. 6, no. 2, article no. 1600707, pp. 1-13. Open access 14 17 13
2016	Yang, G, Kopecki, Z & Cowin, A 2016, 'Role of actin cytoskeleton in the regulation of epithelial cutaneous stem cells', Stem Cells and Development, vol. 25, no. 10, pp. 749-759. 2 3 1
2015	Kirby, G, Mills, S, Cowin, AJ & Smith, L 2015, 'Stem cells for cutaneous wound healing', BioMed Research International, vol. 2015, article no.285869 pp. 1-11. Open access 42 32 4
2015	Kopecki, Z & Cowin, A 2015, 'Commentary: new advances in the development of therapies for treating inherited skin fragility disorders', Wound Practice and Research, vol. 23, no. 4, pp. 184-190.
2015	Kopecki, Z, Yang, GN, Jackson, JE, Melville, EL, Calley, MP, Murrell, DF, Darby, IA, O'Toole, EA, Samuel, MS & Cowin, A 2015, 'Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression', Oncotarget, vol. 6, no. 34, pp. 35426-36440. Open access 15 15
2015	Kular, J, Scheer, KG, Pyne, NT, Allam, AH, Pollard, AN, Magenau, A, Wright, RL, Kolesnikoff, N, Moretti, PA, Wullkopf, L, Stomski, FC, Cowin, AJ, Woodcock, JM, Grimbaldeston, MA, Pitson, SM, Timpson, P, Ramshaw, HS, Lopez, AF & Samuel, MS 2015, 'A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis', Developmental Cell, vol.35, no. 6, pp. 759 - 774. Open access 21 15 25
2015	Martens, PJ, Ly, M, Adams, DH, Penzkover, KR, Strudwick, X, Cowin, AJ & Poole-Warren, LA 2015, 'In vivo delivery of functional Flightless I siRNA using layer-by-layer polymer surface modification', Journal of Biomaterials Applications, vol. 30, no. 3, pp. 257-268. 5 5
2015	McInnes, SJP, Turner, CT, Al-Bataineh, SA, Airaghi Leccardi, MJ, Irani, Y, Williams, KA, Cowin, AJ & Voelcker, N 2015, 'Surface engineering of porous silicon to optimise therapeutic antibody loading and release', Journal of Materials Chemistry B, vol. 3, no. 20, pp. 4123-4133. Open access 24 21 3
2015	Menz, C, Parsi, MK, Adams, JR, Sideek, MA, Kopecki, Z, Cowin, AJ & Gibson, MA 2015, 'LTBP-2 has a single high-affinity binding site for FGF-2 and blocks FGF-2-induced cell proliferation', PLoS One, vol. 10, no. 8, article no. e0135577, pp. 1-18. Open access 10 11 1
2015	Mills, S, Zhuang, L, Arandjelovic, P, Cowin, A & Kaur, P 2015, 'Effects of human pericytes in a murine excision model of wound healing', Clinical and Experimental Dermatology, vol. 24, no. 11, pp. 881-882. Open access 6 8
2015	Sideek, MA, Teia, A, Kopecki, Z, Cowin, AJ & Gibson, MA 2015, 'Co-localization of LTBP-2 with FGF-2 in fibrotic human keloid and hypertrophic scar', Journal of Molecular Histology, vol. 47, no. 1, pp. 35-45. Open access 10 14 1
2015	Strudwick, XL, Lang, DL, Smith, LE & Cowin, AJ 2015, 'Combination of low calcium with Y-27632 rock Inhibitor increases the proliferative capacity, expansion potential and lifespan of primary human keratinocytes while retaining their capacity to differentiate into stratified epidermis in a 3D skin model', PLoS One, vol. 10, no. 4, article no. e0123651, pp. 1-12. Open access 16 12 6
2015	Turner, C, McInnes, S & Cowin, A 2015, 'Therapeutic antibodies for improved wound healing', Wound Practice and Research, vol. 23, no. 1, pp. 16-24. 1
2015	Turner, CT, McInnes, SJ, Voelcker, NH & Cowin, AJ 2015, 'Therapeutic potential of inorganic nanoparticles for the delivery of monoclonal antibodies', Journal of Nanomaterials, vol. 2015, article no. 309602, pp. 1-12. Open access 8 6
2015	Turner, CT, Waters, JM, Jackson, JE, Arkell, RM & Cowin, AJ 2015, 'Fibroblast-specific upregulation of Flightless I impairs wound healing', Experimental Dermatology, vol. 24, no. 9, pp. 692-697. 7 6
2014	Cameron, AM, Adams, DH, Greenwood, J, Anderson, P & Cowin, AJ 2014, 'A novel murine model of hypertrophic scarring using subcutaneous infusion of bleomycin', Plastic and Reconstructive Surgery, vol. 133, no. 1, pp. 69-78. 15 15 1
2014	Chan, H, Kopecki, Z, Walters, J, Powell, B, Arkell, R & Cowin, A 2014, 'Cytoskeletal protein Flightless I differentially affects TGF-β isoform expression in both in vitro and in vivo wound models', Wound Practice and Research, vol. 22, no. 3, pp. 169-181.
