Dr Christopher Hahn

Adjunct Associate Professor Centre for Cancer Biology

email Christopher.Hahn@unisa.edu.au

Research Degree Supervisor

Research

Highlights

Germline mutations in familial haematopoietic malignancies identifies new pan-cancer predisposition genes and may alter clinical decision making, including for known cancer genes. NHMRC, Project Grant.

https://www.youtube.com/watch?v=Ep8_eA2meM0&feature=youtu.be

Biological characterisation and therapeutic options for high risk, DDX41 mutated, haematological malignancies. Beat Cancer Research Project Grant.

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2018	Chong, C-E, Venugopal, P, Stokes, P, Lee, Y, Brautigan, P, Yeung, D, Babic, M, Engler, G, Lane, S, Klingler-Hoffmann, M, Matthews, J, D'Andrea, R, Brown, A, Hahn, C & Scott, H 2018, 'Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes', Leukemia, vol. 32, no. 1, pp. 194-202. Open access 42 39 4
2017	Cheah, JJ, Hahn, CN, Hiwase, DK, Scott, HS & Brown, AL 2017, 'Myeloid neoplasms with germline DDX41 mutation', International Journal of Hematology, vol. 106, no. 2, pp. 163-174. 63 56 2
2017	Venugopal, P, Moore, S, Lawrence, DM, George, AJ, Hannan, RD, Bray, SC, To, LB, D'Andrea, RJ, Feng, J, Tirimacco, A, Yeoman, AL, Young, CC, Fine, M, Schreiber, AW, Hahn, CN, Barnett, C, Saxon, B & Scott, HS 2017, 'Self-reverting mutations partially correct the blood phenotype in a diamond blackfan anemia patient', Haematologica: The Hematology Journal, vol. 102, pp. 506-509. Open access 20 19 15
2015	Hahn, C, Brautigan, P, Chong, C-E, Janssan, A, Venugopal, P, Lee, Y, Tims, A, Horwitz, M, Klingler-Hoffmann, M & Scott, H 2015, 'Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia', Leukemia, vol.29, no.8, pp. 1795-1797. 9 9

