Professor Angel Lopez

Adjunct Professor Centre for Cancer Biology

City West Campus (HB11-10)
tel +61 8 830 27915

email Angel.Lopez@unisa.edu.au

Research Degree Supervisor

About me

Prof Angel Lopez AO is the Head of Human Immunology at SA Pathology, CALHN, in Adelaide, holds an MD from the University of Rosario, Argentina, a PhD from the University of London, UK, and is a Fellow of the Royal College of Pathologists of Australasia. He is an experimental immunologist and haematologist with an international reputation for his work on the structure and function of cytokine receptors and their mechanism of action in health and disease.

Centre for Cancer Biology

Making breakthrough discoveries in the fundamental causes of cancer, and translating these into prevention and treatment.

Tweets by @UniversitySA

About me

Prof Lopez leads a team of hard working and enthusiastic investigators internationally recognized for their work into the βc cytokine family that studies how βc cytokines and their receptors assemble on the cell surface, how they signal and how they influence human health. The work of this laboratory has been highly collaborative involving several academic and clinical groups. His breakthrough discoveries revealed significant new paradigms in cytokine receptor activation that were published in major international journals. Prof Lopez’s team works closely with the pharmaceutical industry enabling the practical application of the laboratory’s insights as demonstrated by the development of several anti-receptor antibodies as potential new treatments of allergic inflammatory conditions and certain leukaemias.

The impact of Prof Lopez’s work has been recognised by his election as a Fellow of the Australian Academy of Health and Medical Science in 2014 and of the Australian Academy of Health and Medical Sciences in 2015. Prof Lopez received the 2010 South Australian Scientist of the Year Award and the 2010 South Australian of the Year - Science Category Award from the SA Government. In June 2017 he was appointed as an Officer to the Order of Australia for his medical and scientific research in the areas of immunology, cell biology and innovative developments in cancer treatment.

Prof Lopez is passionate about mentoring young researchers and promoting medical research excellence. He established (with S Kumar) the Centre for Cancer Biology in 2009 which is a member of the Australian Association of Medical Research Institute, and in 2019 he (together with Prof M Brown and Senator Griffin) was awarded an $80m Commonwealth grant to establish the South Australian immunoGenetics Cancer Institute (SAiGENCI) in South Australia

Research

Research focus

Biochemistry and Cell Biology
Biological Sciences
Clinical Sciences
Medical and Health Sciences
Immunology

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Chapters

Year	Output
2023	Shing, KS, Kan, WL, Nero, TL, Hercus, TR, Tvorogov, D, Metcalfe, RD, Griffin, MD, De Weerd, NA, Guthridge, MA, Hertzog, PJ, Lopez, AF & Parker, MW 2023, 'Cytokine receptors and their ligands', in Ralph A Bradshaw et al. (eds), Encyclopedia of Cell Biology, 2nd, Elsevier, UK, vol. 4, pp. 21-45. 2
2015	Dhagat, U, Nero, T, Kan, W, Hercus, T, Broughton, S, de Weerd, N, Jenkins, B, Mansell, A, Guthridge, M, Hertzog, P, Lopez, A & Parker, M 2015, 'Cytokine receptors and their ligands', Encyclopedia of cell biology, Academic Press, US, vol. 3, pp. 22-36.