2014	Kopecki, Z, Yang, GN, Arkell, RM, Jackson, JE, Melville, E, Iwata, H, Ludwig, RJ, Zillikens, D, Murrell, DF & Cowin, AJ 2014, 'Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering', Journal of Pathology, vol. 232, no. 5, pp. 541-552. 17 20 2
2014	Ruzehaji, N, Kopecki, Z, Melville, E, Appleby, SL, Bonder, CS, Arkell, RM, Fitridge, R & Cowin, AJ 2014, 'Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes', Diabetologia, vol. 57, no. 2, pp. 402-412. Open access 20 17 3
2014	Stevens, LJ, McKenna, S, Marty, J, Cowin, AJ & Kopecki, Z 2014, 'Understanding the outcomes of a home nursing programme for patients with epidermolysis bullosa: an Australian perspective', International Wound Journal, vol. 13, no. 5, pp. 863-869. 6 6
2013	Chong, HT, Kopecki, Z & Cowin, AJ 2013, 'Lifting the silver flakes: the pathogenesis and management of chronic plaque psoriasis', BioMed Research International, vol. 2013, article no. 168321, pp. 1-9. Open access 24 23 12
2013	Jackson, JE, Kopecki, Z & Cowin, AJ 2013, 'Nanotechnological advances in cutaneous medicine', Journal of Nanomaterials, vol. 2013, article no. 808234, pp. 1-8. Open access 5 6
2013	Kopecki, Z, Ruzehaji, N, Turner, C, Iwata, H, Ludwig, RJ, Zillikens, D, Murrell, DF & Cowin, AJ 2013, 'Topically applied flightless I neutralizing antibodies improve healing of blistered skin in a murine model of epidermolysis bullosa acquisita', Journal of Investigative Dermatology, vol. 133, no. 4, pp. 1008-1016. Open access 33 22 4
2013	Krismastuti, FSH, Pace, S, Melville, E, Cowin, AJ, Dargaville, TR & Voelcker, N 2013, 'Matrix metalloproteinase biosensor based on a porous silicon reflector', Australian Journal of Chemistry: An International Journal for Chemical Science, vol. 66, no. 11, pp. 1428-1434. Open access 12 11 3
2013	Lees, JG, Ching, YW, Adams, DH, Bach, CT, Samuel, MS, Kee, AJ, Hardeman, EC, Gunning, P, Cowin, AJ & O'Neill, GM 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, vol. 133, no. 5, pp. 1330-1339. Open access 27 24 1
2013	McInnes, W, Ruzehaji, N, Wright, N, Cowin, AJ & Fitridge, R 2013, 'Venous ulceration contaminated by multi-resistant organisms: larval therapy and debridement', Journal of Wound Care, vol. 22, no. S10, pp. 27-30. 3 2
2013	Mills, SJ & Cowin, AJ 2013, 'MicroRNAs and their roles in wound repair and regeneration', Wound Practice and Research, vol. 21, no. 1, pp. 26-40.
2013	Mills, SJ, Cowin, AJ & Kaur, P 2013, 'Pericytes, Mesenchymal Stem Cells and the wound healing process', Cells, vol. 2, pp. 621-634. Open access 1
2013	Ruzehaji, N, Mills, SJ, Melville, E, Arkell, R, Fitridge, R & Cowin, AJ 2013, 'The influence of flightless I on toll-like-receptor-mediated inflammation in a murine model of diabetic wound healing', BioMed Research International, vol. 2013, article ID 389792, pp. 1-9. Open access 12 11
2013	Waters, JM & Cowin, AJ 2013, 'Lower vibrissa follicle amputation: a mammalian model of regeneration', Methods in Molecular Biology, vol. 1037, pp. 437-448. 1 1
2012	Cowin, AJ, Lei, N, Franken, L, Ruzehaji, N, Offenhäuser, C, Kopecki, Z & Murray, RZ 2012, 'Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation', Communicative and Integrative Biology, vol. 5, no. 6, pp. 546-549. Open access 7 3
2012	Heuch, L, Tyndall, J, Cook-Johnson, R & Cowin, A 2012, 'The effectiveness of methods of off-loading to prevent diabetic foot ulcers in adults with diabetes: A Systematic Review', The JBI Database of Systematic Reviews and Implementation Reports, vol. 10, no. 56, pp. 1-14.
2012	Jackson, JE, Kopecki, Z, Adams, DH & Cowin, AJ 2012, 'Flii neutralizing antibodies improve wound healing in porcine preclinical studies', Wound Repair and Regeneration, vol. 20, no. 4, pp. 523-536. 23 29
2012	Lei, N, Franken, L, Ruzehaji, N, Offenhäuser, C, Cowin, AJ & Murray, RZ 2012, 'Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion', Journal of Cell Science, vol. 125, no. 18, pp. 4288-4296. Open access 18 17
