Associate Professor Ivan Kempson

Associate Professor in Biophysics Future Industries Institute

Mawson Lakes Campus (IW2-21)
tel +61 8 830 23677

email ivan.kempson@unisa.edu.au

Available for media comment
Research Degree Supervisor

About me

I have a background in physics which has evolved into fields of bio-inorganic chemistry and surface science. This has been motivated by applying physical-chemistry concepts and characterization tools to areas of nanotechnology, biotechnology and pharmaceutical sciences.

These interests are being used to develop improvements in understanding disease, therapeutic delivery and pharmaceutical products and novel methodologies for extracting quantitative metrics in determining relevant parameters. This has been a balance between basic and applied research with interest in clinical developments for human health and engaging pharma industries.

My research has been highly multidisciplinary and incorporated strong collaborations world wide for... Read more

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About me

My research has been highly multidisciplinary and incorporated strong collaborations world wide for which I have greatly enjoyed the cultural exchange as well as exposure to exceptional research. I have conducted research in the USA, Canada, Japan, England, The Netherlands, Taiwan and China. I have been the recipient of 5 visiting scholar positions in Canada (the Canadian Light Source and Western University), Taiwan (Institute of Physics, Academia Sinica) and China (Institute of Chemistry, Chinese Academy of Sciences).

I enjoy seeing my research published in high impact journals such as Angewandte Chemie, Small, Chemical Society Reviews, Advanced Materials, the Journal of Controlled Release etc. All up I have over 50 publications including 3 invited book chapters. These are giving rise to rapidly growing citations and an h-index of 19 by PubMed.

Exposure of my work has been given by presentation at over 70 international conference presentations. It is especially recognised by delivering 16 international invited and keynote talks in 8 different countries. The general significance is also demonstrated by being invited twice to represent Australia at the International Atomic Energy Agency (IAEA) technical meetings at the UN headquarters in Vienna, Austria.

Other community duties include:

Editor for Nature Publishing Group’s Scientific Reports
Reviewing for over 30 journals
Reviewing of research grant applications in 5 countries
Member of the Program Advisory Committee for X-ray Fluorescence Microscopy at the Australian Synchrotron
The Australian representative in the IAEA Collaborative Research Program for X-ray fluorescence at the Elettra Synchrotron, Trieste, Italy
I am the first ever foreign recipient of a certificate in recognition of my work for the Supreme Public Prosecutors Office in Taiwan

Research

Research focus

Biological Sciences
Nanotechnology
Biomedical Engineering
Chemical Sciences
Physical Chemistry (Incl. Structural)

Highlights

Nanomedicine
Radiosensitization
Pharmaceutical surface analysis in relation to product attributes (solid form and biologicals)
Biological imaging for heterogeneity in nanoparticle delivery to tumour, nanoparticle fate and nanoparticle contrast agents
Stimuli responsive carriers for drug delivery
Tumour sensitization for radiotherapies (via gene therapy and nanoparticle-radiation interactions)
Trace Analysis and biomonitoring with particular respect to inorganic toxicology
Nanoparticle toxicity and fate

Research

Outputs

Research outputs for the last seven years are shown below. Some long-standing staff members may have older outputs included. To see earlier years visit ORCID, ResearcherID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2020	Howard, D, Sebastian, S, Le, QVC, Thierry, B & Kempson, I 2020, 'Chemical mechanisms of nanoparticle radiosensitization and radioprotection: A review of structure-function relationships influencing reactive oxygen species', International Journal of Molecular Sciences, vol. 21, no. 2, pp. 1-23. Open access 76 74 4
2019	Peukert, D, Kempson, I, Douglass, M & Bezak, E 2019, 'Gold nanoparticle enhanced proton therapy: Monte Carlo modeling of reactive species' distributions around a gold nanoparticle and the effects of nanoparticle proximity and clustering', International Journal of Molecular Sciences, vol. 20, no. 17, pp. 1-22. Open access 28 25
2019	Turnbull, T, Douglass, M, Williamson, NH, Howard, D, Bhardwaj, R, Lawrence, M, Paterson, DJ, Bezak, E, Thierry, B & Kempson, IM 2019, 'Cross-correlative single-cell analysis reveals biological mechanisms of nanoparticle radiosensitization', ACS Nano, vol. 13, no. 5, pp. 5077-5090. Open access 43 44 3
2015	Tseng, S-J, Liao, Z-X, Kao, S-H, Zeng, Y-F, Huang, K-Y, Li, H-J, Yang, C, Deng, Y, Huang, C, Yang, S-C, Yang, P-C & Kempson, IM 2015, 'Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour', Nature Communications, vol. 6, pp. 1-10. Open access 98 99 10

Chapters

Year	Output
2024	Kempson, I 2024, 'Radionuclide-conjugated cancer-specific vectors: nanoparticles', in (eds), Radiotheranostics - A Primer for Medical Physicists I Physics, Chemistry, Biology and Clinical Applications, CRC Press, US, ch. 7, pp. 87-95.
2023	Ghasemi, M, Liang, S, Luu, QM & Kempson, I 2023, 'The MTT assay: a method for error minimization and interpretation in measuring cytotoxicity and estimating cell viability', in Oliver Friedrich & Daniel F Gilbert (eds), Cell Viability Assays: Methods and Protocols, Humana New York, US, ch. 2, pp. 15-33. Open access 28
2016	Kempson, IM & Prestidge, CA 2016, 'Mass spectrometry imaging of pharmaceuticals: from tablets to tissues', in T Rades, Y Perrie & A Mullertz (eds), Analytical techniques in the pharmaceutical sciences, Springer, New York, ch. 19, pp. 629-647.
2012	Kempson, IM, Hwu, Y & Prestidge, CA 2012, 'Probing protein association with nano- and micro-scale structures with ToF-SIMS', in T Horbett, J L Brash & W Norde (eds), Proteins at interfaces III state of the art - volume 1120, American Chemical Society, US, ch. 33, pp. 709-729. 1 1