Journal Articles

Year	Output
2023	Flerlage, JE, Myers, JR, Maciaszek, JL, Oak, N, Hahn, CN, Brown, AL, Scott, HS & Rampersaud, E and 21 other authors 2023, 'Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma', Blood, vol. 141, no. 11, pp. 1293-1307. 3 2
2023	Hiwase, D, Hahn, C, Tran, ENH, Chhetri, R, Wang, P, Kumar, S, Brown, A, Scott, H, Kok, CH & Shah, MV and 41 other authors 2023, 'TP53 mutation in therapy-related myeloid neoplasm defines a distinct molecular subtype', Blood, vol. 141, no. 9, pp. 1087-1091. Open access 6 1 1
2023	Samaraweera, SE, Geukens, T, Casolari, DA, Nguyen, T, Sun, C, Bailey, S, Moore, S, Feng, J, Schreiber, AW, Parker, WT, Brown, AL, Butcher, C, Bardy, PG, Osborn, M, Scott, HS, Talaulikar, D, Grove, CS, Hahn, CN, D'Andrea, RJ & Ross, DM 2023, 'Novel modes of MPL activation in triple-negative myeloproliferative neoplasms', Pathology, vol. 55, no. 1, pp. 77-85. 1
2023	Shah, MV, Tran, ENH, Shah, S, Chhetri, R, Brown, AL, Scott, HS, Kumar, S, Hahn, CN, Kok, CH & Hiwase, DK and 12 other authors 2023, 'TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms', Blood Cancer Journal, vol. 13, no. 1, article no. 51, pp. 1-9. Open access 1
2023	Zerella, JR, Homan, CC, Arts, P, Brown, AL, Scott, HS & Hahn, CN 2023, 'Transcription factor genetics and biology in predisposition to bone marrow failure and hematological malignancy', Frontiers in Oncology, vol. 13, article no. 1183318. Open access
2022	Baranwal, A, Hahn, CN, Shah, MV & Hiwase, DK 2022, 'Role of germline predisposition to therapy-related myeloid neoplasms', Current Hematologic Malignancy Reports, vol. 17, no. 6, pp. 254-265. 4 3
2022	Byrne, AB, Brouillard, P, Sutton, DL, Kazenwadel, J, Montazaribarforoush, S, Secker, GA, Oszmiana, A, Babic, M, Betterman, KL, Brautigan, PJ, Hahn, CN, Arts, P, Scott, HS & Harvey, NL and 18 other authors 2022, 'Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema', Science Translational Medicine, vol. 14, no. 634, article no. eabm4869, pp. 1-14. 7 7 191
2022	Drazer, MW, Homan, CC, Yu, K, de Andrade Silva, M, Feng, J, King-Smith, SL, Lawrence, DM, Schreiber, AW, Hahn, CN, Scott, HS, Brown, AL & Godley, LA and 10 other authors & 1 consortia 2022, 'Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.', Blood Advances, vol. 6, no. 15, pp. 4357-4359. Open access 4 3 1
2022	Feurstein, S, Hahn, CN, Mehta, N & Godley, LA 2022, 'A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias', Genetics in Medicine, vol. 25, no. 4, pp. 931-954. Open access 3 7
2021	Homan, CC, Venugopal, P, Arts, P, Shahrin, NH, Feurstein, S, Rawlings, L, Lawrence, DM, Andrews, J, King-Smith, SL, Harvey, NL, Brown, AL, Scott, HS & Hahn, CN 2021, 'GATA2 deficiency syndrome: a decade of discovery', Human Mutation, vol. 42, no. 11, pp. 1399-1421. Open access 11 10 11
2021	Samaraweera, SE, Wang, PP, Li, KL, Casolari, DA, Feng, J, Maung, KZY, Scott, HS, Schreiber, AW, Brown, AL, Ross, DM, Gonda, TJ, Hahn, CN & D'Andrea, RJ and 13 other authors 2021, 'Childhood acute myeloid leukemia shows a high level of germline predisposition', Blood, vol. 138, no. 22, pp. 2293-2298. 4 5 43
2021	Singhal, D, Hahn, CN, Feurstein, S, Wee, LYA, Eshraghi, L, Schreiber, AW, Feng, J, Brown, AL, D'Andrea, RJ, Scott, HS & Hiwase, DK and 14 other authors 2021, 'Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer', Leukemia, vol. 35, pp. 3245-3256. 28 25 12
2020	Brown, AL, Arts, P, Babic, M, Dobbins, J, Feng, J, Ha, T, Homan, CC, King-Smith, SL, Li, X-C, Brautigan, P, Butcher, C, D'Andrea, RJ, Hahn, CN & Scott, HS and 46 other authors 2020, 'RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML', Blood Advances, vol. 4, no. 6, pp. pp. 1131-1144. Open access 67 61 6
2020	Brown, AL, Hahn, C, Hiwase, D, Godley, LA & Scott, HS 2020, 'Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis', Leukemia and Lymphoma, vol. 61, no. 1, pp. 246-247. 2 2 5
2020	Brown, AL, Hahn, CN & Scott, HS 2020, 'Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA)', Blood, vol. 136, pp. 24-35. Open access 48 47 3
2020	Fox, LC, Tan, M, Brown, AL, Arts, P, Thompson, E, Ryland, GL, Lickiss, J, Scott, HS, Poplawski, NK, Phillips, K, Came, NA, James, P, Ting, SB, Ritchie, DS, Szer, J, Hahn, CN, Schwarer, A & Blombery, P 2020, 'A synonymous GATA2 variant underlying familial myeloid malignancy with striking intrafamilial phenotypic variability', British Journal of Haematology, vol. 190, no. 5, pp. 297-301. Open access 12 12
2020	Venugopal, P, Gagliardi, L, Forsyth, C, Feng, J, Phillips, K, Babic, M, Poplawski, NK, Rienhoff, HY, Schreiber, AW, Hahn, CN, Brown, AL & Scott, HS 2020, 'Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss', BMC Medical Genetics, vol. 21, no. 1, article no. 35, pp. 1-5. Open access 2 2 1