2012	Ruzehaji, N, Grose, R, Krumbiegel, D, Zola, H, Dasari, P, Wallace, H, Stacey, M, Fitridge, R & Cowin, A 2012, 'Cytoskeletal protein Flightless (Flii) is elevated in chronic and acute human wounds and wound fluid: neutralizing its activity in chronic but not acute wound fluid improves cellular proliferation', European Journal of Dermatology, vol. 22, no. 6, pp. 740-750. 11 9
2012	Strudwick, XL & Cowin, AJ 2012, 'Cytoskeletal regulation of dermal regeneration', Cells, vol. 1, no. 4, pp. 1313-1327. Open access
2011	Kopecki, Z, Arkell, RM, Strudwick, XL, Hirose, M, Ludwig, RJ, Kern, JS, Bruckner-Tuderman, L, Zillikens, D, Murrell, DF & Cowin, AJ 2011, 'Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita', Journal of Pathology, vol. 225, no. 3, pp. 401-413. 29 31
2011	Kopecki, Z, O'Neill, GM, Arkell, RM & Cowin, AJ 2011, 'Regulation of focal adhesions by Flightless I involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway', Journal of Investigative Dermatology, vol. 131, no. 7, pp. 1450-1459. Open access 26 29
2011	Lin, C-H, Waters, JM, Powell, BC, Arkell, RM & Cowin, A 2011, 'Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing', Mammalian Genome, vol. 22 no. 5-6, pp. 341-352. 9 10
2011	Thomsen, N, Chappell, A, Ali, RG, Jones, T, Adams, DH, Matthaei, K I, Campbell, HD, Cowin, AJ & Arkell, RM 2011, 'Mouse strains for the ubiquitous or conditional overexpression of the Flii gene', Genesis: The Journal of Genetics and Development, vol. 49, no. 8, pp. 681-688. 12 13
2011	Waters, JM, Lindo, JE, Arkell, RM & Cowin, AJ 2011, 'Regeneration of hair follicles is modulated by flightless I (Flii) in a rodent vibrissa model', Journal of Investigative Dermatology, vol. 131, no. 4, pp. 838-847. Open access 15 13
2010	Cameron, A, Ruzehaji, N & Cowin, A 2010, 'Burn wound management: a surgical perspective', Wound Practice and Research, vol. 18 no. 1, pp. 35-40.
2009	Adams, D, Ruzehaji, N, Strudwick, X, Greenwood, J, Campbell, H, Arkell, R & Cowin, A 2009, 'Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-β1 and TGF-β3', British Journal of Dermatology, vol. 161 no. 2, pp. 326-336. 31 31
2009	Kopecki, Z, Arkell, R, Powell, BC & Cowin, AJ 2009, 'Flightless I Regulates Hemidesmosome Formation and Integrin-Mediated Cellular Adhesion and Migration during Wound Repair', Journal of Investigative Dermatology, vol. 129, no. 8, pp. 2031-2045. Open access 48 51
2009	Kopecki, Z, Murrell, D & Cowin, AJ 2009, 'Raising the roof on epidermolysis bullosa (EB): a focus on new therapies', Wound Practice and Research, vol. 17, no. 2, pp. 76-82. Open access
2009	Leitch, VD, Strudwick, XL, Matthaei, K I, Dent, LA & Cowin, AJ 2009, 'IL-5-overexpressing mice exhibit eosinophilia and altered wound healing through mechanisms involving prolonged inflammation', Immunology and Cell Biology, vol. 87 no. 2, pp. 131-140. 28 28
2008	Adams, DH, Strudwick, XL, Kopecki, Z, Hooper-Jones, JA, Matthaei, K I, Campbell, HD, Powell, BC & Cowin, A 2008, 'Gender specific effects on the actin-remodelling protein Flightless I and TGF-β1 contribute to impaired wound healing in aged skin', The International Journal of Biochemistry and Cell Biology, vol. 40 no. 8, pp. 1555-1569. 26 26
2008	Cowin, A 2008, 'Wound healing: Flii and the elephant in the room', Australian Life Scientist, vol. 5, no. 5, pp. 28-30.
2008	Geary, S, Cowin, AJ, Copeland, B, Baleato, R, Miyazaki, K & Ashman, L 2008, 'The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: Implications for wound healing', Experimental Cell Research, vol. 314, no. 11-12, pp. 2165-2175. 28 24
2008	Kopecki, Z & Cowin, AJ 2008, 'Flightless I: An actin-remodelling protein and an important negative regulator of wound repair', The International Journal of Biochemistry and Cell Biology, vol. 40, no. 8, pp. 1415-1419. 50 52
2008	Kopecki, Z, Adams, D & Cowin, AJ 2008, 'c-myb proto-oncogene is up-regulated in hypertrophic scars and correlates with increased collagen I', Wound Practice and Research, vol. 16, no. 3, pp. 132-137.