Journal Articles

Year	Output
2024	Atkinson, J, Bezak, E, Le, H & Kempson, I 2024, 'DNA Double strand break and response fluorescent assays: choices and interpretation', International Journal of Molecular Sciences, vol. 24, no. 4, article no. 2227, pp. 1-27. Open access 5 5
2024	Atkinson, J, Chopin, J, Bezak, E, Le, H & Kempson, I 2024, 'Gold nanoparticles cause radiosensitization in 4T1 cells by inhibiting DNA double strand break repair: single cell comparisons of DSB formation and γH2AX expression', Chemphyschem: A European Journal of Chemical Physics and Physical Chemistry, online, pp. 1-9.
2024	Ghasemi, M, Holmes, A, Turnbull, T & Kempson, I 2024, 'Gold Nanoparticle Detection with Two-Photon Excitation Fluorescence Lifetime Imaging of NAD(P)H in Cancer Cells: An Analytical Approach to Separate Nanoparticle and NAD(P)H Signals', Analytical Chemistry, vol. 96, no. 52, pp. 20435-20444.
2024	Howard, D, Turnbull, T, Wilson, P, Paterson, DJ, Milanova, V, Thierry, B & Kempson, I 2024, 'Quantitative single-cell comparison of sensitization to radiation and a radiomimetic drug for diverse gold nanoparticle coatings', Small Science, vol. 4, no. 9, article no. 2400053, pp. 1-13. Open access 1 2
2024	Ou, D-L, Liao, Z-X, Kempson, IM, Li, L, Yang, P-C & Tseng, S-J 2024, 'Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer', Journal of Biomedical Science, vol. 31, no. 1, pp. 1-12. Open access 8 8 1
2023	Atkinson, J, Bezak, E, Le, H & Kempson, I 2023, 'The current status of FLASH particle therapy: a systematic review', Physical and Engineering Sciences in Medicine, vol. 46, pp. 529-560. Open access 13 13 4
2023	Liao, ZX, Hsu, Sh, Tang, SC, Kempson, I, Yang, PC & Tseng, SJ 2023, 'Potential targeting of the tumor microenvironment to improve cancer virotherapy', Pharmacology and Therapeutics, vol. 250, article no. 108521, pp. 1-11. 11 9 1
2023	Sebastian, S, Hoffmann, MK, Howard, D, Young, C, Washington, J, Unterweger, H, Alexiou, C, Turnbull, T, D'Andrea, R, Hoffmann, P & Kempson, I 2023, 'Kinetic effects of transferrin-conjugated gold nanoparticles on the antioxidant glutathione-thioredoxin pathway', Antioxidants, vol. 12, no. 8, article no. 16187, pp. 1-21. Open access 4 4 1
2022	Atkinson, J, Bezak, E & Kempson, I 2022, 'Imaging DNA double-strand breaks - are we there yet?', Nature Reviews Molecular Cell Biology, vol. 23, pp. 579-580. Open access 9 9 10
2022	Dehghankelishadi, P, Maritz, MF, Dmochowska, N, Badiee, P, Cheah, E, Kempson, I, Berbeco, R I & Thierry, B 2022, 'Formulation of simvastatin within high density lipoprotein enables potent tumour radiosensitisation', Journal of Controlled Release, vol. 346, pp. 98-109. 12 9 5
2022	Howard, D, Turnbull, T, Paterson, DJ, Thierry, B & Kempson, I 2022, 'Cell size as a primary determinant in targeted nanoparticle uptake', ACS Applied Bio Materials, vol. 5, no. 9, 4222-4231. Open access 5 4
2022	Kempson, I 2022, 'Nanoparticle-based radiosensitization', International Journal of Molecular Sciences, vol. 23, no. 9, article no. 4936. Open access 2 3
2022	Nazarizadeh, A, Staudacher, AH, Wittwer, NL, Turnbull, T, Brown, MP & Kempson, I 2022, 'Aluminium nanoparticles as efficient adjuvants compared to their microparticle counterparts: current progress and perspectives', International Journal of Molecular Sciences, vol. 23, no. 9, article no. 4707. Open access 23 20 4
2022	Tseng, S-J, Kempson, IM, Liao, Z-X, Ho, Y-C & Yang, P-C 2022, 'An acid degradable, lactate oxidizing nanoparticle formulation for non-small cell lung cancer virotherapy', Nano Today, vol. 46, article no. 101582, pp. 1-10. Open access 21 20 1
2021	Ghasemi, M, Turnbull, T, Sebastian, S & Kempson, I 2021, 'The mtt assay: utility, limitations, pitfalls, and interpretation in bulk and single-cell analysis', International Journal of Molecular Sciences, vol. 22, no. 23, pp. 1-30. Open access 507 460 7
2021	Huynh, M, Kempson, I, Bezak, E & Phillips, W 2021, 'Predictive modeling of hypoxic head and neck cancers during fractionated radiotherapy with gold nanoparticle radiosensitization', Medical Physics, vol. 48, no. 6, pp. 3120-3133. Open access 8 8
2021	Kempson, I 2021, 'Mechanisms of nanoparticle radiosensitization', Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 13, no. 1, article no. e1656, pp. 1-19. Open access 59 55
2021	Liao, ZX, Kempson, IM, Hsieh, CC, Tseng, SJ & Yang, PC 2021, 'Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer', Drug Discovery Today, vol. 26, no. 11, pp. 2508-2514. 32 30 1
2021	Ou, DL, Tseng, S J, Kempson, IM, Hsu, CL, Yang, PC & Liao, ZX 2021, 'Enhanced targeting and immune activation of tumor microenvironment by nanomodified anti-PD1 in liver cancer', Advanced Therapeutics, vol. 4, no. 6, pp. 1-8. 9 9
