Professor David Lloyd

Vice Chancellor & President Chancellery and Council Services

City West Campus (H4-26)
tel +61 8 830 20502

email David.Lloyd@unisa.edu.au

Alternative contact

Available for media comment

About me

University of Enterprise

Professor David Lloyd is Vice Chancellor and President of the University of South Australia.

A Dublin-born and educated chemist, who specialises in computer-aided drug design, Professor Lloyd has re-focused institutional culture to position UniSA as Australia's university of enterprise and to shape its activities to better meet the challenges of the 21st century.

A past Chair of the Australian Technology Network group of technology-focused universities, he is now Chair of Universities Australia (UA), the peak body representing the university sector, having previously served as UA's lead Vice-Chancellor: Indigenous and lead Vice-Chancellor Research and Innovation. He was previously appointed to the Australian Research Council's... Read more

UniSA Chancellery and Council Services

Home to the senior executive and facilitating communication between senior management, governing bodies and the University.

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Research

Research focus

Medicinal and Biomolecular Chemistry
Biochemistry and Cell Biology
Pharmacology and Pharmaceutical Sciences
Theoretical and Computational Chemistry
Physical Chemistry (Incl. Structural)

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Journal Articles

Year	Output
2020	Carr, M, Knox, AJ, Nevin, DK, O'Boyle, N, Wang, S, Egan, B, McCabe, T, Twamley, B, Zisterer, DM, Lloyd, DG & Meegan, MJ 2020, 'Optimisation of estrogen receptor subtype-selectivity of a 4-Aryl-4H-chromene scaffold previously identified by virtual screening', Bioorganic and Medicinal Chemistry, vol. 28, no. 5, article no. 115261, pp. 1-16. 9 8 3
2016	Carr, M, Knox, AJ, Lloyd, DG, Zisterer, DM & Meegan, MJ 2016, 'Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. sup3 , pp. 117-130. Open access 7 6
2016	Keely, NO, Carr, M, Yassin, B, Ana, G, Lloyd, DG, Zisterer, D & Meegan, MJ 2016, 'Design, synthesis and biochemical evaluation of novel selective estrogen receptor ligand conjugates incorporating an endoxifen-combretastatin hybrid scaffold', Biomedicines, vol. 4, article no. 15, pp. 1-34. Open access 16 8
2014	Blanco, F, Lloyd, DG, Alkorta, I & Elguero, J 2014, 'Neutral alkaline-metal and alkaline-earth-metal derivatives of imidazole and benzimidazole', The Journal of Physical Chemistry A: Isolated Molecules, Clusters, Radicals, and Ions; Environmental Chemistry, Geochemistry, and Astrochemistry; Theory, vol. 118, no. 23, pp. 4195-4204. 7 6
2014	Caboni, L, Gálvez-Llompart, M, Gálvez, J, Blanco, F, Rubio-Martinez, J, Fayne, D & Lloyd, DG 2014, 'Molecular topology applied to the discovery of 1-benzyl-2-(3-fluorophenyl)-4-hydroxy-3-(3-phenylpropanoyl)-2H-pyrrole-5-one as a non-ligand-binding-pocket antiandrogen', Journal of Chemical Information and Modeling, vol. 54, no. 10, pp. 2953-2966. 11 9
2014	Diez-Cecilia, E, Kelly, B, Perez, c, Zisterer, DM, Nevin, DK, Lloyd, DG & Rozas, I 2014, 'Guanidinium-based derivatives : searching for new kinase inhibitors', European Journal of Medicinal Chemistry, vol. 81, pp. 427-441. Open access 23 22
2014	Kesel, AJ, Huang, Z, Murray, MG, Prichard, MN, Caboni, L, Nevin, DK, Fayne, D, Lloyd, DG, Detorio, MA & Schinazi, RF 2014, 'Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire', Antiviral Chemistry and Chemotherapy, vol. 23, pp. 197-215. Open access 15
2014	Mawhinney, L, Armstrong, ME, O'Reilly, C, Bucala, R, Leng, L, Fingerle-Rowson, G, Fayne, D, Keane, MP, Tynan, A, Maher, L, Cooke, G, Lloyd, D, Conroy, H & Donnelly, SC 2014, 'Macrophage migration inhibitory factor (MIF) enzymatic activity and lung cancer', Molecular Medicine, vol. 20, no. 1, pp. 729-735. Open access 56 61