Reports

Year	Output
2018	Cowin, A, Strudwick, X & Kopecki, Z 2018, Assessment of biofilm solution on wound infection and healing using in-vivo preclinical models, University of South Australia, Australia.

Research

Patents

Details	Registry	Status
Methods and compositions for modulating wound repair Cowin, Allison June; Campbell, Hugh Douglas; Powell, Barry	AU	Filed
Methods and compositions for modulating wound repair Cowin, Allison June; Campbell, Hugh Douglas; Powell, Barry	EP	Filed
Methods and compositions for modulating wound repair Cowin, Allison June; Campbell, Hugh Douglas; Powell, Barry	JP	Filed
Methods and compositions for modulating wound repair Cowin, Allison June; Campbell, Hugh Douglas; Powell, Barry	US	Filed
Methods and products for delivering cells Smith, Louise; Michelmore, Andrew Percival; Kirby, Giles Thomas Sipho; Cowin, Allison June; Mills, Stuart James; Short, Robert David	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Athersys Inc	UNITED STATES
Austin Health	AUSTRALIA
Australian National University	AUSTRALIA
Brightsky Australia	AUSTRALIA
Center for cancer biologly	AUSTRALIA
Central Adelaide Local Health Network Incorporated	AUSTRALIA
Chang Gung University	TAIWAN
Childrens Hospital at Westmead	AUSTRALIA
Curtin University	AUSTRALIA
Dystrophic Epidermolysis Bullosa Research Association	AUSTRALIA
Flinders University	AUSTRALIA
Griffith University	AUSTRALIA
Integria Healthcare	AUSTRALIA
John Curtin School of Medical Research	AUSTRALIA
Kochi Medical School	JAPAN
Kochi University of Technology	JAPAN
Lancaster University	UNITED KINGDOM
Luoda Pharma Pty Ltd	AUSTRALIA
Meijo University	JAPAN
Monash University	AUSTRALIA
Peter MacCallum Cancer Centre	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Queen Mary University of London	UNITED KINGDOM
Queensland University of Technology	AUSTRALIA
ReGenesys	SOUTH AFRICA
RMIT University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Alexandra Hospital for Children	AUSTRALIA
SA Pathology	AUSTRALIA
Southern Cross University	AUSTRALIA
The Kinghorn Cancer Centre	AUSTRALIA
Toyohashi University of Technology	JAPAN
University Medical Centre Freiburg	GERMANY
University of Adelaide	AUSTRALIA
University of Bristol	UNITED KINGDOM
University of California, Berkeley	UNITED STATES
University of Dundee	UNITED KINGDOM
University of Freiburg	GERMANY
University of Liverpool	UNITED KINGDOM
University of London	UNITED KINGDOM
University of Lubeck	GERMANY
University of Melbourne	AUSTRALIA
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Queensland	AUSTRALIA
University of Sheffield	UNITED KINGDOM
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Turku	FINLAND
University of Western Australia	AUSTRALIA
Women and Children's Health Research Institute	CANADA
Women's & Children's Health Research Institute Inc	AUSTRALIA
Women's and Children's Health Network	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA
Wound Management Innovation CRC	AUSTRALIA
Xiamen University	CHINA
Yokohama National University	JAPAN

External engagement & recognition

Engagement/recognition	Year
Board Member and Director of Membership Australasian Society Dermatology Research	2019
Board Member and Director of Membership Australasian Society Dermatology Research	2018
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2018
Joint Editor Wound Practice and Research	2018
Scientific Advisory Board Member Australasian Blistering Diseases Foundation	2018
Senior Research Fellow National Health and Medical Research Council (NHMRC)	2018
Treasurer Australasian Wound and Tissue Repair Society	2018
Board Member and Director of Membership Australasian Society Dermatology Research	2017
