Dr Paul Joyce

Research Fellow UniSA Clinical & Health Sciences

City West Campus (HB6-18)
tel +61 8 830 21429

mob +61491712756
email Paul.Joyce@unisa.edu.au

Research Degree Supervisor

About me

Nanomedicine
Drug formulation
Biomaterials
Biophysics
Pharmacy & Pharmaceutical Sciences

Postdoctoral Research Associate

Paul Joyce completed his PhD in Pharmacy (UniSA) in 2016, where his contribution to the fields of pharmaceutical science and materials engineering were recognised with the Postgraduate Medal for Most Outstanding Thesis and the Norton Jackson Materials Science and Engineering Highly Commended Award. Upon completing his PhD, Paul was awarded a highly competitive, international Postdoctoral Research Fellowship at Chalmers University of Technology (Gothenburg, Sweden) under the supervision of Prof. Fredrik Höök. Paul’s primary research interests have centralised around understanding the biophysical processes of gastrointestinal digestion for the development of innovative oral drug formulations... Read more

UniSA Clinical & Health Sciences

UniSA Clinical & Health Sciences is addressing society’s most critical and emerging health needs through quality teaching, learning and research excellence.

Tweets by @UniversitySA

About me

In the media

Date	Title
14/12/2018	Could eating DIRT be the cure for obesity?, https://www.dailymail.co.uk/health/article-6493241/How-pill-mud-cure-obesity-soaking-fat-stop-body-absorbing-it.html

Research

Research focus

Chemical Sciences
Biomedical Engineering
Chemical Engineering
Engineering
Food Sciences

Highlights

Designing, engineering and applying innovative drug delivery solutions that overcome key biopharmaceutical challenges for the benefit of the wider community. Cutting edge biophysical and synthesis techniques are employed to develop novel strategies and technologies that are well-positioned for rapid clinical translation.

Drug delivery systems
Pharmaceutical formulation
Biomaterials
Biophysical analysis

Research

Outputs

Research outputs for the last seven years are shown below. To see earlier years visit ORCID or Scopus

Open access indicates that an output is open access.

Highlights

Year	Output
2019	Dening, TJ, Joyce, P, Kovalainen, M, Gustafsson, H & Prestidge, CA 2019, 'Spray dried smectite clay particles as a novel treatment against obesity', Pharmaceutical Research, vol. 36, no. 1, article no. 21, pp. 1-14. 7 7 121
2019	Joyce, P, Dening, TJ, Meola, TR, Schultz, HB, Holm, R, Thomas, N & Prestidge, CA 2019, 'Solidification to improve the biopharmaceutical performance of SEDDS: opportunities and challenges', Advanced Drug Delivery Reviews, vol. 142, pp. 102-117. Open access 47 7 4
2017	Joyce, P, Yasmin, R, Bhatt, A, Boyd, BJ, Pham, A & Prestidge, CA 2017, 'Comparison across three hybrid lipid-based drug delivery systems for improving the oral absorption of the poorly water-soluble weak base cinnarizine', Molecular Pharmaceutics, vol. 14, no. 11, pp. 4008-4018. 19 18 6
2016	Joyce, P, Barnes, TJ, Boyd, BJ & Prestidge, CA 2016, 'Porous nanostructure controls kinetics, disposition and self-assembly structure of lipid digestion products', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 6, no. 82 , pp. 78385-78395. 29 30
2015	Joyce, P, Whitby, CP & Prestidge, CA 2015, 'Bioactive hybrid particles from poly(D,L -lactide-co-glycolide) nanoparticle stabilized lipid droplets', ACS Applied Materials and Interfaces, vol. 7, pp. 17460-17470. 28 26 4

