Professor Benjamin Thierry

Professor in Bioengineering Future Industries Institute

Mawson Lakes Campus (MM2-01K)
tel +61 8 830 23689
fax +61 8 830 23683

email benjamin.thierry@unisa.edu.au

Alternative contact

Available for media comment
Research Degree Supervisor

About me

Professor Benjamin Thierry is a Research Leader at the Future Industries Institute and the Head of the South Australia Node of the ARC Centre of Excellence in Convergent Bio and Nano Science and Technology (CBNS). He has received his PhD in Biomedical Engineering from McGill University in 2004 and has since received prestigious awards, including two Career Development Award Fellowships from the NHMRC.

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About me

Prof Thierry leads the translational Bioengineering group which aims to develop and implement novel biodiagnostic and prognostic technologies and is currently involved in several clinical translation/commercialization activities. A significant outcome of his research has been the development of a patented cancer staging diagnostic technology that has received substantial commercial interest and investment through a spin-off company, Ferronova Pty Ltd. With the support of a NHHMRC Dev Grant, a clinical prototype is currently being developed and the pilot clinical trial is scheduled to start in September 2019, which will aim at demonstrating the feasibility and safety of this technology in early-stage oral cancer. A recent research focus has been on the development of biodiagnostic technologies to improve prenatal care. In close collaboration with industry partners and clinicians, he has established a comprehensive research program aimed at enabling better detection of pregnancy complications such as preeclampsia and pre-term birth with a focus on remote/low resource settings. He has also developed and patented a technology aimed at enabling comprehensive non-invasive prenatal genetic testing, which is currently being developed through a spin-off company NIPDx.

Prof Thierry is a Chief Investigator in the ARC Centre of Excellence in Convergent Bio and Nano Science and leads two major research programs of the Centre. The first of this program is focussed on the development of next-generation in vitro organ and disease models, including models based on "organs-on-chips" concept and 3D Bioprinting. With the support of an ARC Linkage grant, intestine-on-chip models developed in his group are being applied to yield better understanding of the intestinal uptake of particulate carriers orally administrated, including oral vaccines. He is also actively collaborating with several water management organisations to utilise these models to study intestinal infections by virus and pathogen. In parallel, cancer-on-chip models are being developed and implemented to assist in the development of better cancer therapeutics, including based on ionizing radiation and immunotherapy. His group has also strong expertise in the design and application of functional nanomaterials. This research theme includes nanoscale solid-state biosensor (supported by an ARC Discovery project in collaboration with Prof Andreas Offenhausser) and nanoparticulate imaging contrast agents (supported by an NHMRC Project grant in collaboration with Prof Eben Rosenthal at Stanford University).

Research

Research themes

Transforming industries
Cancer

Research focus

Chemical Sciences
Engineering
Biological Sciences
Biomedical Engineering
Physical Sciences

Highlights

The Nanobioengineering group aims at bridging the gap between engineering and medicine, with a specific focus on oncology and prenatal diagnostics. To this end, we are developing a range of technologies aimed at providing either basic insights about biological processes or designed to address significant biomedical challenges. More info can be find on our web site: www.bionanoengineering.com.

Current research areas:

“Intestine-on-a-chip” technology: With the support of the ARC, a microfluidic model of the intestinal epithelium has been designed to mimic the characteristic features relevant to the uptake and transport of drugs and particulate carriers.
"Tumour-on-a-chip models": Our research aims to bridge the gap between... Read more

Research

Projects

Excludes commercial-in-confidence projects.

Detection and viability of waterborne pathogens using a gut-on-chip, ARC - Linkage Project, 12/12/2018 - 11/12/2021
Preoperative Imaging of Metastatic Deposits in Regional Lymph Nodes: Preclinical Validation of a New Staging Modality for Head and Neck Cancer, NHMRC - Project Grant, 01/01/2019 - 31/07/2021
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, ARC - Centre of Excellence, 01/04/2014 - 29/06/2021
Nanoscale silicon field-effect transistor diagnostic technology, ARC - Discovery Projects, 27/03/2017 - 31/12/2020
Development of Superior Sentinel Lymph Node Mapping Procedures using Magnetic Tracers, NHMRC - Development Grant, 01/01/2019 - 31/12/2020
AAS - Portable Healthcare: High-Value Micro/Nano-Scale Structures and Coating for Mass Production of Biomedical Devices, Australian Academy of Science, 01/11/2017 - 31/10/2020
Development of Superior Sentinel Lymph Node Staging Procedures in Head and Neck Cancer Using Magnetic Tracers, Garnett Passe and Rodney Williams Memorial Foundation - Conjoint Grant, 01/06/2018 - 31/05/2020
Targeting particulate carriers to epithelial M cells, ARC - Linkage Project, 15/12/2015 - 30/09/2019
Advanced technologies for improved molecular diagnostic and prognostic of gastrointestinal cancers, NHMRC - Career Development Fellowship, 01/01/2015 - 31/12/2018
NHMRC Equip 2015 - Stage-top incubator for live-cell imaging with the Zeiss LSM 710 super-high resolution microscope, NHMRC - Equipment Only Grants, 01/01/2016 - 31/12/2016
Nanomedicines Immunotargeting: Hitting the Target or Lost In Translation?, NHMRC - Project Grant, 01/01/2013 - 31/12/2016
A novel nitric oxide-based treatment for recalcitrant Staphylococcus aureus-associated chronic rhinosinusitis (admin by Uni of Adelaide), NHMRC - Project Grant, 01/01/2013 - 30/06/2016
Functional Nanoparticles: Towards Novel Advanced Cancer Diagnostic, Prognostic and Therapeutic Strategies, NHMRC - Career Development Fellowship, 01/01/2010 - 31/12/2014
'The image stream Mark II: a state-of-the-art imaging flow cytometry facility for the detection of rare cancer cells and bioengineering applications, The Ramaciotti Foundations, 15/10/2013 - 14/10/2014
Digital Holographic Microscope: An advanced imaging facility for the development of lab-on-chip devices., The Ramaciotti Foundation - Major Equipment Grant, 01/01/2012 - 31/12/2013
Microfabricated Devices: A significant advance for the detection and molecular analyses of circulating cancer cells?, NHMRC - Project Grant, 01/01/2010 - 31/12/2013
Advanced nanostructured biointerfaces for cell capture, ARC - Discovery Projects, 01/01/2008 - 30/06/2013
Sentinel lymph node biopsy in oesophagel adenocarcinoma - improving staging accuracy & optimising treatment, Cancer Institute NSW, 01/11/2011 - 31/10/2012