Journal Articles

Year	Output
2025	Kan, WL, Weekley, CM, Nero, TL, Hercus, TR, Yip, KH, Tumes, DJ, Woodcock, JM, Ross, DM, Thomas, D, Terán, D, Owczarek, CM, Liu, NW, Martelotto, LG, Polo, JM, Pant, H, Tvorogov, D, Lopez, AF & Parker, MW 2025, 'The β common cytokine receptor family reveals new functional paradigms from structural complexities', Immunological Reviews, vol. 329, no. 1, pp. 1-25. Open access 1 1
2025	Wang, H, Fung, NH, Aloe, C, Miles, M, Selemidis, S, Lopez, AF, Wilson, N, Owczarek, C & Bozinovski, S 2025, 'CD131 antagonism blocks inflammation, emphysema and fibrosis in an asthma-COPD overlap mouse model originating in early life', Respirology, online, pp. 1-14. Open access 1
2024	Johan, MZ, Pyne, NT, Kolesnikoff, N, Poltavets, V, Esmaeili, Z, Woodcock, JM, Lopez, AF, Cowin, AJ, Pitson, SM & Samuel, MS 2024, 'Accelerated closure of diabetic wounds by efficient recruitment of fibroblasts upon inhibiting a 14-3-3/ROCK regulatory axis', Journal of Investigative Dermatology, vol. 144, no. 11, pp. 2562-2573e4. Open access 3
2024	Lim, K, Kan, WL, Nair, PC, Kutyna, M, Lopez, AF, Hercus, T, Ross, DM, Lane, S, Fong, CY, Brown, A, Yong, A, Yeung, D, Hughes, T, Hiwase, D & Thomas, D 2024, 'CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: implications for targeting', PLoS One, vol. 19, no. 9, pp. 1-19. Open access
2024	Thompson, EJ, Escarbe, S, Tvorogov, D, Farshid, G, Gregory, PA, Khew-Goodall, Y, Madden, S, Ingman, W V, Lindeman, GJ, Lim, E, Lopez, AF & Bonder, CS 2024, 'Interleukin-3 production by basal-like breast cancer cells is associated with poor prognosis', Growth Factors, vol. 42, no. 2, pp. 49–61. Open access 1
2024	Wang, H, Yip, KH, Keam, SP, Vlahos, R, Nichol, K, Wark, P, Toubia, J, Kral, AC, Cildir, G, Pant, H, Hercus, TR, Wilson, N, Owczarek, C, Lopez, AF, Bozinovski, S & Tumes, DJ 2024, 'Dual inhibition of airway inflammation and fibrosis by common β cytokine receptor blockade', Journal of Allergy and Clinical Immunology, vol. 153, no. 3, pp. 672-683.e6. Open access 5 3 67
2023	Kan, WL, Dhagat, U, Kaufmann, KB, Hercus, TR, Toubia, J, Barry, EF, Gomez, GA, Dottore, M, Samaraweera, SE, Goodall, GJ, Thomas, D, Tvorogov, D, D'Andrea, RJ & Lopez, AF and 12 other authors 2023, 'Distinct assemblies of heterodimeric cytokine receptors govern stemness programs in leukemia', Cancer Discovery, vol. 13, no. 8, pp. 1922-1947. Open access 8 7 19
2023	Nair, PC, Piehler, J, Tvorogov, D, Ross, DM, Lopez, AF, Gotlib, J & Thomas, D 2023, 'Next-generation JAK2 inhibitors for the treatment of myeloproliferative neoplasms: lessons from structure-based drug discovery approaches', BLOOD CANCER DISCOVERY, vol. 4, no. 5, pp. 352-364. 8 5 8
2023	Pant, H, Hercus, TR, Tumes, DJ, Yip, KH, Parker, MW, Owczarek, CM, Lopez, AF & Huston, DP 2023, 'Translating the biology of β common receptor-engaging cytokines into clinical medicine', Journal of Allergy and Clinical Immunology, vol. 151, no. 2, pp. 324-344. Open access 11 6 1
2023	Yip, KH, Chao, J, Coolen, C, Pant, H, Kral, A, Smith, W, Schwarz, Q, Grimbaldeston, MA, Pitson, S, Lopez, AF, Woodcock, J & Tumes, DJ 2023, 'IgE receptor of mast cells signals mediator release and inflammation via adaptor protein 14-3-3ζ', Journal of Allergy and Clinical Immunology, vol. 152, no. 3, pp. 725-735. Open access 5 5 2
2022	Brown, GJ, Cañete, PF, Wang, H, Medhavy, A, Tvorogov, D, Lopez, AF & Vinuesa, CG and 37 other authors 2022, 'TLR7 gain-of-function genetic variation causes human lupus', Nature, vol. 605, no. 7909, pp. 349-356. Open access 323 309 1908