2020	Holmes, AM, Kempson, I, Turnbull, T, Paterson, D & Roberts, MS 2020, 'Penetration of zinc into human skin after topical application of nano zinc oxide used in commercial sunscreen formulations', ACS Applied Bio Materials, vol. 3, no. 6, pp. 3640-3647. Open access 29 27 2
2020	Howard, D, Sebastian, S, Le, QVC, Thierry, B & Kempson, I 2020, 'Chemical mechanisms of nanoparticle radiosensitization and radioprotection: A review of structure-function relationships influencing reactive oxygen species', International Journal of Molecular Sciences, vol. 21, no. 2, pp. 1-23. Open access 76 74 4
2020	Huynh, M, Kempson, I, Bezak, E & Phillips, W 2020, 'In silico modeling of cellular probabilistic nanoparticle radiosensitization in head and neck cancers', Nanomedicine, vol. 15, no. 29, pp. 2837-2850. Open access 2 2
2020	Kempson, I 2020, 'Nanoparticle-based radiosensitization', International Journal of Molecular Sciences, vol. 21, no. 8, pp. 1-3. Open access 6 6
2020	Liao, ZX, Huang, KY, Kempson, IM, Li, HJ, Tseng, SJ & Yang, PC 2020, 'Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer', Journal of Controlled Release, vol. 324, pp. 482-492. 18 16 3
2020	Peukert, D, Kempson, I, Douglass, M & Bezak, E 2020, 'Gold nanoparticle enhanced proton therapy: a Monte Carlo simulation of the effects of proton energy, nanoparticle size, coating material, and coating thickness on dose and radiolysis yield', Medical Physics, vol. 47, no. 2, pp. 651-661. Open access 29 26 4
2020	Peukert, D, Kempson, I, Douglass, M & Bezak, E 2020, 'Modelling spatial scales of dose deposition and radiolysis products from gold nanoparticle sensitisation of proton therapy in a cell: from intracellular structures to adjacent cells', International Journal of Molecular Sciences, vol. 21, no. 12, article no. 4431 pp. 1-19. Open access 6 6
2020	Sepand, MR, Ranjbar, S, Kempson, IM, Akbariani, M, Muganda, WCA, Muller, M, Ghahremani, MH & Raoufi, M 2020, 'Targeting non-apoptotic cell death in cancer treatment by nanomaterials: recent advances and future outlook', Nanomedicine: Nanotechnology Biology and Medicine, vol. 29, article no. 102243, pp. 1-20. 33 30
2019	Guo, Z, Yang, C-T, Maritz, MF, Wu, H, Wilson, P, Warkiani, ME, Chien, C-C, Kempson, I, Aref, AR & Thierry, B 2019, 'Validation of a vasculogenesis microfluidic model for radiobiological studies of the human microvasculature', Advanced Materials Technologies, vol. 4, no. 4 article no. 1800726, pp. 1-12. 28 25 58
2019	Kaur, S, Law, CS, Williamson, NH, Kempson, I, Popat, A, Kumeria, T & Santos, A 2019, 'Environmental copper sensor based on polyethylenimine-functionalized nanoporous anodic alumina interferometers', Analytical Chemistry, vol. 91, no. 8, pp. 5011-5020. Open access 52 49 13
2019	Liao, ZX, Fa, YC, Kempson, IM & Tseng, SJ 2019, 'Repolarization of M2 to M1 macrophages triggered by lactate oxidase released from methylcellulose hydrogel', Bioconjugate Chemistry, vol. 30, no. 10, pp. 2697-2702. 37 35 2
2019	Peukert, D, Incerti, S, Kempson, I, Douglass, M, Karamitros, M, Baldacchino, G & Bezak, E 2019, 'Validation and investigation of reactive species yields of Geant4-DNA chemistry models', Medical Physics, vol. 46, no. 2, pp. 983-998. Open access 23 23 2
2019	Peukert, D, Kempson, I, Douglass, M & Bezak, E 2019, 'Gold nanoparticle enhanced proton therapy: Monte Carlo modeling of reactive species' distributions around a gold nanoparticle and the effects of nanoparticle proximity and clustering', International Journal of Molecular Sciences, vol. 20, no. 17, pp. 1-22. Open access 28 25
2019	Turnbull, T, Douglass, M, Williamson, NH, Howard, D, Bhardwaj, R, Lawrence, M, Paterson, DJ, Bezak, E, Thierry, B & Kempson, IM 2019, 'Cross-correlative single-cell analysis reveals biological mechanisms of nanoparticle radiosensitization', ACS Nano, vol. 13, no. 5, pp. 5077-5090. Open access 43 44 3
2019	Turnbull, T, Thierry, B & Kempson, I 2019, 'A quantitative study of intercellular heterogeneity in gold nanoparticle uptake across multiple cell lines', Analytical and Bioanalytical Chemistry, vol. 411, no. 28, pp. 7529-7538. 14 13 1
2018	Holmes, AM, Kempson, I, Turnbull, T, Paterson, D & Roberts, MS 2018, 'Imaging the penetration and distribution of zinc and zinc species after topical application of zinc pyrithione to human skin', Toxicology and Applied Pharmacology, vol. 343, pp. 40-47. 21 18 7
2018	Kaur, S, Kempson, I, Xu, H, Nydén, M & Larsson, M 2018, 'Bio-template assisted synthesis of porous glutaraldehyde-polyethyleneimine particulate resin for selective copper ion binding and recovery', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 8, no. 22, pp. 12043-12052. Open access 10 9