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2017
Joint Editor Wound Practice and Research	2017
Scientific Advisory Board Member Australasian Blistering Diseases Foundation	2017
Senior Research Fellow National Health and Medical Research Council (NHMRC)	2017
Treasurer Australasian Wound and Tissue Repair Society	2017
Award for Excellence, Contribution to Clinical or Preclinical Research World Union of Wound Healing Societies	2016
Award for Science Winnovation Awards	2016
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2016
Life Membership Award Australasian Wound and Tissue Repair Society	2016
Scientific Advisory Board Member Australasian Blistering Diseases Foundation	2016
Board Member Australasian Society Dermatology Research	2015
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2015
Finalist, Government and Academia, Telstra South Australian Business Women Award Telstra	2015
International Expert Reference Group JBI Node for Wound Healing and Management	2015
Invited Delegate DEBRA-International EB Research Conference	2015
Scientific Advisory Board Member Australasian Blistering Diseases Foundation	2015
Board Member Australasian Society Dermatology Research	2014
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2014
Executive committee member Australasian Wound and Tissue Repair Society	2014
Fellow Australian Wound Management Association	2014
International Expert Reference Group JBI Node for Wound Healing and Management	2014
Invited Speaker, Development of new antibody therapies for treating wounds Wound Healing Society Florida	2014
Invited Speaker, New therapeutic approaches for the treatment of fragile skin conditions Joint Australian Indian Workshop on Epithelial Development, Function and Disease, New Frontiers and Therapies	2014
Scientific Advisory Board Member Australasian Blistering Diseases Foundation	2014
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2013
Executive committee member Australasian Wound and Tissue Repair Society	2013
International Expert Reference Group JBI Node for Wound Healing and Management	2013
Plenary Speaker Bacteriosafe Koala workshop Singapore	2013
Scientific Advisory Board Member Australasian Blistering Diseases Foundation	2013
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2012
Founder and inaugural President Australasian Wound and Tissue Repair Society	2012
International Expert Reference Group JBI Node for Wound Healing and Management	2012
Invited Delegate DEBRA-International EB Research Conference	2012
National Committee Member Australian Wound Management Association	2012
Scientific Advisory Board Member Australasian Blistering Diseases Foundation	2012
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2011
Founder and inaugural President Australasian Wound and Tissue Repair Society	2011
International Expert Reference Group JBI Node for Wound Healing and Management	2011
Invited Speaker, Function of secreted and cytoplasmic forms of Flightless in wound healing 21st European Tissue Repair Society Conference, Amsterdam, The Netherlands	2011
MS McLeod Senior Research Fellowship MS McLeod Research Foundation	2011
National Committee Member Australian Wound Management Association	2011
Research Fellowship National Health and Medical Research Council (NHMRC)	2011
Board Member, Chief Scientific Officer AbRegen Pty Ltd	2010
Founder and inaugural President Australasian Wound and Tissue Repair Society	2010
International Expert Reference Group JBI Node for Wound Healing and Management	2010
MS McLeod Senior Research Fellowship MS McLeod Research Foundation	2010
National Committee Member Australian Wound Management Association	2010