2022	Fung, NH, Wang, H, Vlahos, R, Wilson, N, Lopez, AF, Owczarek, CM & Bozinovski, S 2022, 'Targeting the human βc receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure', Respirology, vol. 27, no. 8, pp. 617-629. Open access 6 5
2022	Tvorogov, D, Thompson-Peach, CA, Foßelteder, J, Dottore, M, Stomski, F, Onnesha, SA, Lim, K, Moretti, PA, Pitson, SM, Ross, DM, Reinisch, A, Thomas, D & Lopez, AF 2022, 'Targeting human CALR-mutated MPN progenitors with a neoepitope-directed monoclonal antibody', EMBO Reports, vol. 23, no. 4, article no. e52904. Open access 19 19 12
2022	Wang, H, Tumes, DJ, Hercus, TR, Yip, K, Aloe, C, Vlahos, R, Lopez, AF, Wilson, N, Owczarek, CM & Bozinovski, S 2022, 'Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models', Cell Death and Disease, vol. 13, no. 2, article no. 137, pp. 1-11. Open access 21 17 6
2022	Yip, KH, McKenzie, D, Ramshaw, HS, Chao, J, McClure, BJ, Pant, H, Grimbaldeston, MA, Hercus, TR, Lopez, AF & Tumes, DJ and 12 other authors 2022, 'Targeting the human β𝒸 receptor inhibits contact dermatitis in a transgenic mouse model', Journal of Investigative Dermatology, vol. 142, no. 4, pp 1103-1113.e11. Open access 5 3 1
2021	Cildir, G, Yip, KH, Pant, H, Tergaonkar, V, Lopez, AF & Tumes, DJ 2021, 'Understanding mast cell heterogeneity at single cell resolution', Trends in Immunology, vol. 42, no. 6, pp. 523-535. Open access 30 28 6
2021	De Silva, AP, Schembri, MA, Sarah, AH, Chao, J, Yip, KH, Cildir, G, Lopez, A, Tumes, DJ & Pant, H 2021, 'Short-term oral steroids significantly improves chronic rhinosinusitis without nasal polyps', The Laryngoscope, vol. 131, no. 10, pp. E2618-E2626. 5 5 3
2021	Kan, WL, Cheung Tung Shing, KS, Nero, TL, Hercus, TR, Tvorogov, D, Parker, MW & Lopez, AF 2021, 'Messing with βc: a unique receptor with many goals', Seminars in Immunology, vol. 54, article 101513, pp. 1-14. Open access 4 4 3
2020	Boyle, ST, Poltavets, V, Kular, J, Pyne, NT, Sandow, JJ, Lewis, AC, Murphy, KJ, Kolesnikoff, N, Moretti, PAB, Tea, MN, Tergaonkar, V, Timpson, P, Pitson, SM, Webb, AI, Whitfield, RJ, Lopez, AF, Kochetkova, M & Samuel, MS 2020, 'ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism', Nature Cell Biology, vol. 22, no. 7, pp. 882-895. 54 55 849
2020	Diallo, K, Dussault, S, Noll, C, Lopez, AF, Rivard, A, Carpentier, AC & Lim, GE 2020, '14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance', Molecular Metabolism, vol. 41, article number 101052, pp. 1-12. Open access 1 2
2020	Yip, KH, Wilson, NJ, Pant, H, Brown, CL, Busfield, S, Ng, M, Alhamdoosh, M, Woodman, N, Schembri, M, Tumes, DJ, Vairo, G, Lopez, AF, Nash, AD, Wilson, MJ, Grimbaldeston, MA & Owczarek, CM 2020, 'Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model', Allergy: European Journal of Allergy and Clinical Immunology, vol. 75, no. 2, pp. 475-478. 9 7 6
2019	Cildir, G, Toubia, J, Yip, KH, Zhou, M, Pant, H, Hissaria, P, Zhang, J, Hong, W, Robinson, N, Grimbaldeston, MA, Lopez, AF & Tergaonkar, V 2019, 'Genome-wide analyses of chromatin state in human mast cells reveal molecular drivers and mediators of allergic and inflammatory diseases', Immunity, vol. 51, no. 5, pp. 949-965.e6. Open access 44 44 12
2019	Gartlan, KH, Koyama, M, Lineburg, KE, Chang, K, Ensbey, KS, Kuns, RD, Henden, AS, Samson, LD, Clouston, AD, Lopez, AF, MacDonald, KP & Hill, GR 2019, 'Donor T-cell-derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract', Blood Advances, vol. 3, no. 19, pp. 2859-2865. Open access 20 20
2018	Broughton, SE, Hercus, TR, Nero, TL, Kan, WL, Barry, EF, Dottore, M, Cheung Tung Shing, KS, Morton, CJ, Dhagat, U, Hardy, MP, Wilson, NJ, Downton, MT, Schieber, C, Hughes, TP, Lopez, AF & Parker, MW 2018, 'A dual role for the N-terminal domain of the IL-3 receptor in cell signalling', Nature Communications, vol. 9, no. 1, article no. 386, pp. 1-15. Open access 33 33