2018	Liao, ZX, Kempson, IM, Chen, MJ, Fa, YC, Huang, KY & Wang, LF 2018, 'Micro-scale RNA interference using iron oxide nanoparticle-modified lentivirus', Chemnanomat: Chemistry of Nanomaterials for Energy, Biology and More, vol. 4, no. 1, pp. 98-102. 7 7 11
2018	Peukert, D, Kempson, I, Douglas, M & Bezak, E 2018, 'Metallic nanoparticle radiosensitisation of ion radiotherapy: A review', Physica Medica: An International Journal Devoted to the Applications of Physics to Medicine and Biology, vol. 47, pp. 121-128. Open access 57 48
2018	Tseng, S-J, Kempson, IM, Huang, KY, Li, HJ, Fa, YC, Ho, YC, Liao, ZX & Yang, PC 2018, 'Targeting tumor microenvironment by bioreduction-activated nanoparticles for light-triggered virotherapy', ACS Nano, vol. 12, no. 10, pp 9894-9902. 72 71 7
2017	Kaur, S, Kempson, IM, Lindén, JB, Larsson, M & Nydén, M 2017, 'Unhindered copper uptake by glutaraldehyde-polyethyleneimine coatings in an artificial seawater model system with adsorbed swollen polysaccharides and competing ligand EDTA', Biofouling: The Journal of Bioadhesion and Biofilm Research, vol. 33, no. 2, pp. 184-194. Open access 10 9 1
2017	Larsson, M, Lindén, JB, Kaur, S, Le Cerf, B & Kempson, I 2017, 'Cu K-edge XANES: polymer, organic, inorganic spectra, and experimental considerations', Powder Diffraction, vol. 32, no. S2, pp. S28-S32. Open access 9 9
2017	Liao, ZX, Kempson, IM, Fa, YC, Liu, MC, Hsieh, LC, Huang, KY & Wang, LF 2017, 'Magnetically guided viral transduction of gene-based sensitization for localized photodynamic therapy to overcome multidrug resistance in breast cancer cells', Bioconjugate Chemistry, vol. 28, no. 6, pp. 1702-1708. Open access 13 13
2017	Turnbull, T, Douglass, M, Bezak, E, Thierry, B & Kempson, I 2017, 'An image processing application for quantitative cross-correlative microscopy for large cell-populations: a gold nanoparticle radiosensitisation study', Powder Diffraction, vol. 32, no. S2, pp. S33-S37. Open access 2 2
2017	Zi-Xian, L, Liu, MC, Kempson, IM, Fa, Y-C & Huang, K-Y 2017, 'Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes', International Journal of Nanomedicine, vol. 12, pp. 7603-7611. Open access 14 13 1
2016	Joyce, P, Kempson, IM & Prestidge, CA 2016, 'Orientating lipase molecules through surface chemical control for enhanced activity: a QCM-D and ToF-SIMS investigation', Colloids and Surfaces B: Biointerfaces, vol.142, pp.173-181. 31 29
2015	Joyce, P, Kempson, I & Prestidge, CA 2015, 'QCM-D and ToF-SIMS Investigation to Deconvolute the Relationship between Lipid Adsorption and Orientation on Lipase Activity', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 31, n. 37, pp. 10198-10207. 23 23
2015	Lindén, JB, Larsson, M, Kaur, S, Skinner, W, Miklavcic, S, Nann, T, Kempson, I & Nydén, M 2015, 'Polyethyleneimine for copper absorption II: kinetics, selectivity and efficiency from seawater', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 5, no. 64, pp. 51883-51890. Open access 57 55
2015	Tseng, S-J, Liao, Z-X, Kao, S-H, Zeng, Y-F, Huang, K-Y, Li, H-J, Yang, C, Deng, Y, Huang, C, Yang, S-C, Yang, P-C & Kempson, IM 2015, 'Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour', Nature Communications, vol. 6, pp. 1-10. Open access 98 99 10
2015	Turnbull, T, Douglass, M, Paterson, D, Bezak, E, Thierry, B & Kempson, I 2015, 'Relating intercellular variability in nanoparticle uptake with biological consequence: a quantitative x-ray fluorescence study for radiosensitization of cells', Analytical Chemistry, vol. 87, no. 21, pp. 10693-10697. 14 13
2014	Jing, L, Ding, K, Kershaw, S V, Kempson, IM, Rogach, AL & Gao, M 2014, 'Magnetically engineered semiconductor quantum dots as multimodal imaging probes', Advanced Materials, vol.26, pp. 6367-6386. 67 136
2014	Kempson, I, Smith, E, Gao, M, de Jonge, M & Thierry, B 2014, 'Large area synchrotron X-ray fluorescence mapping of biological samples', Journal of Instrumentation, vol. 9, no. 12, article no. C12040, pp. 1-6. 4 6
2014	Liu, T, Kempson, IM, de Jonge, MD, Howard, DL & Thierry, B 2014, 'Quantitative synchrotron X-ray fluorescence study of the penetration of transferrin-conjugated gold nanoparticles inside model tumour tissues', Nanoscale, vol. 6 no. 16, pp. 9774-9782. 31 30
2014	Sun, X, Wang, B, Kempson, I, Liu, C, Hou, Y & Gao, M 2014, 'Restructuring and remodeling of NaREF4 nanocrystals by electron irradiation', Small, vol. 10, no. 22, Special issue S1, pp. 4711-4717. 13 26
2013	Chien, C-C, Kempson, IM, Wang, CL, Chen, H, Hwu, Y, Chen, N, Lee, T, Tsai, KK-C, Liu, M-S, Chang, K-Y, Yang, C & Margaritondo, G 2013, 'Complete microscale profiling of tumor microangiogenesis. A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization.', Biotechnology Advances, vol. 31, no. 3, pp. 396-401. 9 11