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Alterations in bone -related gene expression pattern induced by growth and sex hormones in growing and ageing rats	Current
Development of new approaches for the treatment of infected wounds	Current
Development of stem cell therapies for the treatment of wounds	Current
Development of therapeutic treatments to combat burn wound infection	Current
Evaluation of the role of pH in wound healing and development of buffered preparations to promote regeneration	Current
New strategies for early detection and treatment of skin cancers	Current
Novel approaches for treatment of infected wounds	Current
Atomic force microscopy and spectroscopic studies of crosslinking induced changes in the extracellular matrix that influence nanomechanical properties	Completed
Flightless I regulation of pericyte function in acute and diabetic wound healing	Completed
Investigating plasma-tissue interactions in the context of wound healing	Completed
Nanoporous anodic alumina-based biosensors for detection of biomarkers in chronic wound	Completed
The role of Flightless I (Flii) in the healing of digital flexor tendon adhesions	Completed
The role of flightless I in epidermal stem cell division, proliferation and differentiation during development, homeostasis, wound healing and epidermolysis bullosa-cutaneous squamous cell carcinoma	Completed
The role of Flightless I in tissue regeneration	Completed

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Professor Allison Cowin

About me

About me

Future Industries Institute

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Highlights

Projects

Outputs

Chapters

Journal Articles

Reports

Current research & highlights

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Board Member and Director of Membership

Board Member and Director of Membership

Board Member, Chief Scientific Officer

Joint Editor

Scientific Advisory Board Member

Senior Research Fellow

Treasurer

Board Member and Director of Membership

Board Member, Chief Scientific Officer

Joint Editor

Scientific Advisory Board Member

Senior Research Fellow

Treasurer

Award for Excellence, Contribution to Clinical or Preclinical Research

Award for Science

Board Member, Chief Scientific Officer

Life Membership Award

Scientific Advisory Board Member

Board Member

Board Member, Chief Scientific Officer

Finalist, Government and Academia, Telstra South Australian Business Women Award

International Expert Reference Group

Invited Delegate

Scientific Advisory Board Member

Board Member

Board Member, Chief Scientific Officer

Executive committee member

Fellow

International Expert Reference Group

Invited Speaker, Development of new antibody therapies for treating wounds

Invited Speaker, New therapeutic approaches for the treatment of fragile skin conditions

Scientific Advisory Board Member

Board Member, Chief Scientific Officer

Executive committee member

International Expert Reference Group

Plenary Speaker

Scientific Advisory Board Member

Board Member, Chief Scientific Officer

Founder and inaugural President

International Expert Reference Group

Invited Delegate

National Committee Member

Scientific Advisory Board Member

Board Member, Chief Scientific Officer

Founder and inaugural President

International Expert Reference Group

Invited Speaker, Function of secreted and cytoplasmic forms of Flightless in wound healing

MS McLeod Senior Research Fellowship

National Committee Member

Research Fellowship

Board Member, Chief Scientific Officer

Founder and inaugural President

International Expert Reference Group

MS McLeod Senior Research Fellowship

National Committee Member

Teaching & student supervision

Courses and programs