2018	Cheung Tung Shing, KS, Broughton, SE, Nero, TL, Gillinder, K, Ilsley, MD, Ramshaw, H, Lopez, AF, Griffin, MD, Parker, MW, Perkins, AC & Dhagat, U 2018, 'EPO does not promote interaction between the erythropoietin and beta-common receptors', Scientific Reports, vol. 8, no. 1, article no. 12457, pp. 1-16. Open access 20 20
2018	Dhagat, U, Hercus, TR, Broughton, SE, Nero, TL, Cheung Tung Shing, KS, Barry, EF, Thomson, CA, Bryson, S, Pai, EF, McClure, BJ, Schrader, JW, Lopez, AF & Parker, MW 2018, 'The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities', mAbs, vol. 10, no. 7, pp. 1018-1029. Open access 10 10 11
2018	Hercus, TR, Kan, WL, Broughton, SE, Tvorogov, D, Ramshaw, HS, Thompson, EJ, McKenzie, DR, Tergaonkar, V, Hughes, T, Samuel, MS, Bonder, CS, Grimbaldeston, MA & Lopez, A F and 10 other authors 2018, 'Role of the β common (βc) family of cytokines in health and disease', Cold Spring Harbor Perspectives in Biology, vol. 10, no. 6, article no. a028514, pp. 1-26. Open access 36 28 14
2018	Paquette, M, Beaudoin, S, Tremblay, M-A, Jean, S, Lopez, AF, Lecomte, R, Guérin, B, Bentourkia, M, Sabbagh, R & Leyton, J V 2018, 'NLS-cholic acid conjugation to IL-5Rα-specific antibody improves cellular accumulation and in vivo tumor-targeting properties in a bladder cancer model', Bioconjugate Chemistry, vol. 29, no. 4, pp. 1352 - 1363. 8 8
2018	Tvorogov, D, Thomas, D, Liau, NP, Dottore, M, Barry, EF, Lathi, M, Kan, WL, Hercus, TR, Stomski, F, Hughes, TP, Tergaonkar, V, Parker, MW, Ross, DM, Majeti, R, Babon, JJ & Lopez, AF 2018, 'Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis', Science Advances, vol. 4, no. 11, article no. eaat3834, pp. 1-13. Open access 41 40 3
2018	Woodcock, JM, Goodwin, KL, Sandow, JJ, Coolen, C, Perugini, MA, Webb, A I, Pitson, SM, Lopez, AF & Carver, JA 2018, 'Role of salt bridges in the dimer interface of 14-3-3ζ in dimer dynamics, N-terminal α-helical order, and molecular chaperone activity', Journal of Biological Chemistry, vol. 293, no. 1, pp. 89-99. Open access 22 21 2
2017	Cildir, G, Pant, H, Lopez, AF & Tergaonkar, V 2017, 'The transcriptional program, functional heterogeneity, and clinical targeting of mast cells', Journal of Experimental Medicine, vol. 214, no. 9, pp. 2491-2506. Open access 79 73 11
2017	Ng, YS, Sorvina, A, Bader, CA, Weiland, F, Lopez, AF, Hoffmann, P, Shandala, T & Brooks, DA 2017, 'Proteome Analysis of drosophila mutants identifies a regulatory role for 14-3-3ϵ in metabolic pathways', Journal of Proteome Research, vol. 16;vol. 16, no. 5, pp. 1976-1987. 1 1 2
2017	Paquette, M, Vilera-Perez, L-G, Beaudoin, S, Ekindi-Ndongo, N, Boudreaut, P-L, Bonin, M-A, Battista, M-C, Bentourkia, M, Lopez, A F, Lecomte, R, Marsault, E, Guérin, B, Sabbagh, R & Leyton, J V 2017, 'Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer', OncoImmunology, vol. 6, no. 10, article no. e1331195, pp. 1-11. Open access 16 16
2017	Powell, JA, Lewis, AC, Zhu, W, Toubia, J, Pitman, MR, Wallington-Beddoe, CT, Moretti, PA, Iarossi, D, Samaraweera, SE, Cummings, N, Ramshaw, HS, Thomas, D, Wei, AH, Lopez, AF, D'Andrea, RJ, Lewis, ID & Pitson, SM 2017, 'Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia', Blood, vol. 126, no. 6, pp. 771-782. Open access 79 75 85
2017	Wittwer, NL, Brumatti, G, Marchant, C, Sandow, JJ, Pudney, MK, Dottore, M, D'Andrea, RJ, Lopez, AF, Ekert, PG & Ramshaw, HS 2017, 'High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression', Blood Advances, vol. 1, no. 15, pp. 1067-1079. Open access 29 27 1