2019	Byrne, AB, Arts, P, Polyak, SW, Feng, J, Schreiber, A, Kassahn, KS, Hahn, CN, Mordaunt, DA, Fletcher, JM, Lipsett, J, Bratkovic, D, Booker, GW, Smith, NJ & Scott, HS 2019, 'Identification and targeted management of a neurodegenerative disorder caused by biallelic mutations in SLC5A6', npj Genomic Medicine, vol. 4, no. 1, article number 28, pp. 1-8. Open access 13 9 56
2019	Cheah, JJ, Brown, AL, Schreiber, AW, Feng, J, Babic, M, Moore, S, Young, C-C, Fine, M, Phillips, K, Guandalini, M, Wilson, P, Poplawski, N, Hahn, CN & Scott, HS 2019, 'A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia', Haematologica: The Hematology Journal, vol. 104, no. 7, pp. e318-e321. Open access 13 12 1
2019	Iacobucci, I, Wen, J, Meggendorfer, M, Choi, JK, Lewis, ID, D'Andrea, RJ, Brown, AL, Scott, HS, Hahn, CN & Mullighan, CG 2019, 'Genomic subtyping and therapeutic targeting of acute erythroleukemia', Nature Genetics, vol. 51, no. 4, pp. 694-704. Open access 86 79 87
2018	Al Seraihi, AF, Rio-Machin, A, Tawana, K, Bödör, C, Scott, H, Hahn, C & Fitzgibbon, J and 18 other authors 2018, 'GATA2 monoallelic expression underlies reduced penetrance in inherited GATA2-mutated MDS/AML', Leukemia, vol. 32, no. 11, pp. 2502-2507. Open access 38 38 3
2018	Beck, D, Thoms, J, Palu, C, Herold, T, Brown, A, Babic, M, Hahn, C, Perugini, M, Scott, H, Lewis, I, D'Andrea, R & Pimanda, J 2018, 'A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients', Leukemia, vol. 32, no. 2, pp. 263-272. Open access 31 27 2
2018	Branford, S, Wang, P, Yeung, DT, Thomson, D, Wadham, C, Shahrin, NH, Marum, JE, Nataren, N, Parker, WT, Shanmuganathan, N, Donaldson, Z, Altamura, H, Georgievski, J, Brown, A, Hahn, C, White, DL, Scott, HS, Schreiber, AW & Hughes, TP and 18 other authors 2018, 'Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease', Blood, vol. 132, no. 9, pp. 948-961. Open access 118 110 9
2018	Chong, C-E, Venugopal, P, Stokes, P, Lee, Y, Brautigan, P, Yeung, D, Babic, M, Engler, G, Lane, S, Klingler-Hoffmann, M, Matthews, J, D'Andrea, R, Brown, A, Hahn, C & Scott, H 2018, 'Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes', Leukemia, vol. 32, no. 1, pp. 194-202. Open access 42 39 4
2017	Casolari, D, Nguyen, T, Butcher, C, Iarossi, D, Hahn, C, Bray, S, Neufing, P, Parker, W, Feng, J, Maung, K, Wee, A, Vidovic, L, Kok, C, Bardy, P, Branford, S, Lewis, I, Lane, S, Scott, H, Ross, D & D'Andrea, R 2017, 'A novel, somatic, transforming mutation in the extracellular domain of epidermal growth factor receptor identified in myeloproliferative neoplasm', Scientific Reports, vol. 7, article no. 2467, pp. 1-9. Open access 5 5 3
2017	Cheah, JJ, Hahn, CN, Hiwase, DK, Scott, HS & Brown, AL 2017, 'Myeloid neoplasms with germline DDX41 mutation', International Journal of Hematology, vol. 106, no. 2, pp. 163-174. 63 56 2
2017	De Sousa, S, Stowasser, M, Feng, J, Schreiber, A, Wang, P, Hahn, C, Gordon, R, Torpy, D, Scott, H & Gagliardi, L 2017, 'ARMC5 is not implicated in familial hyperaldosteronism type II (FH-II)', Journal of Human Hypertension, vol. 31, no. 12, pp. 857-859. 3 2 1
2017	Pagani, IS, Kok, CH, Saunders, VA, Van der Hoek, MB, Heatley, SL, Schwarer, AP, Hahn, CN, Hughes, TP, White, DL & Ross, DM 2017, 'A method for next-generation sequencing of paired diagnostic and remission samples to detect mitochondrial DNA mutations associated with leukemia', Journal of Molecular Diagnostics, vol. 19, no. 5, pp. 711-721. Open access 6 5 3
2017	Venugopal, P, Moore, S, Lawrence, DM, George, AJ, Hannan, RD, Bray, SC, To, LB, D'Andrea, RJ, Feng, J, Tirimacco, A, Yeoman, AL, Young, CC, Fine, M, Schreiber, AW, Hahn, CN, Barnett, C, Saxon, B & Scott, HS 2017, 'Self-reverting mutations partially correct the blood phenotype in a diamond blackfan anemia patient', Haematologica: The Hematology Journal, vol. 102, pp. 506-509. Open access 20 19 15
2016	Oftedal, BE, Ardesjö, BL, Hamm, D, Gan, P-Y, Holdsworth, SR, Hahn, CN, Schreiber, AW & Scott, HS 2016, 'T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ', Journal of Autoimmunity, vol. 81, pp. 24-33. Open access 5 4 1
2015	Hahn, C, Brautigan, P, Chong, C-E, Janssan, A, Venugopal, P, Lee, Y, Tims, A, Horwitz, M, Klingler-Hoffmann, M & Scott, H 2015, 'Characterisation of a compound in-cis GATA2 germline mutation in a pedigree presenting with myelodysplastic syndrome/acute myeloid leukemia with concurrent thrombocytopenia', Leukemia, vol.29, no.8, pp. 1795-1797. 9 9
2014	Gagliardi, L, Schreiber, AW, Hahn, CN, Feng, J, Cranston, T, Boon, H, Hotu, C, Oftedal, BE, Cutfield, R, Adelson, DL, Braund, WJ, Gordon, RD, Rees, DA, Grossman, AB, Torpy, DJ & Scott, HS 2014, 'ARMC5 mutations are common in familial bilateral macronodular adrenal hyperplasia', Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 9, pp. 1784-1792. Open access 89 75
2012	Hahn, CN & Scott, HS 2012, 'Spliceosome mutations in hematopoietic malignancies', Nature Genetics, vol. 44, no. 1, pp. 9-10. 52 45