2013	Kempson, IM, Chang, PKC, Bremmell, KE & Prestidge, CA 2013, 'Low temperature thermal dependent Filgrastim adsorption behavior detected with ToF-SIMS', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 29, no. 50, pp. 15573-15578. 9 10
2013	Lin, C-W, Tseng, S-J, Kempson, IM, Yang, S-C, Hong, T-M & Yang, P-C 2013, 'Extracellular delivery of modified oligonucleotide and superparamagnetic iron oxide nanoparticles from a degradable hydrogel triggered by tumor acidosis', Biomaterials, vol. 34, no. 17, pp. 4387-4393. 39 37
2013	Liu, T, Cousins, A, Chien, C-C, Kempson, I, Thompson, S, Hwu, Y & Thierry, B 2013, 'Immunospecific targeting of CD45 expressing lymphoid cells: towards improved detection agents of the sentinel lymph node', Cancer Letters, vol. 328, pp. 271-277. Open access 13 12
2013	Tseng, S-J, Feng, Y-F, Deng, Y-F, Yang, P-C, Liu, J-R & Kempson, IM 2013, 'Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex', Chemical Communications, vol. 49, pp. 2670-2672. 24 21
2013	Tseng, S-J, Kempson, IM, Peng, S-F, Ke, B-H, Chen, H-H, Chen, P-F & Hwu, Y 2013, 'Environment acidity triggers release of recombinant adeno-associated virus serotype 2 from a tunable matrix', Journal of Controlled Release, vol. 170, no. 2, pp. 252-258. 19 20
2013	Tung, H-T, Chen, I-G, Song, J-M, Tsai, M-G, Kempson, IM, Margaritondo, G & Hwu, Y 2013, 'Cu(In₁₋ₓGaₓ)S₂ nanocrystals and films: low-temperature synthesis with size and composition control', Nanoscale, vol. 5, no. 11, pp. 4706-4710. 10 9
2012	Kempson, IM & Skinner, WM 2012, 'A comparison of washing methods for hair mineral analysis: internal versus external effects', Biological Trace Element Research, vol. 150, no. 1-3, pp. 10-14. 25 25
2012	Kempson, IM 2012, 'Strands of useful information', Chemistry and Industry, vol. 76, no. 2, pp. 42-45.
2012	Kempson, IM, Chien, C-C, Chung, C-Y, Hwu, Y, Paterson, D, de Jonge, MD & Howard, DL 2012, 'Fate of intravenously administered gold nanoparticles in hair follicles: follicular delivery, pharmacokinetic interpretation, and excretion', Advanced Healthcare Materials, vol. 1, no. 6, pp. 736-741. 19 18
2012	Smith, E, Gancarz, D, Rofe, A, Kempson, IM, Weber, J & Juhasz, AL 2012, 'Antagonistic effects of cadmium on lead accumulation in pregnant and non-pregnant mice', Journal of Hazardous Materials, vol. 199-200, pp. 453-456. 32 26
2012	Tung, H-T, Chen, I-G, Kempson, I, Song, JM, Liu, Y-F, Chen, P-W, Hwang, W-S & Hwu, Y 2012, 'Shape-controlled synthesis of silver nanocrystals by X-ray irradiation for inkjet printing', ACS Applied Materials and Interfaces, vol. 4 no. 11, pp. 5930-5935. 16 14
2012	Zeng, Y-F, Tseng, S-J, Kempson, IM, Peng, S-F, Wu, W-T & Liu, J-R 2012, 'Controlled delivery of recombinant adeno-associated virus serotype 2 using pH-sensitive poly(ethylene glycol)-poly-l-histidine hydrogels', Biomaterials, vol. 33 no. 36, pp. 9239-9245. 42 38
2011	Barnes, TJ, Kempson, IM & Prestidge, CA 2011, 'Surface analysis for compositional, chemical and structural imaging in pharmaceutics with mass spectrometry: a ToF-SIMS perspective', International Journal of Pharmaceutics, vol. 417, no. 1-2, pp. 61-69. 48 47
2011	Cai, X, Chen, H-H, Wang, C-L, Chen, S-T, Lai, S-F, Chien, C-C, Chen, Y-Y, Kempson, IM, Hwu, Y, Yang, CS & Margaritondo, G 2011, 'Imaging the cellular uptake of tiopronin-modified gold nanoparticles', Analytical and Bioanalytical Chemistry, vol. 401 no. 3, pp. 809-816. 26 23
2011	Chen, H-H, Chien, C-C, Petibois, C, Wang, C-L, Chu, YS, Lai, S-F, Hua, T-E, Chen, Y-Y, Cai, X, Kempson, IM, Hwu, Y & Margaritondo, G 2011, 'Quantitative analysis of nanoparticle internalization in mammalian cells by high resolution X-ray microscopy', Journal of Nanobiotechnology, vol. 9, no. 14, pp. 1-15. Open access 61 56
2011	Chen, T-Y, Chen, Y-TT, Wang, C-L, Kempson, IM, Lee, W-K, Chu, YS, Hwu, Y & Margaritondo, G 2011, 'Full-field microimaging with 8 keV X-rays achieves a spatial resolutions better than 20 nm', Optics Express, vol. 19, no. 21, pp. 19919-19924. Open access 79 70
2011	Chen, Y-T, Chen, T-Y, Yi, J, Chu, YS, Lee, W-K, Wang, C-L, Kempson, IM, Hwu, Y, Gajdosik, V & Margaritondo, G 2011, 'Hard x-ray Zernike microscopy reaches 30 nm resolution', Optics Letters, vol. 36 no. 7, pp. 1269-1271. Open access 53 51
2011	Kempson, IM & Lombi, E 2011, 'Hair analysis as a biomonitor for toxicology, disease and health status', Chemical Society Reviews, vol. 40, no. 7, pp. 3915-3940. 153 145