2016	Broughton, SE, Hercus, TR, Nero, TL, Dottore, M, McClure, BJ, Dhagat, U, Taing, H, Gorman, MA, King-Scott, J, Lopez, AF & Parker, MW 2016, 'Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling', Structure, vol. 24, no. 8, pp. 1271-1281. Open access 44 43
2016	Ebert, LM, Tan, LY, Johan, MZ, Min, KKM, Cockshell, MP, Parham, KA, Betterman, KL, Szeto, P, Boyle, S, Silva, L, Peng, A, Zhang, Y, Zannettino, AC, Gronthos, S, Koblar, S, Harvey, NL, Lopez, AF, Shackleton, M & Bonder, CS 2016, 'A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis', Angiogenesis, vol. 19, pp. 463-486. Open access 34 35
2016	Gargett, T, Christo, SN, Hercus, TR, Abbas, N, Singhal, N, Lopez, AF & Brown, MP 2016, 'GM-CSF signalling blockade and chemotherapeutic agents act in concert to inhibit the function of myeloid-derived suppressor cells in vitro', Clinical and Translational Immunology, vol. 5, no. 12, article no. e119. Open access 37 30
2016	Lim, GE, Piske, M, Lulo, JE, Ramshaw, HS, Lopez, AF & Johnson, JD 2016, 'Ywhaz/14-3-3ζ deletion improves glucose tolerance through a GLP-1-dependent mechanism', Endocrinology, vol. 157, no. 7, pp. 2649-2659. Open access 25 24
2016	Nievergall, E, Reynolds, J, Kok, C, Watkins, D, Biondo, M, Busfield, S, Vairo, G, Fuller, K, Erber, W, Sadras, T, Grose, R, Yeung, D, Lopez, A, Hiwase, D, Hughes, T & White, D 2016, 'TGF-α and IL-6 plasma levels selectively identify CML patients who fail to achieve an early molecular response or progress in the first year of therapy', Leukemia, vol. 30, no. 6, pp. 1263-1272. 44 40
2016	Panousis, C, Dhagat, U, Edwards, KM, Rayzman, V, Hercus, TR, Dottore, M, McClure, BJ, Lopez, AF & Owczarek, CM and 12 other authors 2016, 'CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors', mAbs, vol. 8, no.3, pp. 436-453. Open access 40 31
2016	Schoenwaelder, SM, Darbousset, R, Cranmer, SL, Ramshaw, HS, Woodcock, J, Pitson, S, Lopez, AF & Jackson, SP and 13 other authors 2016, '14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function', Nature Communications, vol. 7, article no. 12862, pp. 1-15. Open access 53 51 1
2016	Vu, T, Austin, R, Kuhn, CP, Bruedigam, C, Song, A, Guignes, S, Jacquelin, S, Ramshaw, HS, Hill, GR, Lopez, AF & Lane, SW 2016, 'Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling', Haematologica: The Hematology Journal, vol. 101, no. 3, pp. e77-e80. Open access 5 5
2016	Yip, K-H, Kolesnikoff, N, Hauschild, N, Biggs, L, Lopez, AF, Galli, SJ, Kumar, S & Grimbaldeston, MA 2016, 'The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation', Nature Communications, vol. 7, article no.13198, pp. 1-14. Open access 27 27
2015	Broughton, SE, Nero, TL, Dhagat, U, Kan, WL, Hercus, TR, Tvorogov, D, Lopez, AF & Parker, MW 2015, 'The βc receptor family - Structural insights and their functional implications', Cytokine, vol. 74, no. 2, pp. 247-258. 68 60 3
2015	He, SZ, Busfield, S, Ritchie, DS, Hertzberg, MS, Lopez, AF, Ramshaw, HS & Roberts, AW and 16 other authors 2015, 'A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia', Leukemia and Lymphoma, vol. 56, no. 5, pp. 1406-1415. 102 101
2015	Jaehne, EJ, Ramshaw, HS, Xu, X, Saleh, E, Clark, SA, Schubert, KO, Lopez, A, Schwarz, QP & Baune, BT 2015, 'In-vivo administration of clozapine affects behaviour but does not reverse dendritic spine deficits in the 14-3-3ζ KO mouse model of schizophrenia-like disorders', Pharmacology Biochemistry and Behavior, vol. 138, pp. 1-8. 13 12 2
2015	Kular, J, Scheer, KG, Pyne, NT, Allam, AH, Pollard, AN, Magenau, A, Wright, RL, Kolesnikoff, N, Moretti, PA, Wullkopf, L, Stomski, FC, Cowin, AJ, Woodcock, JM, Grimbaldeston, MA, Pitson, SM, Timpson, P, Ramshaw, HS, Lopez, AF & Samuel, MS 2015, 'A negative regulatory mechanism involving 14-3-3ζ limits signaling downstream of ROCK to regulate tissue stiffness in epidermal homeostasis', Developmental Cell, vol.35, no. 6, pp. 759 - 774. Open access 30 24 24