Research

Outputs

Research since 2008 is shown below. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2019	Delon, LC, Guo, Z, Oszmiana, A, Chien, CC, Gibson, R, Prestidge, C & Thierry, B 2019, 'A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models', Biomaterials, vol. 225, Article number 119521 pp. 1-11.
2019	Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12. 58
2019	Rezaei, M, Winter, M, Zander-Fox, D, Whitehead, C, Liebelt, J, Warkiani, ME, Hardy, T & Thierry, B 2019, 'A reappraisal of circulating fetal cell noninvasive prenatal testing', Trends in Biotechnology, vol. 37, no. 6, pp. 632-644. Open access 2 2 2
2019	Tran, DP, Winter, M, Yang, C-T, Stockmann, R, Offenhausser, A & Thierry, B 2019, 'Silicon nanowires field effect transistors: a comparative sensing performance between electrical impedance and potentiometric measurement paradigms', Analytical Chemistry, vol. 91, no. 19, pp. 12568-12573.
2016	Duy Tran, Winter, M, Wolfrum, B, Stockmann, R, Yang, C-T, Pourhassan-Moghaddam, M, Offenhaüsser, A & Thierry, B 2016, 'Toward intraoperative detection of disseminated tumor cells in lymph nodes with silicon nanowire field effect transistors', ACS Nano, vol. 10, no. 2, pp. 2357-2364. Open access 22 22 53

Chapters

Year	Output
2012	Thierry, B, Ma, D & Winnik, FM 2012, 'The design of polysaccharide multilayers for medical applications', in G Decher & JB Schlenoff (eds), Multilayer thin films: sequential assembly of nanocomposite materials, 2nd ed., Wiley-Blackwell, Germany, ch. 26, pp. 637-658.
2011	Thierry, B & Majewski, PJ 2011, 'Superparamagnetic Magnetite Nanoparticles', in HS Nalwa (ed.), Encyclopedia of Nanoscience and Nanotechnology, ASP - American Scientific Publishers, USA, vol. 23, pp. 533-544.
2009	Majewski, P & Thierry, B 2009, 'Functionalized magnetite nanoparticles-synthesis, properties, and bioapplications', in W Sigmund et al. (eds), Particulate systems in nano and biotechnologies, CRC Press, USA, ch. 15, pp. 331-352.