2011	Lai, S-F, Chen, W-C, Wang, C-L, Chen, H-H, Chen, S-T, Chien, C-C, Chen, Y-Y, Hung, W-T, Cai, X, Li, E, Kempson, IM, Hwu, Y, Yang, C, Tok, E-S, Tan, HR, Lin, M & Margaritondo, G 2011, 'One-pot tuning of Au nucleation and growth: from nanoclusters to nanoparticles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 27 no. 13, pp. 8424-8429. 17 16
2011	Lombi, E, Scheckel, K & Kempson, IM 2011, 'In situ analysis of metal(loid)s in plants: state of the art and artefacts', Environmental and Experimental Botany, vol. 72, no. 1, pp. 3-17. 142 130
2011	Smith, ERG, Kempson, IM, Juhasz, AL, Weber, J, Rofe, A, Gancarz, D, Naidu, R, McLaren, R & Grafe, F 2011, 'In vivo-in vitro and XANES spectroscopy assessments of lead bioavailability in contaminated periurban soils', Environmental Science and Technology, vol. 45, no. 14, pp. 6145-6152. 110 102
2011	Tung, H-T, Hwu, Y, Chen, I-G, Tsai, M-g, Song, J-M, Kempson, IM & Margaritondo, G 2011, 'Fabrication of single crystal CuGaS 2 nanorods by X-ray irradiation', Chemical Communications, vol. 47 no. 32, pp. 9152-9154. 25 26
2011	Wang, C-H, Liu, C-J, Chien, C-C, Chen, H-T, Hua, T-E, Leng, W-H, Chen, H-H, Kempson, IM, Hwu, Y, Hsiao, M, Lai, T-C, Wang, J, Yang, C-S, Lin, H-M, Chen, Y-J & Margaritondo, G 2011, 'X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors', Materials Chemistry and Physics, vol. 126 no. 1-2, pp. 352-356. 32 28
2011	Wang, C-L, Hsao, B-J, Lai, S-F, Chen, W-C, Chen, H-H, Chen, Y-Y, Chien, C-C, Cai, X, Kempson, IM, Hwu, Y & Margaritondo, G 2011, 'One-pot synthesis of AuPt alloyed nanoparticles by intense x-ray irradiation', Nanotechnology, vol. 22 no. 6, article no. 065605, pp. 1-7. 29 22
2010	Cai, X, Wang, C-L, Chen, H-H, Chien, C-C, Lai, S-F, Chen, Y-Y, Hua, T-E, Kempson, IM, Hwu, Y, Yang, CS & Margaritondo, G 2010, 'Tailored Au nanorods: Optimizing functionality, controlling the aspect ratio and increasing biocompatibility', Nanotechnology, vol. 21 no. 33, article no. 335604, pp. 1-8. 26 25
2010	Denman, JA, Kirkbride, K, Skinner, WM & Kempson, IM 2010, 'Organic and inorganic discrimination of ballpoint pen inks by ToF-SIMS and multivariate statistics', Applied Surface Science, vol. 256, no. 7, pp. 2155-2163. 72 65
2010	Hwu, Y, Wang, C-L, Chen, Y-J, Kempson, IM, Chen, H-H, Chen, S-T, Chien, C-C, Hsiao, M, Lai, T-C, Leng, W-H, Liu, C-J, Margaritondo, G, Wang, C & Yang, C-S 2010, 'Enhancement of cell radiation sensitivity by pegylated gold nanoparticles', Physics in Medicine and Biology, vol. 55, no. 4, pp. 931-945. 210 198
2010	Kempson, IM & Henry, D 2010, 'Determination of arsenic poisoning and metabolism in hair by synchrotron radiation : the case of Phar Lap', Angewandte Chemie, vol. 122, no. 25, pp. 4333-4336. 25 22
2010	Kempson, IM, Denman, JA, French, PW, Martin, AL, Barnes, TJ & Prestidge, CA 2010, 'Detecting the Presence of Denatured Human Serum Albumin in an Adsorbed Protein Monolayer Using TOF-SIMS', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 26, no. 14, pp. 12075-12080. 32 32
2010	Martin, R, Kempson, IM & Skinner, WM 2010, 'Changes in the metal content of human hair during diagenesis from 500 years, exposure to glacial and aqueous environments', Archaeometry, vol. 52, pp. 450-466. 20 19
2010	Prestidge, CA, Kempson, IM & Barnes, TJ 2010, 'Use of TOF-SIMS to study adsorption and loading behavior of methylene blue and papain in a nano-porous silicon layer', Journal of the American Society for Mass Spectrometry, vol. 21, no. 2, pp. 254-260. Open access 27 21
2010	Voelcker, N, Jani, AM, Losic, D & Kempson, I 2010, 'Dressing in layers: Layering Surface Functionalities in Nanoporous Aluminum Oxide Membranes', Angewandte Chemie, vol. 49, no. 3, pp. 7933-7937. 72 68
2009	Beattie, DA, Kempson, IM, Fan, L-J & Skinner, WM 2009, 'Synchrotron XPS studies of collector adsorption and co-adsorption on gold and gold: silver alloy surfaces', International Journal of Mineral Processing, vol. 92, no. 3-4, pp. 162-168. 31 29
2009	Kempson, IM, Henry, D & Francis, J 2009, 'Characterizing arsenic in preserved hair for assessing exposure potential and discriminating poisoning', Journal of Synchrotron Radiation, vol. 16, no. 3, pp. 422-427. 19 19
2009	Smith, E, Kempson, I, Juhasz, AL, Weber, J, Skinner, WM & Gräfe, M 2009, 'Localization and speciation of arsenic and trace elements in rice tissues', Chemosphere, vol. 76, no. 4, pp. 529-535. 63 57
2008	Mierczynska-Vasilev, A, Prestidge, CA, Peddie, F, Barnes, TJ, Barnett, C & Kempson, IM 2008, 'Peptide and Protein Loading into Porous Silicon Wafers', Physica Status Solidi A: Applications and Materials Science, vol. 205, no. 2, pp. 311-315. 42 39
2008	Skinner, WM, Denman, JA, Kirkbride, K & Kempson, IM 2008, 'Discrimination of pencil markings on paper using elemental analysis: An initial investigation', Forensic Science International, vol. 175, no. 2-3, pp. 123-129. 42 36