2015	Lee, EM, Yee, D, Busfield, SJ, McManus, JF, Cummings, N, Vairo, G, Wei, A, Ramshaw, HS, Powell, JA, Lopez, AF, Lewis, ID, McCall, MN & Lock, RB 2015, 'Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice', Haematologica: The Hematology Journal, vol. 100, pp. 914-926. Open access 55 50
2015	Lim, GE, Albrecht, T, Piske, M, Sarai, K, Lee, JT, Ramshaw, HS, Sinha, S, Guthridge, MA, Acker-Palmer, A, Lopez, AF, Clee, SM, Nislow, C & Johnson, JD 2015, '14-3-3ζ coordinates adipogenesis of visceral fat', Nature Communications, vol. 6, article no. 7671, pp. 1-17. Open access 54 53
2015	Moldenhauer, LM, Cockshell, MP, Frost, L, Parham, KA, Tvorogov, D, Tan, LY, Ebert, LM, Tooley, K, Worthley, S, Lopez, AF & Bonder, CS 2015, 'Interleukin-3 greatly expands non-adherent endothelial forming cells with pro-angiogenic properties', Stem Cell Research, vol. 14, no. 3, pp. 380-395. Open access 16 15 4
2015	Woodcock, JM, Coolen, C, Goodwin, KL, Baek, DJ, Bittman, R, Samuel, MS, Pitson, SM & Lopez, AF 2015, 'Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics', Oncotarget, vol. 6, no. 16, pp. 14522-14536. Open access 33 29 3
2015	Xu, X, Jaehne, EJ, Greenberg, Z, McCarthy, P, Saleh, E, Parish, CL, Camera, D, Heng, J, Haas, M, Baune, BT, Ratnayake, U, Van den Buuse, M, Lopez, AF, Ramshaw, HS & Schwarz, Q 2015, '14-3-3 zeta deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders', Scientific Reports, vol. 5, article no. 12434, pp. 1-15. Open access 37 35 1
2014	Broughton, SE, Hercus, TR, Hardy, MP, McClure, BJ, Nero, TL, Dottore, M, Huyhn, H, Braley, H, Barry, EF, Kan, WL, Dhagat, U, Scotney, P, Hartman, D, Busfield, SJ, Owczarek, CM, Nash, AD, Wilson, NJ, Parker, MW & Lopez, AF 2014, 'Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody', Cell Reports, vol. 8, no. 2, pp. 410-419. Open access 52 45
2014	Busfield, S, Biondo, M, Wong, M, Ramshaw, H, Lee, E, Ghosh, S, Braley, H, Panousis, C, Roberts, A, He, S, Thomas, D, Fabri, L, Vairo, G, Lock, R, Lopez, A & Nash, A 2014, 'Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC', Leukemia, vol. 28, no. 11, pp. 2213-2221. Open access 48 113
2014	Nievergall, E, Ramshaw, HS, Yong, AS, Biondo, M, Busfield, SJ, Vairo, G, Lopez, AF, Hughes, TP, White, DL & Hiwase, DK 2014, 'Monoclonal antibody targeting of IL-3 receptor alpha with CSL362 effectively depletes CML progenitor and stem cells', Blood, vol. 123, pp. 1218-1228. Open access 89 82
2014	Sadras, T, Perugini, M, Kok, CH, Iarossi, DG, Heatley, SL, Brumatti, G, Samuel, MS, To, LB, Lewis, ID, Lopez, AF, Ekert, PG, Ramshaw, HS & D'Andrea, RJ 2014, 'Interleukin-3-mediated regulation of Beta-catenin in myeloid transformation and acute myeloid leukemia', Journal of Leukocyte Biology, vol. 96 no. 1, pp. 83-91. Open access 17 16
2014	Toyo-oka, K, Wachi, T, Hunt, RF, Baraban, SC, Taya, S, Ramshaw, H, Kaibuchi, K, Schwarz, QP, Lopez, AF & Wynshaw-Boris, A 2014, '14-3-3 epsilon and zeta regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain', Journal of Neuroscience, vol. 34, no. 36, pp. 12168-12181. Open access 93 93
2014	Yip, K-H, Kolesnikoff, N, Yu, C, Hauschild, N, Taing, H, Biggs, L, Goltzman, D, Gregory, PA, Anderson, PH, Samuel, MS, Galli, SJ, Lopez, A & Grimbaldeston, MA 2014, 'Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation', Journal of Allergy and Clinical Immunology, vol. 133, no. 5, pp. 1356-1364. Open access 99 88