Journal Articles

Year	Output
2020	Dong, D, Thomas, N, Ramezanpour, M, Psaltis, AJ, Huang, S, Zhao, Y, Thierry, B, Wormald, PJ, Prestidge, CA & Vreugde, S 2020, 'Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations', Experimental Biology and Medicine, vol. 245, no. 1, pp. 34-41.
2019	Delon, LC, Guo, Z, Oszmiana, A, Chien, CC, Gibson, R, Prestidge, C & Thierry, B 2019, 'A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models', Biomaterials, vol. 225, Article number 119521 pp. 1-11.
2019	Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12. 58
2019	Klisuric, A, Thierry, B, Delon, L, Prestidge, CA & Gibson, RJ 2019, 'Identifying human and murine M cells in vitro', Experimental Biology and Medicine, online. 6
2019	Pocock, K, Delon, LC, Khatri, A, Prestidge, C, Gibson, R, Barbe, C & Thierry, B 2019, 'Uptake of silica particulate drug carriers in an intestine-on-a-chip: towards a better in vitro model of nanoparticulate carrier and mucus interactions', Biomaterials Science, vol. 7, pp. 2410-2420. 1 1
2019	Rezaei, M, Winter, M, Zander-Fox, D, Whitehead, C, Liebelt, J, Warkiani, ME, Hardy, T & Thierry, B 2019, 'A reappraisal of circulating fetal cell noninvasive prenatal testing', Trends in Biotechnology, vol. 37, no. 6, pp. 632-644. Open access 2 2 2
2019	Thuy, TTP, Tran, D P & Thierry, B 2019, 'High performance indium oxide nanoribbon FETs: mitigating devices signal variation from batch fabrication', Nanoscale Advances, vol. 1, no. 12, pp. 4870-4877. Open access
2019	Tran, DP, Winter, M, Yang, C-T, Stockmann, R, Offenhausser, A & Thierry, B 2019, 'Silicon nanowires field effect transistors: a comparative sensing performance between electrical impedance and potentiometric measurement paradigms', Analytical Chemistry, vol. 91, no. 19, pp. 12568-12573.
2019	Turnbull, T, Douglass, M, Williamson, NH, Howard, D, Bhardwaj, R, Lawrence, M, Paterson, DJ, Bezak, E, Thierry, B & Kempson, IM 2019, 'Cross-correlative single-cell analysis reveals biological mechanisms of nanoparticle radiosensitization', ACS Nano, vol. 13, no. 5, pp. 5077-5090. 2 2 3
2019	Turnbull, T, Thierry, B & Kempson, I 2019, 'A quantitative study of intercellular heterogeneity in gold nanoparticle uptake across multiple cell lines', Analytical and Bioanalytical Chemistry, vol. 411, no. 28, pp. 7529-7538.
2019	Winter, M, Cai, Z, Winkler, K, Georgiou, K, Inglis, D, Lavranos, T, Rezaei, M, Warkiani, M & Thierry, B 2019, 'Circulating tumour cell RNA characterisation from colorectal cancer patient blood after inertial microfluidic enrichment', MethodsX, vol. 6, pp. 1512-1520. Open access 1 1 3
2019	Zhou, X, Yang, C-T, Xu, Q, Lou, Z, Xu, Z, Thierry, B & Gu, N 2019, 'Gold nanoparticle probe-assisted antigen-counting chip using SEM', ACS Applied Materials and Interfaces, vol. 11, no. 7, pp 6769-6776. 2 1 7
2018	Chen, F, Tang, F, Yang, CT, Zhao, X, Wang, J, Thierry, B, Bansal, V, Dai, J & Zhou, X 2018, 'Fast and highly sensitive detection of pathogens wreathed with magnetic nanoparticles using dark-field microscopy', ACS Sensors, vol. 3, no. 10, pp. 2175-2181. Open access 1
2018	Cousins, A, Tsopelas, C, Balalis, G, Thompson, SK, Bartholomeusz, D, Wedding, AB & Thierry, B 2018, 'Hybrid ⁹⁹m-Tc-magnetite tracer for dual modality sentinel lymph node mapping', Journal of Materials Science: Materials in Medicine, vol. 29, no. 6, article no. 76, pp. 1-11. Open access
2018	Diéguez, L, Winter, M, Molan, S, Monis, P, King, B & Thierry, B 2018, 'Disposable microfluidic micromixers for effective capture of Cryptosporidium parvum oocysts from water samples', Journal of Biological Engineering, vol. 12, no. 1, article no. 4, pp. 1-8. Open access 1 1
2018	Hasan, S, Albayaty, YN, Thierry, B, Prestidge, CA & Thomas, N 2018, 'Mechanistic studies of the antibiofilm activity and synergy with antibiotics of isosorbide mononitrate', European Journal of Pharmaceutical Sciences, vol. 115, pp. 50-56. 1 1 1
2018	Tran, DP, Pham, TTT, Wolfrum, B, Offenhäusser, A & Thierry, B 2018, 'CMOS-compatible silicon nanowire field-effect transistor biosensor: technology development toward commercialization', Materials, vol. 11, no. 5, article no. 785, pp. 1-26. Open access 15 12 8
2018	Winter, M, Hardy, T, Rezaei, M, Nguyen, V, Zander-Fox, D, Warkiani, ME & Thierry, B 2018, 'Isolation of circulating fetal trophoblasts using inertial microfluidics for noninvasive prenatal testing', Advanced Materials Technologies, vol. 3, no. 7, article no. 1800066 , pp. 1-10. Open access 7 7 63
2017	Hasan, S, Thomas, N, Thierry, B & Prestidge, CA 2017, 'Biodegradable nitric oxide precursor-loaded micro- and nanoparticles for the treatment of Staphylococcus aureus biofilms', Journal of Materials Chemistry B, vol. 5, pp. 1005-1014. Open access 6 6
2017	Hasan, S, Thomas, N, Thierry, B & Prestidge, CA 2017, 'Controlled and localized nitric oxide precursor delivery from chitosan gels to staphylococcus aureus biofilms', Journal of Pharmaceutical Sciences, vol. 106, no. 12, pp. 3556-3563. 1
2017	Pai, J-H, Yang, C-T, Hsu, HY, Wedding, AB & Thierry, B 2017, 'Development of a simplified approach for the fabrication of localised surface plasmon resonance sensors based on gold nanorods functionalized using mixed polyethylene glycol layers', Analytica Chimica Acta, vol. 974, pp. 87-92. 7 8 1