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Adaptive Biotechnologies	UNITED STATES
Auckland District Health Board	NEW ZEALAND
Australian National University	AUSTRALIA
Box Hill Hospital	AUSTRALIA
Canberra Hospital	AUSTRALIA
Cardiff University	UNITED KINGDOM
de Duve Institute	BELGIUM
Eastern Health	AUSTRALIA
Federal University of Alagoas	BRAZIL
Flinders Medical Centre	AUSTRALIA
Flinders University	AUSTRALIA
Imago Biosciences	UNITED STATES
Jarrett St Specialist Centre	AUSTRALIA
Lady Cilento Children's Hospital	AUSTRALIA
Mayo Clinic	UNITED STATES
Memorial Sloan-Kettering Cancer Center	UNITED STATES
MLL Münchner Leukämielabor GmbH	GERMANY
Monash University	AUSTRALIA
National Institutes of Health	UNITED STATES
Peter MacCallum Cancer Centre	AUSTRALIA
Queen Elizabeth Hospital	AUSTRALIA
Queen Mary University of London	UNITED KINGDOM
Queensland Institute of Medical Research	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Royal Melbourne Hospital	AUSTRALIA
SA Pathology	AUSTRALIA
Semmelweis University	HUNGARY
Sir Charles Gardiner Hospital	AUSTRALIA
South Australian Health and Medical Research Institute (SAHMRI)	AUSTRALIA
St Jude Children's Research Hospital	UNITED STATES
St. Jude Children's Research Hospital	UNITED STATES
University of Adelaide	AUSTRALIA
University of Bergen	NORWAY
University of Chicago	UNITED STATES
University of Melbourne	AUSTRALIA
University of Munich	GERMANY
University of New South Wales	AUSTRALIA
University of Oxford	UNITED KINGDOM
University of Queensland	AUSTRALIA
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Washington	UNITED STATES
Uppsala University	SWEDEN
Waitemata District Health Board	NEW ZEALAND
Women's and Children's Hospital	AUSTRALIA

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
109455 - Examining the impact of environmental stressors and mutant microenvironment on disease development in models of inherited predisposition to haematological malignancies	Current

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Dr Christopher Hahn

About me

About me

Centre for Cancer Biology

About me

Professional Associations

Research

Highlights

Projects

Outputs

Highlights

Journal Articles

Current research & highlights

External engagement & recognition

Collaborations

Collaborations

Teaching & student supervision

Courses and programs

Research degree supervision

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