2013	Hercus, TR, Dhagat, U, Kan, WL, Broughton, SE, Nero, TL, Perugini, M, Sandow, JJ, D'Andrea, RJ, Ekert, PG, Hughes, T, Parker, MW & Lopez, AF 2013, 'Signalling by the βc family of cytokines', Cytokine and Growth Factor Reviews, vol. 24, no. 3, pp. 189-201. Open access 83 76
2013	Lim, Y-Y, Wright, JA, Attema, JL, Gregory, PA, Bert, AG, Smith, E, Thomas, D, Lopez, AF, Drew, PA, Khew-Goodall, Y & Goodall, GJ 2013, 'Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem cell-like state', Journal of Cell Science, vol. 126, no. 10, pp. 2256-2266. Open access 171 155
2012	Broughton, SE, Dhagat, U, Hercus, TR, Nero, TL, Grimbaldeston, MA, Bonder, CS, Lopez, AF & Parker, MW 2012, 'The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling', Immunological Reviews, vol. 250, no. 1, pp. 277-302. 203 185
2012	Cheah, P-s, Ramshaw, H, Thomas, P, Toyo-Oka, K, Xu, X, Martin, S, Coyle, P, Guthridge, M, Stomski, F, van den Buuse, M, Wynshaw-Boris, A, Lopez, A & Schwarz, Q 2012, 'Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency', Molecular Psychiatry, vol. 17, no. 4, pp. 451-466. Open access 93 89
2012	Hercus, TR, Broughton, SE, Ekert, PG, Ramshaw, HS, Perugini, M, Grimbaldeston, M, Woodcock, JM, Thomas, D, Pitson, S, Hughes, T, D'Andrea, RJ, Parker, MW & Lopez, AF 2012, 'The GM-CSF receptor family: mechanism of activation and implications for disease', Growth Factors, vol. 30, no. 2, pp. 63-75. Open access 62 57
2012	Markey, KA, Koyama, M, Kuns, RD, Lineburg, KE, Wilson, YA, Olver, SD, Raffelt, NC, Don, AL, Varelias, A, Robb, RJ, Cheong, M, Engwerda, CR, Steptoe, RJ, Ramshaw, HS, Lopez, AF, Vega-Ramos, J, Lew, AM & Villadangos, JA 2012, 'Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets', Blood, vol. 119, no. 24, pp. 5918-5930. Open access 35 30
2010	Kim, S, Prout, M, Ramshaw, H, Lopez, AF, LeGros, G & Min, B 2010, 'Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3', Journal of Immunology, vol. 184, no. 3, pp. 1143-1147. Open access 129 117
2010	Lopez, AF, Hercus, TR, Ekert, P, Littler, DR, Guthridge, M, Thomas, D, Ramshaw, HS, Stomski, FC, Perugini, M, D'Andrea, RJ, Grimbaldeston, M & Parker, MW 2010, 'Molecular basis of cytokine receptor activation', IUBMB Life, vol. 62, no. 7, pp. 509-518. Open access 61 55
2009	Barry, EF, Felquer, FA, Powell, JA, Biggs, L, Stomski, FC, Urbani, A, Ramshaw, H, Hoffmann, P, Wilce, MC, Grimbaldeston, MA, Lopez, A F & Guthridge, MA 2009, '14-3-3: Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survial', Journal of Biological Chemistry, vol. 284, no. 18, pp. 12080-12090. Open access 34 31
2009	Bonder, CS, Sun, WY, Matthews, T, Cassano, C, Li, X, Ramshaw, HS, Pitson, SM, Lopez, AF, Coates, PT, Proia, RL, Vadas, MA & Gamble, JR 2009, 'Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation', Blood, vol. 113, no. 9, pp. 2108-2117. Open access 38 36
2009	Jin, L, Lee, EM, Ramshaw, HS, Busfield, SJ, Peoppl, AG, Wilkinson, L, Guthridge, MA, Thomas, D, Barry, EF, Boyd, A, Gearing, DP, Vairo, G, Lopez, A, Dick, JE & Lock, RB 2009, 'Monoclonal antibody-mediated targeting of CD123, IL-3 receptor a chain, eliminates human acute myeloid leukemic stem cells', Cell Stem Cell, vol. 5, no. 1, pp. 31-42. Open access 458 412
2008	Asquith, KL, Ramshaw, HS, Hansbro, PM, Beagley, Kw, Lopez, AF & Foster, PS 2008, 'The IL-3/IL-5/GM-CSF common {beta} receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation', Journal of Immunology, vol. 180, pp. 1199-1206. Open access 110 106
2008	Hansen, G, Hercus, T, McClure, BJ, Stomski, FC, Dottore, M, Powell, J, Ramshaw, H, Woodcock, JM, Xu, Y, Guthridge, M, McKinstry, WJ, Lopez, AF & Parker, M 2008, 'The Structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation', Cell, vol. 134, no. 3, pp. 496-507. Open access 266 246