2017	Pocock, K, Delon, L, Bala, V, Rao, S, Priest, C, Prestidge, C & Thierry, B 2017, 'Intestine-on-a-chip microfluidic model for efficient in vitro screening of oral chemotherapeutic uptake', ACS Biomaterial Science and Engineering, vol. 3, no. 6, pp. 951-959. 10 9
2017	Turnbull, T, Douglass, M, Bezak, E, Thierry, B & Kempson, I 2017, 'An image processing application for quantitative cross-correlative microscopy for large cell-populations: a gold nanoparticle radiosensitisation study', Powder Diffraction, vol. 32, no. S2, pp. S33-S37. 1 1
2017	Yang, C-T, Pourhassan-Moghaddam, M, Wu, L, Bai, P & Thierry, B 2017, 'Ultrasensitive detection of cancer prognostic miRNA biomarkers based on surface plasmon enhanced light scattering', ACS Sensors, vol. 2, no. 5, pp. 635-640.
2016	Duy Tran, Winter, M, Wolfrum, B, Stockmann, R, Yang, C-T, Pourhassan-Moghaddam, M, Offenhaüsser, A & Thierry, B 2016, 'Toward intraoperative detection of disseminated tumor cells in lymph nodes with silicon nanowire field effect transistors', ACS Nano, vol. 10, no. 2, pp. 2357-2364. Open access 22 22 53
2016	Fong, W-K, Hanley, TL, Thierry, B, Hawley, A, Boyd, BJ & Landersdorfer, CB 2016, 'External manipulation of nanostructure in photoresponsive lipid depot matrix to control and predict drug release in vivo', Journal of Controlled Release, vol. 228, pp. 67-73. 19 16 1
2016	Hasan, S, Thomas, N, Thierry, B, Vreugde, S, Wormald, P-J & Prestidge, CA 2016, 'Recent trends on the use of nanoparticles for nitric oxide delivery in antimicrobial applications', Drug Delivery Letters, vol. 6, no. 1, pp. 3-10. 2
2016	Pelttari, L, Khan, S, Vuorela, M, Kiiski, J, Thierry, B & Zeps, N and 349 other authors 2016, 'RAD51B in familial breast cancer', PLoS One, vol. 11, no. 5, article no. e0153788, pp. 1-18. Open access 9 7 3
2016	Pocock, KJ, Gao, X, Wang, C, Priest, C, Prestidge, CA, Mawatari, K, Kitamori, T & Thierry, B 2016, 'Low-temperature bonding process for the fabrication of hybrid glass-membrane organ-on-a-chip devices', Journal of Micro/ Nanolithography, MEMS, and MOEMS, vol. 15, no. 4, pp. 1-9. 1 2
2016	Thomas, N, Thorn, C, Richter, K, Thierry, B & Prestidge, C 2016, 'Efficacy of poly-lactic-co-glycolic acid micro- and nanoparticles of ciprofloxacin against bacterial biofilms', Journal of Pharmaceutical Sciences, vol. 105, no. 10, pp.3115-3122. Open access 13 12 2
2016	Yang, C-T, Wu, L, Bai, P & Thierry, B 2016, 'Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags', Journal of Materials Chemistry C, vol. 4, no. 41, pp. 9897-9904. 15 17 1
2016	Yang, C-T, Wu, L, Liu, X, Tran, NT, Bai, P, Liedberg, B, Wang, Y & Thierry, B 2016, 'Exploiting surface-plasmon-enhanced light scattering for the design of ultrasensitive biosensing modality', Analytical Chemistry, vol. 88, no. 23, pp. 11924-11930. 12 11
2015	Cousins, A, Balalis, G, Thompson, S, Morales, DF, Mohtar, A, Wedding, A & Thierry, B 2015, 'Novel handheld magnetometer probe based on magnetic tunnelling junction sensors for intraoperative sentinel lymph node identification', Scientific Reports, vol. 5, article no. 10842, pp. 1-10. Open access 10 11
2015	Diéguez, LM, Winter, MA, Pocock, KJ, Bremmell, KE & Thierry, B 2015, 'Efficient microfluidic negative enrichment of circulating tumor cells in blood using roughened PDMS', The Analyst, vol. 140, no. 10, pp. 3365-3372. 26 27
2015	Dong, D, Thomas, N, Thierry, B, Vreugde, S, Prestidge, CA & Wormald, P-J 2015, 'Distribution and inhibition of liposomes on staphylococcus aureus and pseudomonas aeruginosa biofilm', PLoS One, vol. 10, no. 6, article no. e0131806, pp. 1-16. Open access 26 27 2
2015	Hardingham, JE, Grover, P, Winter, M, Hewett, PJ, Price, TJ & Thierry, B 2015, 'Detection and clinical significance of circulating tumor cells in colorectal cancer: 20 years of progress', Molecular Medicine, vol. 21, pp. S21-S25. Open access 59 54
2015	Ho, TT, Bremmell, KE, Krasowska, M, Stringer, DN, Thierry, B & Beattie, DA 2015, 'Tuning polyelectrolyte multilayer structure by exploiting natural variation in fucoidan chemistry', Soft Matter, vol. 11, no. 11, pp. 2110-2124. 23 22 9
2015	Jardeleza, C, Thierry, B, Rao, S, Rajiv, S, Drilling, A, Miljkovic, D, Paramasivan, S, James, C, Dong, D, Thomas, N, Vreugde, S, Prestidge, CA & Wormald, P-J 2015, 'An in vivo safety and efficacy demonstration of a topical liposomal nitric oxide donor treatment for Staphylococcus aureus biofilm-associated rhinosinusitis', Translational Research: The Journal of Laboratory and Clinical Medicine, vol. 166, no. 6, pp. 683-692. 9 10 1
2015	Thomas, N, Dong, D, Richter, K, Ramezanpour, M, Vreugde, S, Thierry, B, Wormald, P-J & Prestidge, CA 2015, 'Quatsomes for the treatment of Staphylococcus aureus biofilm', Journal of Materials Chemistry B, vol. 3, no. 14, pp. 2770-2777. 14 12
2015	Turnbull, T, Douglass, M, Paterson, D, Bezak, E, Thierry, B & Kempson, I 2015, 'Relating intercellular variability in nanoparticle uptake with biological consequence: a quantitative x-ray fluorescence study for radiosensitization of cells', Analytical Chemistry, vol. 87, no. 21, pp. 10693-10697. 7 7
2015	Winter, M, Gibson, R, Ruszkiewicz, A, Thompson, SK & Thierry, B 2015, 'Beyond conventional pathology: towards preoperative and intraoperative lymph node staging', International Journal of Cancer, vol. 136, no. 4, pp. 743-751. Open access 6 5 3