Conferences

Year	Output
2010	Jani, AM, Kempson, IM, Losic, D & Voelcker, N 2010, 'Controlling the surface functionalities of nanoporous alumina membranes', 2010 3rd International Conference on Nanoscience and Nanotechnology, IEEE Press, article no. 6045249, pp. 200-202. Open access

Research

Patents

Details	Registry	Status
Nanoparticle cancer therapy Kempson, Ivan; Turnbull, Tyron	US	Filed

External engagement & recognition

Collaborations

External engagement & recognition

Collaborations

Organisation	Country
Academia Sinica	TAIWAN
Argonne National Laboratory	UNITED STATES
Australian Nuclear Science and Technology Organisation	AUSTRALIA
Australian Synchrotron	AUSTRALIA
Brookhaven National Laboratory	UNITED STATES
Chang Gung University of Science and Technology	TAIWAN
China Medical University, Taiwan	TAIWAN
Chinese Academy of Sciences	CHINA
Chung Yuan Christian University	TAIWAN
City University of Hong Kong (CityU)	HONG KONG
Commonwealth Department of the Environment and Water Resources	AUSTRALIA
CSIRO Australia (Commonwealth Scientific Industrial Research organisation)	AUSTRALIA
Dana-Farber Cancer Institute	UNITED STATES
Ecole Polytechnique	FRANCE
Fermiscan Holdings Ltd.	AUSTRALIA
Flinders University	AUSTRALIA
Harvard University	UNITED STATES
Heifei University of Technology	CHINA
Institute of Medical and Veterinary Science	AUSTRALIA
Kaohsiung Medical University	TAIWAN
Lincoln University	NEW ZEALAND
Mackay Memorial Hospital	TAIWAN
Museum of Victoria	AUSTRALIA
National Center for High-Performance Computing	TAIWAN
National Cheng Kung University	TAIWAN
National Chiayi University	TAIWAN
National Chung Hsing University	TAIWAN
National Defense Medical Center	TAIWAN
National Health Research Institute	CHINA
National Health Research Institutes	TAIWAN
National Sun Yat-Sen University	TAIWAN
National Synchrotron Radiation Research Centre	TAIWAN
National Synchrotron Radiation Research Centre (NSSRC)	TAIWAN
National Taiwan Ocean University	TAIWAN
National Taiwan University	TAIWAN
National Taiwan University College of Medicine	TAIWAN
National Taiwan University Hospital	TAIWAN
National Tsing Hua University	TAIWAN
National University of Singapore	SINGAPORE
National Yunlin University of Science and Technology	TAIWAN
niversity of Notre Dame	UNITED STATES
Paris-Saclay University	FRANCE
pSiMedica Ltd	UNITED KINGDOM
Queensland University of Technology	AUSTRALIA
Royal Adelaide Hospital	AUSTRALIA
Southeast University	CHINA
Sun Yat-Sen University	CHINA
Swiss Federal Institute of Technology Lausanne	SWITZERLAND
Tatung University	TAIWAN
Tehran University of Medical Sciences	IRAN
Tunghai University	TAIWAN
University College London	UNITED KINGDOM
University of Adelaide	AUSTRALIA
University of Bordeaux	FRANCE
University of Erlangen-Nuremberg	GERMANY
University of Queensland	AUSTRALIA
University of Siegen	GERMANY
University of South Australia	AUSTRALIA
University of Sydney	AUSTRALIA
University of Tasmania	AUSTRALIA
University of Technology Sydney	AUSTRALIA
US Environmental Protection Agency	UNITED STATES
Western University	CANADA