Journal Articles

Year	Output
2023	Maghrebi, S, Thomas, N, Prestidge, CA & Joyce, P 2023, 'Inulin-lipid hybrid (ILH) microparticles promote pH-triggered release of rifampicin within infected macrophages', Drug Delivery and Translational Research, online, pp. 1-14. Open access
2022	Almasri, R, Schultz, HB, Møller, A, Bremmell, KE, Garcia-Bennett, A, Joyce, P & Prestidge, CA 2022, 'Role of silica intrawall microporosity on abiraterone acetate solubilization and in vivo oral absorption', Molecular Pharmaceutics, vol. 19, no. 4, pp. 1091-1103. 3
2022	Awad, M, Barnes, TJ, Joyce, P, Thomas, N & Prestidge, CA 2022, 'Liquid crystalline lipid nanoparticle promotes the photodynamic activity of gallium protoporphyrin against S. aureus biofilms', Journal of Photochemistry and Photobiology B: Biology, vol. 232, article no. 112474, pp. 1-9. 6
2022	Awad, M, Barnes, TJ, Thomas, N, Joyce, P & Prestidge, CA 2022, 'Gallium protoporphyrin liquid Crystalline lipid nanoparticles: a third-generation photosensitizer against pseudomonas aeruginosa biofilms', Pharmaceutics, vol. 14, no. 10, article no. 2124, pp. 1-15. Open access
2022	Chen, J, Hanrahan, JP, McGrath, J, Courtney, MA, Prestidge, CA & Joyce, P 2022, 'The anti-obesity effect of porous silica is dependent on pore nanostructure, particle size, and surface chemistry in an in vitro digestion model', Pharmaceutics, vol. 14, no. 9, article no. 1813, pp. 1-16. Open access
2022	Joyce, P, Wignall, A, Peressin, K, Wright, L, Williams, DB & Prestidge, CA 2022, 'Chitosan nanoparticles facilitate improved intestinal permeation and oral pharmacokinetics of the mast cell stabiliser cromoglycate', International Journal of Pharmaceutics, vol. 612, article no. 121382. 1 1 3
2022	Wang, W, Joyce, P, Bremmell, K, Milne, R & Prestidge, CA 2022, 'Liposomal 5-fluorouracil polymer complexes facilitate tumor-specific delivery: pharmaco-distribution kinetics using microdialysis', Pharmaceutics, vol. 14, no. 2, article no. 221, pp. 1-16. Open access 335
2022	Wright, L, Barnes, TJ, Joyce, P & Prestidge, CA 2022, 'Optimisation of a high-throughput model for mucus permeation and nanoparticle discrimination using biosimilar mucus', Pharmaceutics, vol. 14, no. 12, pp. 1-15. Open access
2022	Wright, L, Wignall, A, Joemetsa, S, Joyce, P & Prestidge, CA 2022, 'A membrane-free microfluidic approach to mucus permeation for efficient differentiation of mucoadhesive and mucopermeating nanoparticulate systems', Drug Delivery and Translational Research, online, pp. 1-14.
2021	Hedge, OJ, Höök, F, Joyce, P & Bergström, CA 2021, 'Investigation of self-emulsifying drug-delivery system interaction with a biomimetic membrane under conditions relevant to the small intestine', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 37, no. 33, pp. 10200-10213. Open access 1 2
2021	Meola, T, Abuhelwa, AY, Joyce, P, Clifon, P & Prestidge, C 2021, 'A safety, tolerability, and pharmacokinetic study of a novel simvastatin silica-lipid hybrid formulation in healthy male participants', Drug Delivery and Translational Research, vol. 11, no. 3, pp. 1261-1272. Open access 7 6 4
2021	Meola, TR, Joyce, P, Wignall, A, Bremmell, KE & Prestidge, CA 2021, 'Harnessing the potential of nanostructured formulations to mimic the food effect of lurasidone', International Journal of Pharmaceutics, vol. 608, article no. 121098, pp. 1-10. Open access 3 3 4
2021	Olsén, E, Jõemetsa, S, González, A, Joyce, P, Zhdanov, VP, Midtvedt, D & Höök, F 2021, 'Diffusion of lipid nanovesicles bound to a lipid membrane is associated with the partial-slip boundary condition', Nano Letters: A Journal Dedicated to Nanoscience and Nanotechnology, vol. 21, no. 19, pp. 8503-8509. 2 2 1
2021	Subramaniam, S, Joyce, P, Thomas, N & Prestidge, CA 2021, 'Bioinspired drug delivery strategies for repurposing conventional antibiotics against intracellular infections', Advanced Drug Delivery Reviews, vol. 177, article no. 113948, pp. 1-23. 10 10 11