2014	Cousins, A, Thompson, SK, Wedding, AB & Thierry, B 2014, 'Clinical relevance of novel imaging technologies for sentinel lymph node identification and staging', Biotechnology Advances, vol. 32, no. 2, pp. 269-279. 27 27 1
2014	Duy Tran, Macdonald, TJ, Wolfrum, B, Stockmann, R, Nann, T, Offenhäusser, A & Thierry, B 2014, 'Photoresponsive properties of ultrathin silicon nanowires', Applied Physics Letters, vol. 105, no. 23, article no. 231116, pp. 1- 5. 15 16
2014	Duy Tran, Wolfrum, B, Stockmann, R, Offenhaüsser, A & Thierry, B 2014, 'Fabrication of locally thinned down silicon nanowires', Journal of Materials Chemistry C, vol. 2, no. 26, pp. 5229-5234. Open access 10 10
2014	Duy Tran, Wolfrum, B, Stockmann, R, Pai, J-H, Pourhassan-Moghaddam, M, Offenhaüsser, A & Thierry, B 2014, 'Complementary metal oxide semiconductor compatible silicon nanowires-on-a-chip: fabrication and preclinical validation for the detection of a cancer prognostic protein marker in serum', Analytical Chemistry, vol. 87, no. 3, pp. 1662-1668. 17 17 1
2014	Fong, W-K, Hanley, TL, Thierry, B, Tilley, A, Kirby, N, Waddington, LJ & Boyd, BJ 2014, 'Understanding the photothermal heating effect in non-lamellar liquid crystalline systems, and the design of new mixed lipid systems for photothermal on-demand drug delivery', Physical Chemistry Chemical Physics, vol. 16, no. 45, pp. 24936-24953. 16 15
2014	Jardeleza, C, Rao, S, Thierry, B, Gajjar, P, Vreugde, S, Prestidge, CA & Wormald, P-J 2014, 'Liposome-encapsulated ISMN: a novel nitric oxide-based therapeutic agent against Staphylococcus aureus biofilms', PLoS One, vol. 9 no. 3, article no. e92117, pp. 1-9. Open access 23 20 1
2014	Kempson, I, Smith, E, Gao, M, de Jonge, M & Thierry, B 2014, 'Large area synchrotron X-ray fluorescence mapping of biological samples', Journal of Instrumentation, vol. 9, no. 12, article no. C12040, pp. 1-6. 1 5
2014	Liu, T, Chien, C-C, Parkinson, L & Thierry, B 2014, 'Advanced micromachining of concave microwells for long term on-chip culture of multicellular tumor spheroids', ACS Applied Materials and Interfaces, vol. 6, no. 11, pp. 8090-8097. 14 13
2014	Liu, T, Kempson, IM, de Jonge, MD, Howard, DL & Thierry, B 2014, 'Quantitative synchrotron X-ray fluorescence study of the penetration of transferrin-conjugated gold nanoparticles inside model tumour tissues', Nanoscale, vol. 6 no. 16, pp. 9774-9782. 18 16
2014	Liu, T, Winter, M & Thierry, B 2014, 'Quasi-spherical microwells on superhydrophobic substrates for long term culture of multicellular spheroids and high throughput assays', Biomaterials, vol. 35, no. 23, pp. 6060-6068. 19 21 6
2014	Liu, TM, Yang, C-T, Dieguez, LM, Denman, JA & Thierry, B 2014, 'Robust and flexible fabrication of chemical micropatterns for tumor spheroid preparation', ACS Applied Materials and Interfaces, vol. 6, no. 13, pp. 10162-10171. 4 4
2014	Mejard, R, Griesser, HJ & Thierry, B 2014, 'Optical biosensing for label-free cellular studies', Trends in Analytical Chemistry, vol. 53, pp. 178-186. 34 30
2014	Mejard, RR & Thierry, B 2014, 'Systematic study of the surface plasmon resonance signals generated by cells for sensors with different characteristic lengths', PLoS One, vol. 9, no. 10, pp. 1-11. Open access 10 11
2014	Pai, J-H, Liu, T, Hsu, H-Y, Wedding, AB, Thierry, B & Bagnaninchi, PO 2014, 'Molecular photo-thermal optical coherence phase microscopy using gold nanorods', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 4, no. 51, pp. 27067-27073. 4 3
2014	Sivanathan, K, Gronthos, S, Rojas-Canales, D, Thierry, B & Coates, PT 2014, 'Interferon-gamma modification of mesenchymal stem cells: implications of autologous and alogeneic mesenchymal stem cell therapy in allotransplantation', Stem Cell Reviews, vol. 10, no. 3, pp. 351-375. 77 74 1
2014	Tse, BW-C, Cowin, GJ, Soekmadji, C, Jovanovic, L, Vasireddy, RS, Ling, M-T, Khatria, A, Liu, T, Thierry, B & Russell, P 2014, 'PSMA-targeting iron oxide magnetic nanoparticles enhance MRI of preclinical prostate cancer', Nanomedicine, vol. 10, no. 3, pp. 375-386. Open access 39 38 5
2014	Wan, Y, Winter, M, Delalat, B, Hardingham, JE, Grover, PK, Wrin, J, Voelcker, N, Price, TJ & Thierry, B 2014, 'Nanostructured polystyrene well plates allow unbiased high-throughput characterization of circulating tumor cells', ACS Applied Materials and Interfaces, vol. 6, no. 23, pp. 20828-20836. 22 21
2014	Yang, C-T, Méjard, R, Griesser, HJ, Bagnaninchi, PO & Thierry, B 2014, 'Cellular micromotion monitored by long-range surface plasmon resonance with optical fluctuation analysis', Analytical Chemistry, vol. 87, no. 3, pp 1456-1461. 25 23 1
2013	Liu, T, Cousins, A, Chien, C-C, Kempson, I, Thompson, S, Hwu, Y & Thierry, B 2013, 'Immunospecific targeting of CD45 expressing lymphoid cells: towards improved detection agents of the sentinel lymph node', Cancer Letters, vol. 328, pp. 271-277. Open access 12 11
2013	Mejard, R, Dostálek, J, Huang, C-J, Griesser, H & Thierry, B 2013, 'Tuneable and robust long range surface plasmon resonance for biosensing applications', Optical Materials, vol. 35, no. 12, pp. 2507-2513. 23 20