Research

Patents

Details	Registry	Status
Markers of endothelial progenitor cells and uses thereof Bonder, Claudine Sharon; Lopez, Angel Fransciso; Talbo, Gert Hoy	AU	Granted
Markers of endothelial progenitor cells and uses thereof Bonder, Claudine Sharon; López, Ángel Fransciso; Talbo, Gert Hoy	EP	Filed
Markers of endothelial progenitor cells and uses thereof Bonder, Claudine Sharon; Lopez, Angel Fransciso; Talbo, Gert Hoy	US	Filed
Markers of endothelial progenitor cells and uses thereof Bonder, Claudine Sharon; Lopez, Angel Fransciso; Talbo, Gert Hoy	WO	Filed
Method of culturing cells Bonder, Claudine Sharon; Lopez, Angel Fransciso	WO	Filed
Method of treatment Lopez, Angel; Schwarz, Quenten	Australia	Filed
Methods for treating inflammatory skin conditions Owczarek, Catherine; Lopez, Angel; Yip, Kwok Ho; Tumes, Damon	WO	Granted
Methods for treating or preventing acute respiratory distress syndrome Owczarek, Catherine; Campbell, Ian; Krstevski, Karolina; Bozinovski, Steven; Lopez, Angel; Tumes, Damon	World	Granted
Modulators of 14-3-3 functionality and uses thereof Woodcock, Joanna; Lopez, Angel; Pitson, Stuart M; Samuel, Michael S; Coolen, Carl	United States	Filed
Modulators of 14-3-3 functionality and uses thereof Woodcock, Joanna; Lopez, Angel; Pitson, Stuart; Samuel, Michael; Coolen, Carl	WO	Filed
Novel cancer treatment involving modulation of il-3 activity Lopez, Angel F; Bonder, Claudine S; Thompson, Emma	WO	Filed
Screening Method Schwarz, Quenten; Lopez, Angel	Australia	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
A-Star, Institute of Molecular and Cell Biology	SINGAPORE
Austin Health	AUSTRALIA
Australian Cancer Research Foundation	AUSTRALIA
Australian National University	AUSTRALIA
BreastScreen SA	AUSTRALIA
Case Western Reserve University	UNITED STATES
Children's Cancer Institute Australia	AUSTRALIA
City University of New York	UNITED STATES
City University Of New York, Queens College	UNITED STATES
Cleveland Clinic Foundation	UNITED STATES
CSL Limited	AUSTRALIA
CSL LTD	AUSTRALIA
CSL Pharmaceutical Group	AUSTRALIA
Deakin University	AUSTRALIA
Drexel University	UNITED STATES
Envoi Specialist Pathologists	AUSTRALIA
Flinders University	AUSTRALIA
Genentech, Inc.	UNITED STATES
Harry Perkins Institute of Medical Research	AUSTRALIA
Hudson Institute of Medical Research	AUSTRALIA
IBM Australia	AUSTRALIA
Institute of Medical and Veterinary Science	AUSTRALIA
La Trobe University	AUSTRALIA
Leland Stanford Junior University (Stanford)	UNITED STATES
Malaghan Institute of Medical Research	NEW ZEALAND
McGill University	CANADA
Medical University of Graz	AUSTRIA
Mental Health Research Institute of Victoria	AUSTRALIA
Monash University	AUSTRALIA
Murdoch Childrens Research Institute	AUSTRALIA
Nagoya University	JAPAN
National Institutes of Health	UNITED STATES
Osnabrueck University	GERMANY
Peter MacCallum Cancer Centre	AUSTRALIA
Prince Henry's Institute of Medical Research	AUSTRALIA
Princess Alexandra Hospital	AUSTRALIA
QIMR Berghofer Medical Research Institute	AUSTRALIA
Queensland Institute of Medical Research	AUSTRALIA
RMIT University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Children's Hospital	UNITED KINGDOM
Royal College of Surgeons in Ireland	IRELAND
Royal Melbourne Hospital	AUSTRALIA
Royal Victorian Eye and Ear Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
South Australian Health and Medical and Research Institute (SAHMRI)	AUSTRALIA
St Vincents Hospital	UNITED STATES
St. Vincent's Institute of Medical Research	AUSTRALIA
Stanford University	UNITED STATES
Texas A and M University	UNITED STATES
The Kinghorn Cancer Centre	AUSTRALIA
The Queen Elizabeth Hospital	AUSTRALIA
UCSF School of Medicine	UNITED STATES
University College London	UNITED KINGDOM
University Health Network	CANADA
University of Adelaide	AUSTRALIA
University of British Columbia	CANADA
University of California	UNITED STATES
University of Frankfurt	GERMANY
University of Melbourne	AUSTRALIA
University of Montreal	CANADA
University of New South Wales	AUSTRALIA
University of Newcastle	AUSTRALIA
University of Queensland	AUSTRALIA
University of Rome Tor Vergata	ITALY
University of Sherbrooke	CANADA
University of South Australia	AUSTRALIA
University of Southern California	UNITED STATES
University of Sydney	AUSTRALIA
University of Toronto	CANADA
University of Western Australia	AUSTRALIA
Walter and Eliza Hall Institute of Medical Research	AUSTRALIA
Westmead Hospital	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Officer of the Order of Australia (AO) Order of Australia	2017
Project Grant National Health and Medical Research Council (NHMRC)	2016
Fellow Australian Academy of Health and Medical Science	2015
Fellow Australian Academy of Science	2014
Research Excellence Award, Top Ranked Application National Health and Medical Research Council (NHMRC)	2013

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Deciphering how airway epithelial programming and inflammation cause chronic allergic airways disease	Current
Interleukin-3 (IL-3) promotes blood vessel development in breast cancer	Current
Revealing the role of ICAM1 in breast cancer progression	Current
Understanding the role of 14-3-3 proteins in lung cancer initiation, progression and metastasis.	Current

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Professor Angel Lopez

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Chapters

Journal Articles

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Officer of the Order of Australia (AO)

Project Grant

Fellow

Fellow

Research Excellence Award, Top Ranked Application

Teaching & student supervision

Courses and programs

Research degree supervision

Gallery