2021	Wright, L, Joyce, P, Barnes, TJ & Prestidge, CA 2021, 'Mimicking the gastrointestinal mucus barrier: laboratory-based approaches to facilitate an enhanced understanding of mucus permeation', ACS Biomaterial Science and Engineering, online, pp. 1-19. 1
2021	Wright, L, Joyce, P, Barnes, TJ, Lundmark, R, Bergström, CA, Hubert, M & Prestidge, CA 2021, 'A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics', Journal of Pharmaceutical Sciences, vol. 110, no. 1, pp. 217-227. Open access 4 4 10
2020	Almasri, R, Joyce, P, Schultz, HB, Thomas, N, Bremmell, KE & Prestidge, CA 2020, 'Porous nanostructure, lipid composition, and degree of drug supersaturation modulate in vitro fenofibrate solubilization in silica-lipid hybrids', Pharmaceutics, vol. 12, no. 7, article no. 687, pp. 1-12. Open access 3 3 2
2020	Joyce, P, Dening, TJ, Meola, TR, Wignall, A, Ulmefors, H, Kovalainen, M & Prestidge, CA 2020, 'Contrasting anti-obesity effects of smectite clays and mesoporous silica in sprague-dawley rats', ACS Applied Bio Materials, vol. 3, no. 11, pp. 7779-7788. 1 1
2020	Joyce, P, Meola, TR, Schultz, HB & Prestidge, CA 2020, 'Biomaterials that regulate fat digestion for the treatment of obesity', Trends in Food Science and Technology, vol. 100, pp. 235-245. 9 9 4
2020	Joyce, P, Ulmefors, H, Garcia-Bennett, A & Prestidge, CA 2020, 'Microporosity, pore size, and diffusional path length modulate lipolysis kinetics of triglycerides adsorbed onto SBA-15 mesoporous silica particles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 36, no. 13, pp. 3367-3376. 6 5 1
2020	Maghrebi, S, Jambhrunkar, M, Joyce, P & Prestidge, CA 2020, 'Engineering PLGA-lipid hybrid microparticles for enhanced macrophage uptake', ACS Applied Bio Materials, vol. 3, no. 7, pp. 4159-4167. 7 7
2020	Maghrebi, S, Joyce, P, Jambhrunkar, M, Thomas, N & Prestidge, CA 2020, 'Poly(lactic-co-glycolic) acid-lipid hybrid microparticles enhance the intracellular uptake and antibacterial activity of rifampicin', ACS Applied Materials and Interfaces, vol. 12, no. 7, pp. 8030-8039. 13 13 2
2020	Meola, TR, Paxton, K, Joyce, P, Schultz, HB & Prestidge, C 2020, 'The effect of drug ionization on lipid-based formulations for the oral delivery of anti-psychotics', ADMET and DMPK, vol. 8, no. 4, pp. 437-451. Open access 3 3
2020	Schultz, HB, Joyce, P, Thomas, N & Prestidge, CA 2020, 'Supersaturated-silica lipid hybrids improve in vitro solubilization of abiraterone acetate', Pharmaceutical Research, vol. 37, no. 4, article number. 77, pp. 1-15. Open access 10 10 13
2019	Dening, TJ, Joyce, P & Prestidge, CA 2019, 'Improving correlations between drug solubilization and in vitro lipolysis by monitoring the phase partitioning of lipolytic species for lipid-based formulations', Journal of Pharmaceutical Sciences, vol. 108, no. 1, pp. 295-304. Open access 13 13
2019	Dening, TJ, Joyce, P, Kovalainen, M, Gustafsson, H & Prestidge, CA 2019, 'Spray dried smectite clay particles as a novel treatment against obesity', Pharmaceutical Research, vol. 36, no. 1, article no. 21, pp. 1-14. 7 7 121
2019	Joyce, P, Dening, TJ, Meola, TR, Gustafsson, H, Kovalainen, M & Prestidge, CA 2019, 'Nanostructured clay particles supplement orlistat action in inhibiting lipid digestion: an in vitro evaluation for the treatment of obesity', European Journal of Pharmaceutical Sciences, vol. 135, pp. 1-11. 5 5 2
2019	Joyce, P, Dening, TJ, Meola, TR, Schultz, HB, Holm, R, Thomas, N & Prestidge, CA 2019, 'Solidification to improve the biopharmaceutical performance of SEDDS: opportunities and challenges', Advanced Drug Delivery Reviews, vol. 142, pp. 102-117. Open access 47 7 4
2019	Maghrebi, S, Prestidge, CA & Joyce, P 2019, 'An update on polymer-lipid hybrid systems for improving oral drug delivery', Expert Opinion on Drug Delivery, vol. 16, no. 5, pp. 507-524. 22 19