2013	Blanco, F, Lloyd, DG, Azofra, L, Alkorta, I & Elguero, J 2013, 'Theoretical studies of parent 1- ,2- , 3-pyrazolines and their methylated derivatives', Structural Chemistry: Computational and Experimental Studies of Chemical and Biological Systems, vol. 24, no. 2, pp. 421-432. 16 15
2013	Caboni, L & Lloyd, DG 2013, 'Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors', Medicinal Research Reviews, vol. 33, no. 5, pp. 1081-1118. 56 52
2013	Caboni, L, Egan, B, Kelly, B, Blanco, F, Fayne, D, Meegan, MJ & Lloyd, DG 2013, 'Structure-activity relationships in non-ligand binding pocket (non-LBP) diarylhydrazide antiandrogens', Journal of Chemical Information and Modeling, vol. 58, no. 8, pp. 2116-2130. 8 7
2012	Blanco, F, Egan, B, Caboni, L, Elguero, J, O'Brien, J, McCabe, T, Fayne, D, Meegan, MJ & Lloyd, DG 2012, 'Study of E/Z isomerization in a series of novel non-ligand binding pocket androgen receptor antagonists', Journal of Chemical Information and Modeling, vol. 52, no. 9, pp. 2387-2397. 14 14
2012	Caboni, L, Kinsella, GK, Blanco, F, Fayne, D, Jagoe, WN, Carr, M, Williams, DC, Meegan, MJ & Lloyd, DG 2012, '"True" antiandrogens - selective non-ligand-binding pocket disruptors of androgen receptor-coactivator interactions : novel tools for prostate cancer', Journal of Medicinal Chemistry, vol. 55, no. 4, pp. 1635-1644. Open access 48 48
2012	Mckay, P, Fayne, D, Horn, H, James, T, Peters, M, Carta, G, Caboni, L, Nevin, D, Price, T, Bradley, G, Williams, D, Rice, J & Lloyd, DG 2012, 'Consensus computational ligand-based design for the identification of novel modulators of human estrogen receptor alpha', Molecular Informatics, vol. 31, no. 3-4, pp. 246-258. 4 4
2012	Nevin, DK, Peters, MB, Carta, G, Fayne, D & Lloyd, DG 2012, 'Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds', Journal of Medicinal Chemistry, vol. 55, no. 11, pp. 4978-4989. 26 25
2011	Mckay, PB, Peters, MB, Carta, G, Flood, CT, Dempsey, E, Bell, A, Berry, C, Lloyd, DG & Fayne, D 2011, 'Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design', Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 11, pp. 3335-3341. Open access 18 15
2011	Nevin, D, Lloyd, DG & Fayne, D 2011, 'Rational targeting of peroxisome proliferating activated receptor subtypes', Current Medicinal Chemistry, vol. 18, no. 36, pp. 5598-5623. 20 19
2011	O'Boyle, NM, Carr, M, Greene, LM, Keely, NO, Knox, AJ, McCabe, T, Lloyd, DG, Zisterer, DM & Meegan, MJ 2011, 'Synthesis, biochemical and molecular modelling studies of antiproliferative azetidinones causing microtubule disruption and mitotic catastrophe', European Journal of Medicinal Chemistry, vol. 46, no. 9, pp. 4595-4607. Open access 45 39
2011	O'Boyle, NM, Greene, LM, Bergin, O, Fichet, J-B, McCabe, T, Lloyd, DG, Zisterer, DM & Meegan, MJ 2011, 'Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones', Bioorganic and Medicinal Chemistry, vol. 19, no. 7, pp. 2306-2325. Open access 73 66
2011	O'Boyle, NM, Knox, AJ, Price, TT, Williams, DC, Zisterer, DM, Lloyd, DG & Meegan, MJ 2011, 'Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90', Bioorganic and Medicinal Chemistry, vol. 19, no. 20, pp. 6055-6068. 22 22
2010	Barrett, I, Carr, M, O'Boyle, N, Greene, L, Knox, A, Lloyd, DG, Zisterer, D & Meegan, M 2010, 'Lead identification of conformationally restricted benzoxepin type combretastatin analogs : synthesis, antiproliferative activity, and tubulin effects', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 25, no. 2, pp. 180-194. 16 16
2010	Carr, M, Greene, L, Knox, A, Lloyd, DG, Zisterer, D & Meegan, M 2010, 'Lead identification of conformationally restricted β-lactam type combretastatin analogues : synthesis, antiproliferative activity and tubulin targeting effects', European Journal of Medicinal Chemistry, vol. 45, no. 12, pp. 5752-5766. Open access 79 77