External engagement & recognition

Engagement/recognition	Year
College of Experts Australian Research Council	2024
College of Experts Australian Research Council	2023
Committee Member Romania's National Recovery and Resilience Plan - The Executive Agency for Higher Education, Research, Development and Innovation Funding	2023
Editorial Board Member International Journal of Molecular Sciences	2023
Editorial Board Member Radiation	2023
International Expert Kazakhstan National Centre of Science and Technology Evaluation	2023
Invited membership Sigma Xi, The Scientific Research Honour Society	2023
Member Australian Radiation Protection Society	2023
Member Australian and New Zealand Society of Nuclear Medicine	2023
MRFF Grant Assessment Committee, Panel Member Medical Research Future Fund	2023
NHMRC Development Grant Panel Member National Health and Medical Research Council	2023
$4000000 grant Australian Cancer Research Foundation	2022
College of Experts Australian Research Council	2022
Committee Member Romania's National Recovery and Resilience Plan - The Executive Agency for Higher Education, Research, Development and Innovation Funding	2022
Editorial Board Member International Journal of Molecular Sciences	2022
Editorial Board Member Radiation	2022
International Expert Kazakhstan National Centre of Science and Technology Evaluation	2022
International Journal of Molecular Sciences Best Paper MDPI	2022
Invited membership Mark Hughes Foundation for Brain Cancer Research	2022
Invited membership Sigma Xi, The Scientific Research Honour Society	2022
Invited speaker IUPESM World Congress, June, 2022, Singapore	2022
Invited speaker 12th International Nanomedicine Conference, 27-29 June 2022, Sydney	2022
Invited speaker 8th International Symposium on Metallomics, Kanazawa, 11-14 July 2022, Japan	2022
Invited speaker International Conference on Nanomedicine	2022
Invited speaker Mark Hughes Foundation for Brain Cancer Research Symposium	2022
Member Australian Radiation Protection Society	2022
Member Australian and New Zealand Society of Nuclear Medicine	2022
MRFF Grant Assessment Committee, Panel Member Medical Research Future Fund	2022
NHMRC Development Grant Panel Member National Health and Medical Research Council	2022
Visiting Professor FAU Erlangen-Nürnberg	2022
Editorial Board Member International Journal of Molecular Sciences	2021
Editorial Board Member International Journal of Molecular Sciences	2020
Invited speaker ANSTO User Meeting, 19-20 Nov, 2020	2020
Editorial Board Member International Journal of Molecular Sciences	2019
Invited speaker 17th International Conference on Biomedical Engineering (ICBME) 2019, 9 – 12 December, Singapore	2019
Invited speaker Nanomedicine, 24-26 June, 2019, Sydney	2019
Invited speaker Engineering and Physical Sciences in Medicine, November 2018, Adelaide	2018
Member American Chemical Society (ACS)	2018
Certificate in Recognition of Work (First ever foreign recipient) Supreme Public Prosecutors Office, Taiwan	2017
Member American Chemical Society (ACS)	2017
National Representation at the International Atomic Energy Agency Trends in Analytical Applications and Instrumental Developments of Synchrotron Based X-Ray Spectrometry Techniques, Vienna, Austria, 2-6 October	2017
Keynote Speaker World Congress on Medical Physics and Biomedical Engineering	2015
Keynote Speaker 16th International Workshop on Radiation Imaging Detectors, Italy	2014

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
110450 - Development of a theranostic agent for image-guided and radiosensitisation of pancreatic cancer	Current
Immunofluorescent visualisation of genotoxicity: characterising DNA double-strand break kinetics of experimental cancer therapeutics	Current
Investigation of radiosensitization mechanisms using gold and aluminium nanoparticles under clinical beam radiation in the 4T1 mouse model of breast cancer	Current
Single cell analysis of nanoparticle uptake: Impact of environmental plastic pollutants	Current
Tumour cell population heterogeneity: Therapeutic challenges and opportunities	Current
Development of a tumour microenvironment sensitive polymeric nanoparticle to formulate multiple chemotherapy agents for cancer treatment	Completed
Fundamental understanding, development and industrial applications of copper binding glutaraldehyde-polyethyleneimine coatings: antifouling, remediation, and sensing	Completed
High density lipoprotein: a natural multi-functional nanomedicine for targeted delivery of radiosensitisers to the tumour microenvironment	Completed
Linking the intracellular journey of gold nanoparticles to protein expression changes in prostate cancer cells	Completed
Percutaneous absorption: towards a mechanistic understanding of skin disease, topical product and end-user effects	Completed
Radiosensitization of cell sub-populations by gold nanoparticles: cross-correlative microscopy for elucidating fundamental mechanisms	Completed
Single cell analysis of gold and gold-core/silica-shell nanoparticles for radiosensitisation	Completed
Stochastic modelling of gold nanoparticle enhancement of dose and reactive species yield for proton therapy	Completed
Unravelling biochemical effects of radiosensitizing gold nanoparticles on cancer cells at the cell population, single-cell, and molecular levels	Completed

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Associate Professor Ivan Kempson

About me

About me

Future Industries Institute

About me

Professional Associations

Experience

Qualifications

Research

Research focus

Highlights

Projects

Outputs

Highlights

Chapters

Journal Articles

Conferences

Current research & highlights

Patents

External engagement & recognition

Collaborations

Collaborations

External engagement & recognition

College of Experts

College of Experts

Committee Member

Editorial Board Member

Editorial Board Member

International Expert

Invited membership

Member

Member

MRFF Grant Assessment Committee, Panel Member

NHMRC Development Grant Panel Member

$4000000 grant

College of Experts

Committee Member

Editorial Board Member

Editorial Board Member

International Expert

International Journal of Molecular Sciences Best Paper

Invited membership

Invited membership

Invited speaker

Invited speaker

Invited speaker

Invited speaker

Invited speaker

Member

Member

MRFF Grant Assessment Committee, Panel Member

NHMRC Development Grant Panel Member

Visiting Professor

Editorial Board Member

Editorial Board Member

Invited speaker

Editorial Board Member

Invited speaker

Invited speaker

Invited speaker

Member

Certificate in Recognition of Work (First ever foreign recipient)

Member

National Representation at the International Atomic Energy Agency

Keynote Speaker

Keynote Speaker

Teaching & student supervision

Courses and programs

Courses I teach

Research degree supervision

Gallery