2018	Dening, TJ, Joyce, P, Webber, JL, Beattie, DA & Prestidge, CA 2018, 'Inorganic surface chemistry and nanostructure controls lipolytic product speciation and partitioning during the digestion of inorganic-lipid hybrid particles', Journal of Colloid and Interface Science, vol. 532, pp. 666-679. 13 11 5
2018	Joyce, P & Prestidge, CA 2018, 'Synergistic effect of PLGA nanoparticles and submicron triglyceride droplets in enhancing the intestinal solubilisation of a lipophilic weak base', European Journal of Pharmaceutical Sciences, vol. 118, pp. 40-48. 11 11 7
2018	Joyce, P, Gustafsson, H & Prestidge, CA 2018, 'Engineering intelligent particle-lipid composites that control lipase-mediated digestion', Advances in Colloid and Interface Science, vol. 260, pp. 1-23. 17 18
2018	Joyce, P, Gustafsson, H & Prestidge, CA 2018, 'Enhancing the lipase-mediated bioaccessibility of omega-3 fatty acids by microencapsulation of fish oil droplets within porous silica particles', Journal of Functional Foods, vol. 47, pp. 491-502. 17 17 2
2017	Joyce, P, Dening, TJ, Gustafsson, H & Prestidge, CA 2017, 'Modulating the lipase-mediated bioactivity of particle-lipid conjugates through changes in nanostructure and surface chemistry', European Journal of Lipid Science and Technology, vol. 119, no. 12, article no. 1700213 pp. 1-9. Open access 10 9
2017	Joyce, P, Yasmin, R, Bhatt, A, Boyd, BJ, Pham, A & Prestidge, CA 2017, 'Comparison across three hybrid lipid-based drug delivery systems for improving the oral absorption of the poorly water-soluble weak base cinnarizine', Molecular Pharmaceutics, vol. 14, no. 11, pp. 4008-4018. 19 18 6
2017	Wang, L, Barclay, T, Song, Y, Joyce, P, Sakala, IG, Petrovsky, N & Garg, S 2017, 'Investigation of the biodistribution, breakdown and excretion of delta inulin adjuvant', Vaccine, vol. 35, pp. 4382-4388. Open access 13 13
2016	Dening, TJ, Joyce, P, Rao, S, Thomas, N & Prestidge, CA 2016, 'Nanostructured montmorillonite clay for controlling the lipase-mediated digestion of medium chain triglycerides', ACS Applied Materials and Interfaces, vol. 8, no. 48, pp. 32732-32742. Open access 31 31
2016	Joyce, P, Barnes, TJ, Boyd, BJ & Prestidge, CA 2016, 'Porous nanostructure controls kinetics, disposition and self-assembly structure of lipid digestion products', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 6, no. 82 , pp. 78385-78395. 29 30
2016	Joyce, P, Kempson, IM & Prestidge, CA 2016, 'Orientating lipase molecules through surface chemical control for enhanced activity: a QCM-D and ToF-SIMS investigation', Colloids and Surfaces B: Biointerfaces, vol.142, pp.173-181. 29 26
2016	Joyce, P, Whitby, CP & Prestidge, CA 2016, 'Interfacial processes that modulate the kinetics of lipase-mediated catalysis using porous silica host particles', RSC Advances: An International Journal to Further the Chemical Sciences, vol. 6, no. 49, pp. 43802-43813. 22 23 1
2016	Joyce, P, Whitby, CP & Prestidge, CA 2016, 'Nanostructuring biomaterials with specific activities towards digestive enzymes for controlled gastrointestinal absorption of lipophilic bioactive molecules', Advances in Colloid and Interface Science, vol. 237, pp. 52-75. 25 27
2015	Joyce, P, Kempson, I & Prestidge, CA 2015, 'QCM-D and ToF-SIMS Investigation to Deconvolute the Relationship between Lipid Adsorption and Orientation on Lipase Activity', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 31, n. 37, pp. 10198-10207. 21 21
2015	Joyce, P, Whitby, CP & Prestidge, CA 2015, 'Bioactive hybrid particles from poly(D,L -lactide-co-glycolide) nanoparticle stabilized lipid droplets', ACS Applied Materials and Interfaces, vol. 7, pp. 17460-17470. 28 26 4
2014	Joyce, P, Tan, A, Whitby, CP & Prestidge, CA 2014, 'The role of porous nanostructure in controlling lipase-mediated digestion of lipid loaded into silica particles', Langmuir: The ACS Journal of Surfaces and Colloids, vol. 30, no. 10, pp. 2779-2788. Open access 44 45