2010	Greene, L, Nathwani, S, Bright, S, Fayne, D, Croke, A, Gagliardi, M, McElligott, A, O'Connor, L, Carr, M, Keely, N, O'Boyle, N, Carroll, P, Sarkadi, B, Conneally, E, Lloyd, DG, Lawler, M, Meegan, M & Zisterer, D 2010, 'The vascular targeting agent combretastatin-A4 and a novel cis-restricted ß-lactam analogue, CA-432, induce apoptosis in human chronic myeloid leukemia cells and ex vivo patient samples including those displaying multidrug resistance', Journal of Pharmacology and Experimental Therapeutics, vol. 335, no. 2, pp. 302-313. Open access 29 31
2010	Nathwani, S-M, Butler, S, Fayne, D, McGovern, NN, Sarkadi, B, Meegan, MJ, Lloyd, DG, Campiani, G, Lawler, M, Williams, DC & Zisterer, DM 2010, 'Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells', Cancer Chemotherapy and Pharmacology, vol. 66, no. 3, pp. 585-596. Open access 26 24
2010	O'Boyle, N, Carr, M, Greene, L, Bergin, O, Nathwani, S, McCabe, T, Lloyd, DG, Zisterer, D & Meegan, M 2010, 'Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents', Journal of Medicinal Chemistry, vol. 53, no. 24, pp. 8569-8584. Open access 132 124
2010	Onnis, V, Kinsella, G, Carta, G, Jagoe, W, Price, T, Williams, D, Fayne, D & Lloyd, DG 2010, 'Virtual screening for the identification of novel nonsteroidal glucocorticoid modulators', Journal of Medicinal Chemistry, vol. 53, no. 8, pp. 3065-3074. 22 19
2010	Yang, Y, Carta, G, Peters, MB, Price, T, O'Boyle, N, Knox, AJ, Fayne, D, Williams, DC, Meegan, MJ & Lloyd, DG 2010, ''tieredScreen' - Layered virtual screening tool for the identification of novel estrogen receptor alpha modulators', Molecular Informatics, vol. 29, no. 5, pp. 421-430. 7 7
2009	Cloonan, S, Keating, J, Butler, S, Knox, A, Jorgensen, A, Peters, G, Rai, D, Corrigan, D, Lloyd, DG, Williams, D & Meegan, M 2009, 'Synthesis and serotonin transporter activity of sulphur-substituted a-alkyl phenethylamines as a new class of anticancer agents', European Journal of Medicinal Chemistry, vol. 44, no. 12, pp. 4862-4888. 23 21
2009	Knox, AJ, Price, T, Pawlak, M, Golfis, G, Flood, CT, Fayne, D, Williams, DC, Meegan, MJ & Lloyd, DG 2009, 'Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin', Journal of Medicinal Chemistry, vol. 52, no. 8, pp. 2177-2180. 44 45
2009	Onnis, V, Kinsella, GK, Carta, G, Fayne, D & Lloyd, DG 2009, 'Rational ligand-based virtual screening and structure-activity relationship studies in the ligand-binding domain of the glucocorticoid receptor-α', Future Medicinal Chemistry, vol. 1, no. 3, pp. 483-499. 4 8
2009	Onnis, V, Kinsella, GK, Carta, G, Fayne, D & Lloyd, DG 2009, 'Rational structure-based drug design and optimization in the ligand-binding domain of the glucocorticoid receptor-α', Future Medicinal Chemistry, vol. 1, no. 2, pp. 345-359. 5 5
2009	Veith, H, Southall, N, Huang, R, James, T, Fayne, D, Artemenko, N, Shen, M, Inglese, J, Austin, CP, Lloyd, DG & Auld, DS 2009, 'Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries', Nature Biotechnology, vol. 27, no. 11, pp. 1050-1055. Open access 171 159
2008	Barrett, I, Meegan, MJ, Hughes, RB, Carr, M, Knox, AJ, Artemenko, N, Golfis, G, Zisterer, DM & Lloyd, DG 2008, 'Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators', Bioorganic and Medicinal Chemistry, vol. 16, no. 21, pp. 9554-9573. 51 46
2008	Lloyd, DG, Yang, Y, Meegan, M & Knox, A 2008, 'Virtual screening of the estrogen receptor', Expert Opinion on Drug Discovery, vol. 3, no. 8, pp. 853-866. 3 3
2008	Meegan, MJ, Carr, M, Knox, AJ, Zisterer, DM & Lloyd, DG 2008, 'β-Lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 23, no. 5, pp. 668-685. Open access 20 19