2012	Beattie, DA, Beaussart, A, Mierczynska-Vasilev, A, Harmer-Bassell, SL, Thierry, B, Puskar, L & Tobin, M 2012, 'Synchrotron FTIR microscopy of Langmuir-Blodgett monolayers and polyelectrolyte multilayers at the solid-solid interface', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 28, no. 3, pp. 1683-1688. 11 8 2
2012	Fong, W-K, Hanley, TL, Thierry, B, Kirby, N, Waddington, L & Boyd, B 2012, 'Controlling the nanostructure of gold nanorod-lyotropic liquid-crystalline hybrid materials using near-infrared laser irradiation', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 28, no. 40, pp. 14450-14460. 36 34
2012	Liu, TM & Thierry, B 2012, 'A solution to the PEG dilemma: efficient bioconjugation of large gold nanoparticles for biodiagnostic applications using mixed layers', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 28, no. 44, pp. 15634-15642. 35 35
2012	Thierry, B & Griesser, HJ 2012, 'Dense PEG layers for efficient immunotargeting of nanoparticles to cancer cells', Journal of Materials Chemistry, vol. 22, no. 18, pp. 8810-8819. 25 23
2011	Garvey, M, Griesser, S, Griesser, HJ, Thierry, B, Nussio, M, Shapter, J, Ecroyd, H, Giorgetti, S, Bellotti, V, Gerrard, JA & Carver, J 2011, 'Enhanced molecular chaperone activity of the small heat-shock protein aB-crystallin following covalent immobilization onto a solid-phase support', Biopolymers, vol. 95, no. 6, pp. 376-389. 8 8
2011	Kurkuri, MD, Al-Ejeh, F, Shi, JY, Palms, D, Prestidge, C, Griesser, HJ, Brown, MP & Thierry, B 2011, 'Plasma functionalized PDMS microfluidic chips : towards point-of-care capture of circulating tumor cells', Journal of Materials Chemistry, vol. 21, no. 24, pp. 8841-8848. 26 24 9
2010	Fong, W-K, Hanley, TL, Thierry, B, Kirby, N & Boyd, BJ 2010, 'Plasmonic Nanorods Provide Reversible Control over Nanostructure of Self-Assembled Drug Delivery Materials', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 26, no. 9, pp. 6136-6139. 64 61
2010	Losic, D, Yu, Y, Simovic, S, Thierry, B & Addai-Mensah, J 2010, 'Surface functionalisation of diatoms with dopamine modified iron-oxide nanoparticles: toward magnetically guided drug microcarriers with biologically derived morphologies', Chemical Communications, vol. 46, no. 34, pp. 6323-6325. 120 112
2010	Thierry, B, Kurkuri, M, Shi, JY, Lwin, EMPL & Palms, D 2010, 'Herceptin functionalized microfluidic polydimethylsiloxane devices for the capture of human epidermal growth factor receptor 2 positive circulating breast cancer cells', Biomicrofluidics, vol. 4, article no. 032205, pp. 1-10. Open access 26 25
2010	Truong, MY, Dutta, NK, Choudhury, NR, Kim, M, Elvin, C, Hill, A, Thierry, B & Vasilev, KA 2010, 'A pH-responsive interface derived from resilin-mimetic protein Rec1-Resilin', Biomaterials, vol. 31, no. 15, pp. 4434-4446. 38 36
2010	Vreuls, C, Zocchi, G, Thierry, B, Garitte, G, Griesser, SS, Archambeau, C, Van, dWC, Martial, J & Griesser, H 2010, 'Prevention of bacterial biofilms by covalent immobilization of peptides onto plasma polymer functionalized substrates', Journal of Materials Chemistry, vol. 20, no. 37, pp. 8092-8098. 37 33
2009	Al-Ejeh, F, Darby, JM, Thierry, B & Brown, MP 2009, 'A simplified suite of methods to evaluate chelator conjugation of antibodies : effects on hydrodynamic radius and biodistribution', Nuclear Medicine and Biology, vol. 36, no. 4, pp. 395-402. 20 18
2009	Thierry, B 2009, 'Drug Nanocarriers and Functional Nanoparticles: Applications in Cancer Therapy', Current Drug Delivery, vol. 6, no. 4, pp. 391-403. 56
2009	Thierry, B, Al-Ejeh, F, Brown, MP, Majewski, PJ & Griesser, HJ 2009, 'Immunotargeting of functional nanoparticles for MRI detection of apoptotic tumor cells', Advanced Materials, vol. 21, pp. 541-545. 27 24
2009	Thierry, B, Al-Ejeh, F, Khatri, A, Yuan, Z, Russell, PJ, Ping, S, Brown, MP & Majewski, P 2009, 'Multifunctional core-shell magnetic cisplatin nanocarriers', Chemical Communications, vol. 2009, no. 47, pp. 7348-7350. 24 25
2009	Thierry, B, Ng, J, Krieg, T & Griesser, HJ 2009, 'A robust procedure for the functionalization of gold nanorods and noble metal nanoparticles', Chemical Communications, vol. 13, pp. 1724-1726. 84 84
2008	Majewski, PJ & Thierry, B 2008, 'Superparamagnetic Magnetite Nanoparticles for Bio-applications', Recent Patents on Materials Science, vol. 1, no. 2, pp. 116-127.
2008	Pan, W, W, M, Stretch, J, Thierry, B, Ashton, M & Corlett, R 2008, 'Advanced Imaging Technologies for Mapping Cadaveric Lymphatic Anatomy: Magnetic Resonance and Computed Tomography Lymphangiography', Lymphology, vol. 41, no. 3, pp. 126-130. 3 2
2008	Thierry, B, Jasieniak, M, de Smet, LCPM, Vasilev, KA & Griesser, HJ 2008, 'Reactive epoxy-functionalized thin films by a pulsed plasma polymerization process', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 18, pp. 10187-10195. 64 64
2008	Thierry, B, McNiven, S, Finnie, K, Barbe, C & Griesser, HJ 2008, 'Electrostatic Self-Assembly of PEG Copolymers onto Porous Silica Nanoparticles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 15, pp. 8143-8150. 69 67
2008	Thierry, B, Winnik, F, Merhi, Y, Griesser, HJ & Tabrizian, M 2008, 'Biomimetic Hemocompatible Coatings through Immobilization of Hyaluronan Derivatives on Metal Surfaces', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 24, no. 20, pp. 11834-11841. 30 28