Other outputs

Patents

Prestidge & Joyce, ‘Novel Drug Delivery Composition Comprising Polymer-Lipid Hybrid Microparticles’ (PCT/AU2016/000080)

Research

Patents

Details	Registry	Status
Drug delivery composition comprising polymer-lipid hybrid microparticles Prestidge, Clive Allan; Joyce, Paul Matthew	Australia	Filed

External engagement & recognition

Collaborations

Highlights

Build long-term & meaningful collaborations
Research degree reviewer
Peer-reviewed over 50 journal articles
Committee member for conferences/meetings

External engagement & recognition

Collaborations

Organisation	Country
Chalmers University of Technology	SWEDEN
Glantreo Limited	IRELAND
Johnson & Johnson	UNITED STATES
Macquarie University	AUSTRALIA
Massey University	NEW ZEALAND
Monash University	AUSTRALIA
Oulun Yliopisto	FINLAND
Russian Academy of Sciences	RUSSIAN FEDERATION
Umeå University	SWEDEN
University of Gothenburg	SWEDEN
University of South Australia	AUSTRALIA
Uppsala University	SWEDEN
Vaxine Pty Ltd	AUSTRALIA

External engagement & recognition

Engagement/recognition	Year
Chair of Frontiers in Bio-Nano Science 2021 ARC Centre of Excellence in Convergent Bio-Nano Science and Technology	2021
ECR Representative Australasian Society for Biomaterials and Tissue Engineering	2021
Member American Association of Pharmaceutical Scientists	2021
Member Australasian Colloid and Interface Society	2021
Member Controlled Release Society	2021
Member Australian Nanotechnology Network (ANN)	2021
Member European Colloid & Interface Society	2021
Outreach Committee Member ARC Centre of Excellence in Convergent Bio-Nano Science and Technology	2021
STEM Professional in Schools Commonwealth Scientific and Industrial Research Organisation (CSIRO)	2021
Topic Editor Membranes	2021
Topic Editor Antibiotics	2021
YourVoice Lung Advocate Lung Foundation Australia	2021
Chair of Frontiers in Bio-Nano Science 2021 ARC Centre of Excellence in Convergent Bio-Nano Science and Technology	2020
ECR Representative Australasian Society for Biomaterials and Tissue Engineering	2020
Keynote Lecture Royal Australian Chemical Institute (RACI) Chemistry Teachers Association	2020
Member American Association of Pharmaceutical Scientists	2020
Member Australasian Colloid and Interface Society	2020
Member Controlled Release Society	2020
Member Australian Nanotechnology Network (ANN)	2020
Member European Colloid & Interface Society	2020
Outreach Committee Member ARC Centre of Excellence in Convergent Bio-Nano Science and Technology	2020
STEM Professional in Schools Commonwealth Scientific and Industrial Research Organisation (CSIRO)	2020
Topic Editor Membranes	2020
Topic Editor Antibiotics	2020
YourVoice Lung Advocate Lung Foundation Australia	2020
Member Australasian Pharmaceutical Science Association (APSA)	2019
Member American Association of Pharmaceutical Scientists	2019
Member Australasian Colloid and Interface Society	2019
Member Controlled Release Society	2019
Member Australian Nanotechnology Network (ANN)	2019
Member European Colloid & Interface Society	2019
Postdoctoral Research Fellowship Aforsk Foundation	2019
STEM Professional in Schools Commonwealth Scientific and Industrial Research Organisation (CSIRO)	2019
Topic Editor Antibiotics	2019
Keynote Presentation International Conference on Advanced Nano Materials	2018
Member Australasian Pharmaceutical Science Association (APSA)	2018
Member American Association of Pharmaceutical Scientists	2018
Member Australasian Colloid and Interface Society	2018
Member Controlled Release Society	2018
Member European Colloid & Interface Society	2018
Postdoctoral Research Fellowship Aforsk Foundation	2018
Best ECR Oral Presentation EuroFed Lipid Conference	2017
Keynote Lecture European Colloid and Interface Science Symposium	2017
Member American Association of Pharmaceutical Scientists	2017
Member Australasian Colloid and Interface Society	2017
Member Controlled Release Society	2017
Member European Colloid & Interface Society	2017
Postdoctoral Research Fellowship Aforsk Foundation	2017
Member Australasian Colloid and Interface Society	2016