Research

Patents

Details	Registry	Status
Thiazolhydrazides for treatment of neurodegenerative diseases Mandelkow, Eckhard; Mandelkow, Eva-Maria; Pickhardt, Markus; Biernat, Jacek; Lloyd, David George; Schmidt, Boris; Larbig, Gregor	EP	Granted
Thiazolhydrazides for treatment of neurodegenerative diseases Mandelkow, Eckhard; Mandelkow, Eva-Maria; Pickhardt, Markus; Biernat, Jacek; Lloyd, David George; Schmidt, Boris; Larbig, Gregor	US	Granted

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Cardiff University	UNITED KINGDOM
Emory University	UNITED STATES
Hungarian Academy of Sciences	HUNGARY
IBM Almaden Research Centre	UNITED STATES
Institute of Medical Chemistry (IQM-CSIC)	SPAIN
Irish Centre for High-End Computing	IRELAND
National Institutes of Health	MALAYSIA
Private Individual	UNITED KINGDOM
Semmelweis University	HUNGARY
Southern Research Institute	UNITED STATES
Spanish National Research Council	SPAIN
St. James's Hospital	UNITED STATES
Technical University of Denmark	DENMARK
The Queen Elizabeth Hospital	AUSTRALIA
Trinity College Dublin	IRELAND
University College Dublin	IRELAND
University Hospital Cologne	GERMANY
University of Alabama	UNITED STATES
University of Barcelona	SPAIN
University of Dublin	IRELAND
University of Queensland	AUSTRALIA
University of Siena	ITALY
University of Valencia	SPAIN
Yale University	UNITED STATES

External engagement & recognition

Engagement/recognition	Year
Chair Universities Australia	2023
Board Member Universities Australia	2021
Chair Committee for Adelaide	2021
Fellow Australian Academy of Technology and Engineering (ATSE)	2021
Board Member Universities Australia	2020
Fellow Australian Academy of Technology and Engineering (ATSE)	2020
Board Member Universities Australia	2019
National Research Priorities Panel Member Australian Research Council	2019
Advisory Board Member Australian Research Council (ARC)	2018
Member South Australia Economic Development Board	2018
Board Member Universities Australia	2017
Inaugural Chair SATAC Council	2017
Lead VC Research and Innovation Universities Australia	2017
Member South Australia Economic Development Board	2017
Chair Australian Technology Network (ATN)	2016
Member South Australia Economic Development Board	2016
Chair Australian Technology Network (ATN)	2015
Member South Australia Economic Development Board	2015
Member South Australia Economic Development Board	2014
Honorary Professorship Tianjin University	2013
Fellow Royal Society of Chemistry	2012
Inaugural Chairman Irish Research Council	2012
Master of Arts Trinity College Dublin (j.o.)	2009
Fellowship Trinity College Dublin	2008
Honorary Doctorate Sir Terry Pratchett fictional Unseen University	2008
Advisory Board Member Science Foundation Ireland
Board Member, TCD Irish Centre for High End Computing
Chartered Chemist Royal Society of Chemistry
Committee Member Naughton Fellowship Program
Governing Board Member, Centre for Next Generation Localisation Science Foundation Ireland
Governing Board Member, Centre for Research on Adaptive Nanostructures and Nanodevices Science Foundation Ireland
Governing Board Member, Centre for Telecommunications Value Chain Research Science Foundation Ireland
Governing Board Member, Institute for Biomedical Informatics IDA Ireland
Member Irish Technology Leadership Group
Member Dublin Chamber of Commerce Knowledge Economy Group
Member Advisory Council for Science Technology and Innovation, Ireland
Member IBEC Pharmachemical Ireland Strategy Group
Member, Strategic Evaluation Panel US National Cancer Institute
Strategic Council Member Irish Universities Association

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Professor David Lloyd

Alternative contact

Alternative contact details

About me

About me

UniSA Chancellery and Council Services

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Projects

Outputs

Journal Articles

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

Chair

Board Member

Chair

Fellow

Board Member

Fellow

Board Member

National Research Priorities Panel Member

Advisory Board Member

Member

Board Member

Inaugural Chair

Lead VC Research and Innovation

Member

Chair

Member

Chair

Member

Member

Honorary Professorship

Fellow

Inaugural Chairman

Master of Arts

Fellowship

Honorary Doctorate

Advisory Board Member

Board Member, TCD

Chartered Chemist

Committee Member

Governing Board Member, Centre for Next Generation Localisation

Governing Board Member, Centre for Research on Adaptive Nanostructures and Nanodevices

Governing Board Member, Centre for Telecommunications Value Chain Research

Governing Board Member, Institute for Biomedical Informatics

Member

Member

Member

Member

Member, Strategic Evaluation Panel

Strategic Council Member

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