Conferences

Year	Output
2015	Cousins, A, Howard, D, Henning, AM, Nelson, MR, Tilley, RD & Thierry, B 2015, 'Application of novel iron core/iron oxide shell nanoparticles to sentinel lymph node identification', SPIE Conference on Micro+Nano Materials, Devices, and Systems, SPIE, vol. 9668, article no. 96685Q, pp. 1-6. Open access
2015	Pocock, KJ, Gao, X, Wang, C, Priest, C, Prestidge, C, Mawatari, K, Kitamori, T & Thierry, B 2015, 'Low-temperature bonded glass-membrane microfluidic device for in vitro organ-on-a-chip cell culture models', SPIE Micro+nano materials, devices, and applications symposium, SPIE - The International Society for Optical Engineering, vol. 9668, article no. 96690W, pp. 1-8. 1
2015	Yang, C-T & Thierry, B 2015, 'Comparison of sensor structures for the signal amplification of surface plasmon resonance immunoassay using enzyme precipitation', SPIE Micro+Nano Materials, Devices, and Applications 2015 Conference, SPIE, vol. 9668, article no. 96682J, pp. 1-7. 2 2
2013	Duy Tran, Wolfrum, B, Stockmann, R, Offenhausser, A & Thierry, B 2013, 'Wafer-scale fabrication of ultra-thin silicon nanowire devices', 2013 13th IEEE International Conference on Nanotechnology (IEEE-NANO 2013), IEEE, pp. 405-409. 2 2

Research

Current research & highlights

Current research areas:

“Intestine-on-a-chip” technology: With the support of the ARC, a microfluidic model of the intestinal epithelium has been designed to mimic the characteristic features relevant to the uptake and transport of drugs and particulate carriers.
"Tumour-on-a-chip models": Our research aims to bridge the gap between simplistic in vitro and irrelevant in vivo tumour models towards providing a novel way to observe not only the growth of solid tumours but also their response to treatments. This research is supported by the ARC Centre of Excellence in Convergent Bio Nano Science.
"Molecular Imaging": At the convergence of nanoscience and molecular biology, our research aims at developing new molecular imaging tracers and to elucidate their behaviour within biological and/or pathological tissues.
"Isolation and molecular characterization of circulating tumour cells": We are applying cutting edge microfluidic technologies for the isolation and phenotypical analyses of CTCs, with a focus on metastatic colorectal and prostate cancer.
"Solid-state biosensing technologies": We are conducting research aimed at developing translational sensing platforms with a focus on improving cancer prognostic. These developments are based on improved understanding of the physical mechanisms underpinning solid-state biosensors and are focused on Field Effect Transistor and plasmonic sensing platforms.
"Intraoperative cancer staging": With the support of BioSA and Powerhouse Ventures Ferronova ltd pty has been recently spun off to develop and commercialize our cancer staging technology.
"Prenatal diagnostics": We are actively collaborating with clinicians and industry partners to develop the next generation of prenatal diagnostic technology.

Research

Patents

Details	Registry	Status
Sensor for detection of magnetic particles Cousins, Aidan Mark Francis; Thierry, Benjamin; Wedding, A Bruce; Forero Morales, Daniel	WO	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Academia Sinica	TAIWAN
Adelaide Pathology Partners	AUSTRALIA
Agency for Science, Technology and Research (A*STAR)	SINGAPORE
Australian National Fabrication Facility Limited	AUSTRALIA
Australian Nuclear Science and Technology Organisation	AUSTRALIA
Australian Nuclear Science Technology Organisation	AUSTRALIA
Australian Synchrotron Company Ltd	AUSTRALIA
Austrian Institute of Technology	SWITZERLAND
Bionomics Ltd.	AUSTRALIA
Boutiq Science Ltd	NEW ZEALAND
Ceramisphere	AUSTRALIA
CeramiSphere Pty Ltd	AUSTRALIA
Children's Cancer Institute Australia	AUSTRALIA
Chinese Academy of Sciences	CHINA
CSIRO Australia (Commonwealth Scientific Industrial Research Organisation)	AUSTRALIA
Curtin University	AUSTRALIA
Dana-Farber Cancer Institute	UNITED STATES
ETH Zürich	SWITZERLAND
Flinders University	AUSTRALIA
Forschungszentrum Jülich	GERMANY
Hanson Institute	AUSTRALIA
Harbin Institute of Technology	CHINA
High Performance Computing	SINGAPORE
Imperial College of Science, Technology and Medicine	UNITED KINGDOM
Institute of Medical and Veterinary Science	AUSTRALIA
Laboratoire de Biologie Moleculaire et de Genie genetique	BELGIUM
Marinova Pty Ltd	AUSTRALIA
McGill University	CANADA
Memorial Sloan Kettering Cancer Centre	UNITED STATES
Minomic Pty Ltd	AUSTRALIA
Monash IVF Group	AUSTRALIA
Monash University	AUSTRALIA
Montreal Heart Institute	CANADA
Murdoch University	AUSTRALIA
Nanjing Agricultural University	CHINA
Nanjing Forestry University	CHINA
Nanjing Medical University	CHINA
Nanyang Technological University	SINGAPORE
Peter Grunberg Institute (PGI)	GERMANY
Prince of Wales Hospital	AUSTRALIA
Private Individual	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Queensland University of Technology	AUSTRALIA
Repromed	AUSTRALIA
RMIT University	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Adelaide Hospital Cancer Centre	AUSTRALIA
SA Pathology	AUSTRALIA
SA Water Corporation	AUSTRALIA
Sechenov First Moscow State Medical University	RUSSIAN FEDERATION
Shanghai Jiao Tong University	CHINA
Soochow Uiniversity	CHINA
Southeast University	CHINA
Southern Medical University	CHINA
St George Hospital	AUSTRALIA
Stanford University	UNITED STATES
Sung Kyun Kwan University	KOREA, REPUBLIC OF (SOUTH)
Tabriz University of Medical Sciences	IRAN
Technical University Munich	GERMANY
Universita degli Studi di Pavia (AKA Institute for Advanced Study of Pavia)	ITALY
University College Dublin	IRELAND
University of Adelaide	AUSTRALIA
University of California, Berkeley	UNITED STATES
University of Canterbury	NEW ZEALAND
University of Edinburgh	UNITED KINGDOM
University of Helsinki	FINLAND
University of Melbourne	AUSTRALIA
University of Montreal	CANADA
University of New South Wales	AUSTRALIA
University of Nottingham	UNITED KINGDOM
University of Oulu	FINLAND
University of Pavia	ITALY
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Technology Sydney	AUSTRALIA
University of Tokyo	JAPAN
University of Toronto	CANADA
University of Warwick	UNITED KINGDOM
University of Wisconsin-Madison	UNITED STATES
WARTN	AUSTRALIA
Women's and Children's Hospital	AUSTRALIA
Yangzhou University	CHINA