Other

Member of a number of key scientific societies
Promote STEM to secondary students
Involved in 'pop science' events

Teaching & student supervision

Teaching strengths

Biomedical engineering
Pharmaceutical sciences
Colloid and interface science

Teaching & student supervision

Research degree supervision

Supervisions from 2010 shown

Thesis title	Student status
110496 - Lipid-based Nanocarrier Enabled Delivery for Improved T-cell Immunotherapy	Current
Beyond the gastrointestinal cell layer: replication of the complex oral absorption barrier through enhanced in vitro models for nanoparticulate oral protein delivery	Current
Conquering antimicrobial resistant Gram-negative bacteria to address unmet clinical needs	Current
Design of Lipid Nanoparticles (LNPs) for mRNA-Based Cancer Vaccines	Current
Developing advanced oral delivery systems for antiviral drugs	Current
Development of a safe biomaterial-based therapy for obesity	Current
Exploring the impact of formulation design on PUFA pharmacokinetics and biodistribution	Current
Lipid liquid crystalline nanoparticles: a delivery system for antimicrobial photodynamic therapy	Current
Lipid-based formulations to overcome challenges in oral drugdelivery	Current
Mesoporous silica nanoparticle for the delivery of antibacterialdrugs to treat intracellular infection	Current
Optimising treatment of haematological malignancies through the development of evidence-based dose individualisation strategies	Current
Polymer-lipid hybrid microparticles enhance the intracellular uptake and activity of rifampicin against bacterially infected macrophages	Completed

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Dr Paul Joyce

About me

About me

UniSA Clinical & Health Sciences

About me

Professional Associations

In the media

Experience

Qualifications

Work history

Research

Research focus

Highlights

Projects

Other projects

Outputs

Highlights

Journal Articles

Other outputs

Current research & highlights

Patents

External engagement & recognition

Collaborations

Highlights

Collaborations

External engagement & recognition

Chair of Frontiers in Bio-Nano Science 2021

ECR Representative

Member

Member

Member

Member

Member

Outreach Committee Member

STEM Professional in Schools

Topic Editor

Topic Editor

YourVoice Lung Advocate

Chair of Frontiers in Bio-Nano Science 2021

ECR Representative

Keynote Lecture

Member

Member

Member

Member

Member

Outreach Committee Member

STEM Professional in Schools

Topic Editor

Topic Editor

YourVoice Lung Advocate

Member

Member

Member

Member

Member

Member

Postdoctoral Research Fellowship

STEM Professional in Schools

Topic Editor

Keynote Presentation

Member

Member

Member

Member

Member

Postdoctoral Research Fellowship

Best ECR Oral Presentation

Keynote Lecture

Member

Member

Member

Member

Postdoctoral Research Fellowship

Member

Other

Teaching & student supervision

Teaching strengths

Courses and programs

Courses I teach and/or co-ordinate