External engagement & recognition

Engagement/recognition	Year
Editorial Board Member Scientific Reports (Nature Publishing Group)	2018
Panel member, Early Career Fellowship Scheme National Health and Medical Research Council (NHMRC)	2015
Career Development Fellowship National Health and Medical Research Council (NHMRC)	2014
Expert panel member, Program Grant Scheme National Health and Medical Research Council (NHMRC)	2014
Best paper award, Wafer-Scale Fabrication of Ultra-Thin Silicon Nanowire Devices 13th IEEE International Conference on Nanotechnology, Beijing	2013
Panel member, Project Grants Peer Review Process National Health and Medical Research Council (NHMRC)	2012
Career Development Fellowship National Health and Medical Research Council (NHMRC)	2010

Teaching & student supervision

Highlights

Prof Thierry is the head of the BioEngineering group at the UniSA Future Industries Institute. The group is hosted in the state-of-the-art MM building and is a dynamic multidisciplinary team with expertise in physics, nanoscience, pharmaceutical science, molecular biology and biomedical engineering. Prof Thierry has a strong network of collaborators and students and ECRs in his group directly benefit from these links which have resulted in long term scientific visits (over 8 weeks and up to 1 year stay) in prestigious international research institutions such as the University of Stanford, the University of Tokyo, the Beijing CAS Centre for Nanoscience and Technology, the Forschungszentrum Juelich, Harvard University Dana-Farber Cancer Institute and McGill University. Several current and dpapst members of the group have received prestigiouss awards, inluding a 2019 Tall Poppy award (Dr. Marnie Winter), a Women in Technology Rising Star Award (Dr Michelle Liu) and a finalist award in the 2018 Prime Minister’s Prizes for Science (Dr Aidan Cousins).

Prof Thierry served as the Program Coordinator of the UniSA NanoBioMaterials Honours degree from 2010 to 2017. He is also teaching in various undergraduate and postgraduate programs, including Monash University and SouthEast University (Nanjing, China).

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
Cation exchange reaction in colloidal nanocrystals: a versatile approach towards improved cancer imaging and radiotherapy	Current
Characterizing the role of intestinal M cells in the transport of nanoparticles in an advanced microfluidic model of the small intestinal follicle-associated epithelium	Current
Development of a lab-on-chip technology for single cell whole genome amplification	Current
Development of a wearable electrocardiogram nanosensor for screening hypertensive pregnancy complications	Current
Development of nanomedicines for the radiosensitization of proton beam therapy	Current
Development of targeted nanocarriers for oral vaccination and or delivery of biologics	Current
Functional antigen carrier particles for oral vaccination	Current
In vivo manufacturing of CAR-T cells using targeted non-viral nanocarriers	Current
Microfluidic intestine-on-a-chip in vitro models for improved understanding of intestinal particulate carrier absorption and interaction with mucus	Current
Microfluidic manufacturing of Chimeric Anitgen Receptor T cells	Current
Next generation bioengineered in vitro tumour models	Current
The role of metal nanoparticles and the metal core/metal oxinde shell structure when utilised as radiosensitisers in X-ray radiation therapy	Current
Understanding and targeting preeclampsia molecular mechanisms for improved pregnancy outcomes.	Current
Amplification of surface plasmon resonance biomolecular binding events: towards improved biosensing based cancer prognostics	Completed
Bioengineered vascularized microfluidic model: towards improved cancer therapy risk reduction and in vitro evaluation of the metastatic process	Completed
Detection and characterisation of rare disseminated cancer cells; towards improved patient prognostication	Completed
Development of a solid-state biodiagnostic platform based on indium oxide nanoribbon field effect transistors	Completed
Formation and characterisation of fucoidan-based polyelectrolyte multilayers for applications in biomaterials	Completed
Improving nitric oxide delivery to staphylococcus aureus biofilms	Completed
Isolation and analysis of circulating fetal cells: towards improved non-invasive prenatal diagnosis of genetic disorders	Completed
Long-range surface plasmon resonance biosensing structures for mammalian-cell studies	Completed
Microfluidic intestine-on-a-chip in vitro models for improved mechanistic understanding of intestinal drug and particulate carrier uptake	Completed
Novel fabrication and operation of integrated silicon nanowire field effect biosensors for reliable detection of cancer prognostic biomarkers	Completed
Novel handheld magnetometer probe for improved intraoperative detection of sentinel lymph nodes in cancer patients	Completed
Radiosensitization of cell sub-populations by gold nanoparticles: cross-correlative microscopy for elucidating fundamental mechanisms	Completed
Transport of immuno-targeted nanoparticles in 3D tumor spheroids and in vivo models	Completed

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Professor Benjamin Thierry

Alternative contact

Alternative contact details

About me

About me

Future Industries Institute

About me

Professional Associations

Experience

Qualifications

Research

Research themes

Research focus

Highlights

Projects

Outputs

Highlights

Chapters

Journal Articles

Conferences

Current research & highlights

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Editorial Board Member

Panel member, Early Career Fellowship Scheme

Career Development Fellowship

Expert panel member, Program Grant Scheme

Best paper award, Wafer-Scale Fabrication of Ultra-Thin Silicon Nanowire Devices

Panel member, Project Grants Peer Review Process

Career Development Fellowship

Teaching & student supervision

Highlights

Courses and programs

Courses I teach and/or co-ordinate

Research degree supervision

Gallery